EKS-SUS-00104

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00104

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	393.2	7.2E-118	46	308	263

Status

Unreviewed

Ensembl Protein

ENSSSCP00000008900

UniProt Accession

I3L548;

Protein Name

Protein Synonyms/Alias

AP2-associated protein kinase 1;

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000008337	ENSSSCP00000008900	ENSSSCT00000009130

Organism

Sus scrofa

Functional Description

Protein Length

959

Protein Sequence
(FASTA)

MKKFFDSRRE QGGSGLGSGS SGGGGSTSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTESE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSFF SFKLLKKECP VPNVQNSPIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRAMVQPPP QVAGSSNQPG LLASVPQPKT 420

QAPPSQPLPQ SQAKQPQAPP APQQPPSAPA QGLPAQAQAT PQHQQQLFLK QQPQPPQPQP 480

QAQAPPETCY QYEIKVSPAQ FQAVHPAAQQ PAIAQFPAVS QGSSQQQLIQ NFYQQQQQQQ 540

QQQQLATTLH QQQLLTQQAA LQQKTTVAAI QPPQAQPATA SQPPPAQEPA IQAPVRQQPK 600

VQTTPPPAIQ GQKLGSLTPP SSPKAQRAGH RRILSDVTHS AVFGVPASKS TQLLQAAAAE 660

ASLNKSKSAT TTPSGSPRAS QQNVYNPSEG STWNPFDDDN FSKLTAEELL NKDFAKLGEG 720

KHPEKLGGSA ESLIPGFQPT QGDAFAASSF AAGTAEKRKG GQAVDSSLPL LSVSDPFIPL 780

QVPDAPEKLI EGLKSPDTSL LLPDLLPMTD PFGSTSDAVI EKADVAVESL IPGLEPPVPQ 840

RLPSQTESVA SNRTDSLTGE DALIDCSLLS NPTTDLLEEF APIAISAPAH KAAEDSNLIS 900

GFDVPEGSDK VAEDEFDPIP VLITKNPQGG HSRNSSGSSE SSLPNLARSL LLVDQLIDL 959

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC CAGGCGAGAG CAGGGAGGCT CTGGCCTGGG CTCCGGCTCC 60

AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG GGTCTTTGGC 120

ATTGGGCGAC AGCAGGTTAC TGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATCGTG 180

TTTCTGGTGA GGACAAGCAA TGGAATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGACCT GTCTGGGCAC 300

AAGAACATCG TGGGTTACAT TGATTCCAGT ATCAACAACG TGAGTAGCGG TGACGTGTGG 360

GAAGTGCTCA TTCTGATGGA CTTCTGCAGG GGAGGCCAGG TGGTCAACCT AATGAACCAG 420

CGCCTGCAAA CAGGTTTTAC AGAGAGTGAA GTGCTCCAGA TATTTTGTGA CACCTGTGAA 480

GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCGATTATCC ACCGCGATCT GAAGGTTGAA 540

AATATTCTGT TGCATGACCG AGGCCACTAC GTCCTGTGTG ACTTTGGAAG TGCTACCAAC 600

AAATTCCAGA ATCCCCAAAC TGAAGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 660

ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 720

ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AGTTATGCTA CTTCACTTTG 780

CCATTTGGGG AGAGTCAAGT GGCAATTTGT GACGGAAACT TCACAATTCC TGACAACTCT 840

CGGTATTCCC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 900

AGGCCAGATA TTTACCAGGT CTCCTTCTTC TCATTTAAAC TACTCAAGAA AGAATGCCCA 960

GTTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGC 1020

GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 1080

GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AAACTCAGCC CAACCCAGGA 1140

ATTCTTCCCA TCCAGCCAGC CCTGACCCCT CGAAAGAGGG CCATGGTTCA ACCCCCACCT 1200

CAGGTCGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GCGTTCCTCA ACCAAAAACC 1260

CAGGCTCCCC CCAGCCAACC CCTACCGCAA TCTCAGGCCA AGCAGCCCCA GGCTCCACCC 1320

GCCCCACAGC AGCCACCTTC TGCTCCAGCC CAGGGTCTGC CTGCGCAGGC CCAGGCCACA 1380

CCCCAGCACC AGCAGCAGCT CTTCCTCAAG CAGCAGCCGC AGCCTCCCCA GCCGCAGCCA 1440

CAGGCGCAGG CACCACCAGA AACATGTTAC CAATATGAGA TAAAAGTCTC TCCTGCTCAG 1500

TTTCAGGCTG TACACCCAGC AGCCCAACAG CCAGCAATCG CTCAATTCCC TGCGGTATCC 1560

CAAGGAAGCT CTCAACAGCA GCTGATACAG AACTTCTACC AGCAGCAGCA GCAGCAGCAG 1620

CAGCAGCAGC AGCTGGCTAC AACCCTGCAT CAACAACAGC TGCTGACTCA GCAGGCTGCC 1680

TTGCAGCAGA AGACCACGGT GGCAGCCATA CAGCCACCCC AGGCACAGCC GGCCACAGCC 1740

TCCCAGCCAC CCCCTGCCCA AGAGCCAGCG ATTCAGGCCC CGGTAAGACA ACAGCCAAAG 1800

GTTCAGACAA CGCCACCTCC TGCCATCCAG GGGCAGAAAC TCGGATCTCT CACTCCTCCA 1860

TCCTCGCCCA AGGCCCAGCG TGCTGGGCAC AGGCGGATTC TCAGTGACGT GACCCACAGT 1920

GCGGTCTTCG GGGTCCCTGC CAGCAAATCA ACCCAGCTGC TCCAGGCAGC TGCAGCTGAG 1980

GCCAGTCTCA ATAAGTCCAA GTCTGCAACC ACCACTCCTT CAGGCTCCCC TCGGGCCTCC 2040

CAGCAAAACG TTTATAATCC TTCAGAAGGT TCTACGTGGA ACCCCTTTGA CGACGACAAT 2100

TTCTCCAAAC TCACAGCTGA AGAACTGCTA AACAAGGACT TTGCCAAGCT GGGGGAAGGC 2160

AAACATCCTG AGAAGCTTGG TGGCTCAGCC GAGAGTTTGA TTCCAGGCTT TCAACCAACC 2220

CAGGGTGATG CTTTTGCTGC TTCCTCATTT GCTGCTGGAA CTGCTGAAAA AAGGAAGGGT 2280

GGGCAGGCTG TGGATTCTAG CCTTCCTCTT CTAAGTGTAT CTGATCCTTT CATTCCTCTT 2340

CAAGTACCTG ATGCACCAGA AAAACTAATT GAAGGACTCA AATCTCCTGA CACTTCTCTT 2400

CTGCTCCCTG ACCTCTTGCC TATGACAGAC CCTTTTGGTA GCACTTCTGA CGCTGTAATT 2460

GAAAAAGCTG ATGTCGCTGT TGAGAGTCTC ATACCAGGAC TGGAGCCCCC GGTGCCCCAG 2520

CGCCTCCCAT CTCAGACGGA ATCCGTGGCC TCCAACCGCA CAGATTCTCT CACCGGGGAA 2580

GATGCCCTGA TTGATTGCTC TCTGCTTTCT AACCCTACTA CTGACCTTCT GGAAGAATTT 2640

GCCCCCATAG CGATCTCTGC TCCGGCCCAT AAAGCTGCAG AAGATAGTAA TCTCATCTCA 2700

GGTTTTGATG TCCCTGAGGG CTCGGACAAG GTGGCAGAAG ATGAGTTTGA CCCTATTCCT 2760

GTATTGATAA CCAAAAACCC ACAAGGTGGG CACTCTAGAA ACAGCAGTGG GAGCTCTGAG 2820

TCCAGTCTTC CCAACCTAGC CAGGTCTTTA CTGCTGGTGG ATCAGCTCAT AGACCTGTAG 2880

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTESEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvl  267

         ys+++++li++mle+dp++Rp+i+qv+

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVS  308

         *************************96

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTESEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVS 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013