EKS-SUS-00242

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00242

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.2	2.4E-140	205	492	288

Status

Unreviewed

Ensembl Protein

ENSSSCP00000029422

UniProt Accession

Q19ML3;

Protein Name

Protein Synonyms/Alias

TGF-beta receptor type-1; Transforming growth factor beta type 1 receptor; Transforming growth factor beta type 1 receptor isoform 3; Transforming growth factor beta type 1 receptor isoform 4; Transforming growth factor beta type 1 receptor isoform 5;

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000005382	ENSSSCP00000026318	ENSSSCT00000026821
ENSSSCG00000005382	ENSSSCP00000030696	ENSSSCT00000033114
ENSSSCG00000005382	ENSSSCP00000029214	ENSSSCT00000034121
ENSSSCG00000005382	ENSSSCP00000030910	ENSSSCT00000034224
ENSSSCG00000005382	ENSSSCP00000029422	ENSSSCT00000036612
ENSSSCG00000005382	ENSSSCP00000005775	ENSSSCT00000005922

Organism

Sus scrofa

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MEVAAGAPRS RLLLFVLAAT ATLVPEATAL QCFCHLCTKD NFTCVTDGLC FVSVTETTDK 60

VIHNSMCIAE IDLIPRDRPF VCAPSSKTGS VTTTYCCNQD HCNKIELPTV GPFPGKPPSG 120

LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 180

IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 240

SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300

GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 360

ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 420

HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 480

ARLTALRIKK TLSQLSQQEG IKM 503

Nucleotide Sequence
(FASTA)

ATGGAGGTGG CGGCCGGTGC TCCGCGTTCC CGGCTGCTCC TCTTCGTGCT GGCGGCGACG 60

GCCACGCTGG TCCCGGAGGC GACGGCATTA CAGTGTTTCT GCCACCTTTG CACAAAAGAC 120

AATTTTACTT GTGTCACAGA TGGGCTCTGC TTTGTCTCTG TCACAGAGAC CACAGACAAA 180

GTTATACACA ATAGCATGTG TATAGCTGAA ATTGACCTAA TTCCGCGAGA CAGGCCATTT 240

GTATGTGCAC CTTCTTCAAA AACTGGGTCT GTTACTACAA CATATTGCTG CAATCAGGAC 300

CATTGCAATA AAATAGAACT CCCAACTGTT GGTCCTTTTC CAGGAAAGCC ACCATCTGGC 360

CTTGGTCCTG TTGAACTGGC AGCTGTCATT GCTGGACCAG TCTGCTTTGT CTGCATCTCA 420

CTCATGTTGA TGGTCTATAT CTGCCATAAC CGTACAGTCA TTCACCATCG AGTGCCAAAT 480

GAAGAGGATC CTTCATTAGA TCGCCCTTTT ATTTCAGAGG GTACTACATT AAAAGATTTA 540

ATTTATGATA TGACAACATC AGGTTCTGGA TCAGGTTTAC CATTGCTTGT TCAGAGAACA 600

ATTGCAAGAA CTATTGTGCT ACAAGAAAGT ATTGGCAAAG GTCGATTTGG AGAGGTTTGG 660

CGAGGAAAAT GGAGAGGAGA GGAAGTTGCT GTTAAAATAT TCTCCTCCAG GGAAGAACGT 720

TCATGGTTCC GTGAGGCAGA GATTTATCAG ACTGTTATGT TACGTCATGA AAACATCTTG 780

GGATTTATAG CAGCAGACAA TAAAGATAAT GGTACATGGA CTCAGCTTTG GTTGGTGTCA 840

GATTATCATG AACATGGATC CCTTTTTGAT TACTTGAATA GATACACAGT TACTGTGGAA 900

GGAATGATAA AACTTGCTCT GTCCACAGCA AGTGGACTTG CCCATCTTCA CATGGAGATA 960

GTTGGTACCC AAGGAAAACC AGCTATTGCT CATAGAGATT TGAAATCAAA GAATATCTTG 1020

GTAAAAAAGA ATGGAACTTG CTGTATTGCA GACTTAGGAC TGGCAGTAAG ACATGATTCA 1080

GCCACAGATA CAATTGATAT TGCTCCAAAC CACAGAGTGG GAACAAAAAG GTACATGGCC 1140

CCTGAAGTTC TAGATGATTC CATAAATATG AAACACTTTG AATCCTTCAA ACGTGCTGAC 1200

ATCTATGCAA TGGGCTTAGT ATTCTGGGAA ATAGCTCGAC GATGTTCCAT TGGTGGAATT 1260

CATGAAGATT ACCAGCTGCC TTATTATGAT CTTGTACCTT CTGATCCATC AGTTGAAGAA 1320

ATGAGAAAAG TTGTTTGTGA ACAGAAGTTA AGGCCAAATA TTCCTAACAG ATGGCAGAGC 1380

TGTGAAGCCT TAAGAGTAAT GGCTAAAATT ATGAGAGAAT GTTGGTATGC CAATGGAGCA 1440

GCCAGGCTCA CAGCTTTGCG GATTAAGAAA ACATTGTCAC AACTCAGTCA GCAGGAAGGC 1500

ATCAAAATGT AA 1512

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 205   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  264

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 265   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 383   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  441

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013