EKS-SUS-00326

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00326

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	419.9	4.2E-126	243	496	254

Status

Unreviewed

Ensembl Protein

ENSSSCP00000004783

UniProt Accession

F1RZK6;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000004434	ENSSSCP00000004783	ENSSSCT00000004899

Organism

Sus scrofa

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MGNFCLRLRA YLEPYLPCLS REGADKPLGI RNPGAVCPPD PPPPAPKPVT SQGHYFVALF 60

DYQARTAEDL SFRAGDKLQV LDTSHEGWWL ARHLEKRADG SGQLLQGYIP SNYVAEDRSL 120

QAEPWFFGAI KRADAEKQLL YPENQEGAFL IRESESQKGD FSLSVLHEGI VKHYRIRRLD 180

EGGFFLTRRR TFSTLNEFVS HYSRTSDGLC VKLGKPCLKI QVPATIDLSY KTADQWEIDR 240

NSIQLLKRLG SGQFGEVWEG LWNNTTPVAV KTLKPGSMDP NDFLREAQIM KNLRHPKLIQ 300

LYAVCTLEDP IYIITELMRH GSLQEYLQND AGSKIHLTQQ VDMAAQVASG MAYLESQNYI 360

HRDLAARNVL VGEHNIYKVA DFGLARVFKV DNEDIYESKH EIKLPVKWTA PEAIRANKFS 420

IKSDVWSFGV LLYEIITYGK MPYSGMTGAQ VIQMLGQNYR LPQPANCPPE FYNIMLECWN 480

EEPKERPTFE MLHWKFEDYF DIDSSYSDTN N 511

Nucleotide Sequence
(FASTA)

ATGGGTAACT TTTGCCTGAG GCTCCGGGCA TACCTGGAGC CCTATCTGCC CTGCTTGTCC 60

CGGGAGGGAG CAGACAAGCC TTTGGGGATT AGAAATCCAG GGGCTGTTTG CCCCCCTGAC 120

CCTCCCCCTC CAGCTCCAAA GCCTGTGACA AGCCAGGGCC ACTACTTTGT GGCTCTGTTT 180

GATTACCAGG CTCGGACCGC TGAGGACCTT AGCTTCCGAG CAGGCGACAA GCTCCAGGTC 240

CTGGATACTT CCCACGAGGG CTGGTGGTTG GCAAGGCACT TGGAGAAAAG GGCAGACGGC 300

TCTGGCCAGC TGCTGCAGGG CTATATCCCT TCTAACTATG TGGCCGAGGA CAGGAGCCTC 360

CAGGCAGAGC CGTGGTTCTT CGGAGCAATC AAGAGAGCAG ATGCAGAAAA ACAACTATTA 420

TATCCAGAAA ATCAGGAGGG TGCTTTTCTA ATCAGAGAAA GTGAAAGTCA GAAAGGCGAT 480

TTCTCCCTTT CAGTTTTACA CGAAGGGATT GTGAAACACT ACAGAATCAG AAGACTGGAT 540

GAAGGGGGTT TTTTTCTCAC CCGGAGAAGA ACCTTTTCAA CATTGAATGA GTTCGTGAGT 600

CACTACAGCA GGACAAGTGA TGGCCTGTGT GTTAAGCTGG GAAAACCATG CTTAAAGATA 660

CAAGTCCCGG CTACCATTGA TCTGTCATAT AAAACTGCGG ATCAGTGGGA GATCGACCGC 720

AACTCCATAC AACTTCTGAA GCGATTAGGA TCTGGTCAGT TCGGAGAAGT GTGGGAAGGC 780

CTATGGAACA ATACCACTCC AGTAGCCGTA AAAACATTAA AACCAGGTTC AATGGATCCA 840

AATGACTTCC TGAGGGAGGC ACAGATAATG AAGAATCTAA GGCATCCCAA GCTTATCCAG 900

CTCTATGCTG TTTGCACTTT AGAAGATCCA ATTTATATTA TTACAGAGTT GATGCGACAT 960

GGAAGTCTGC AAGAATATCT CCAAAATGAC GCTGGATCAA AAATCCATCT GACACAGCAG 1020

GTAGACATGG CAGCCCAGGT TGCCTCTGGG ATGGCCTACC TGGAGTCCCA GAACTACATC 1080

CATAGAGATC TGGCTGCTAG AAATGTCCTT GTGGGTGAAC ATAATATCTA CAAAGTGGCA 1140

GATTTTGGAC TTGCAAGAGT TTTTAAGGTA GATAATGAAG ACATCTATGA ATCTAAACAC 1200

GAAATAAAGC TGCCGGTAAA GTGGACTGCG CCTGAAGCTA TTCGTGCTAA TAAATTCAGC 1260

ATTAAGTCCG ATGTGTGGTC ATTTGGAGTC CTTCTTTATG AAATCATTAC TTATGGCAAA 1320

ATGCCTTATA GTGGTATGAC AGGTGCTCAA GTAATCCAGA TGTTGGGGCA AAACTATAGA 1380

CTTCCTCAAC CAGCCAACTG TCCACCGGAA TTCTACAACA TCATGTTGGA GTGCTGGAAT 1440

GAAGAGCCTA AGGAACGGCC AACATTTGAG ATGCTGCATT GGAAATTTGA GGATTATTTT 1500

GATATAGACT CTTCATATTC AGATACAAAC AACTGA 1536

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 243   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  302

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 303   AVCTLEDPIYIITELMRHGSLQEYLQNDAGSKIHLTQQVDMAAQVASGMAYLESQNYIHR  362

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+ +kf+ik

Q: 363   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRANKFSIK  422

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfG+ll+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp e+y+++lecw+++

Q: 423   SDVWSFGVLLYEIITYGKMPYSGMTGAQVIQMLGQNYRLPQPANCPPEFYNIMLECWNEE  482

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfe+l++++

Q: 483   PKERPTFEMLHWKF  496

         **********9975

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG SKIHLTQQVD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRANKFSIK 180

SDVWSFGVLL YEIITYGKMP YSGMTGAQVI QMLGQNYRLP QPANCPPEFY NIMLECWNEE 240

PKERPTFEML HWKF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

ssc:100157810

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013