EKS-SUS-00217

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00217

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	269.0	4.4E-80	3	191	189

Status

Unreviewed

Ensembl Protein

ENSSSCP00000004154

UniProt Accession

F1S786;

Protein Name

Protein Synonyms/Alias

5'-AMP-activated protein kinase catalytic subunit alpha-2;

Gene Name

PRKAA2

Gene Synonyms/Alias

PRKAA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000003837	ENSSSCP00000004154	ENSSSCT00000004249

Organism

Sus scrofa

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

KRYQVISTPT DFFMVMEYVS GGELFDYICK HGRVEEMEAR RLFQQILSAV DYCHRHMVVH 60

RDLKPENVLL DAQMNAKIAD FGLSNMMSDG EFLRTSCGSP NYAAPEVISG RLYAGPEVDI 120

WSCGVILYAL LCGTLPFDDE HVPTLFKKIR GGVFYIPEYL NRSVATLLMH MLQVDPLKRA 180

TIKDIREHEW FKQDLPSYLF PEDPSYDANV IDDEAVKEVC EKFECTESEV MNSLYSGDPQ 240

DQLAVAYHLV IDNRRIMNQA SEFYLASSPP TGSFMDDSAM HIPPGLKPHP ERMPPLIADS 300

PKARCPLDAL NTTKPKSLAV KKAKWHLGIR SQSKPYDIMA EVYRAMKQLD FEWKVVNAYH 360

LRVRRKNPVT GNYVKMSLQL YLVDNRSYLL DFKSIDDEVL EQRSGSSTPQ RSCSAAGLHR 420

PRSSLDSVTA ESHSLSGSLS GSLTGSMLPS VPPRLGSHTM DFFEMCASLI TTLAR 475

Nucleotide Sequence
(FASTA)

AAAAGATACC AGGTGATCAG CACTCCGACA GATTTTTTTA TGGTAATGGA ATATGTGTCT 60

GGTGGTGAAT TATTTGATTA CATCTGTAAA CATGGACGGG TTGAAGAGAT GGAAGCCAGG 120

CGGCTCTTTC AGCAGATTCT CTCTGCCGTG GATTACTGTC ACAGGCATAT GGTTGTTCAT 180

CGAGACCTGA AACCAGAGAA TGTGCTATTG GATGCACAGA TGAATGCCAA GATAGCAGAT 240

TTTGGATTAT CTAATATGAT GTCAGATGGT GAGTTTCTGC GAACTAGTTG TGGGTCTCCA 300

AATTACGCAG CACCTGAAGT CATCTCAGGC AGATTGTATG CAGGTCCTGA GGTCGATATC 360

TGGAGCTGCG GTGTTATTTT GTATGCTCTT CTTTGTGGCA CACTCCCATT TGATGATGAG 420

CATGTGCCTA CATTGTTTAA GAAGATCCGA GGGGGTGTTT TTTATATCCC AGAATATCTC 480

AATCGTTCTG TTGCCACTCT CCTGATGCAT ATGCTGCAGG TTGACCCCCT GAAACGAGCA 540

ACTATCAAAG ACATAAGAGA GCATGAATGG TTTAAACAAG ATTTGCCCAG TTACTTATTT 600

CCTGAAGACC CCTCCTATGA TGCTAACGTC ATTGATGATG AGGCTGTGAA AGAAGTGTGT 660

GAAAAATTTG AGTGTACAGA ATCAGAAGTA ATGAACAGTT TGTATAGTGG TGACCCTCAA 720

GACCAGCTTG CAGTGGCTTA TCATCTTGTC ATTGACAATC GGAGAATAAT GAACCAAGCC 780

AGTGAGTTCT ACCTCGCCTC TAGTCCCCCA ACTGGTTCTT TTATGGATGA TAGTGCCATG 840

CATATTCCCC CAGGCCTGAA ACCTCATCCA GAAAGGATGC CACCTCTTAT AGCAGACAGC 900

CCTAAAGCAA GATGTCCATT GGATGCACTG AATACAACCA AGCCCAAATC TTTAGCTGTG 960

AAAAAAGCCA AGTGGCATCT TGGGATTCGA AGTCAAAGCA AACCATATGA CATTATGGCT 1020

GAAGTTTACC GAGCTATGAA GCAGCTGGAT TTTGAATGGA AGGTAGTGAA TGCATACCAT 1080

CTACGTGTAA GAAGAAAAAA TCCAGTGACT GGCAATTATG TGAAAATGAG CTTACAGTTG 1140

TACCTGGTTG ACAATAGAAG CTATCTTTTG GACTTTAAAA GCATTGATGA TGAGGTGCTG 1200

GAGCAGAGGT CTGGTTCCTC AACACCTCAG CGGTCCTGCT CTGCTGCTGG CTTGCACAGA 1260

CCGCGGTCAA GCTTGGATTC TGTCACTGCG GAGAGCCACT CACTCTCTGG CTCTCTCTCT 1320

GGCTCCTTGA CCGGAAGCAT GCTGCCTTCA GTTCCACCTC GCCTGGGCAG TCACACCATG 1380

GATTTTTTCG AAATGTGTGC CAGTCTGATC ACTACTTTAG CCCGTTGA 1428

Domain Profile

S: 64    levietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrD  123

         ++vi+t +++++v+ey+sggeLfdyi ++gr++e ear+lf+q++sav+Y+h++ +vHrD

Q: 3     YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD  62

         89**********************************************************

S: 124   lKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWs  183

         lKpeN+lld+++n kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws

Q: 63    LKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS  122

         ************************************************************

S: 184   lGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekRati  243

         +Gv+Lyal++g+lPfd+e++ +l++ki  g + ip++l++++++Ll ++L+vdp kRati

Q: 123   CGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATI  182

         ************************************************************

S: 244   eeilkhewl  252

         ++i++hew+

Q: 183   KDIREHEWF  191

         ********7

Domain Sequence
(FASTA)

YQVISTPTDF FMVMEYVSGG ELFDYICKHG RVEEMEARRL FQQILSAVDY CHRHMVVHRD 60

LKPENVLLDA QMNAKIADFG LSNMMSDGEF LRTSCGSPNY AAPEVISGRL YAGPEVDIWS 120

CGVILYALLC GTLPFDDEHV PTLFKKIRGG VFYIPEYLNR SVATLLMHML QVDPLKRATI 180

KDIREHEWF 189

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0042593	; P:glucose homeostasis
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013