EKS-SUS-00303
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00303
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK264.71.2E-7830338309
StatusUnreviewed
Ensembl ProteinENSSSCP00000008113
UniProt AccessionF1RFM6;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000007592ENSSSCP00000008113ENSSSCT00000008332
OrganismSus scrofa
Functional Description
Protein Length385
Protein Sequence
(FASTA)
DRISVQLPSL KVIDQDNHRD GYDVKSDESN SSSIVFAEFT PEEEKSFVES GVDSDKNRVV 60
ACTAGLVPRN ASEFESSLDC QEKGLSDGSS TSIGGPHLPL QHHSNLEENF TSTEESSEEH 120
LDLLGHTEVQ YRLMLHIQMQ LCELSLWDWI ADRNQRGREN VDESACPYVM ASVATKIFQE 180
LVEGVFYIHN MGIVHRDLKP RNIFLHGPDQ QVKIGDFGLA CTDIIQKNTD WANGNGKRTP 240
THTSRVGTCL YASPEQLEGS EYDAKSDMYS LGVILLELFQ PFGTEMERAQ VLTGLRSGRI 300
PESLGKRCPV QAKYIQHLTR RNASQRPSAL QLLQSELFQN SGNVNLTLQM KILEQEKEIE 360
DLKQQLRLLS QDRGVEEDVR DEREP 385
Nucleotide Sequence
(FASTA)
GATAGAATTT CTGTTCAGTT GCCATCTCTG AAAGTGATCG ACCAGGACAA CCACAGAGAT 60
GGATATGATG TTAAAAGTGA TGAAAGTAAC AGCTCATCTA TTGTCTTTGC CGAATTCACC 120
CCGGAGGAAG AAAAATCCTT CGTTGAATCG GGTGTGGACA GTGACAAGAA CAGAGTGGTG 180
GCCTGCACCG CCGGTTTAGT CCCGAGAAAT GCCAGTGAAT TTGAATCGTC CCTTGATTGC 240
CAAGAAAAAG GCTTGTCTGA TGGGTCTTCC ACTTCGATCG GTGGCCCTCA CCTGCCACTT 300
CAGCATCATT CCAACCTGGA AGAGAATTTC ACCTCCACCG AGGAATCTTC GGAAGAACAC 360
TTAGACTTGC TGGGGCACAC AGAGGTGCAG TACCGCCTGA TGCTGCACAT CCAGATGCAG 420
CTGTGCGAGC TCTCGCTGTG GGACTGGATC GCGGACAGGA ACCAGCGGGG CCGGGAGAAC 480
GTGGACGAGT CCGCCTGTCC TTATGTTATG GCCAGTGTTG CAACAAAAAT TTTTCAAGAA 540
TTGGTGGAAG GTGTGTTTTA CATACACAAC ATGGGAATTG TACATAGAGA TCTAAAGCCC 600
AGAAATATTT TTCTTCATGG CCCCGATCAG CAAGTGAAAA TTGGAGACTT TGGCCTGGCC 660
TGCACAGACA TCATACAGAA GAACACAGAC TGGGCCAACG GAAATGGGAA GAGAACGCCA 720
ACACACACCT CCAGAGTGGG CACTTGTCTG TATGCGTCAC CTGAGCAGTT GGAAGGCTCC 780
GAGTATGATG CCAAGTCAGA CATGTACAGC CTGGGGGTCA TCCTGCTGGA GCTCTTCCAG 840
CCGTTTGGAA CAGAGATGGA GCGAGCGCAG GTTCTCACAG GTTTGAGAAG CGGCCGGATA 900
CCCGAGTCCC TCGGGAAAAG GTGCCCCGTC CAAGCCAAGT ACATCCAGCA CCTGACCAGG 960
AGAAACGCGT CCCAGAGGCC GTCTGCGCTT CAGCTGCTGC AGAGCGAACT TTTCCAAAAT 1020
TCTGGAAACG TTAATCTCAC CCTGCAGATG AAGATACTAG AGCAAGAGAA AGAAATCGAA 1080
GACCTGAAGC AGCAGCTGCG CCTCCTCTCT CAGGACAGAG GGGTGGAGGA GGACGTGAGA 1140
GACGAGCGGG AGCCC 1155
Domain Profile
S: 75    tdsseveaeaeleesesseesdtk....................................  98
         ++ss v+ae+++ee++s+ es ++                                    
Q: 30    NSSSIVFAEFTPEEEKSFVESGVDsdknrvvactaglvprnasefessldcqekglsdgs  89
         248889999999999999998888889999999999999999999999999999999999
S: 99    ............................................llyiqmelceketLkd  114
                                                     +l+iqm+lce  +L+d
Q: 90    stsiggphlplqhhsnleenftsteesseehldllghtevqyrlMLHIQMQLCE-LSLWD  148
         99999999999999999999999999999*************************.*****
S: 115   widerk......llesrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.s  162
         wi +r+      ++es++ +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  
Q: 149   WIADRNqrgrenVDESACPYVMasvatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgP  208
         ***9998988889999999999************************************99
S: 163   ddqvKigDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDi  222
         d+qvKigDFgLa++++ ++++d+++ + +++++ht++vgt+ly+sPeqle+s+Y++k+D+
Q: 209   DQQVKIGDFGLACTDIIQKNTDWANGNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDM  268
         ************************************************************
S: 223   fsLGlilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRps  282
         +sLG+il+eL++pf temer+++lt lr+g+ipe++ +++p+++k++q+l++r++++Rps
Q: 269   YSLGVILLELFQPFGTEMERAQVLTGLRSGRIPESLGKRCPVQAKYIQHLTRRNASQRPS  328
         ************************************************************
S: 283   asellksell  292
         a +ll+sel+
Q: 329   ALQLLQSELF  338
         *******986
Domain Sequence
(FASTA)
NSSSIVFAEF TPEEEKSFVE SGVDSDKNRV VACTAGLVPR NASEFESSLD CQEKGLSDGS 60
STSIGGPHLP LQHHSNLEEN FTSTEESSEE HLDLLGHTEV QYRLMLHIQM QLCELSLWDW 120
IADRNQRGRE NVDESACPYV MASVATKIFQ ELVEGVFYIH NMGIVHRDLK PRNIFLHGPD 180
QQVKIGDFGL ACTDIIQKNT DWANGNGKRT PTHTSRVGTC LYASPEQLEG SEYDAKSDMY 240
SLGVILLELF QPFGTEMERA QVLTGLRSGR IPESLGKRCP VQAKYIQHLT RRNASQRPSA 300
LQLLQSELF 309
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CII-00191
EKS-CIS-00092
EKS-DAR-00704
EKS-EQC-00332
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-LOA-00351
EKS-MAM-00345
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORA-00299
EKS-ORC-00319
EKS-ORL-00411
EKS-OTG-00345
EKS-PAT-00323
EKS-PES-00300
EKS-PEM-00181
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XIM-00431
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013