EKS-SUS-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	543.5	9.2E-164	999	1266	268

Status

Unreviewed

Ensembl Protein

ENSSSCP00000005181

UniProt Accession

F1CK17;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000004812	ENSSSCP00000028723	ENSSSCT00000034979
ENSSSCG00000004812	ENSSSCP00000029028	ENSSSCT00000035767
ENSSSCG00000004812	ENSSSCP00000005181	ENSSSCT00000005311

Organism

Sus scrofa

Functional Description

Protein Length

1367

Protein Sequence
(FASTA)

MKSGSGGGSP TSLWGLLFFS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 60

ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120

EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 180

LCPGTLEEKP LCEKTTINNE YNYRCWTTNR CQKMCPSVCG KRACTENHEC CHPECLGSCS 240

APDNDTACVA CRHYYYAGVC VPSCPPNTYR FEGWRCVDRD FCANIPSAES SDSEGFVIHD 300

GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 360

LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRQILG EEQLEGNYSF 420

YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 480

NNGERASCES DVLHFTSTTT WKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 540

QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 600

ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDSYLYRH 660

NYCSKDKIPI RKYADGTIDV EEATENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 720

VFENFLHNAI FVPRPERKRR EVMQVANTTM SSRSRNTTVV DTYNVTDPEE LETEYPFFES 780

RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 840

EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 900

YTARIQATSL SGNGSWTEPV FFYVQAKTTY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR 960

KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG 1020

VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 1080

LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 1140

CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT THSDVWSFGV 1200

VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL 1260

EIISSIKDEM EPGFREVSFY YSEENKPPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH 1320

SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC 1367

Nucleotide Sequence
(FASTA)

ATGAAGTCTG GCTCCGGAGG AGGGTCCCCG ACCTCGCTGT GGGGGCTCCT GTTTTTCTCC 60

GCCGCGCTCT CGCTCTGGCC GACGAGTGGA GAAATCTGCG GGCCGGGCAT TGACATCCGC 120

AACGACTACC AGCAGCTGAA GCGCCTGGAG AACTGCACGG TGATCGAGGG CTACCTCCAC 180

ATCCTGCTCA TCTCCAAGGC TGAGGACTAC CGCAGCTACC GCTTTCCCAA GCTCACGGTC 240

ATCACCGAGT ACCTGCTGCT GTTCCGTGTG GCTGGCCTTG AGAGCCTTGG CGACCTCTTC 300

CCCAATCTCA CGGTCATCCG CGGCTGGAAG CTCTTCTACA ACTACGCCCT GGTCATCTTC 360

GAGATGACCA ACCTCAAGGA CATCGGGCTC TACAACCTGA GGAATATTAC CCGGGGGGCC 420

ATCAGGATCG AGAAGAATGC CGACCTCTGC TACCTCTCTA CGGTGGACTG GTCCCTGATC 480

CTGGATGCCG TGTCCAATAA CTACATCGTG GGCAACAAGC CCCCTAAGGA ATGCGGGGAC 540

TTGTGCCCAG GGACGCTGGA GGAGAAGCCG CTGTGTGAGA AGACGACCAT CAACAACGAG 600

TACAACTATC GCTGCTGGAC CACGAACCGC TGCCAGAAAA TGTGCCCGAG CGTGTGCGGG 660

AAGCGGGCGT GCACAGAGAA CCACGAGTGC TGCCACCCCG AGTGCCTGGG CAGCTGCAGC 720

GCACCCGACA ACGACACAGC CTGTGTGGCC TGCCGCCACT ACTACTACGC CGGAGTCTGC 780

GTGCCCAGCT GCCCACCCAA CACCTACCGC TTCGAGGGCT GGCGCTGCGT GGACCGCGAC 840

TTTTGCGCCA ACATCCCCAG TGCGGAGAGC AGTGACTCCG AGGGCTTTGT GATCCATGAT 900

GGCGAGTGCA TGCAGGAGTG CCCTTCAGGC TTCATCCGCA ATGGCAGCCA GAGCATGTAC 960

TGTATCCCTT GCGAAGGCCC TTGCCCCAAA GTCTGTGAGG AAGAGAAGAA GACAAAGACC 1020

ATTGATTCTG TCACTTCTGC TCAGATGCTC CAAGGATGCA CCATCTTCAA GGGCAACCTG 1080

CTCATTAACA TCCGACGCGG CAACAACATT GCCTCGGAGC TAGAGAACTT CATGGGGCTC 1140

ATCGAGGTGG TGACGGGCTA CGTGAAGATC CGCCACTCCC ATGCCTTGGT CTCCTTGTCC 1200

TTCCTGAAAA ATCTTCGCCA GATCCTAGGG GAGGAGCAGC TGGAGGGGAA TTACTCCTTC 1260

TACGTCCTTG ACAACCAGAA CTTGCAGCAG CTGTGGGACT GGGACCATCG CAACCTGACC 1320

ATCAAAGCTG GGAAAATGTA CTTTGCTTTC AATCCCAAAT TGTGTGTCTC CGAGATTTAC 1380

CGCATGGAGG AAGTGACAGG GACTAAAGGG CGCCAGAGCA AAGGGGACAT AAACACCAGG 1440

AACAATGGAG AGAGAGCCTC CTGTGAAAGT GACGTCCTGC ACTTCACCTC CACCACCACG 1500

TGGAAGAACC GCATCATCAT CACCTGGCAC CGATACCGGC CCCCTGACTA CAGGGACCTC 1560

ATCAGCTTCA CTGTCTACTA CAAGGAAGCG CCCTTTAAAA ACGTCACGGA GTATGATGGG 1620

CAGGATGCCT GTGGCTCCAA CAGCTGGAAC ATGGTGGACG TGGACCTCCC TCCCAATAAG 1680

GACGTCGAGC CTGGCATTCT ACTGCATGGG CTGAAGCCCT GGACACAGTA CGCTGTTTAC 1740

GTCAAGGCCG TGACCCTCAC CATGGTGGAG AATGACCACA TCCGTGGGGC CAAGAGTGAG 1800

ATCTTGTACA TTCGCACCAA TGCTTCAGTT CCTTCCATTC CCCTGGATGT CCTCTCAGCA 1860

TCAAACTCCT CTTCTCAGCT GATAGTGAAG TGGAACCCGC CCTCCCTGCC CAATGGCAAC 1920

CTGAGCTACT ACATCGTGCG GTGGCAGCGC CAGCCTCAGG ACAGCTATCT CTACCGGCAT 1980

AATTACTGCT CCAAAGACAA AATCCCCATC AGGAAGTATG CTGATGGCAC CATTGATGTC 2040

GAGGAGGCTA CAGAGAACCC CAAGACTGAA GTGTGTGGCG GGGAGAAGGG ACCATGCTGT 2100

GCTTGCCCCA AAACAGAAGC TGAGAAGCAG GCAGAGAAGG AGGAGGCTGA GTACCGCAAG 2160

GTCTTCGAGA ACTTCCTGCA CAATGCCATC TTTGTGCCCA GACCTGAACG GAAGCGGAGG 2220

GAGGTCATGC AGGTCGCCAA CACCACCATG TCCAGCCGGA GCAGAAACAC CACAGTGGTG 2280

GACACCTACA ATGTCACGGA CCCAGAGGAG CTTGAGACAG AGTACCCTTT TTTTGAGAGC 2340

AGAGTGGATA ACAAGGAGAG AACTGTCATT TCCAACCTCC GGCCTTTTAC TTTGTACCGA 2400

ATTGACATCC ACAGCTGTAA CCATGAGGCT GAGAAGCTGG GCTGCAGTGC CTCCAACTTT 2460

GTCTTTGCAA GAACCATGCC TGCAGAAGGA GCAGATGACA TTCCTGGGCC AGTGACCTGG 2520

GAGCCACGGC CTGAGAACTC CATCTTTTTA AAGTGGCCAG AACCTGAGAA TCCTAATGGA 2580

TTGATTCTAA TGTATGAAAT AAAATACGGA TCACAAGTCG AGGATCAGCG GGAATGTGTG 2640

TCCAGACAGG AGTACAGGAA GTATGGAGGG GCCAAGCTGA ACAGGCTCAA CCCGGGGAAC 2700

TACACGGCCC GGATTCAGGC CACCTCTCTC TCCGGGAATG GGTCATGGAC GGAACCTGTG 2760

TTCTTCTACG TCCAGGCCAA AACGACATAT GAAAACTTCA TCCATCTGAT CATCGCCCTA 2820

CCAGTGGCCG TTCTGTTGAT AGTAGGAGGG TTGGTTATAA TGTTGTACGT CTTCCACAGA 2880

AAGAGAAATA ACAGCAGGCT GGGGAATGGA GTGCTGTATG CTTCCGTGAA CCCGGAGTAC 2940

TTCAGCGCAG CTGATGTGTA CGTGCCCGAC GAGTGGGAGG TCGCCCGGGA GAAGATCACC 3000

ATGAGCCGGG AGCTGGGACA GGGCTCCTTC GGGATGGTTT ATGAAGGCGT CGCCAAGGGT 3060

GTGGTCAAAG ATGAGCCTGA GACCAGGGTG GCCATTAAGA CAGTGAATGA GGCCGCCAGC 3120

ATGCGTGAGA GGATTGAGTT TCTCAACGAG GCCTCCGTGA TGAAGGAGTT CAACTGTCAC 3180

CACGTGGTGC GGCTGCTGGG TGTGGTGTCC CAGGGCCAGC CAACGCTGGT CATCATGGAA 3240

CTGATGACCC GGGGGGACCT CAAAAGTTAT CTCCGGTCTC TGAGACCAGA AATGGAGAAT 3300

AATCCAGTCC TAGCACCTCC AAGCCTAAGC AAAATGATCC AGATGGCTGG AGAGATTGCA 3360

GATGGCATGG CATACCTCAA CGCCAATAAG TTTGTCCACA GAGACCTCGC TGCCCGGAAC 3420

TGTATGGTGG CCGAAGACTT CACAGTCAAA ATCGGAGATT TTGGGATGAC GAGAGACATC 3480

TATGAGACAG ACTATTACCG CAAGGGAGGG AAAGGGCTGC TGCCTGTGCG CTGGATGTCC 3540

CCTGAGTCCC TCAAGGACGG AGTCTTCACC ACGCACTCTG ATGTCTGGTC CTTCGGGGTC 3600

GTCCTCTGGG AGATTGCCAC GCTGGCCGAG CAGCCATACC AGGGCTTGTC CAACGAGCAA 3660

GTCCTTCGCT TCGTCATGGA GGGCGGCCTT CTGGACAAGC CGGACAACTG TCCCGACATG 3720

CTGTTTGAGC TGATGCGCAT GTGCTGGCAG TACAACCCCA AGATGAGGCC TTCCTTCCTG 3780

GAGATCATCA GCAGCATCAA GGATGAGATG GAGCCTGGCT TCCGGGAGGT CTCCTTCTAC 3840

TACAGTGAGG AGAACAAGCC GCCTGAGCCG GAGGAGCTGG ACCTGGAGCC GGAGAACATG 3900

GAGAGCGTCC CCCTGGACCC CTCGGCCTCC TCGTCCTCCC TGCCGCTGCC CGACAGACAC 3960

TCAGGACACA AGGCTGAGAA CGGCCCAGGC CCTGGCGTGC TGGTGCTGCG AGCCAGCTTC 4020

GACGAGAGAC AGCCTTACGC GCACATGAAC GGGGGCCGCA AGAACGAGCG GGCCCTGCCT 4080

CTGCCCCAGT CCTCGACCTG CTGA 4104

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 999   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  1058

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en+++lapp+l+k+iqma+e

Q: 1059  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGE  1118

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1119  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1178

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+ncp

Q: 1179  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP  1238

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsflei++++

Q: 1239  DMLFELMRMCWQYNPKMRPSFLEIISSI  1266

         *************************976

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEM ENNPVLAPPS LSKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP 240

DMLFELMRMC WQYNPKMRPS FLEIISSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

ssc:397350

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013