EKS-SUS-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.52.2E-151615874260
StatusUnreviewed
Ensembl ProteinENSSSCP00000008197
UniProt AccessionF1RMX5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB4
Gene Synonyms/Alias EPHB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000007675ENSSSCP00000008197ENSSSCT00000008416
OrganismSus scrofa
Functional Description
Protein Length987
Protein Sequence
(FASTA)
MELRALLCWA SLAAALEETL LNTKLETADL KWVTFPQVEG QWEELSGLDE EQHSVRTYEV 60
CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYFESDA 120
DTATAHTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLT KAGFYLAFQD 180
QGACMALLSL HLFYKKCAQL TVNLTHFPET VPRELVVPVA GSCVADAMPG SGPSPSLYCR 240
EDGQWAEQPV TGCSCAPGFE AAEGNTRCRA CGQGTFKSQS GEGSCQTCPA NSQSNTIGSS 300
VCQCRIGYFR ARTDSRGAPC TTPPSAPRSV VSRLNGSSLR LEWSAPLESG GREDLTYALR 360
CRECRPGGSC MPCGGDLTFD PGPRDLVEPW VAIRGLRPDF TYTFEVTALN GVSSLASGPV 420
PFEAVNVTTD REVPPPVSDI RVTRSSPSSL SLAWTVPRAP SGAVLDYEVK YHEKGAEGPS 480
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE HESWREQLAL 540
IAGTAVVGVV LVLVVIVIAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 600
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 660
FLSEASIMGQ FEHPNIIRLE GVVTNSVPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 720
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 780
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 840
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 900
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISTEDLLRI GVTLAGHQKK 960
ILASVQHMKS QAKPGAPGGS GAPAPQY 987
Nucleotide Sequence
(FASTA)
ATGGAGCTCC GGGCTCTGCT TTGCTGGGCT TCGCTTGCAG CCGCTTTAGA AGAGACCCTA 60
TTGAACACAA AATTGGAAAC TGCCGATTTG AAGTGGGTGA CATTTCCTCA GGTGGAGGGG 120
CAGTGGGAGG AGCTGAGTGG CCTGGATGAG GAGCAGCACA GCGTTCGGAC CTACGAGGTG 180
TGTGACGTGC AGCGGGCCCC AGGCCAGGCG CACTGGCTGC GCACCGGCTG GGTGCCCCGG 240
CGAGGGGCCG TCCACGTGTA TGCCACGCTG CGCTTCACCA TGCTGGAGTG CCTCTCCCTG 300
CCGCGGGCTG GCCGCTCCTG CAAGGAGACC TTCACCGTCT TCTACTTTGA GAGTGACGCG 360
GACACGGCCA CAGCCCACAC TCCAGCCTGG ATGGAGAACC CCTACATCAA GGTGGACACA 420
GTGGCTGCGG AGCACCTGAC CCGGAAGCGT CCCGGGGCCG AGGCCACCGG CAAGGTCAAT 480
GTCAAGACGC TGCGTCTGGG CCCGCTCACC AAGGCCGGTT TCTACCTGGC CTTCCAGGAC 540
CAGGGTGCCT GCATGGCCCT GCTGTCCCTG CACCTCTTCT ACAAGAAGTG CGCCCAGCTG 600
ACTGTGAACC TGACCCACTT CCCGGAGACG GTGCCTCGTG AGCTTGTGGT GCCTGTGGCA 660
GGGAGCTGCG TGGCGGATGC CATGCCTGGC TCTGGCCCGA GCCCCAGCCT CTACTGCCGG 720
GAGGATGGCC AGTGGGCCGA GCAGCCGGTC ACGGGCTGCA GCTGTGCTCC AGGGTTCGAG 780
GCTGCCGAGG GGAATACCAG GTGCCGAGCC TGTGGTCAGG GCACCTTCAA GTCTCAGTCC 840
GGAGAGGGGT CCTGCCAGAC ATGCCCAGCC AACAGCCAAT CCAACACCAT CGGCTCGTCT 900
GTCTGCCAGT GCCGCATTGG CTATTTCCGG GCCCGCACGG ACTCCCGGGG TGCACCCTGT 960
ACCACCCCAC CATCCGCTCC GAGAAGTGTG GTATCCCGCC TGAACGGCTC CTCCCTGCGC 1020
CTGGAGTGGA GCGCCCCCCT CGAGTCGGGC GGCAGAGAGG ACCTCACCTA CGCGCTCCGC 1080
TGCCGGGAGT GCCGGCCTGG GGGTTCCTGC ATGCCCTGTG GGGGAGACCT GACCTTCGAC 1140
CCTGGCCCCC GGGACCTGGT GGAGCCCTGG GTGGCAATTC GTGGGCTGCG TCCTGACTTC 1200
ACCTACACCT TCGAGGTCAC TGCCTTGAAC GGGGTGTCCT CCTTAGCCAG CGGGCCAGTC 1260
CCATTTGAGG CTGTGAATGT CACCACCGAC CGAGAGGTGC CGCCCCCAGT GTCTGACATC 1320
AGGGTGACTC GGTCATCCCC CAGCAGCTTG AGCCTGGCAT GGACTGTCCC TCGGGCACCC 1380
AGCGGGGCCG TGCTGGACTA CGAGGTCAAG TACCATGAGA AGGGCGCAGA GGGTCCTAGC 1440
AGCGTGCGGT TCCTCAAGAC GTCGGAGAAC CGGGCAGAGC TGCGGGGACT GAAGCGGGGA 1500
GCCAGCTACC TGGTCCAGGT GCGGGCACGC TCTGAGGCTG GCTACGGGCC CTTTGGCCAG 1560
GAGCATCACA GCCAGACCCA GCTGGACGAG CATGAGAGCT GGCGGGAGCA GCTGGCCCTG 1620
ATTGCAGGCA CCGCAGTCGT GGGTGTGGTG CTGGTGCTGG TGGTCATTGT CATTGCCGTT 1680
CTCTGTCTCA GGAAGCAGAG CAACGGGAGA GAAGCTGAAT ATTCGGACAA ACACGGACAG 1740
TATCTCATCG GGCACGGTAC TAAGGTCTAC ATTGACCCCT TCACTTACGA AGACCCGAAC 1800
GAGGCTGTGA GGGAATTTGC GAAAGAGATC GACGTCTCCT ACGTCAAGAT TGAAGAGGTG 1860
ATTGGCGCAG GCGAGTTCGG GGAGGTGTGC CGGGGGCGCC TCAAGGCCCC CGGGAAGAAG 1920
GAGAGCTGCG TGGCCATCAA GACCCTGAAG GGCGGCTACA CGGAGCGGCA GCGGCGGGAG 1980
TTCCTGAGTG AGGCCTCCAT CATGGGCCAG TTTGAGCACC CCAACATCAT CCGCCTGGAG 2040
GGCGTGGTCA CCAACAGCGT GCCCGTCATG ATCCTCACGG AGTTCATGGA GAACGGCGCC 2100
CTGGACTCCT TCCTGCGGCT GAACGACGGG CAGTTCACCG TCATCCAGCT CGTGGGCATG 2160
TTACGGGGCA TCGCCTCGGG CATGCGGTAC CTCGCGGAGA TGAGCTACGT CCACCGAGAC 2220
CTGGCCGCCC GCAACATCCT GGTCAATAGC AACCTGGTCT GCAAAGTTTC AGACTTTGGC 2280
CTCTCCCGAT TCTTGGAGGA GAACTCATCT GATCCCACCT ACACGAGCTC TCTGGGAGGA 2340
AAGATTCCCA TCCGATGGAC AGCCCCCGAG GCCATTGCCT TCCGGAAGTT CACATCTGCC 2400
AGTGATGCCT GGAGCTACGG GATTGTGATG TGGGAAGTCA TGTCGTTTGG GGAACGACCA 2460
TACTGGGACA TGAGCAATCA GGACGTGATC AATGCCATCG AACAGGACTA CCGGTTGCCC 2520
CCGCCCCCAG ACTGCCCCAC CTCCCTGCAT CAGCTCATGC TGGACTGTTG GCAGAAAGAT 2580
CGGAATGCCC GGCCCCGCTT CCCCCAGGTG GTCAGCGCCC TTGACAAGAT GATCCGGAAC 2640
CCTGCCAGCC TCAAAATTGT GGCCAGGGAG AATGGCGGGG CCTCGCACCC ACTCCTGGAT 2700
CAGCGGCAGC CTCACTACTC AGCTTTTGGC TCTGTGGGCG AATGGCTTCG AGCCATCAAG 2760
ATGGGAAGAT ATGAAGAAAG TTTTGCAGCC GCTGGGTTTG GCTCCTTCGA GCTGGTCAGC 2820
CAGATCTCCA CTGAGGACCT TCTCCGCATC GGAGTCACTC TGGCGGGACA CCAGAAGAAA 2880
ATCCTGGCCA GTGTTCAGCA CATGAAGTCC CAGGCCAAGC CTGGAGCCCC AGGCGGGTCG 2940
GGAGCACCAG CCCCCCAGTA CTGA 2964
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pgk+e++vaiktlk+g+te+qrr+flseasi+Gqf+hp
Q: 615   VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHP  674
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+s pvmi+te+mengaldsflr +dgqftviqlvgmlrGiasgm+yl++m
Q: 675   NIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM  734
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+le++s +++yt+s ggkipirwtapeaia+
Q: 735   SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSsDPTYTSSlGGKIPIRWTAPEAIAF  794
         *******************************99988*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasd+wsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlppp dcp++l+qlml
Q: 795   RKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLML  854
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f q+vs+l
Q: 855   DCWQKDRNARPRFPQVVSAL  874
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KAPGKKESCV AIKTLKGGYT ERQRREFLSE ASIMGQFEHP 60
NIIRLEGVVT NSVPVMILTE FMENGALDSF LRLNDGQFTV IQLVGMLRGI ASGMRYLAEM 120
SYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEENSSDPTY TSSLGGKIPI RWTAPEAIAF 180
RKFTSASDAW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPPD CPTSLHQLML 240
DCWQKDRNAR PRFPQVVSAL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00008
EKS-BOT-00007
EKS-CAJ-00008
EKS-CAF-00009
EKS-CAP-00006
EKS-DAR-00013
EKS-EQC-00009
EKS-FEC-00006
EKS-GAA-00011
EKS-GOG-00008
EKS-HOS-00009
EKS-ICT-00008
EKS-LAC-00014
EKS-LOA-00009
EKS-MAM-00007
EKS-MOD-00008
EKS-MUM-00009
EKS-MUP-00009
EKS-MYL-00010
EKS-NOL-00008
EKS-ORN-00012
EKS-ORA-00007
EKS-ORC-00008
EKS-ORL-00012
EKS-OTG-00009
EKS-PAT-00009
EKS-POA-00006
EKS-PRC-00003
EKS-RAN-00008
EKS-SAH-00007
EKS-TEN-00011
EKS-TUT-00005
EKS-XIM-00010
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0007155; P:cell adhesion
GO:0002042; P:cell migration involved in sprouting angiogenesis
GO:0046777; P:protein autophosphorylation
KEGG
ssc:100517028;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013