EKS-SUS-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	548.1	4.0E-165	587	852	266

Status

Unreviewed

Ensembl Protein

ENSSSCP00000005116

UniProt Accession

F1SSV9;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000004744	ENSSSCP00000005116	ENSSSCT00000005243

Organism

Sus scrofa

Functional Description

Protein Length

959

Protein Sequence
(FASTA)

QERPRGPCAA DGRRGDSQRA RVSERGPSAA PRPPAALPHL AAPPLLPPPS SLAGRARHGA 60

ASPPMALRRS MGRSGLLPLP LPPPSPPLLL LLLLAGLAAL LLPESAAAGL KLMGAPVKLT 120

VSQGQPVKLN CSVEGMEEPE IQWVKDGAVV QSVDQVYIPV SEQHWIGFLS LKSVERSDAG 180

RYWCQVEDGG ETETSQPVWL TVEGVPFFTV EPKDLAVPPN APFQLSCEAV GPPEPVTIVW 240

WRGGTKVGGP APSPSVLNVT GVTQSTEFSC EAHNLKGLAS SRPATVRLQA LPAAPFNITV 300

TKLSSSNASV AWMPGADGRA LLQSCTVQVT QAPGGWEVLA VVVPVPPFTC LLRDLAPATN 360

YSLRVRCANA LGPSPYADWV PFRTKGLGTA PASAPQNLHA IRTESGLILE WEEVIPEGPM 420

EGPLGPYKLS WVQDNGTQGE LTVEGTRANL TGWDPQKDLT VRVCVSNAVG CGPWSQPLVV 480

SPHDHAGQHG PPHSRTSWVP VVLGVLTALV TAAALALILL RKRRKETRFG QAFDSVMARG 540

EPAVHFRAAR SFNRERPERI EATLDSLGIS DELKDKLEDV LIPEQQFTLG RMLGKGEFGS 600

VREAQLKQED GSFVKVAVKM LKADIIASSD IEEFLREAAC MKEFDHPHVA KLVGVSLRSR 660

AKGRLPIPMV ILPFMKHGDL HAFLLASRIG ENPFNLPLQT LVRFMVDIAC GMEYLSSRNF 720

IHRDLAARNC MLAEDMTVCV ADFGLSRKIY SGDYYRQGCA SKLPVKWLAL ESLADNLYTV 780

HSDVWAFGVT MWEIMTRGQT PYAGIENAEI YNYLIGGNRL KQPPECMEDV YELMYQCWSA 840

DPKQRPSFTC LRMELENVLG RLSVLSTSQD PLYINLEGAQ EPAEGGSLEL PGGDQASGRA 900

GDGSGLEAVG GIPSDYRYIL SPGGLAERPE QEEQQPESPV NEAQGLLLLQ QGLLPHSSC 959

Nucleotide Sequence
(FASTA)

CAGGAGCGGC CCCGGGGACC CTGTGCGGCT GACGGCCGCC GCGGCGACTC GCAGCGGGCG 60

CGGGTCTCGG AGCGCGGCCC CAGCGCCGCC CCCCGCCCTC CCGCTGCCCT CCCCCACCTC 120

GCCGCTCCTC CTCTCCTCCC TCCTCCCTCG TCGCTCGCGG GCCGGGCCCG GCATGGTGCG 180

GCGTCGCCGC CGATGGCGCT GAGGCGGAGC ATGGGGCGGT CGGGGCTCCT GCCGCTGCCG 240

CTGCCGCCGC CGTCGCCGCC GCTGCTGCTG CTGCTGCTGC TGGCGGGTCT GGCCGCGCTG 300

CTGCTCCCGG AGTCCGCGGC CGCAGGCCTG AAGCTCATGG GAGCCCCTGT GAAGCTGACA 360

GTGTCCCAGG GGCAGCCGGT GAAGCTCAAC TGCAGCGTGG AGGGGATGGA GGAGCCTGAG 420

ATACAGTGGG TGAAGGACGG GGCTGTGGTC CAGAGCGTGG ATCAGGTGTA CATCCCAGTC 480

AGTGAGCAGC ACTGGATTGG CTTCCTCAGC CTGAAGTCAG TGGAGCGCTC TGATGCGGGC 540

CGGTACTGGT GCCAGGTGGA GGATGGAGGC GAAACTGAGA CCTCCCAGCC AGTGTGGCTC 600

ACTGTTGAAG GTGTGCCATT TTTCACTGTG GAGCCAAAAG ACCTGGCAGT GCCACCCAAT 660

GCCCCTTTCC AACTGTCTTG TGAGGCCGTG GGTCCCCCAG AACCTGTTAC CATTGTCTGG 720

TGGAGAGGAG GCACGAAGGT TGGGGGACCT GCTCCTTCTC CTTCTGTGTT AAATGTAACA 780

GGGGTGACCC AGAGCACCGA GTTCTCCTGT GAAGCTCACA ACCTAAAAGG CCTGGCTTCC 840

TCTCGCCCAG CCACGGTTCG TCTTCAAGCA CTGCCTGCAG CCCCCTTCAA CATCACAGTG 900

ACGAAGCTCT CCAGCAGCAA TGCTAGCGTG GCCTGGATGC CAGGTGCTGA TGGCCGAGCC 960

CTGCTCCAGT CCTGTACAGT CCAGGTGACG CAGGCCCCAG GAGGCTGGGA GGTCCTGGCT 1020

GTCGTGGTCC CTGTACCACC TTTTACGTGC TTGCTCCGGG ACCTGGCACC TGCTACCAAC 1080

TACAGCCTCA GGGTTCGCTG TGCCAATGCC TTGGGGCCTT CTCCATATGC TGACTGGGTA 1140

CCCTTTCGGA CAAAGGGTCT AGGAACAGCC CCAGCCAGCG CTCCCCAGAA CCTCCATGCC 1200

ATCCGCACAG AATCAGGCCT CATCCTGGAA TGGGAAGAAG TGATCCCTGA GGGCCCTATG 1260

GAAGGCCCCC TGGGACCCTA TAAACTGTCC TGGGTTCAAG ACAACGGAAC CCAGGGTGAG 1320

CTGACAGTGG AGGGGACCAG GGCCAACCTG ACGGGCTGGG ATCCCCAGAA GGACCTGACT 1380

GTGCGTGTGT GCGTCTCCAA TGCAGTTGGC TGTGGGCCCT GGAGTCAGCC ACTGGTGGTC 1440

TCTCCTCATG ACCACGCAGG CCAGCATGGC CCTCCCCACA GCCGCACATC TTGGGTGCCT 1500

GTGGTCCTGG GTGTGCTGAC AGCCCTAGTG ACAGCTGCTG CCCTGGCCCT TATCCTGCTT 1560

CGAAAGAGGC GGAAGGAGAC ACGGTTTGGG CAAGCCTTTG ACAGCGTTAT GGCCCGTGGG 1620

GAGCCAGCTG TTCACTTCCG GGCAGCGCGG TCCTTCAATC GAGAAAGGCC TGAGCGCATT 1680

GAGGCCACAC TGGACAGCTT GGGCATCAGC GATGAGCTGA AGGACAAACT GGAGGATGTG 1740

CTCATCCCAG AGCAGCAGTT CACCCTGGGC CGGATGTTGG GCAAAGGAGA GTTTGGTTCA 1800

GTGAGGGAAG CCCAGCTGAA GCAGGAGGAT GGCTCCTTTG TGAAAGTGGC CGTAAAGATG 1860

CTGAAAGCTG ACATCATTGC CTCAAGCGAC ATTGAAGAGT TCCTCAGAGA AGCGGCCTGC 1920

ATGAAGGAGT TTGACCACCC ACACGTGGCC AAGCTTGTTG GGGTGAGCCT CCGGAGCAGG 1980

GCCAAAGGCC GTCTCCCCAT TCCCATGGTC ATCCTGCCTT TCATGAAGCA CGGGGACCTG 2040

CACGCCTTCC TGCTCGCCTC CCGGATTGGG GAGAACCCCT TTAACCTGCC CCTGCAGACC 2100

CTGGTCCGGT TCATGGTGGA CATTGCCTGT GGCATGGAGT ATCTGAGCTC CCGGAACTTT 2160

ATCCACCGAG ACCTGGCTGC TCGGAACTGC ATGCTGGCGG AAGACATGAC AGTGTGTGTG 2220

GCCGACTTTG GACTGTCCCG GAAGATCTAT AGCGGGGACT ACTATCGCCA GGGCTGTGCC 2280

TCCAAACTGC CCGTCAAGTG GCTGGCCCTG GAGAGCCTGG CTGACAACCT GTATACTGTG 2340

CACAGTGACG TGTGGGCCTT TGGGGTGACC ATGTGGGAGA TCATGACTCG TGGGCAGACA 2400

CCATATGCTG GCATCGAGAA CGCTGAGATT TACAACTACC TCATCGGCGG GAACCGCCTG 2460

AAACAGCCTC CGGAGTGTAT GGAGGACGTG TATGAGCTCA TGTACCAGTG CTGGAGCGCC 2520

GACCCCAAGC AGCGCCCGAG CTTCACATGT CTGCGGATGG AGCTAGAGAA TGTCCTGGGC 2580

CGCCTGTCTG TGCTGTCCAC CAGTCAGGAC CCCTTGTACA TCAATCTTGA GGGAGCTCAG 2640

GAGCCTGCTG AGGGAGGCAG CCTGGAGCTG CCTGGTGGGG ACCAGGCCAG TGGCAGAGCT 2700

GGGGATGGCA GTGGCCTAGA GGCAGTGGGG GGCATCCCCA GTGACTATCG GTACATTCTC 2760

AGTCCCGGGG GGCTGGCTGA GCGGCCTGAG CAGGAGGAGC AGCAGCCAGA AAGCCCCGTC 2820

AATGAGGCCC AGGGGCTGCT GCTGCTGCAG CAAGGGCTAC TACCCCACAG TAGCTGTTAG 2880

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh

Q: 587   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  646

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtlv+fmv

Q: 647   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMV  706

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 707   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  766

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c

Q: 767   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  826

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ++++y+lmy+cw+adpk+rpsf+ lr

Q: 827   MEDVYELMYQCWSADPKQRPSFTCLR  852

         ***********************998

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLVRFMV 120

DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240

MEDVYELMYQ CWSADPKQRP SFTCLR 266

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0016021	; C:integral to membrane
GO:0005635	; C:nuclear envelope
GO:0005524	; F:ATP binding
GO:0043548	; F:phosphatidylinositol 3-kinase binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0021885	; P:forebrain cell migration
GO:0001779	; P:natural killer cell differentiation
GO:0050728	; P:negative regulation of inflammatory response
GO:0045824	; P:negative regulation of innate immune response
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0034122	; P:negative regulation of toll-like receptor signaling pathway
GO:0070050	; P:neuron homeostasis
GO:0042698	; P:ovulation cycle
GO:0070527	; P:platelet aggregation
GO:0046777	; P:protein autophosphorylation
GO:0043491	; P:protein kinase B signaling cascade
GO:0032940	; P:secretion by cell
GO:0007283	; P:spermatogenesis
GO:0034446	; P:substrate adhesion-dependent cell spreading
GO:0060068	; P:vagina development

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013