EKS-SUS-00188
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00188
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2597.11.1E-179169526358
StatusUnreviewed
Ensembl ProteinENSSSCP00000003807
UniProt AccessionF1SU10;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000003506ENSSSCP00000003807ENSSSCT00000003896
OrganismSus scrofa
Functional Description
Protein Length599
Protein Sequence
(FASTA)
AARRRPSRGT MVVRQALGRG LQLGRALLLR FTAKPGPTYA WGRPERPGPA AGWGRGERPG 60
PAAGPGAEPR RLALGLPGRY RFFRQSVAGL AARLQRQFVV RARGGAGPCG RAVFLAFGLG 120
LGLIEEKQAE GRRAASACRE IQAIFTQKNK LPPDPLDTRR WQGFQLEEYL IGQSIGQGCS 180
AAVYEATMPV WPQNLEAAKS TRLLPGRGPE IIPQGEEEAR APQAPAFPLA IKMMWNISAG 240
SSSEAILSTM SQELVPASRV ALAGEYGAVP HRKSRSGPKQ LAPHPNIIRV FRAFTSSVPL 300
LPGALVDYPD VLPPRLHPEG LGHGRTLFLV MKNYPCTLRQ YLRGNTPSPR LATVMTLQLL 360
EGVDHLVQQG IAHRDLKSDN ILVELDAADG CPWLVIADFG CCLADERVGL QLPFTSWYVD 420
RGGNGCLMAP EVSTACPGPR AVIDYSKADA WAVGALAYEI FGLSNPFYGQ GRAHLESRSY 480
QEAQLPALPE SVPLDVRQLV RSLLQRDASK RPSARVAANV LHLSLWGEDT LALKNLKLDK 540
MVGWLLQQSA ATLLANRLTE KNCVETKMKM LFLANLEYEA LSQAALLLYA WRAAPCQLM 599
Nucleotide Sequence
(FASTA)
GCGGCTCGGA GGCGACCCAG CCGCGGCACC ATGGTGGTGC GACAGGCTCT GGGCCGGGGC 60
CTGCAGCTAG GCCGAGCGCT GCTGCTGCGC TTCACAGCCA AGCCTGGCCC GACCTATGCC 120
TGGGGGCGGC CCGAACGCCC GGGCCCAGCG GCGGGCTGGG GCCGCGGAGA GCGCCCTGGC 180
CCTGCCGCGG GACCCGGAGC GGAGCCGCGC AGGCTCGCGC TCGGGCTCCC CGGCCGCTAC 240
CGCTTCTTCC GCCAGTCAGT GGCCGGGCTG GCGGCGCGGC TCCAGCGACA GTTCGTAGTG 300
CGGGCCCGGG GCGGCGCGGG CCCTTGCGGC CGGGCTGTCT TTCTGGCCTT CGGGCTGGGG 360
CTGGGCCTCA TTGAGGAGAA GCAAGCGGAG GGTCGGCGGG CGGCCTCCGC CTGTCGTGAG 420
ATCCAGGCCA TTTTCACCCA GAAAAACAAG CTGCCACCTG ACCCGTTGGA CACTAGACGC 480
TGGCAGGGCT TCCAGCTGGA GGAGTATCTG ATCGGGCAGT CCATCGGCCA GGGCTGCAGC 540
GCTGCTGTGT ATGAGGCCAC CATGCCTGTG TGGCCCCAGA ACCTGGAGGC GGCGAAGAGC 600
ACCAGGCTTC TTCCCGGGAG AGGCCCAGAG ATCATTCCCC AGGGGGAAGA GGAGGCACGG 660
GCTCCACAGG CCCCCGCCTT TCCCTTGGCC ATCAAGATGA TGTGGAACAT CTCGGCGGGC 720
TCGTCCAGCG AAGCCATCCT CAGTACAATG AGCCAGGAGC TCGTCCCAGC CAGTCGGGTG 780
GCCTTGGCCG GGGAGTATGG AGCAGTCCCT CACAGAAAAT CCAGGAGCGG TCCCAAGCAG 840
CTGGCCCCTC ACCCCAACAT CATCCGGGTC TTCCGTGCCT TCACCTCGTC TGTGCCGCTG 900
TTGCCAGGGG CTCTGGTCGA CTACCCCGAT GTGCTGCCCC CACGTCTTCA CCCCGAAGGC 960
CTGGGCCATG GGCGGACACT CTTCCTCGTC ATGAAGAACT ACCCCTGTAC GCTGCGCCAG 1020
TACCTTCGCG GGAACACCCC AAGCCCCCGC CTCGCCACTG TGATGACGCT GCAGCTCCTG 1080
GAAGGGGTGG ATCACCTGGT CCAGCAGGGC ATCGCTCACA GAGACCTGAA GTCTGACAAC 1140
ATCCTTGTGG AGCTGGATGC AGCAGACGGC TGCCCCTGGT TGGTGATCGC AGACTTCGGC 1200
TGCTGCCTGG CCGATGAGCG CGTGGGCCTG CAGCTGCCTT TCACCAGCTG GTACGTGGAC 1260
CGCGGCGGAA ACGGCTGCCT GATGGCTCCT GAGGTGTCCA CAGCCTGCCC TGGCCCCAGG 1320
GCGGTGATTG ACTACAGCAA GGCTGACGCC TGGGCGGTGG GAGCGCTCGC CTACGAAATC 1380
TTCGGGCTCT CCAACCCCTT TTATGGCCAA GGCAGGGCCC ACCTTGAAAG CCGCAGTTAC 1440
CAAGAAGCTC AGCTTCCAGC GCTGCCCGAA TCAGTGCCTC TAGACGTGAG ACAGCTGGTG 1500
AGGTCGCTGC TCCAGCGAGA TGCCAGCAAG AGGCCATCCG CCCGCGTGGC TGCTAACGTG 1560
CTTCATTTAA GCCTCTGGGG TGAAGATACT CTGGCCCTGA AGAACCTGAA ACTAGACAAG 1620
ATGGTCGGCT GGCTCCTCCA GCAATCAGCT GCCACTCTGT TGGCCAACAG GCTCACAGAG 1680
AAGAACTGCG TGGAGACAAA AATGAAGATG TTATTTCTGG CCAACCTGGA GTATGAGGCG 1740
CTGAGCCAGG CAGCCCTCCT CCTCTACGCC TGGAGGGCAG CCCCATGCCA GCTGATGTAG 1800
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++g+gc+aavyeat++  +q+le+ak++ ll g++++ + +++++ +a+ a++fp
Q: 169   YLIGQSIGQGCSAAVYEATMPVWPQNLEAAKSTRLLpGRGPEIIPQGEEEARAPQAPAFP  228
         99********************************999***********************
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPniv  111
         laik+m+ni+a+sssea+l++msqelvpasrval+geygav        pk+la+hPni+
Q: 229   LAIKMMWNISAGSSSEAILSTMSQELVPASRVALAGEYGAVphrksrsgPKQLAPHPNII  288
         ************************************************************
S: 112   rvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrs  171
         rv+raf++sv+llP+al+dyPd+lp+rl+peglg+g+tl+lvmk+y++tlr+yl  +++s
Q: 289   RVFRAFTSSVPLLPGALVDYPDVLPPRLHPEGLGHGRTLFLVMKNYPCTLRQYLRGNTPS  348
         ************************************************************
S: 172   trlaalllaqlleavdhlvkhgvahrdlksdnilveld.ddeiPvlviadfGCcladkvd  230
         +rla+++++qlle+vdhlv++g+ahrdlksdnilveld  d++P+lviadfGCclad+ +
Q: 349   PRLATVMTLQLLEGVDHLVQQGIAHRDLKSDNILVELDaADGCPWLVIADFGCCLADERV  408
         **************************************99********************
S: 231   glrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfy  290
         gl+lp++s++vd+GGn++lmaPe+sta pGp+avi+y+kad+WavGalayeifglsnPfy
Q: 409   GLQLPFTSWYVDRGGNGCLMAPEVSTACPGPRAVIDYSKADAWAVGALAYEIFGLSNPFY  468
         ************************************************************
S: 291   gegkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         g+g+a+les+syqeaqlPalpesvp ++rqlv++ll+r+askr+sa++aanvl+lsl+
Q: 469   GQGRAHLESRSYQEAQLPALPESVPLDVRQLVRSLLQRDASKRPSARVAANVLHLSLW  526
         *********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGQG CSAAVYEATM PVWPQNLEAA KSTRLLPGRG PEIIPQGEEE ARAPQAPAFP 60
LAIKMMWNIS AGSSSEAILS TMSQELVPAS RVALAGEYGA VPHRKSRSGP KQLAPHPNII 120
RVFRAFTSSV PLLPGALVDY PDVLPPRLHP EGLGHGRTLF LVMKNYPCTL RQYLRGNTPS 180
PRLATVMTLQ LLEGVDHLVQ QGIAHRDLKS DNILVELDAA DGCPWLVIAD FGCCLADERV 240
GLQLPFTSWY VDRGGNGCLM APEVSTACPG PRAVIDYSKA DAWAVGALAY EIFGLSNPFY 300
GQGRAHLESR SYQEAQLPAL PESVPLDVRQ LVRSLLQRDA SKRPSARVAA NVLHLSLW 358
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013