EKS-SUS-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.6	1.5E-134	276	525	250

Status

Unreviewed

Ensembl Protein

ENSSSCP00000028933

UniProt Accession

F1SEK8;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000007334	ENSSSCP00000007811	ENSSSCT00000008025
ENSSSCG00000007334	ENSSSCP00000029882	ENSSSCT00000033033
ENSSSCG00000007334	ENSSSCP00000030676	ENSSSCT00000034998
ENSSSCG00000007334	ENSSSCP00000028933	ENSSSCT00000033397

Organism

Sus scrofa

Functional Description

Protein Length

542

Protein Sequence
(FASTA)

MGSNKSKPKD ASQRRRSLEP AENTHGGGGG GGGGGGAFPT SQTPSKPASA DGHRGPSTAF 60

APAAAEPKLF GGFNSSDTVT SPQRAGPLAG GVTTFVALYD YESRTETDLS FKKGERLQIV 120

NNTEGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180

FLVRESETTK GAYCLSVSDF DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS 240

KHADGLCHRL TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR 300

VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK 360

GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLACK VADFGLARLI 420

EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELTTKGRV PYPGMVNREV 480

LDQVERGYRM PCPPECPESL HDLMCQCWRK DPEERPTFEY LQAFLEDYFT STEPQYQPGE 540

NL 542

Nucleotide Sequence
(FASTA)

ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCAGCCAGC GGCGCCGCAG CCTGGAGCCT 60

GCGGAGAACA CCCACGGCGG CGGGGGCGGC GGCGGCGGTG GCGGTGGTGC CTTTCCCACC 120

TCACAGACCC CCAGCAAGCC AGCCTCCGCG GATGGTCATC GAGGCCCCAG CACGGCCTTC 180

GCCCCTGCGG CCGCCGAGCC CAAGCTGTTT GGTGGCTTCA ACTCCTCGGA CACTGTCACC 240

TCCCCGCAGA GGGCGGGGCC CCTGGCTGGC GGGGTGACCA CCTTTGTAGC CCTCTATGAC 300

TATGAGTCAC GGACAGAGAC TGACCTGTCT TTCAAGAAAG GGGAACGGCT CCAGATTGTC 360

AACAACACAG AGGGAGACTG GTGGCTGGCC CACTCACTCA GCACAGGACA GACGGGCTAC 420

ATCCCCAGCA ACTACGTGGC ACCTTCCGAC TCCATCCAAG CTGAGGAGTG GTACTTTGGC 480

AAGATCACCA GACGCGAGTC AGAAAGGTTA CTGCTCAATG CGGAGAACCC AAGAGGGACC 540

TTCTTAGTGC GAGAAAGCGA AACCACGAAA GGCGCCTACT GCCTCTCTGT GTCCGACTTC 600

GACAACGCCA AGGGCCTCAA TGTGAAGCAC TACAAGATCC GCAAGCTGGA CAGCGGCGGC 660

TTCTACATCA CCTCACGCAC CCAGTTCAAC AGCCTGCAGC AGCTGGTGGC CTACTACTCC 720

AAACACGCAG ATGGCCTGTG CCACCGCCTC ACCACTGTGT GCCCCACGTC CAAGCCGCAG 780

ACTCAGGGCC TGGCCAAGGA TGCCTGGGAG ATCCCCCGGG AGTCGCTGCG GCTGGAGGTC 840

AAGCTGGGCC AGGGCTGCTT TGGAGAGGTG TGGATGGGGA CCTGGAATGG CACCACTAGG 900

GTAGCCATCA AAACCCTGAA GCCTGGCACG ATGTCTCCGG AGGCCTTCCT GCAGGAGGCC 960

CAGGTCATGA AGAAACTGAG GCATGAGAAG CTGGTGCAGC TGTACGCGGT GGTGTCGGAG 1020

GAGCCCATCT ACATCGTCAC GGAATACATG AGCAAGGGGA GTTTGCTGGA CTTTCTCAAG 1080

GGTGAGACGG GCAAGTACCT GCGACTGCCT CAGCTGGTGG ACATGGCTGC TCAGATCGCC 1140

TCGGGCATGG CCTACGTGGA GCGGATGAAC TATGTCCACC GAGACCTCCG TGCTGCCAAC 1200

ATCCTGGTTG GAGAGAACCT CGCGTGCAAA GTGGCCGACT TCGGGCTGGC TCGGCTCATC 1260

GAAGACAATG AGTACACAGC TCGGCAAGGT GCCAAATTCC CCATCAAGTG GACGGCTCCA 1320

GAAGCTGCCC TCTATGGCCG GTTCACCATC AAGTCCGACG TGTGGTCCTT TGGGATCCTG 1380

CTGACGGAGC TCACAACCAA GGGACGGGTG CCCTACCCTG GGATGGTGAA CCGCGAGGTG 1440

CTGGACCAGG TGGAGCGGGG CTACCGGATG CCCTGTCCGC CTGAGTGTCC CGAGTCTCTG 1500

CATGACCTCA TGTGCCAGTG CTGGCGGAAG GACCCGGAGG AACGGCCCAC CTTCGAGTAC 1560

CTGCAGGCCT TCCTGGAGGA CTACTTCACG TCCACCGAGC CCCAGTACCA GCCCGGAGAG 1620

AACCTATAG 1629

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 276   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  335

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 336   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  394

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+l++kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 395   DLRAANILVGENLACKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  454

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+kdpee

Q: 455   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEE  514

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 515   RPTFEYLQAFL  525

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLACKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005770	; C:late endosome
GO:0005764	; C:lysosome
GO:0005743	; C:mitochondrial inner membrane
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0060444	; P:branching involved in mammary gland duct morphogenesis
GO:0016477	; P:cell migration
GO:0030900	; P:forebrain development
GO:0007243	; P:intracellular protein kinase cascade
GO:2001237	; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243	; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477	; P:oogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146	; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555	; P:response to interleukin-1
GO:0060065	; P:uterus development

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013