EKS-SUS-00139
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00139
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb490.71.1E-147420677258
StatusUnreviewed
Ensembl ProteinENSSSCP00000004346
UniProt AccessionF1SBY1;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000004022ENSSSCP00000004346ENSSSCT00000004447
OrganismSus scrofa
Functional Description
Protein Length738
Protein Sequence
(FASTA)
LSHFRMGDPF ERSGADRPQD KVSEARRLPW LSRIPPCPEE GVVKEVDISH HVKAGFEKAD 60
PSQFELLKVL GQGSYGKVFL VRKVKGSDAG QLYAMKVLKK ATLKVRDRVR SKMERDILAE 120
VNHPFIVKLH YAFQTEGKLY LILDFLRGGD LFTRLSKEVM FTEEDVKFYL AELALALDHL 180
HGLGIIYRDL KPENILLDEE GHIKITDFGL SKEAIDHDKR AYSFCGTIEY MAPEVVNRRG 240
HTQSADWWSF GVLMFEMLTG SLPFQGKDRK ETMALVLKAK LGMPQFLSAE AQSLLRALFK 300
RNPCNRLGAG LDGVEEIKRH PFFATIDWNK LYRKEIKPPF KPAVGRPEDT FHFDPEFTTR 360
TPTDSPGVPP SANAHHLFRG FSFVASSLVQ EPSQQDLHKA TVHPIVQQLH GNNIHFTDGY 420
EIKEDIGVGS YSVCKRCVHK ATDAEYAVKI IDKSKRDPSE EIEILLRYGQ HPNIITLKDV 480
YDDGKCVYLV MELMRGGELL DRILRQRCFS EREASDVLCT IAKTMDYLHS QGVVHRDLKP 540
SNILYMDESG NPESIRICDF GFAKQLRAEN GLLMTPCYTA NFVAPEVLKR QGYDAACDIW 600
SLGILLYTML AGFTPFANGP DDTPEDILAR IGSGKYALSG GNWDSISDAA KDVVSKMLHV 660
DPHQRLTAVQ VLKHPWIVNR EYLSQNQLSR QDVHLVKGAM AATYFALNRT PQAPRLEPVL 720
SSSLAQRRGM KRLTSTRL 738
Nucleotide Sequence
(FASTA)
CTAAGCCACT TCCGCATGGG GGACCCTTTT GAGCGGAGCG GTGCAGACAG ACCTCAAGAC 60
AAAGTCTCAG AGGCCCGTCG CCTCCCATGG CTTTCCCGTA TCCCTCCCTG TCCGGAAGAA 120
GGCGTCGTCA AGGAGGTTGA CATCAGCCAT CATGTGAAGG CCGGCTTTGA GAAGGCCGAC 180
CCATCCCAGT TCGAGCTGCT GAAAGTTCTG GGTCAAGGAT CCTATGGGAA GGTGTTCCTG 240
GTGAGGAAGG TCAAGGGGTC CGACGCGGGG CAGCTCTACG CCATGAAGGT CCTAAAGAAG 300
GCCACCTTGA AAGTTCGGGA CCGAGTCAGA TCGAAGATGG AGAGAGACAT TTTGGCAGAA 360
GTGAACCACC CCTTCATCGT AAAGCTTCAC TACGCCTTCC AGACGGAGGG GAAACTCTAC 420
CTGATTCTGG ACTTCCTGCG GGGAGGGGAC CTCTTCACCA GGCTCTCCAA GGAGGTGATG 480
TTCACCGAGG AGGATGTCAA GTTCTACCTG GCGGAGCTGG CCTTGGCCTT AGACCACCTG 540
CACGGCCTGG GGATCATCTA CAGGGATCTG AAACCGGAGA ACATCCTCCT GGACGAAGAG 600
GGGCACATTA AAATCACAGA TTTCGGGCTG AGTAAGGAGG CCATCGACCA CGACAAGAGA 660
GCGTACTCCT TCTGCGGGAC CATAGAGTAC ATGGCGCCCG AGGTGGTGAA CCGGAGGGGA 720
CACACGCAGA GCGCGGACTG GTGGTCCTTC GGCGTGCTCA TGTTCGAGAT GCTCACGGGG 780
TCCCTGCCGT TCCAGGGGAA GGACAGGAAG GAGACCATGG CCCTCGTCCT AAAAGCCAAG 840
CTGGGCATGC CCCAGTTCCT CAGCGCGGAG GCCCAGAGTC TGCTCAGAGC CCTCTTCAAA 900
CGGAACCCCT GCAACCGGCT GGGTGCTGGC CTCGACGGCG TGGAGGAGAT CAAGCGTCAC 960
CCTTTCTTTG CCACCATCGA CTGGAATAAG CTGTACAGGA AGGAGATCAA GCCGCCCTTC 1020
AAGCCGGCGG TGGGCAGGCC GGAGGACACC TTCCACTTCG ACCCCGAGTT CACCACCAGG 1080
ACGCCCACAG ACTCACCTGG CGTCCCCCCC AGTGCCAACG CTCATCATCT GTTTAGAGGA 1140
TTCAGTTTTG TGGCCTCCAG CCTGGTCCAG GAGCCCTCGC AGCAAGATCT GCACAAAGCC 1200
ACAGTTCACC CCATCGTGCA GCAGTTACAC GGGAACAACA TCCACTTCAC CGACGGCTAC 1260
GAGATCAAGG AGGACATTGG CGTGGGCTCC TACTCCGTGT GCAAGCGCTG TGTGCACAAA 1320
GCCACGGATG CCGAGTACGC CGTGAAGATC ATCGACAAGA GCAAAAGGGA CCCCTCGGAG 1380
GAGATCGAGA TCCTGCTGCG CTACGGCCAG CACCCCAACA TCATCACGCT CAAGGACGTC 1440
TACGACGACG GGAAGTGCGT GTACCTGGTG ATGGAGCTGA TGCGCGGCGG GGAGCTCCTG 1500
GACCGCATCC TCCGGCAGAG GTGCTTCTCG GAGCGGGAGG CCAGCGACGT GCTGTGCACC 1560
ATCGCCAAGA CCATGGACTA CCTCCACTCC CAGGGGGTGG TTCATCGGGA CCTGAAGCCG 1620
AGCAATATCC TCTACATGGA CGAGTCTGGA AACCCCGAGT CCATCCGCAT CTGTGACTTC 1680
GGCTTTGCCA AGCAGCTGCG AGCCGAGAAC GGGCTGCTGA TGACGCCGTG CTACACGGCC 1740
AACTTCGTGG CCCCGGAGGT CCTGAAGCGG CAAGGCTATG ACGCGGCATG TGACATCTGG 1800
AGCCTGGGGA TCCTGTTGTA CACCATGCTG GCAGGATTTA CCCCTTTTGC CAACGGCCCC 1860
GACGACACGC CCGAGGACAT CCTGGCGAGG ATCGGCAGCG GGAAGTACGC GCTCTCGGGG 1920
GGGAACTGGG ACTCCATATC CGACGCGGCC AAGGACGTCG TGTCCAAGAT GCTCCACGTG 1980
GACCCCCATC AGCGCCTGAC GGCCGTTCAA GTCCTCAAAC ACCCGTGGAT CGTGAACAGA 2040
GAGTACCTGT CCCAGAACCA GCTCAGCAGA CAAGACGTCC ACCTGGTGAA GGGAGCCATG 2100
GCCGCCACCT ACTTCGCCCT GAACAGAACG CCTCAGGCCC CGAGGCTGGA GCCCGTGCTG 2160
TCGTCCAGCC TGGCCCAGCG CCGTGGCATG AAGAGACTCA CGTCCACGCG GCTATAG 2217
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 420   YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  479
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 480   VYDDGKCVYLVMELMRGGELLDRILRQRCFSEREASDVLCTIAKTMDYLHSQGVVHRDLK  539
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 540   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  599
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+e+ila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 600   WSLGILLYTMLAGFTPFANGPDDTPEDILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  659
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 660   VDPHQRLTAVQVLKHPWI  677
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATDAEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKCVYL VMELMRGGEL LDRILRQRCF SEREASDVLC TIAKTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEDILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013