EPS-SUS-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SUS-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	290.6	1.6E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSSSCP00000009019

UniProt Accession

F1S5K0;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000008451	ENSSSCP00000009019	ENSSSCT00000009253

Organism

Sus scrofa

Functional Description

Protein Length

483

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT NNEDFRAAGK SGSALEPSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPV 300

SDEAMRKDSE LDKYLESRVE EIMEKSGEEG MPDLAHVMRI LSAENIPNLP PGGGLAGNII 360

FFRRNVIEAV YSRLNPHRES DGASDEAEEG GSQGKLVEAL RQMRINHRGN YRQLLEEMLT 420

SYRLAKVEGE ESPADPAATA TSSNSDAGNP VTMQESHTES KNDLAELDSC TEDAGTKMGG 480

GKI 483

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAGAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCCTGAG CAGCATGCAA GGCTGGAGAG TGGAAATGGA AGATGCACAT 120

ACAGCTGTTG TAGGTATTCC TCACGGCTTG GAAGACTGGT CATTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT AGCAAATTAT TGCTCCACAC ACTTACTAGA ACACATCACT 240

AATAACGAAG ACTTCAGGGC AGCTGGAAAA TCAGGATCTG CTCTTGAGCC TTCCGTGGAA 300

AACGTCAAGA ATGGCATCAG AACTGGCTTT TTGAAAATCG ATGAATACAT GCGTAACTTT 360

TCAGACCTCA GAAATGGCAT GGACAGGAGC GGTTCGACTG CAGTGGGAGT TATGATTTCC 420

CCTAAGCATA TCTACTTCAT CAACTGTGGC GACTCACGAG CTGTTCTCTA TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGCAACC CAAGGGAGAA GGAGCGAATC 540

CAAAATGCAG GAGGCAGTGT AATGATACAG CGTGTTAATG GTTCATTAGC GGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCAACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AAGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCCCCCGTC 900

TCAGATGAAG CAATGAGAAA AGACTCAGAA TTGGATAAGT ACTTGGAATC ACGGGTGGAA 960

GAAATTATGG AGAAGTCTGG TGAGGAAGGA ATGCCTGATC TTGCCCATGT CATGCGCATC 1020

TTGTCTGCCG AAAATATCCC AAATTTGCCT CCTGGGGGAG GTCTTGCTGG CAACATAATT 1080

TTTTTTAGGC GCAATGTTAT TGAAGCTGTT TATAGTAGGC TGAATCCACA TAGAGAAAGT 1140

GATGGGGCCT CCGATGAAGC AGAGGAAGGT GGATCACAGG GAAAATTGGT GGAAGCTCTC 1200

AGGCAAATGA GAATTAATCA TAGGGGAAAC TACCGACAAC TTCTGGAGGA GATGCTGACT 1260

AGTTACAGGC TAGCTAAAGT AGAGGGAGAA GAAAGCCCTG CTGACCCAGC TGCTACAGCT 1320

ACTTCTTCGA ACAGTGATGC TGGAAACCCA GTGACAATGC AGGAAAGCCA TACTGAATCA 1380

AAAAATGATC TTGCTGAATT AGACAGCTGT ACTGAAGATG CAGGGACAAA GATGGGTGGT 1440

GGAAAAATAT GA 1452

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfraagksgsALEPSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********999********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITNN 60

EDFRAAGKSG SALEPSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HIYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013