EPS-SUS-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SUS-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	293.0	3.0E-87	23	289	267

Status

Unreviewed

Ensembl Protein

ENSSSCP00000005464

UniProt Accession

F1SSI1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1A

Gene Synonyms/Alias

PPM1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000005084	ENSSSCP00000005464	ENSSSCT00000005604

Organism

Sus scrofa

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ETWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 120

GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 240

IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE 300

AVKKEAELDK YLESRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 360

VYNRLNPYKN DDTDSTSTDD MW 382

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA ACCAAAGATG GAAAAACATA ACGCCCAAGG CCAGGGTAAT 60

GGGTTGCGAT ATGGGCTAAG CAGCATGCAA GGCTGGCGAG TTGAAATGGA GGATGCACAT 120

ACAGCTGTGA TTGGTTTGCC AAGTGGACTT GAAACATGGT CATTCTTTGC TGTATATGAT 180

GGGCATGCTG GTTCTCAGGT TGCCAAATAC TGCTGTGAGC ATTTGTTAGA TCACATCACC 240

AATAACCAGG ATTTTAAAGG GTCTGCAGGA GCACCTTCTG TGGAAAATGT GAAGAATGGA 300

ATCAGAACAG GTTTTCTGGA AATTGATGAA CACATGAGAG TCATGTCAGA GAAGAAACAT 360

GGTGCTGATA GAAGTGGGTC AACAGCTGTA GGTGTCTTAA TATCTCCTCA GCATACTTAT 420

TTCATTAACT GTGGAGACTC GAGAGGTTTA CTTTGTAGGA ACAGGAAAGT TCACTTCTTC 480

ACACAAGATC ACAAACCAAG TAATCCGCTG GAAAAAGAAC GAATTCAGAA TGCAGGTGGT 540

TCTGTGATGA TTCAGCGTGT GAATGGCTCT TTGGCTGTGT CAAGGGCCCT TGGGGACTTT 600

GATTACAAAT GTGTCCATGG AAAAGGTCCT ACCGAGCAGC TTGTTTCACC AGAGCCTGAA 660

GTCCATGATA TTGAAAGATC TGAAGAAGAT GATCAGTTCA TTATTCTTGC ATGTGATGGT 720

ATTTGGGATG TTATGGGAAA TGAAGAGCTC TGTGATTTTG TAAGATCCAG ACTTGAAGTC 780

ACTGATGACC TTGAGAAAGT TTGCAATGAA GTAGTCGACA CCTGTTTGTA TAAGGGAAGT 840

CGAGACAACA TGAGTGTGAT ATTGATCTGT TTTCCAAATG CACCCAAAGT ATCACCAGAA 900

GCAGTGAAGA AGGAGGCAGA GTTGGACAAG TACCTGGAAA GCAGAGTAGA AGAAATCATA 960

AAGAAGCAGG GGGAAGGCGT CCCTGACTTA GTCCATGTGA TGCGCACATT AGCGAGTGAG 1020

AACATCCCCA GCCTCCCACC AGGGGGTGAA TTGGCAAGCA AGCGGAATGT AATTGAAGCC 1080

GTTTACAATA GACTGAATCC TTACAAAAAT GATGACACTG ATTCTACATC AACTGATGAT 1140

ATGTGGTAA 1149

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++ +     + ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTAVIGLPSGL---ETWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************9855554444...45***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         +++ +    +++++ ++vk+ ++++Fl++de+++v++ek++  d+sGstav +li++++

Q: 80    TNNQDfkgsAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHT  139

         ***9999999999***********************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcrn+k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+ +++++ed+ f+iLa+DG+wdv+ nee++++vr+

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVHDIERSEEDDqFIILACDGIWDVMGNEELCDFVRS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++++++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPSGLET WSFFAVYDGH AGSQVAKYCC EHLLDHITNN 60

QDFKGSAGAP SVENVKNGIR TGFLEIDEHM RVMSEKKHGA DRSGSTAVGV LISPQHTYFI 120

NCGDSRGLLC RNRKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVH DIERSEEDDQ FIILACDGIW DVMGNEELCD FVRSRLEVTD 240

DLEKVCNEVV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004871	; F:signal transducer activity
GO:0010991	; P:negative regulation of SMAD protein complex assembly
GO:0030512	; P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0030177	; P:positive regulation of Wnt receptor signaling pathway
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

ssc:100738389

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013