EKS-SUS-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	398.8	1.3E-119	37	321	285

Status

Unreviewed

Ensembl Protein

ENSSSCP00000004213

UniProt Accession

B8XSK1;

Protein Name

Protein Synonyms/Alias

MAP kinase interacting serine/threonine kinase 1;

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000003898	ENSSSCP00000004213	ENSSSCT00000004313

Organism

Sus scrofa

Functional Description

Protein Length

416

Protein Sequence
(FASTA)

MGSSEPVPIA ESDKRRRKKR KARATDSLPG KFEDMYKLTS ELLGEGAYAK VQGAVSLQNG 60

KEYAVKIIEK QSGHSRSRVF REVETLYQCQ GNKNILELIE FFEDDTRFYL VFEKLQGGSI 120

LAHIQRQKHF NELEASRVVR DVATALDFLH TKGIAHRDLK PENILCESPE KVSPVKICDF 180

DLGSGVKLNN SCTPITTPEL TTPCGSAEYM APEVVEVFTD EATFYDKRCD LWSLGVVLYI 240

MLSGYPPFVG HCGADCGWDR GEVCPVCQNK LFESIQEGKY EFPDKDWAHI SSEAKDLISK 300

LLVRDAKQRL SAAQVLQHPW VQGQAPERGL PTPQVLQRNS STMDLTLFAA EAIALNRQLS 360

QHEENELAKE SEALAEGLCS VKLSPPSKSR LARRRALAQA GRSGDTQSCP TTPTGL 416

Nucleotide Sequence
(FASTA)

ATGGGCAGCA GTGAACCCGT TCCCATTGCA GAAAGTGACA AGAGGAGAAG GAAGAAGCGG 60

AAGGCCCGGG CCACCGATTC CTTGCCGGGG AAGTTTGAAG ATATGTACAA GCTGACCTCG 120

GAACTGCTCG GAGAGGGAGC CTATGCCAAA GTTCAAGGTG CCGTGAGCCT GCAGAATGGC 180

AAGGAGTATG CTGTCAAAAT CATCGAAAAA CAATCAGGAC ACAGTCGGAG TAGGGTGTTT 240

CGAGAGGTGG AGACGCTCTA TCAGTGTCAA GGAAACAAGA ACATTTTGGA GCTGATTGAG 300

TTCTTTGAAG ATGACACAAG GTTTTACTTG GTCTTTGAGA AACTGCAAGG AGGCTCCATC 360

CTGGCCCACA TCCAGAGGCA GAAGCACTTC AATGAGCTAG AAGCCAGCCG AGTGGTGCGG 420

GATGTTGCCA CTGCCCTTGA TTTCCTGCAC ACCAAGGGCA TTGCTCACCG CGATCTGAAG 480

CCAGAAAATA TATTGTGTGA ATCTCCAGAA AAGGTGTCTC CAGTGAAAAT CTGTGACTTT 540

GACTTGGGCA GTGGGGTGAA ACTGAACAAC TCCTGCACCC CCATAACCAC ACCAGAGCTG 600

ACGACTCCAT GCGGCTCTGC AGAATACATG GCCCCCGAGG TGGTGGAGGT CTTCACGGAC 660

GAGGCCACCT TTTACGACAA GCGCTGTGAC CTGTGGAGCC TGGGCGTGGT CCTCTACATC 720

ATGCTGAGCG GCTACCCGCC CTTCGTGGGT CACTGCGGGG CCGACTGCGG CTGGGACCGG 780

GGAGAGGTCT GCCCGGTGTG CCAGAACAAG CTGTTTGAGA GCATCCAGGA AGGCAAGTAT 840

GAGTTTCCGG ACAAGGACTG GGCACACATC TCCAGCGAGG CCAAAGACCT CATCTCCAAG 900

CTCCTGGTTC GAGACGCAAA GCAGAGACTG AGCGCTGCCC AAGTCCTGCA GCACCCGTGG 960

GTTCAAGGGC AAGCTCCAGA AAGGGGACTC CCCACGCCGC AAGTCCTCCA GAGAAATAGC 1020

AGCACAATGG ACCTGACACT CTTCGCAGCC GAGGCCATCG CCCTGAACCG CCAGCTGTCT 1080

CAGCACGAGG AGAATGAACT GGCAAAGGAG TCGGAGGCGC TGGCCGAGGG CCTCTGCTCT 1140

GTGAAGCTTT CCCCTCCCTC CAAGTCACGC CTGGCCCGCC GGAGGGCACT GGCCCAGGCA 1200

GGCCGCAGTG GAGACACACA GTCATGCCCA ACAACACCCA CAGGGCTCTG A 1251

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+

Q: 37    KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIekqsgHSRSRVFREVETLYQCQGNKNIL  96

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq++k+f+e eas+vv+d+a+al+flh+k

Q: 97    ELIEFFE----DDTRFYLVFEKLQGGSILAHIQRQKHFNELEASRVVRDVATALDFLHTK  152

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaket.eee........eelktpcltaeyva  166

         +iahrDlkpen+L+es+ek++pvk+cDf+l++++   +        +el+tpc++aey+a

Q: 153   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVkL-NnsctpittPELTTPCGSAEYMA  211

         ********************************9952.345899999**************

S: 167   PevleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskkl  215

         Pev+e++++ea++ydk+CDlWslGv+lyi+l+GypPf++++g             +++kl

Q: 212   PEVVEVFTDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcPVCQNKL  271

         *****************************************99*********99******

S: 216   keriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +e+iqegkyefP+++W+++s+eakdli+klL+rd+k+rl++++vl+hpwv

Q: 272   FESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV  321

         *************************************************8

Domain Sequence
(FASTA)

KLTSELLGEG AYAKVQGAVS LQNGKEYAVK IIEKQSGHSR SRVFREVETL YQCQGNKNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQR QKHFNELEAS RVVRDVATAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGV KLNNSCTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDEATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCPV CQNKLFESIQ 240

EGKYEFPDKD WAHISSEAKD LISKLLVRDA KQRLSAAQVL QHPWV 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0018105	; P:peptidyl-serine phosphorylation

KEGG

ssc:100233194

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013