EKS-SUS-00363
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00363
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk556.11.5E-167453724272
StatusUnreviewed
Ensembl ProteinENSSSCP00000005487
UniProt AccessionF1SRS9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK3
Gene Synonyms/Alias NTRK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000005106ENSSSCP00000005487ENSSSCT00000005628
OrganismSus scrofa
Functional Description
Protein Length740
Protein Sequence
(FASTA)
HIENWRGLHT LNAVDMELYT GLQKLTIKNS GLRSIQPRAF AKNPHLRYIN LSSNRLTTLS 60
WQLFQTLSLR ELRLEQNFFN CSCDIRWMQL WQEQGEAKLN SQSLYCISAD GSQLPLFRMN 120
ISQCDLPEIS VSHVNLTVRE GDNAVVTCNG SGSPLPDVDW IVTGLQSINT HQTNLNWTNV 180
HAINLTLVNV TSEDNGFTLT CIAENVVGMS NASVALTVHY PPRVVSLEEP ELRLEHCIEF 240
VVRGNPPPTL HWLHNGQPLR ESKITHVEYY QEGEVSEGCL LFNKPTHYNN GNYTLIAKNP 300
LGTANQTING HFLKEPFPES TDNFVSFYEV SPTPPITVTH KPEEDTFGVS IAVGLAAFAC 360
VLLVVLFIMI NKYGRRSKFG MKGPVAVISG EEDSASPLHH QPWHHHTLIT GRRAGHVIGM 420
TRIPVIENPQ YFRQGHNCHK PDTYVQHIKR RDIVLKRELG EGAFGKVFLA ECYNLSPTKD 480
KMLVAVKALK DPTLAARKDF QREAELLTNL QHEHIVKFYG VCGDGDPLIM VFEYMKHGDL 540
NKFLRAHGPD AMILVDGQPR QAKGELGLSQ MLHIASQIAS GMVYLASQHF VHRDLATRNC 600
LVGANLLVKI GDFGMSRDVY STDYYRVGGH TMLPIRWMPP ESIMYRKFTT ESDVWSFGVI 660
LWEIFTYGKQ PWFQLSNTEV IECITQGRVL ERPRVCPKEV YDVMLGCWQR EPQQRLNIKE 720
IYKILHALGK ATPIYLDILG 740
Nucleotide Sequence
(FASTA)
CACATAGAGA ACTGGCGCGG TCTGCACACG CTCAACGCTG TGGACATGGA GCTCTACACC 60
GGCCTCCAGA AGCTGACCAT CAAGAACTCA GGACTTCGGA GCATCCAGCC CAGAGCCTTT 120
GCCAAGAACC CCCACCTGCG CTACATAAAC CTGTCGAGTA ACCGGCTCAC CACACTCTCA 180
TGGCAGCTCT TCCAGACGCT GAGTCTTCGG GAATTGAGAT TGGAGCAGAA CTTCTTCAAC 240
TGCAGCTGTG ACATCCGCTG GATGCAGCTG TGGCAGGAGC AGGGGGAGGC CAAGCTGAAC 300
AGCCAGAGCC TCTATTGCAT CAGTGCCGAT GGCTCCCAGC TCCCCCTCTT CCGCATGAAC 360
ATTAGCCAGT GTGACCTTCC TGAGATCAGT GTGAGCCACG TCAATCTGAC CGTTCGGGAG 420
GGTGACAATG CTGTTGTCAC CTGCAATGGC TCTGGATCAC CCCTGCCCGA CGTGGACTGG 480
ATCGTCACTG GACTGCAGTC CATCAACACC CACCAGACAA ATCTGAATTG GACCAACGTA 540
CACGCCATCA ACCTGACACT GGTCAATGTG ACGAGTGAGG ACAACGGCTT CACCCTGACG 600
TGCATTGCAG AGAACGTGGT GGGCATGAGC AATGCCAGCG TCGCCCTCAC TGTTCACTAC 660
CCCCCACGAG TGGTGAGCCT GGAGGAGCCA GAGCTGCGCC TGGAACACTG CATCGAGTTT 720
GTGGTGCGTG GCAACCCGCC GCCCACGCTG CACTGGCTGC ACAACGGGCA GCCGCTGCGT 780
GAGTCCAAGA TCACCCACGT GGAGTACTAC CAGGAGGGCG AGGTCTCCGA GGGCTGCCTG 840
CTCTTCAACA AGCCCACCCA CTACAACAAT GGCAACTACA CACTCATCGC CAAGAACCCC 900
TTGGGCACAG CCAACCAGAC CATCAATGGC CACTTCCTCA AGGAGCCTTT TCCAGAGAGC 960
ACGGATAACT TTGTCTCTTT CTATGAAGTG AGCCCCACCC CTCCCATCAC TGTGACGCAC 1020
AAGCCAGAGG AAGATACATT TGGGGTATCC ATAGCTGTTG GACTTGCCGC TTTTGCCTGT 1080
GTCCTTCTGG TGGTTCTCTT TATCATGATC AACAAGTATG GTCGACGGTC TAAATTTGGA 1140
ATGAAGGGTC CTGTGGCTGT CATCAGTGGT GAAGAGGACT CAGCCAGCCC ACTGCATCAC 1200
CAACCATGGC ATCACCACAC CCTCATCACT GGACGCCGGG CCGGACACGT CATTGGCATG 1260
ACCCGCATCC CAGTCATTGA GAACCCCCAG TACTTCCGCC AGGGACACAA CTGCCACAAG 1320
CCAGACACGT ATGTGCAGCA CATTAAAAGG AGGGACATCG TGCTGAAGCG AGAACTGGGT 1380
GAGGGAGCCT TTGGGAAGGT CTTCCTGGCC GAGTGCTACA ACCTCAGCCC CACCAAGGAC 1440
AAGATGCTCG TGGCTGTGAA GGCCCTGAAG GATCCCACCC TGGCCGCCCG GAAGGATTTC 1500
CAGAGGGAGG CTGAGCTGCT CACCAACCTG CAGCATGAGC ACATTGTCAA GTTCTATGGG 1560
GTGTGCGGCG ACGGGGACCC ACTCATCATG GTTTTTGAGT ACATGAAACA CGGGGATCTG 1620
AACAAGTTCC TCAGGGCCCA TGGGCCAGAT GCCATGATCC TCGTGGACGG CCAGCCACGC 1680
CAGGCGAAAG GCGAGCTGGG GCTCTCCCAG ATGCTGCACA TTGCCAGTCA GATTGCCTCT 1740
GGCATGGTGT ACCTGGCCTC CCAGCATTTT GTGCACCGGG ACCTGGCCAC CAGGAACTGC 1800
CTGGTTGGAG CCAACCTGCT GGTGAAGATT GGCGATTTCG GCATGTCCAG AGATGTCTAC 1860
AGCACGGATT ACTACAGGGT AGGAGGACAC ACCATGCTCC CAATTCGCTG GATGCCTCCT 1920
GAAAGCATCA TGTACCGGAA GTTCACTACT GAGAGTGACG TGTGGAGCTT CGGGGTGATC 1980
CTCTGGGAGA TCTTCACCTA CGGAAAGCAG CCATGGTTCC AACTCTCAAA CACAGAGGTC 2040
ATTGAGTGCA TCACCCAAGG TCGCGTTTTG GAACGGCCCC GGGTCTGCCC CAAAGAGGTG 2100
TATGATGTCA TGCTGGGGTG CTGGCAGAGG GAACCGCAGC AGCGGCTGAA CATCAAGGAA 2160
ATCTACAAAA TCCTCCATGC TTTGGGGAAA GCCACCCCCA TCTACCTGGA CATCCTTGGC 2220
TAG 2223
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlkrelgegafgkvflaecynl+p+kdk+lvavkalkd++ aarkdf+reaelltnlqh
Q: 453   IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQH  512
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep...kgelglsqll  117
         ehivk+yGvc +gdpl++vfeymkhGdlnkflrahgpda++lv+g+p   kgelglsq+l
Q: 513   EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPrqaKGELGLSQML  572
         ***********************************************9999*********
S: 118   aiakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtm  177
         +ia+qia+G+vylasqhfvhrdlatrnclvg++llvkigdfgmsrdvystdyyrvgg+tm
Q: 573   HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM  632
         ************************************************************
S: 178   lpirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvler  237
         lpirw+ppesi+yrkfttesdvws+Gv+lwei+tyGkqp++qlsnteviecitqGrvler
Q: 633   LPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLER  692
         ************************************************************
S: 238   pracpkevydlmlgcwqrepqkrlnikeiyal  269
         pr+cpkevyd+mlgcwqrepq+rlnikeiy++
Q: 693   PRVCPKEVYDVMLGCWQREPQQRLNIKEIYKI  724
         *****************************985
Domain Sequence
(FASTA)
IVLKRELGEG AFGKVFLAEC YNLSPTKDKM LVAVKALKDP TLAARKDFQR EAELLTNLQH 60
EHIVKFYGVC GDGDPLIMVF EYMKHGDLNK FLRAHGPDAM ILVDGQPRQA KGELGLSQML 120
HIASQIASGM VYLASQHFVH RDLATRNCLV GANLLVKIGD FGMSRDVYST DYYRVGGHTM 180
LPIRWMPPES IMYRKFTTES DVWSFGVILW EIFTYGKQPW FQLSNTEVIE CITQGRVLER 240
PRVCPKEVYD VMLGCWQREP QQRLNIKEIY KI 272
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00381
EKS-ANC-00398
EKS-BOT-00410
EKS-CAJ-00415
EKS-CAF-00412
EKS-CAP-00438
EKS-DAR-00796
EKS-EQC-00403
EKS-FEC-00393
EKS-GAG-00347
EKS-GAA-00497
EKS-GOG-00402
EKS-HOS-00417
EKS-ICT-00390
EKS-LAC-00425
EKS-LOA-00419
EKS-MAM-00409
EKS-MEG-00340
EKS-MIM-00063
EKS-MOD-00388
EKS-MUM-00443
EKS-MUP-00405
EKS-MYL-00406
EKS-NOL-00374
EKS-ORN-00522
EKS-ORA-00358
EKS-ORC-00385
EKS-ORL-00475
EKS-OTG-00413
EKS-PAT-00388
EKS-PES-00363
EKS-PEM-00224
EKS-POA-00403
EKS-PTV-00117
EKS-RAN-00425
EKS-SAH-00380
EKS-TAG-00481
EKS-TAR-00517
EKS-TEN-00518
EKS-TUT-00124
EKS-XIM-00513
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0042490; P:mechanoreceptor differentiation
GO:0048691; P:positive regulation of axon extension involved in regeneration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR001611; Leu-rich_rpt.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020446; Tyr_kin_neurotrophic_rcpt_3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS51450; LRR; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01942; NTKRECEPTOR3.
PR00109; TYRKINASE.
Created Date20-Feb-2013