EKS-SUS-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.42.5E-155606865260
StatusUnreviewed
Ensembl ProteinENSSSCP00000003828
UniProt AccessionF1STZ2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000003527ENSSSCP00000003828ENSSSCT00000003918
OrganismSus scrofa
Functional Description
Protein Length971
Protein Sequence
(FASTA)
ETLMDSTTAT AELGWIVHPP SGPQWEEVSG YDENMNTIRT YQVCNVFESS QNNWLRTKFI 60
RRRGAHRIHV EMKFSVRDCS SIPSVPGSCK ETFNLYYYEA DFDSATKTFP NWMENPWVKV 120
DTIAADESFS QVDLGGRVMK INTEVRSFGP VSRSGFYLAF QDYGGCMSLI AVRVFYRKCP 180
RIIQNGAVFQ ETLSGAESTS LVAARGSCIA NAEEVDVPIK LYCNGDGEWL VPIGRCMCKA 240
GFEAVENGTV CRGCPSGTFK ANQGDEACTH CPINSRTTSE GATNCVCRNG YYRADLDPLD 300
MPCTTIPSAP QAVISSVNET SLMLEWTPPR DSGGREDLVY NIICKSCGSG RGACTRCGDN 360
VQYAPRQLGL TEPRIYISDL LAHTQYTFEI QAVNGVTDQS PFSPQFASVN ITTNQAAPSA 420
VSIMHQVSRT VDSITLSWSQ PDQPNGVILD YELQYYEKGS QGPVSTRFAI KSPTNTVTVQ 480
GLKAGAIYVF QVRARTVAGY GRYSGKMYFQ TMTEAEYQTS IQEKLPLIIG SSAAGLVFLI 540
AVVVIAIVCN RRRGFERADS EYTDKLQHYT SGHMTPGMKI YIDPFTYEDP NEAVREFAKE 600
IDISCVKIEQ VIGAGEFGEV CSGHLKLPGK REIFVAIKTL KSGYTEKQRR DFLSEASIMG 660
QFDHPNVIHL EGVVTKSTPV MIITEFMENG SLDSFLRQND GQFTVIQLVG MLRGIAAGMK 720
YLADMNYVHR DLAARNILVN SNLVCKVSDF GLSRFLEDDT SDPTYTSALG GKIPIRWTAP 780
EAIQYRKFTS ASDVWSYGIV MWEVMSYGER PYWDMTNQDV INAIEQDYRL PPPMDCPSAL 840
HQLMLDCWQK DRNHRPKFGQ IVNTLDKMIR NPNSLKAMAP LSSGINLPLL DRTIPDYTSF 900
NTVDEWLEAI KMGQYKESFA NAGFTSFDVV SQMMMEDILR VGVTLAGHQK KILNSIQVMR 960
AQMNQIQSVE V 971
Nucleotide Sequence
(FASTA)
GAAACGCTGA TGGACTCAAC CACAGCGACG GCAGAGCTGG GTTGGATCGT GCATCCTCCA 60
TCAGGGCCAC AGTGGGAAGA GGTGAGTGGC TACGATGAGA ACATGAACAC CATCCGTACG 120
TACCAGGTGT GCAATGTGTT TGAGTCGAGC CAGAACAACT GGCTACGGAC CAAGTTCATC 180
CGGCGCCGTG GCGCCCACCG CATCCACGTG GAGATGAAGT TCTCCGTGCG TGACTGCAGC 240
AGCATCCCCA GTGTGCCCGG CTCCTGCAAG GAGACCTTCA ATCTCTATTA CTATGAGGCT 300
GACTTTGACT CAGCCACCAA GACCTTCCCC AACTGGATGG AGAACCCGTG GGTGAAGGTG 360
GACACCATTG CCGCTGACGA GAGCTTCTCG CAGGTGGACC TTGGAGGCCG GGTCATGAAG 420
ATCAACACCG AGGTACGGAG CTTCGGGCCT GTGTCCCGCA GCGGTTTCTA CCTGGCCTTC 480
CAGGACTATG GTGGCTGCAT GTCGCTCATC GCCGTGCGTG TCTTCTACCG CAAGTGCCCC 540
CGCATCATCC AGAACGGGGC CGTCTTCCAG GAGACACTGT CGGGGGCTGA GAGCACATCG 600
CTGGTGGCTG CCCGGGGTAG CTGCATCGCC AACGCCGAGG AGGTGGACGT GCCCATCAAG 660
CTCTACTGTA ACGGGGACGG CGAGTGGCTG GTGCCTATCG GGCGCTGCAT GTGCAAAGCA 720
GGCTTCGAGG CCGTGGAGAA TGGCACGGTC TGCCGAGGCT GCCCATCTGG AACCTTCAAG 780
GCCAACCAAG GGGACGAGGC CTGTACCCAC TGTCCCATCA ATAGCCGGAC CACTTCGGAA 840
GGGGCCACCA ACTGCGTCTG CCGCAATGGC TACTACAGAG CAGACCTGGA CCCCCTGGAC 900
ATGCCCTGCA CAACCATCCC CTCCGCACCC CAGGCCGTGA TCTCCAGTGT CAACGAGACC 960
TCCCTCATGC TGGAGTGGAC CCCACCCCGC GACTCTGGAG GCCGTGAGGA TCTCGTCTAC 1020
AACATCATCT GCAAGAGCTG CGGCTCCGGC CGGGGCGCCT GCACCCGCTG CGGGGACAAC 1080
GTGCAATACG CACCCCGCCA GCTGGGCCTG ACCGAGCCTC GCATTTACAT CAGTGACCTG 1140
CTGGCCCACA CCCAGTACAC CTTCGAGATC CAGGCCGTGA ACGGCGTCAC CGACCAGAGC 1200
CCCTTCTCAC CGCAGTTCGC CTCCGTGAAC ATCACCACCA ACCAGGCAGC TCCATCTGCT 1260
GTGTCCATCA TGCACCAGGT GAGCCGCACC GTGGACAGCA TCACCCTGTC CTGGTCCCAG 1320
CCCGACCAGC CCAACGGTGT CATCCTGGAT TACGAGCTGC AGTACTACGA GAAGGGAAGC 1380
CAGGGACCAG TCTCCACACG ATTTGCCATA AAAAGCCCCA CCAACACAGT CACTGTGCAG 1440
GGCCTCAAAG CCGGCGCCAT CTATGTCTTC CAGGTGCGGG CACGCACCGT GGCGGGCTAC 1500
GGGCGCTACA GTGGCAAGAT GTACTTCCAG ACCATGACAG AAGCCGAGTA CCAGACAAGC 1560
ATCCAGGAGA AGCTGCCACT CATCATCGGC TCCTCGGCTG CTGGCCTGGT CTTCCTCATC 1620
GCCGTGGTTG TTATTGCCAT CGTGTGTAAC AGAAGACGGG GGTTTGAGCG TGCTGACTCT 1680
GAGTACACGG ACAAGCTGCA GCACTACACC AGCGGCCACA TGACCCCGGG CATGAAGATC 1740
TACATCGACC CTTTCACCTA CGAGGACCCT AATGAGGCAG TGCGGGAGTT TGCCAAGGAA 1800
ATTGACATCT CCTGTGTCAA AATTGAGCAG GTGATCGGAG CAGGGGAGTT TGGTGAGGTA 1860
TGCAGTGGCC ACCTGAAGCT GCCAGGCAAG AGAGAGATCT TCGTAGCCAT CAAGACACTC 1920
AAGTCGGGCT ATACTGAGAA GCAGCGCCGG GACTTTCTGA GCGAGGCCTC CATCATGGGC 1980
CAGTTCGACC ACCCCAATGT CATCCACCTG GAGGGCGTGG TCACCAAGAG CACACCTGTG 2040
ATGATCATCA CTGAGTTCAT GGAGAATGGC TCCCTGGACT CCTTCCTCCG GCAAAATGAT 2100
GGGCAGTTCA CAGTCATCCA GCTGGTGGGC ATGCTCCGGG GCATCGCAGC TGGCATGAAG 2160
TACCTGGCAG ATATGAACTA CGTCCACCGC GACCTGGCCG CCCGCAACAT CCTTGTCAAC 2220
AGCAACCTGG TCTGCAAGGT GTCTGACTTT GGGCTCTCAC GCTTTCTGGA GGACGATACT 2280
TCAGACCCCA CCTACACCAG CGCCCTGGGT GGGAAGATCC CCATCCGCTG GACGGCCCCA 2340
GAAGCCATCC AGTACCGGAA GTTCACCTCG GCCAGTGACG TCTGGAGCTA TGGTATCGTC 2400
ATGTGGGAGG TGATGTCCTA TGGGGAGCGG CCCTACTGGG ACATGACCAA CCAGGATGTA 2460
ATCAACGCCA TAGAGCAGGA CTATCGGCTG CCACCACCCA TGGACTGCCC AAGCGCCCTG 2520
CACCAGCTCA TGCTGGACTG CTGGCAGAAG GACCGAAACC ACCGGCCCAA GTTCGGCCAG 2580
ATCGTCAACA CGCTGGACAA GATGATCCGC AACCCCAACA GCCTCAAAGC CATGGCGCCC 2640
CTCTCTTCTG GAATCAACCT GCCGCTGCTG GACCGCACGA TCCCTGACTA CACCAGCTTT 2700
AACACGGTGG ATGAGTGGCT GGAGGCCATC AAGATGGGGC AGTACAAGGA GAGCTTCGCC 2760
AACGCCGGCT TCACCTCCTT CGACGTCGTG TCACAGATGA TGATGGAGGA CATTCTCCGG 2820
GTTGGAGTCA CCTTGGCTGG TCACCAGAAA AAAATCCTGA ACAGTATCCA GGTGATGCGG 2880
GCACAGATGA ACCAGATCCA GTCTGTGGAG GTTTGA 2916
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 606   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  665
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 666   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  725
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 726   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  785
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 786   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  845
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 846   DCWQKDRNHRPKFGQIVNTL  865
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00004
EKS-CAF-00005
EKS-CAP-00004
EKS-DAR-00002
EKS-DRM-00001
EKS-EQC-00005
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-ICT-00004
EKS-LOA-00005
EKS-MAM-00005
EKS-MEG-00004
EKS-MIM-00001
EKS-MOD-00005
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-NOL-00005
EKS-ORN-00004
EKS-ORC-00004
EKS-ORL-00005
EKS-OTG-00003
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SAH-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XET-00003
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0048593; P:camera-type eye morphogenesis
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0007612; P:learning
GO:0050771; P:negative regulation of axonogenesis
GO:0021631; P:optic nerve morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013