EKS-SUS-00364
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00364
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk537.28.3E-162509778270
StatusUnreviewed
Ensembl ProteinENSSSCP00000006889
UniProt AccessionF1RHK6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK1
Gene Synonyms/Alias NTRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000006464ENSSSCP00000006889ENSSSCT00000007081
OrganismSus scrofa
Functional Description
Protein Length795
Protein Sequence
(FASTA)
MPRDGQRGQL GGHGRAKGLG SLLAWLMLAS AGAASCPEVC CPHGPSGLRC TKVAALDIIR 60
HLPGAENLTE LYIENQQHLQ HLTLSDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSHL 120
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALFWLQ RWEQEGRAGV REQKLQCPGQ 180
GPLALMPNAS CGEPELKIQM PNGSVDVGDD VLLQCQVEGQ GLEQAGWILM DLEESATVMQ 240
SGSLPSLGLT LAHVTSDLNR KNVTCWAENH VGRAEISVQV NVSFPPIVSL HTAVEQHHWC 300
IPFSVDGQPA PSLRWFFNGS VLNETSFIFT EFMEPAANET MRHGCLRLNQ PTHVNNGNYT 360
LLATNPLGQN ASSIMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSGNPVEK DETPFGVSMA 420
VGLAVFACLF LSTMFLVLNK CGRRNKFGIN RPAVLAPEDG LAMSLHFMTL GGSSLSPTES 480
KGSGLQGHII ENPQYFSDAC VHHIKRRDIV LKWELGEGAF GKVFLAECHN LLPEQDKMLV 540
AVKALKEVSE SARQDFQREA ELLTMLQHQH IVRFFGVCTE GRPLLMVFEY MRHGDLNRFL 600
RSHGPDAKLL AGGEDVAPGP LGLGQLLAVA SQVAAGMVYL AGLHFVHRDL ATRNCLVGQG 660
LVVKIGDFGM SRDIYSTDYY RVGGRTMLPI RWMPPESILY RKFTTESDVW SFGVVLWEIF 720
TYGKQPWYQL SNTEAIECIT QGRELERPRA CPPEVYAIMR GCWQREPQQR HSIKDVHAQL 780
QALAQAPPVY LDVLG 795
Nucleotide Sequence
(FASTA)
ATGCCGCGAG ACGGACAGCG CGGGCAGCTC GGCGGACATG GCCGGGCTAA GGGGCTGGGC 60
AGCCTACTGG CCTGGCTGAT GCTGGCATCT GCGGGCGCCG CATCCTGTCC CGAAGTCTGC 120
TGCCCCCACG GCCCTTCGGG GCTGCGCTGC ACGAAGGTTG CGGCCCTGGA TATCATCCGC 180
CACCTGCCGG GCGCCGAGAA TCTGACGGAG CTCTACATCG AGAACCAGCA GCACCTGCAG 240
CATCTGACGC TCAGTGACCT GAGAGGCCTG GGGGAGCTGA GGAACCTCAC CATTGTGAAG 300
AGTGGTCTCC GTTTCGTGGC GCCAGATGCT TTCCATTTCA CTCCTCGGCT CAGTCATCTG 360
AATCTCTCCT TCAATGCTCT GGAGTCTCTC TCCTGGAAAA CCGTCCAGGG CCTCTCCTTA 420
CAGGAACTAG TCCTGTCGGG AAACCCTCTG CACTGTTCCT GTGCCCTGTT CTGGCTGCAG 480
CGCTGGGAGC AGGAGGGGCG GGCCGGAGTG CGGGAACAGA AGCTGCAGTG TCCGGGCCAG 540
GGACCCCTGG CCCTCATGCC CAATGCCAGC TGTGGTGAGC CTGAGCTGAA GATCCAGATG 600
CCCAATGGCT CTGTGGATGT GGGGGACGAC GTGTTGCTAC AGTGCCAGGT GGAGGGGCAG 660
GGCCTGGAGC AGGCCGGCTG GATCCTCATG GACCTGGAGG AATCAGCCAC AGTGATGCAA 720
TCTGGGAGTC TGCCGTCCTT GGGACTGACC CTGGCCCATG TCACCAGTGA CCTCAATAGG 780
AAGAACGTGA CGTGCTGGGC CGAGAATCAT GTGGGCCGGG CTGAAATCTC CGTCCAGGTC 840
AACGTCTCCT TCCCTCCCAT CGTGAGCCTG CACACAGCAG TGGAGCAGCA CCACTGGTGC 900
ATTCCCTTCT CGGTGGACGG GCAGCCCGCA CCCTCCCTGC GCTGGTTCTT CAATGGCTCC 960
GTGCTCAATG AGACCAGCTT CATCTTCACT GAGTTCATGG AGCCGGCAGC CAATGAGACT 1020
ATGCGGCACG GCTGCCTGCG CCTCAACCAG CCCACCCACG TCAACAACGG CAACTACACG 1080
CTGCTGGCTA CCAACCCCTT GGGCCAGAAT GCCTCCTCCA TCATGGCCGC CTTCATGGAC 1140
AACCCTTTTG AGTTCAACCC TGAGGACCCC ATCCCTGTCT CCTTCTCGCC AGTCGACACC 1200
AACAGCACAT CTGGAAACCC AGTGGAGAAG GATGAAACAC CTTTTGGGGT CTCGATGGCC 1260
GTGGGCCTGG CCGTTTTTGC CTGCCTCTTC CTTTCTACCA TGTTCCTTGT GCTCAACAAA 1320
TGTGGACGGA GGAACAAGTT TGGGATCAAC CGCCCCGCTG TGCTGGCTCC AGAGGATGGA 1380
CTGGCCATGT CCCTGCATTT CATGACACTG GGTGGCAGCT CCTTGTCCCC CACCGAGAGC 1440
AAAGGCTCTG GGCTCCAAGG CCACATCATT GAGAACCCAC AGTACTTCAG TGATGCCTGT 1500
GTTCATCACA TCAAGCGCCG GGATATCGTG CTCAAGTGGG AGCTGGGTGA GGGCGCCTTT 1560
GGGAAGGTCT TCCTTGCCGA GTGCCACAAC CTGCTGCCCG AGCAGGACAA GATGCTAGTG 1620
GCCGTCAAGG CGCTGAAGGA AGTGTCCGAG AGCGCCAGGC AGGACTTCCA GCGGGAGGCC 1680
GAGCTGCTCA CCATGCTGCA GCACCAGCAC ATCGTGCGCT TCTTTGGCGT CTGCACCGAG 1740
GGCCGTCCGC TGCTCATGGT CTTTGAGTAC ATGCGGCATG GGGACCTTAA CCGCTTCCTT 1800
CGGTCCCACG GGCCTGATGC CAAGCTGTTG GCCGGCGGGG AAGACGTGGC TCCAGGGCCC 1860
CTGGGCCTGG GGCAGCTGCT GGCTGTGGCT AGCCAGGTCG CTGCGGGGAT GGTGTACCTA 1920
GCGGGTCTGC ACTTCGTGCA TCGCGACCTG GCCACGCGCA ACTGTTTGGT GGGTCAGGGC 1980
CTCGTGGTCA AGATCGGCGA TTTCGGCATG AGCCGGGATA TCTACAGCAC CGACTATTAC 2040
CGCGTGGGAG GCCGAACCAT GCTGCCCATC CGCTGGATGC CGCCCGAGAG CATCCTCTAC 2100
CGCAAGTTCA CCACCGAGAG CGACGTGTGG AGCTTCGGCG TGGTGCTCTG GGAGATCTTC 2160
ACCTATGGCA AGCAACCCTG GTACCAGCTC TCCAACACCG AGGCGATCGA GTGCATCACG 2220
CAGGGACGTG AGCTGGAGCG ACCGCGTGCC TGTCCGCCAG AGGTCTATGC CATTATGCGG 2280
GGCTGCTGGC AGCGGGAGCC CCAACAACGC CACAGCATCA AGGATGTACA TGCCCAGCTG 2340
CAAGCCCTGG CCCAGGCGCC TCCTGTCTAC CTGGATGTCC TGGGCTAG 2388
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlk+elgegafgkvflaec+nllpe+dk+lvavkalk+ se+ar+df+reaellt+lqh
Q: 509   IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEVSESARQDFQREAELLTMLQH  568
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         +hiv+++Gvcteg+pll+vfeym+hGdln+flr+hgpdakll++ge+  +g+lgl+qlla
Q: 569   QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDvaPGPLGLGQLLA  628
         ***********************************************999**********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         +a+q+aaG+vyla +hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml
Q: 629   VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  688
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238
         pirw+ppesilyrkfttesdvws+Gvvlwei+tyGkqp+yqlsnte+iecitqGr+lerp
Q: 689   PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERP  748
         ************************************************************
S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268
         racp+evy++m+gcwqrepq+r++ik+++a
Q: 749   RACPPEVYAIMRGCWQREPQQRHSIKDVHA  778
         ****************************97
Domain Sequence
(FASTA)
IVLKWELGEG AFGKVFLAEC HNLLPEQDKM LVAVKALKEV SESARQDFQR EAELLTMLQH 60
QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA 120
VASQVAAGMV YLAGLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180
PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEAIEC ITQGRELERP 240
RACPPEVYAI MRGCWQREPQ QRHSIKDVHA 270
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00382
EKS-ANC-00399
EKS-BOT-00411
EKS-CAJ-00416
EKS-CAF-00411
EKS-CAP-00439
EKS-DAR-00800
EKS-DIO-00067
EKS-EQC-00404
EKS-FEC-00394
EKS-GAM-00238
EKS-GAG-00348
EKS-GAA-00500
EKS-GOG-00403
EKS-HOS-00418
EKS-ICT-00391
EKS-LAC-00427
EKS-LOA-00421
EKS-MAM-00410
EKS-MEG-00341
EKS-MOD-00400
EKS-MUM-00444
EKS-MUP-00404
EKS-NOL-00373
EKS-OCP-00087
EKS-ORN-00525
EKS-ORC-00386
EKS-OTG-00414
EKS-PAT-00389
EKS-PES-00364
EKS-POA-00402
EKS-RAN-00426
EKS-SAH-00381
EKS-TEN-00519
EKS-TUT-00123
EKS-XET-00523
EKS-XIM-00515
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0010465; F:nerve growth factor receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0060385; P:axonogenesis involved in innervation
GO:0030183; P:B cell differentiation
GO:0042490; P:mechanoreceptor differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0045766; P:positive regulation of angiogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0032320; P:positive regulation of Ras GTPase activity
GO:0046579; P:positive regulation of Ras protein signal transduction
GO:0046777; P:protein autophosphorylation
GO:0048485; P:sympathetic nervous system development
KEGG
ssc:100154471;
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020461; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01940; NTKRECEPTOR1.
PR00109; TYRKINASE.
Created Date20-Feb-2013