EKS-SUS-00324
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00324
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src436.05.0E-131245494250
StatusUnreviewed
Ensembl ProteinENSSSCP00000003912
UniProt AccessionF1SV94;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000003608ENSSSCP00000003912ENSSSCT00000004003
OrganismSus scrofa
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKATLPMRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQNGEWWKA QSLTTGLEGF IPFNFVAKAN 120
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180
YKIRNLDKGG FYISPRITFP GLHELVHHYT NSSDGLCTRL NRPCQTQKPQ KPWWEDEWEV 240
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NGSLVDFLKT STGIKLTINK LLDMAAQIAE GMAFIEDRNY 360
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
SDVWSFGILL TEIVTHGRIP YPGMTNTEVI QNLERGYRMV RPDNCPEELY HLMMLCWKER 480
PEERPTFDYL RSVLEDFFTA TEGQYQPQP 509
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACCCTGAA GATGACTGGA TGGAAAACAT CGACGTATGT 60
GAGAACTGCC ATTACCCCAT AGTCCCACTG GATGGCAAGG CCACGCTGCC CATGCGGAAT 120
GGCTCTGAAG TTCGGGATCC ACTGGTCACC TATGAGGGCT CCAACCCCCC AGCCTCTCCA 180
CTGCAAGACA ACCTGGTGAT CGCCCTGCAC AGCTATGAGC CTTCTCACGA TGGAGACCTG 240
GGCTTCGAGA AGGGTGAACA GCTACGTATA TTAGAGCAGA ACGGCGAGTG GTGGAAAGCA 300
CAGTCCCTGA CCACGGGCCT GGAAGGTTTC ATCCCTTTCA ACTTCGTGGC CAAAGCAAAC 360
AGCCTTGAGC CGGAACCCTG GTTCTTCAAG AATCTGAGCC GCAAGGATGC GGAGAGGCAG 420
CTTTTGGCGC CAGGGAACAC GCACGGCTCC TTCCTGATCC GGGAGAGCGA GAGCACAGCG 480
GGATCCTTTT CATTGTCCGT CCGGGACTTC GACCAGAACC AAGGAGAAGT GGTGAAACAT 540
TACAAGATCC GTAACCTGGA CAAAGGCGGC TTCTACATCT CTCCCCGCAT CACTTTTCCT 600
GGCTTGCACG AACTGGTCCA TCATTACACG AATTCTTCGG ACGGGTTGTG CACGCGATTG 660
AACCGGCCCT GCCAGACCCA GAAGCCCCAG AAGCCTTGGT GGGAGGACGA GTGGGAAGTT 720
CCCAGGGAGA CGCTGAAGCT GGTGGAGCGG CTGGGGGCTG GCCAGTTCGG GGAGGTGTGG 780
ATGGGGTACT ACAACGGGCA CACGAAGGTG GCAGTAAAGA GCCTGAAGCA GGGCAGCATG 840
TCCCCCGATG CCTTCCTGGC CGAGGCCAAC CTCATGAAGC AGCTGCAACA CCAGCGACTG 900
GTCCGGCTCT ATGCGGTGGT CACCCAGGAG CCCATCTACA TCATCACGGA ATACATGGAG 960
AATGGGAGCC TGGTGGATTT CCTCAAGACC TCCACAGGCA TCAAGCTGAC CATCAACAAA 1020
CTCTTGGACA TGGCAGCCCA AATTGCAGAG GGCATGGCAT TCATTGAAGA TCGGAATTAC 1080
ATCCACCGTG ACTTGAGGGC TGCCAATATC CTGGTGTCTG ATACCCTGAG CTGCAAGATT 1140
GCAGACTTTG GCCTAGCGCG CCTCATTGAG GACAACGAGT ACACAGCCAG GGAGGGGGCC 1200
AAGTTCCCCA TTAAGTGGAC AGCACCAGAA GCCATCAACT ACGGGACATT CACCATCAAG 1260
TCTGATGTGT GGTCTTTCGG GATCCTGCTG ACAGAGATTG TCACTCACGG TCGCATCCCA 1320
TACCCAGGAA TGACCAATAC TGAGGTGATT CAGAACCTGG AGCGAGGCTA CCGCATGGTA 1380
CGACCTGACA ACTGCCCAGA GGAGTTGTAC CACCTCATGA TGCTGTGCTG GAAGGAGCGC 1440
CCGGAGGAAC GGCCCACTTT TGACTACCTG CGCAGCGTGC TGGAGGACTT CTTCACGGCC 1500
ACGGAGGGCC AGTACCAGCC CCAGCCCTGA 1530
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  304
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+++g kl+++kl+d+aaq+aeGma++e++n+ihr
Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTSTGIKLTINKLLDMAAQIAEGMAFIEDRNYIHR  363
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 364   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn+ev++++ergyr+ rp++cpeely+l++ cwk++pee
Q: 424   WSFGILLTEIVTHGRIPYPGMTNTEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEE  483
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 484   RPTFDYLRSVL  494
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTSTGI KLTINKLLDM AAQIAEGMAF IEDRNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNTEVIQNLE RGYRMVRPDN CPEELYHLMM LCWKERPEER 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAG-00313
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MAM-00369
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-PEM-00194
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-TAG-00442
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013