EKS-SUS-00411

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00411

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	346.4	1.4E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSSSCP00000004983

UniProt Accession

F1RZB8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000004624	ENSSSCP00000004983	ENSSSCT00000005107

Organism

Sus scrofa

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 420

TEPCWQYPDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCEKNGL VKAQIALEEA SQQLAEKERE KNQGFDFDSF IAGTIQLSSQ 540

HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SREKQEKGKA NLAQLEALYQ SSWDSQFVGG 600

GEDCFLINQF CCEVRKDEHI EKENNYTSYL DKFFSRKEDT EMLETEPVED GKLGERENEE 660

GFLNNSGEFL FNKQLESIGI PQFHSPVGSP LKSIQATLTP SAMKSSPQIP HKTYSSILKH 720

LN 722

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATAGTCCTTA CTGATCCCCA GAGTGTCAAA 180

CATGCTCTAC GTGAAATTAA AATTATTAGA AGACTTGACC ATGATAACAT TGTGAAGGTG 240

TTTGAAATTC TTGGTCCTAG TGGAAGCCAG TTAACAGATG ATGTGGGCTC TCTTACCGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAA 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGTGGGCTC 420

AAATATATTC ACTCAGCAAA CGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AACACTGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCC 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ACATGTGGGC TGCAGGTTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACT CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTT GTGCATGAGG AAGATCGTCA GGAGCTTCTC 780

AGCGTAATTC CAGTTTACAT TAGAAATGAT ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACTTTTAGC 900

CCCATGGATC GGTTGACAGC AGAAGAAGCG CTTTCCCATC CTTACATGAG CATTTATTCT 960

TTTCCAATGG ATGAGCCTAT TTCAAGTCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC TCATAGTCAC ATTTATAACT GGGAAAGGTA CCATGATTGT 1080

CAGTTTTCAG AGCATGATTG GCCTATACAT AACAACTTTG ATATTGACGA AGTTCAGCTT 1140

GACCCAAGAG CTCTGTCTGA TGTCACTGAC GAAGAAGAAG TACAAGTCGA TCCTCGAAAA 1200

TATTTGGATG GAGATCGTGA AAAGTATTTG GAGGATCCTG CTTTTGATAC CAATTACTCT 1260

ACTGAGCCTT GTTGGCAGTA CCCAGATCAT CATGAAAACA AATATTGTGA TCTGGAGTGT 1320

AGCCATACTT GTAACTACAA AACCAGGTCA TCATCCTATT TAGATAATTT AGTTTGGAGA 1380

GAGAGTGAAG TTAATCATTA CTATGAACCC AAGCTTATTA TAGATCTTTC CAATTGGAAA 1440

GAACAAAGCA AAGAAAAATC TGATAAGAAA GGCAAGTCAA AATGTGAAAA GAATGGATTG 1500

GTTAAAGCCC AGATAGCCCT AGAGGAAGCA TCACAGCAGT TGGCTGAAAA AGAAAGGGAA 1560

AAGAATCAGG GATTTGACTT TGATTCCTTT ATTGCAGGAA CTATTCAACT TAGTTCACAA 1620

CATGAGCCTA CTGATGTTGT TGACAAATTA AATGACTTGA ATAGCTCAGT GTCCCAACTA 1680

GAATTGAAAA GTTTGATATC GAAGTCAGTA AGCCGAGAAA AACAGGAAAA AGGAAAGGCA 1740

AATTTAGCTC AGTTAGAAGC CTTGTACCAG TCTTCTTGGG ATAGCCAGTT TGTGGGTGGT 1800

GGAGAGGACT GTTTTCTCAT AAATCAGTTT TGTTGTGAGG TAAGGAAGGA TGAGCATATT 1860

GAAAAGGAAA ATAATTACAC CAGTTACCTG GACAAGTTCT TTAGCAGGAA GGAAGATACT 1920

GAAATGCTAG AAACTGAGCC GGTAGAAGAT GGGAAGCTTG GGGAGAGAGA AAATGAGGAA 1980

GGATTTCTGA ATAACAGTGG GGAGTTCCTC TTTAACAAGC AGCTTGAATC CATAGGCATC 2040

CCGCAGTTTC ACAGTCCAGT TGGGTCACCG CTTAAGTCAA TACAGGCCAC ATTAACACCT 2100

TCTGCTATGA AATCTTCCCC TCAGATTCCT CATAAAACAT ACAGCAGCAT TCTGAAACAT 2160

CTGAACTAA 2169

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity

KEGG

ssc:396833

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013