EKS-SUS-00327
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00327
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src416.64.1E-125249498250
StatusUnreviewed
Ensembl ProteinENSSSCP00000006663
UniProt AccessionF1RT53;
Protein Name
Protein Synonyms/Alias
Gene NameLYN
Gene Synonyms/Alias LYN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000006250ENSSSCP00000006663ENSSSCT00000006849
OrganismSus scrofa
Functional Description
Protein Length513
Protein Sequence
(FASTA)
MGCIKSKRKD NLNDDGVDLK TQPVRNTDRT IYVRDPTSNK QQRPVADSQL LPGQRFQTKD 60
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLSTKRE GFIPSNYVAK 120
VNTLETEEWF FKDITRKDAE RQLLAPGNSP GAFLIRESET LKGSYSLSVR DYDPVHGDVI 180
KHYKIRSLDN GGYYISPRIT FPCISDMIKY YQSSGPFLCC RRNQKSCFHC KTKSLWNLPS 240
WFLPRVNIKI YKRKAAGAAQ EVYFRYYNNS TKVAVKTLKP GTMSVQAFLE EANLMKTLQH 300
DKLVRLYAVV TKEEPIYIIT EYMAKGSLLD FLKSDEGGKV LLPKLIDFSA QIAEGMAYIE 360
RKNYIHRDLR AANVLVSESL MCKIADFGLA RVIEDNEYTA REGAKFPIKW TAPEAINFGC 420
FTIKSDVWSF GILLYEIVTY GKIPYPGRTN ADVMAALSQG YRMPRMENCP DELYDIMKMC 480
WKEKAEERPT FDYLQSVLDD FYTATEGQYQ QQP 513
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGATGGAGT AGATTTGAAG 60
ACTCAACCAG TACGTAATAC TGACCGCACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120
CAGCAAAGGC CAGTGGCAGA CTCTCAGCTT TTACCAGGAC AGAGGTTTCA AACCAAAGAT 180
CCCGAGGAGC AAGGAGACAT CGTGGTGGCT TTGTACCCCT ATGATGGCAT CCACCCGGAT 240
GACTTGTCAT TCAAGAAAGG GGAGAAGATG AAAGTCCTGG AGGAGCACGG AGAGTGGTGG 300
AAAGCGAAAT CCCTTTCAAC CAAGAGAGAA GGCTTCATCC CCAGCAACTA CGTGGCCAAA 360
GTCAACACCT TGGAAACAGA AGAGTGGTTT TTCAAGGACA TAACCAGGAA AGACGCTGAA 420
AGGCAGCTTT TGGCACCAGG GAACAGCCCC GGAGCTTTTC TTATCAGAGA AAGTGAAACA 480
TTAAAAGGAA GTTACTCTCT GTCGGTCAGA GATTACGACC CGGTGCATGG AGATGTTATT 540
AAGCACTACA AAATCAGAAG CCTGGACAAT GGGGGTTATT ACATCTCCCC ACGAATCACT 600
TTTCCTTGTA TCAGTGACAT GATTAAGTAT TACCAAAGCA GCGGTCCTTT CCTTTGTTGT 660
CGTAGAAATC AGAAGTCCTG TTTCCACTGT AAGACCAAAT CTCTGTGGAA TCTTCCATCA 720
TGGTTTCTCC CAAGAGTAAA TATAAAAATA TATAAACGAA AGGCTGCAGG AGCTGCTCAG 780
GAGGTGTACT TTCGTTACTA CAACAATAGC ACCAAAGTGG CTGTGAAAAC CCTGAAGCCA 840
GGCACGATGT CGGTGCAGGC GTTCCTGGAG GAGGCCAACC TCATGAAGAC TCTGCAGCAC 900
GACAAGCTGG TGAGGCTGTA CGCCGTGGTC ACCAAGGAGG AGCCCATCTA CATCATCACC 960
GAGTACATGG CCAAGGGCAG CTTGCTGGAC TTCCTGAAGA GCGACGAAGG GGGCAAAGTG 1020
CTGCTTCCGA AGCTGATTGA CTTCTCCGCT CAGATCGCGG AGGGAATGGC TTACATCGAG 1080
AGAAAGAACT ACATTCACCG GGACCTTCGA GCCGCCAACG TCCTGGTCTC CGAGTCCCTC 1140
ATGTGCAAAA TCGCAGATTT TGGCCTCGCC CGAGTCATTG AAGATAACGA GTACACAGCG 1200
AGGGAAGGTG CTAAATTCCC CATTAAGTGG ACGGCTCCAG AGGCCATCAA CTTCGGATGC 1260
TTCACTATTA AATCTGACGT GTGGTCCTTC GGAATCCTGC TGTATGAGAT CGTCACCTAC 1320
GGGAAGATTC CCTACCCAGG GAGAACTAAC GCGGACGTGA TGGCCGCCCT GTCGCAGGGC 1380
TACAGGATGC CCCGTATGGA GAACTGCCCC GATGAGCTCT ATGACATCAT GAAGATGTGC 1440
TGGAAAGAGA AGGCGGAGGA GAGGCCCACC TTCGACTACC TGCAGAGCGT CCTGGACGAC 1500
TTCTACACGG CCACCGAGGG CCAGTACCAG CAGCAGCCCT AG 1542
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
         k+ k+  +G   ev+  ++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+lya
Q: 249   KIYKRKAAGAAQEVYFRYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA  308
         677888999***************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihrd
Q: 309   VVTKEEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD  368
         ************************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdvW
Q: 369   LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW  428
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGill+eivt+Gk+PypG tn++v+ ++++gyr+pr+e+cp+ely+++++cwk+++eer
Q: 429   SFGILLYEIVTYGKIPYPGRTNADVMAALSQGYRMPRMENCPDELYDIMKMCWKEKAEER  488
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptf++lq+vl
Q: 489   PTFDYLQSVL  498
         *******986
Domain Sequence
(FASTA)
KIYKRKAAGA AQEVYFRYYN NSTKVAVKTL KPGTMSVQAF LEEANLMKTL QHDKLVRLYA 60
VVTKEEPIYI ITEYMAKGSL LDFLKSDEGG KVLLPKLIDF SAQIAEGMAY IERKNYIHRD 120
LRAANVLVSE SLMCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GCFTIKSDVW 180
SFGILLYEIV TYGKIPYPGR TNADVMAALS QGYRMPRMEN CPDELYDIMK MCWKEKAEER 240
PTFDYLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00342
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-GAM-00222
EKS-GAG-00312
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MAM-00368
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-ORN-00477
EKS-ORA-00322
EKS-ORC-00346
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-POA-00358
EKS-PTV-00094
EKS-RAN-00382
EKS-SAH-00338
EKS-TAG-00441
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0097028; P:dendritic cell differentiation
GO:0030218; P:erythrocyte differentiation
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175; P:neuron projection development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0002513; P:tolerance induction to self antigen
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013