EKS-SUS-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	340.7	8.0E-102	390	649	260

Status

Unreviewed

Ensembl Protein

ENSSSCP00000029110

UniProt Accession

J9JIK9;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000005215	ENSSSCP00000029236	ENSSSCT00000034678
ENSSSCG00000005215	ENSSSCP00000030662	ENSSSCT00000033681
ENSSSCG00000005215	ENSSSCP00000005606	ENSSSCT00000005748
ENSSSCG00000005215	ENSSSCP00000029110	ENSSSCT00000034494

Organism

Sus scrofa

Functional Description

Protein Length

705

Protein Sequence
(FASTA)

WRHDFLYGWV KIPVTHETQE ECLGMAVLDM MRIAKEKDQT PLDIYSSVSY KTFLPKCVRA 60

KIQDYHILTR KRIRYRFRRF IEQFSHCKAT ARNLKLKYLI NLETLQSAFY TEQFEVKEPG 120

RGPSGEEIFA TIIITGNGGI QWSRGKHKES ETLTEQDLQL YCDFPDIIDV SIKQANQEGS 180

NESRIVTIHK QDGKSLEIEL SSLREALSFV SLIDGYYRLT ADAHHYLCKE VAPPMVLENI 240

QSNCHGPISM DFAISKLKKA GNQTGLFVLR CSPKDFNKYF LTFAVEREMS LNISTVLITK 300

NDEWRIHLSG TRKNFSNLKD LLNCYQMETV RSDSIIFQFT KCCPPKPKDK SNLLVFRTNG 360

ISDVPTSPTL QRHNNVNQMV FHKIRNEDLI FNESLGQGTF TKIFKGVRRE VGDYGQLHET 420

EVLLKVLDKA HRNYSESFFE AASMMSQLSH KHLVLNYGVC VCGEENILVQ EFVKFGSLDT 480

YLKKNKNSIN ILWKLEVAKQ LAWAMHFLEE KTLIHGNVCA KNILLIREED RKTGNPPFIK 540

LSDPGISITV LPKDILQERI PWVPPECIEN PKNLNLATDK WSFGTTLWEI CSGGDKPLNA 600

LDSQRKLQFY EDRHQLPAPK WTELANLINN CMDYEPDFRP SFRAIIRDLN SLFTPDYELL 660

TENDMLPNMR IGALGFSGAF EDRDPTQFEE RHLKFLQQLG KVGVI 705

Nucleotide Sequence
(FASTA)

TGGCGACATG ATTTTTTGTA TGGATGGGTA AAGATACCTG TGACTCATGA AACTCAGGAA 60

GAATGTCTTG GGATGGCAGT GTTAGATATG ATGAGAATAG CCAAAGAAAA GGATCAAACC 120

CCACTGGACA TCTATAGTTC TGTCAGCTAC AAGACATTCT TACCAAAATG TGTTCGAGCA 180

AAGATCCAAG ACTATCATAT TTTGACAAGG AAGCGAATAA GGTACAGATT TCGCAGATTT 240

ATTGAGCAAT TCAGCCATTG CAAAGCCACT GCCAGAAACT TGAAACTTAA ATATCTTATA 300

AATCTGGAAA CTCTTCAGTC TGCCTTCTAC ACAGAACAGT TTGAAGTAAA AGAACCTGGA 360

AGAGGTCCTT CAGGTGAGGA GATTTTTGCA ACCATTATAA TAACTGGAAA CGGTGGAATT 420

CAGTGGTCAA GAGGGAAACA TAAAGAAAGT GAGACACTGA CAGAACAGGA TTTACAATTA 480

TATTGTGATT TTCCTGATAT CATTGATGTC AGTATTAAAC AGGCAAACCA AGAAGGCTCA 540

AATGAAAGCA GAATTGTAAC TATTCATAAG CAAGATGGCA AAAGTCTGGA AATTGAGCTT 600

AGCTCATTAA GAGAAGCTTT GTCTTTTGTA TCGTTAATTG ATGGATATTA TAGATTAACT 660

GCAGACGCAC ATCATTACCT TTGTAAAGAA GTAGCACCTC CAATGGTGCT TGAAAATATA 720

CAAAGCAACT GTCATGGCCC AATTTCAATG GATTTTGCCA TCAGTAAACT GAAGAAAGCA 780

GGTAATCAGA CTGGACTCTT TGTACTTCGA TGCAGTCCTA AGGACTTTAA TAAATATTTT 840

CTGACTTTTG CTGTTGAGCG AGAAATGTCA CTGAATATAA GCACTGTGTT GATTACAAAA 900

AATGATGAAT GGCGAATACA CCTCAGTGGT ACTAGGAAGA ACTTCAGTAA CCTTAAAGAT 960

CTTTTGAATT GTTACCAAAT GGAAACTGTT CGTTCAGACA GTATAATTTT CCAGTTTACT 1020

AAATGCTGTC CCCCAAAGCC AAAAGATAAG TCAAACCTTC TAGTCTTTAG AACCAATGGT 1080

ATTTCTGATG TGCCAACCTC ACCAACATTA CAGAGGCATA ATAATGTGAA CCAAATGGTG 1140

TTTCACAAAA TCAGAAATGA AGATTTGATA TTTAATGAAA GTCTTGGCCA AGGCACGTTT 1200

ACAAAAATTT TTAAAGGTGT AAGAAGAGAA GTAGGAGACT ATGGTCAACT GCATGAAACA 1260

GAAGTTCTTT TAAAAGTTTT GGATAAAGCA CATAGAAACT ACTCAGAGTC TTTCTTTGAA 1320

GCAGCAAGCA TGATGAGCCA GCTTTCTCAT AAACATCTGG TTTTAAATTA TGGAGTATGT 1380

GTCTGTGGAG AGGAGAATAT TCTGGTTCAG GAGTTTGTAA AATTTGGGTC ACTGGATACA 1440

TATCTGAAAA AGAATAAAAA TTCTATAAAT ATATTGTGGA AACTTGAAGT GGCTAAACAG 1500

TTGGCATGGG CCATGCATTT TCTAGAAGAG AAAACCCTTA TTCATGGGAA TGTGTGCGCC 1560

AAAAATATTC TTCTTATCAG AGAAGAAGAC AGGAAGACAG GAAATCCTCC CTTCATCAAA 1620

CTTAGTGATC CTGGCATCAG TATTACAGTT TTGCCCAAGG ACATTCTGCA GGAGAGAATA 1680

CCATGGGTGC CTCCTGAATG CATTGAAAAT CCTAAAAATC TAAACTTGGC AACAGATAAA 1740

TGGAGTTTTG GTACCACTTT GTGGGAAATC TGCAGTGGAG GTGATAAGCC TCTGAATGCT 1800

TTGGATTCTC AAAGAAAGTT ACAGTTTTAT GAAGATAGGC ATCAGCTTCC TGCACCAAAG 1860

TGGACAGAAT TAGCAAATCT TATTAATAAT TGTATGGATT ATGAACCAGA TTTTAGACCT 1920

TCTTTCAGAG CCATCATACG AGACCTTAAT AGCTTGTTTA CTCCAGATTA TGAACTACTA 1980

ACAGAAAATG ATATGTTACC AAATATGAGA ATAGGTGCCC TAGGGTTTTC TGGTGCATTT 2040

GAAGACCGAG ACCCTACACA GTTTGAAGAG AGACACTTGA AATTTCTACA GCAACTGGGC 2100

AAGGTCGGCG TAATCTAA 2118

Domain Profile

S: 2     kqiesLgkgtftkvfevred...aegdsteeevalkvLkesgedisrdfkreaeilsqls  58

          ++esLg+gtftk+f++ ++   ++g+ +e+ev+lkvL+++++++s++f+++a+++sqls

Q: 390   IFNESLGQGTFTKIFKGVRRevgDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSQLS  449

         6899*************9966779************************************

S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         h+h+v ++gvcv+++en+lV+e+v+ GsLd+yL+k+k+++++ ++l+vakqla+am++Le

Q: 450   HKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMHFLE  509

         ************************************************************

S: 119   dkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripwl  176

         +k+l+h++v+a+n+L+ re++  +g+ppf+klsdpg++ +v      l+++  ++ripw+

Q: 510   EKTLIHGNVCAKNILLIREEDrkTGNPPFIKLSDPGISITV------LPKDILQERIPWV  563

         ******************9998899****************......*************

S: 177   apeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkc  236

         +pec+++ knl++a+d+WsFg+tl+e+  cs g++pl++ +++rkl+++e++++lp+pk+

Q: 564   PPECIENPKNLNLATDKWSFGTTLWEI--CSGGDKPLNALDSQRKLQFYEDRHQLPAPKW  621

         ***************************..*******************************

S: 237   paelaelmtnclsyepsqrpsFrailedl  265

         + ela+l++nc++yep++rpsFrai++dl

Q: 622   T-ELANLINNCMDYEPDFRPSFRAIIRDL  649

         *.*************************98

Domain Sequence
(FASTA)

IFNESLGQGT FTKIFKGVRR EVGDYGQLHE TEVLLKVLDK AHRNYSESFF EAASMMSQLS 60

HKHLVLNYGV CVCGEENILV QEFVKFGSLD TYLKKNKNSI NILWKLEVAK QLAWAMHFLE 120

EKTLIHGNVC AKNILLIREE DRKTGNPPFI KLSDPGISIT VLPKDILQER IPWVPPECIE 180

NPKNLNLATD KWSFGTTLWE ICSGGDKPLN ALDSQRKLQF YEDRHQLPAP KWTELANLIN 240

NCMDYEPDFR PSFRAIIRDL 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013