EKS-SUS-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	408.6	1.3E-122	418	675	258

Status

Unreviewed

Ensembl Protein

ENSSSCP00000003861

UniProt Accession

F1STS3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000003558	ENSSSCP00000003861	ENSSSCT00000003952

Organism

Sus scrofa

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MPLAQLKEPW PLMELVPLDP ENGHAPGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS 60

HFELLKVLGQ GSFGKVFLVR KITRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120

HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180

LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT 240

HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300

PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360

KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRATQAPL HSVVQQLHGK NLVFSDGYVV 420

KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVFE 480

MGQCKQIILQ PLGGGVILLK LFCQFTLPPP EALVLLYIFL MTDEGLHSMG VVHRDLKPSN 540

ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600

GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSDAAKD LVSKMLHVDP 660

HQRLTAKQVL QHPWITQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 720

ILAQRRVRKL PSTTL 735

Nucleotide Sequence
(FASTA)

ATGCCTCTCG CTCAGCTCAA GGAGCCCTGG CCGCTCATGG AGCTGGTGCC GCTGGACCCG 60

GAGAATGGAC ACGCCCCAGG AGAAGAAGCT GGCCTTCAGC CGTCCAAGGA TGAGGGCGTC 120

CTCAAGGAGA TCTCCATCAC GCACCACGTC AAGGCAGGCT CCGAGAAGGC CGACCCGTCC 180

CATTTTGAGC TCCTCAAGGT TCTGGGCCAG GGATCCTTTG GCAAAGTCTT CCTGGTTCGG 240

AAGATCACCC GGCCTGACAG TGGACACCTG TACGCCATGA AGGTACTAAA GAAGGCGACG 300

CTGAAAGTGC GTGACCGTGT TCGGACTAAG ATGGAGCGAG ACATCCTTGC TGACGTAAAC 360

CACCCGTTTG TGGTGAAGCT GCACTACGCC TTCCAGACCG AGGGCAAGCT CTACCTTATT 420

CTGGACTTCC TGCGTGGCGG GGACCTCTTC ACACGGCTCT CCAAAGAGGT TATGTTCACG 480

GAGGAGGATG TGAAGTTTTA CCTGGCCGAG CTGGCTTTGG GCCTGGACCA CCTGCACAGC 540

CTAGGCATCA TTTACAGAGA CCTGAAGCCT GAGAACATCC TTCTGGATGA GGAGGGCCAC 600

ATCAAGCTCA CTGACTTCGG CTTGAGCAAG GAGGCCATTG ACCACGAGAA GAAGGCCTAC 660

TCCTTCTGCG GAACAGTGGA GTACATGGCC CCCGAGGTCG TCAACCGCCA GGGCCACACC 720

CACAGTGCAG ACTGGTGGTC CTATGGGGTG CTGATGTTTG AGATGCTGAC GGGCTCCCTG 780

CCCTTCCAGG GGAAGGATCG GAAAGAGACC ATGACACTGA TTCTGAAGGC GAAGCTAGGC 840

ATGCCCCAGT TTCTGAGCAC GGAAGCCCAG AGCCTCCTGC GGGCCCTGTT CAAGCGGAAT 900

CCTGCCAACC GGCTCGGCTC GGGCCCTGAC GGGGCCGAGG AGATCAAGCG GCATGTCTTC 960

TACTCCACCA TTGACTGGAA CAAGCTGTAC CGGCGTGAGA TCAAGCCACC CTTCAAGCCG 1020

GCCGTGGCAC AACCCGATGA TACCTTCTAC TTTGACACCG AGTTCACGTC CCGCACGCCC 1080

AAGGACTCCC CAGGCATCCC CCCCAGCGCT GGTGCTCATC AGCTGTTCCG TGGCTTCAGC 1140

TTCGTGGCCA CTGGCCTAAT GGAGGATGAC GGCAAGCCCC GGGCCACGCA GGCGCCCCTG 1200

CACTCGGTGG TACAGCAACT ACACGGGAAG AACCTGGTTT TTAGTGATGG CTACGTGGTA 1260

AAAGAGACCA TTGGTGTAGG CTCCTACTCC GAGTGCAAGC GCTGCGTCCA CAAGGCCACC 1320

AACATGGAGT ATGCTGTCAA GGTCATTGAC AAGAGCAAGC GAGATCCCTC GGAAGAGATT 1380

GAGATTCTTC TGCGGTACGG ACAGCACCCC AACATCATCA CCTTGAAAGA TGTTTTTGAA 1440

ATGGGCCAGT GCAAACAGAT AATATTACAG CCACTCGGTG GAGGTGTAAT TTTGTTAAAG 1500

TTGTTTTGCC AGTTTACCCT CCCCCCCCCA GAAGCATTGG TTTTACTTTA CATTTTCCTG 1560

ATGACTGATG AAGGCCTGCA CAGCATGGGT GTTGTGCACA GGGACCTCAA GCCCAGCAAC 1620

ATCCTGTATG TTGACGAGTC TGGAAACCCT GAGTGCCTGC GTATCTGTGA CTTTGGCTTT 1680

GCCAAGCAGC TGCGGGCTGA GAATGGGCTT CTCATGACAC CTTGCTATAC TGCCAACTTC 1740

GTGGCACCTG AGGTACTGAA GCGCCAGGGC TATGACGAGG GCTGCGACAT CTGGAGCCTG 1800

GGCATCCTGC TCTACACCAT GCTGGCGGGA TATACTCCAT TTGCCAACGG ACCCAGTGAC 1860

ACACCGGAGG AAATCCTGAC CCGGATCGGC AGTGGGAAGT TCACCCTCAG CGGGGGAAAT 1920

TGGAACACGG TTTCGGATGC AGCCAAGGAC CTAGTGTCCA AGATGCTGCA CGTGGACCCC 1980

CACCAACGCC TCACAGCTAA GCAGGTCCTG CAGCACCCAT GGATCACGCA GAAAGACAAG 2040

CTTCCCCAGA GCCAGCTGTC CCACCAGGAC TTGCAGCTTG TAAAGGGCGC CATGGCAGCT 2100

ACATACTCTG CGCTCAACAG CTCCAAGCCC ACCCCTCAGC TGAAGCCCAT TGAGTCATCT 2160

ATCCTGGCCC AGCGGCGGGT GAGGAAGCTG CCATCCACCA CCCTGTGA 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsys ckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 418   YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  477

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++ g+   ++l+ l GG +l ++  +  +   ea  +l+ +  + e lh+ Gvvhrdlk

Q: 478   VFEMGQCKQIILQPLGGGVILLKLFCQFTLPPPEALVLLYIFLMTDEGLHSMGVVHRDLK  537

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 538   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vs++akdlvsk+l+

Q: 598   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSDAAKDLVSKMLH  657

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 658   VDPHQRLTAKQVLQHPWI  675

         *****************8

Domain Sequence
(FASTA)

YVVKETIGVG SYSECKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VFEMGQCKQI ILQPLGGGVI LLKLFCQFTL PPPEALVLLY IFLMTDEGLH SMGVVHRDLK 120

PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSDA AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:2000491	; P:positive regulation of hepatic stellate cell activation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013