EKS-SUS-00353
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00353
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR593.81.5E-178563897335
StatusUnreviewed
Ensembl ProteinENSSSCP00000009430
UniProt AccessionC4PFJ6;
Protein Name
Protein Synonyms/Alias Mast/stem cell growth factor receptor;
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000008842ENSSSCP00000009430ENSSSCT00000009679
OrganismSus scrofa
Functional Description
Protein Length949
Protein Sequence
(FASTA)
GSSQPSVSPE ELSPPSIHPA KSELIVSAGD EIRLFCTDPG SVKWTFETLG QLSENTHAEW 60
IVEKAEAMNT GNYTCTNEGG LSSSIYVFVR DPEKLFLVDP PLYGKEDNDA LVRCPLTDPE 120
VTNYSLTGCE GKPLPKDLTF VADPKAGITI RNVKREYHRL CLHCSANQGG KSVLSKKFTL 180
KVRAAIRAVP VVAVSKASYL LREGEEFAVM CLIKDVSSSV DSMWIRENSQ TKAQVKRNSW 240
HQGDFNFLRQ ERLTISSARV NDSGVFMCYA NNTFGSANVT TTLEVVDKGF INIFPMMNTT 300
VFVNDGEDVD LIVEYEAYPK PEHRQWIYMN RTATDKWEDY PKSENESNIR YVSELHLTRL 360
KGTEGGTYTF LVSNADVNSS VTFNVYVNTK PEILTHDRLM NGMLQCVAAG FPEPTIDWYF 420
CPGTEQRCSV PVGPVDVQIQ NSSVSPFGKL VIHSSIDYSA FKHNGTVECR AYNDVGKSSA 480
FFNFAFKEQI HAHTLFTPLL IGFVIAAGMM CIIVMILTYK YLQKPMYEVQ WKVVEEINGN 540
NYVYIDPTQL PYDHKWEFPR NRLSFGKTLG AGAFGKVVEA TAYGLIKSDA AMTVAVKMLK 600
PSAHLTEREA LMSELKVLSY LGNHMNIVNL LGACTIGGPT LVITEYCCYG DLLNFLRRKR 660
DSFICSKQED HAEAALYKNL LHSKESSCSD STNEYMDMKP GVSYVVPTKA DKRRSARIGS 720
YIERDVTPAI MEDDELALDL EDLLSFSYQV AKGMAFLASK NCIHRDLAAR NILLTHGRIT 780
KICDFGLARD IKNDSNYVVK GNARLPVKWM APESIFNCVY TFESDVWSYG IFLWELFSLG 840
SSPYPGMPDS KFYKMIKEGF RMLSPEHAPV EMYDIMKTCW DADPLKRPTF KQIVQLIEKQ 900
ISESTNHIYS NLANCSPHRE NPAVDHSVRI NSVGSSASST QPLLVHEDV 949
Nucleotide Sequence
(FASTA)
GGCTCTTCTC AGCCATCTGT GAGTCCAGAG GAACTGTCTC CACCATCCAT CCATCCAGCA 60
AAATCAGAGT TAATCGTCAG TGCTGGCGAT GAGATTAGGC TGTTCTGCAC CGATCCAGGA 120
TCTGTCAAAT GGACTTTTGA GACCCTGGGT CAGCTGAGTG AGAATACACA CGCAGAGTGG 180
ATCGTGGAGA AAGCAGAGGC CATGAATACA GGCAATTATA CATGCACCAA TGAAGGCGGT 240
TTAAGCAGTT CCATTTATGT GTTTGTTAGA GATCCTGAGA AGCTTTTCCT CGTCGACCCT 300
CCCTTGTATG GGAAGGAGGA CAATGACGCG CTGGTCCGAT GTCCTCTGAC GGACCCAGAG 360
GTGACCAATT ACTCCCTCAC GGGCTGCGAG GGGAAACCCC TTCCCAAGGA TTTGACCTTC 420
GTCGCGGACC CCAAGGCCGG CATCACCATC AGAAACGTGA AGCGCGAGTA TCATCGGCTC 480
TGTCTCCACT GCTCCGCCAA CCAGGGGGGC AAGTCCGTGC TGTCGAAGAA ATTCACCCTG 540
AAAGTGAGGG CAGCCATCAG AGCTGTACCT GTTGTGGCTG TGTCCAAAGC AAGCTACCTT 600
CTCAGGGAAG GGGAGGAATT TGCCGTGATG TGCTTGATCA AAGACGTGTC TAGTTCCGTG 660
GACTCCATGT GGATCAGGGA GAACAGCCAG ACTAAAGCAC AGGTGAAGAG GAATAGCTGG 720
CATCAGGGTG ACTTCAATTT TCTGCGGCAG GAAAGGCTGA CAATCAGCTC AGCAAGAGTT 780
AATGATTCTG GCGTGTTCAT GTGTTACGCC AATAATACTT TTGGATCTGC AAATGTCACA 840
ACCACCTTAG AAGTAGTAGA TAAAGGATTC ATTAATATCT TCCCTATGAT GAATACCACT 900
GTGTTTGTAA ATGATGGCGA GGATGTGGAT CTAATTGTTG AATACGAGGC GTACCCCAAA 960
CCTGAACACC GACAGTGGAT ATATATGAAC CGCACTGCCA CTGATAAGTG GGAGGATTAT 1020
CCCAAGTCTG AGAATGAAAG TAACATCAGA TATGTAAGTG AACTTCACTT GACCAGATTA 1080
AAAGGGACCG AAGGAGGCAC TTACACATTT CTCGTGTCCA ATGCTGATGT CAATTCTTCT 1140
GTGACATTTA ATGTTTACGT GAACACAAAA CCAGAAATCC TGACTCATGA CAGGCTCATG 1200
AACGGCATGC TCCAGTGTGT GGCGGCAGGC TTCCCAGAGC CCACCATCGA TTGGTATTTC 1260
TGTCCAGGCA CCGAGCAGAG ATGTTCCGTT CCCGTTGGGC CAGTGGACGT GCAGATCCAA 1320
AACTCATCTG TATCACCGTT TGGAAAACTA GTGATTCACA GCTCCATTGA TTACAGTGCA 1380
TTCAAACACA ACGGCACAGT GGAGTGCAGG GCTTACAACG ATGTGGGCAA GAGTTCTGCC 1440
TTTTTTAACT TTGCATTTAA AGAACAAATC CATGCCCACA CCCTCTTCAC GCCTTTGCTG 1500
ATTGGTTTTG TGATCGCAGC GGGTATGATG TGTATCATCG TGATGATTCT CACCTATAAA 1560
TATCTACAGA AGCCCATGTA TGAAGTACAG TGGAAGGTTG TCGAGGAGAT AAATGGAAAC 1620
AATTATGTCT ACATAGACCC AACGCAACTT CCTTATGATC ACAAATGGGA ATTTCCCAGG 1680
AACAGGCTGA GTTTTGGCAA AACCTTGGGT GCTGGCGCCT TCGGGAAAGT CGTTGAGGCC 1740
ACTGCATACG GCTTAATTAA GTCAGATGCG GCCATGACCG TTGCCGTGAA GATGCTCAAA 1800
CCAAGTGCCC ATTTAACGGA ACGAGAAGCC CTAATGTCTG AACTCAAAGT CTTAAGTTAC 1860
CTCGGTAATC ACATGAATAT TGTGAATCTT CTCGGCGCCT GCACCATTGG AGGGCCCACC 1920
CTGGTCATTA CAGAATATTG TTGCTATGGT GATCTCCTGA ATTTTTTGAG ACGGAAACGT 1980
GATTCGTTTA TTTGCTCAAA GCAGGAAGAT CACGCAGAAG CGGCGCTTTA TAAGAACCTT 2040
CTGCATTCAA AGGAGTCTTC CTGCAGTGAC AGTACTAACG AGTACATGGA CATGAAACCC 2100
GGAGTGTCTT ATGTGGTACC AACCAAGGCA GACAAAAGGA GATCTGCGAG AATAGGCTCA 2160
TACATAGAAC GAGATGTGAC TCCTGCCATC ATGGAAGATG ATGAGTTGGC CCTAGACCTG 2220
GAGGACTTGC TCAGCTTTTC TTACCAAGTG GCAAAGGGCA TGGCCTTCCT CGCCTCGAAG 2280
AATTGTATTC ACAGAGACTT GGCGGCCAGA AATATCCTCC TTACTCATGG TCGAATCACA 2340
AAGATTTGTG ATTTTGGTCT AGCCAGAGAC ATCAAGAATG ATTCTAATTA CGTGGTCAAA 2400
GGAAACGCTC GGCTACCCGT GAAGTGGATG GCACCCGAGA GCATTTTCAA CTGTGTCTAC 2460
ACATTTGAAA GCGATGTCTG GTCCTATGGG ATTTTTCTGT GGGAGCTCTT CTCTTTAGGG 2520
AGCAGCCCCT ACCCCGGAAT GCCAGATTCT AAATTCTACA AGATGATCAA GGAGGGTTTC 2580
CGAATGCTCA GCCCTGAGCA TGCACCTGTG GAAATGTATG ACATCATGAA GACTTGCTGG 2640
GATGCGGATC CCCTCAAAAG ACCAACGTTT AAGCAGATCG TGCAGCTGAT TGAGAAGCAG 2700
ATTTCGGAGA GCACCAATCA CATTTATTCC AACTTAGCGA ACTGCAGCCC CCACCGGGAG 2760
AACCCCGCGG TGGATCATTC TGTGCGGATC AACTCCGTGG GCAGCAGTGC CTCCTCCACG 2820
CAGCCGCTGC TTGTCCACGA AGACGTCTGA 2850
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 563   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  622
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 623   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  679
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++s+s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 680   L-----LHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  734
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 735   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  794
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++ dskfy
Q: 795   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP-DSKFY  853
         ****************************************************99.9****
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a+ e+y+im++cw+a+p krp+fkq+v+l+
Q: 854   KMIKEGFRMLSPEHAPVEMYDIMKTCWDADPLKRPTFKQIVQLI  897
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCSDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPDSKF YKMIKEGFRM 300
LSPEHAPVEM YDIMKTCWDA DPLKRPTFKQ IVQLI 335
KeywordATP-binding; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-DRM-00197
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013