EKS-SUS-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/VEGFR	603.2	1.6E-181	834	1160	327

Status

Unreviewed

Ensembl Protein

ENSSSCP00000029403

UniProt Accession

F1RWF1;

Protein Name

Protein Synonyms/Alias

Gene Name

KDR

Gene Synonyms/Alias

KDR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000008844	ENSSSCP00000029403	ENSSSCT00000036588
ENSSSCG00000008844	ENSSSCP00000029589	ENSSSCT00000036335
ENSSSCG00000008844	ENSSSCP00000009434	ENSSSCT00000009683
ENSSSCG00000008844	ENSSSCP00000030628	ENSSSCT00000033870

Organism

Sus scrofa

Functional Description

Protein Length

1356

Protein Sequence
(FASTA)

MKSKALLALA LWLCVETRAA SVGLSSVSLD PPRLSIQKDI LTIMANTTLQ ITCRGQRDLD 60

WLWPNNQSGS EERVEVTDCS DGFFCKMLTI PKVIGNDTGA YKCFYPDTDM ASVVYVYVQD 120

YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGTISNLNVS LCARYPEKRF VPDGNRISWD 180

SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YKIYDVVLSP PHGVELSVGE 240

KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFMS TLTIDSVTRN 300

DQGRYTCAAS SGLMTKKNIT FVRVHEKPFV AFGSGMDSLV EATVGDRVRI PVKYLGYPPP 360

EIKWYKNGRP IESNHTIKVG HILTIMEVSE KDTGNYTVVL TNPISKEKQS HVVSLVVNVP 420

PQIGEKSLIS PVDSYQYGTS QTLTCTVYAV PPPSYIHWYW QLETECSYKP TQAALATNPY 480

TCKEWRNVED FQGGNRIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKAGRRE 540

RVISFHVTRG PEITLQPSIQ PTEQETVSLL CSADRTMFEN LTWYRLDPQA LPIHTGELPT 600

PVCKNLDALW KMNATMVSNS TNDILIMELQ NASLQDQGDY VCFAQDRKTK KRHCVARQLT 660

VLERMAPAIT GNLENQTTSI GETIEVSCTA SGNPSPQITW FKDNETLVED SGIVLKDGNR 720

NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIVEGAQEK TNLEVIILVG TAVIAMFFWL 780

LLVIVLRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL 840

GRGAFGQVIE ADAFGIDKTA TCKTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN 900

LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKE YVGEITVDPK 960

RRLDSITSSQ SSASSGFVEE KSLSDVEEEE VSEDLYKNFL TLEHLICYSF QVAKGMEFLA 1020

SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR 1080

VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML 1140

DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS 1200

CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDSQTDS 1260

GMVLASEELK TLEDRTKLAP SFSGLMPSKS KESVASEGSN QTSGYQSGYH SDDTDTTVYS 1320

SEEAELLRLM EMGPQAGSAA QILQPDSGTT LSSPPV 1356

Nucleotide Sequence
(FASTA)

ATGAAGAGCA AGGCGCTGCT GGCCCTTGCT CTGTGGCTCT GCGTGGAGAC CCGGGCTGCC 60

TCCGTGGGTT TGTCTAGTGT TTCTCTTGAT CCACCCAGGC TCAGCATACA AAAAGACATA 120

CTTACCATTA TGGCTAACAC AACGCTTCAA ATTACTTGCA GGGGTCAGAG GGACTTGGAC 180

TGGCTCTGGC CCAACAATCA GAGTGGCTCT GAGGAACGAG TGGAGGTGAC AGATTGCAGT 240

GACGGCTTCT TCTGTAAGAT GCTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC 300

TACAAGTGCT TCTACCCGGA CACTGACATG GCCTCTGTCG TCTATGTGTA CGTTCAAGAT 360

TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAGCATG GAGTTGTGTA CATCACTGAG 420

AATAAAAACA AAACTGTCGT GATTCCATGT CTGGGGACCA TTTCAAACCT CAATGTGTCC 480

CTTTGTGCGA GGTATCCAGA AAAGAGGTTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC 540

AGCAAGAAAG GCTTCACTAT TCCCAGCTAC ATGATCAGCT ATGCAGGCAT GGTCTTCTGT 600

GAAGCTAAAA TTAATGATGA AAGTTACCAG TCCATTATGT ACATAGTTGT GGTTGTAGGG 660

TACAAGATTT ATGATGTGGT TCTGAGCCCC CCTCACGGAG TCGAGCTGTC TGTTGGAGAG 720

AAGCTTGTCT TAAACTGTAC AGCAAGAACT GAACTAAACG TGGGCATTGA CTTCAACTGG 780

GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTCA ACCGGGACCT AAAAACCCAG 840

TCTGGGAGTG AGATGAAGAA GTTTATGAGC ACTTTGACTA TAGACAGTGT CACCCGGAAC 900

GACCAAGGGA GGTACACCTG TGCAGCTTCC AGTGGGCTCA TGACCAAGAA GAACATCACG 960

TTTGTCAGGG TCCATGAAAA GCCTTTTGTT GCTTTTGGCA GTGGCATGGA CTCTTTGGTG 1020

GAAGCCACCG TGGGAGACCG CGTCAGAATC CCTGTGAAGT ACCTGGGTTA CCCTCCCCCA 1080

GAAATAAAGT GGTATAAAAA TGGAAGACCC ATTGAGTCCA ATCACACAAT CAAAGTGGGG 1140

CATATACTGA CTATCATGGA AGTGAGTGAG AAGGATACCG GAAATTACAC TGTCGTCCTT 1200

ACCAATCCCA TTTCAAAGGA GAAACAGAGC CACGTGGTAT CTCTGGTTGT GAATGTCCCA 1260

CCCCAGATTG GTGAGAAATC TCTGATCTCC CCCGTGGACT CTTACCAGTA CGGCACCTCC 1320

CAAACGCTCA CCTGCACAGT CTATGCTGTT CCTCCCCCGA GCTACATCCA CTGGTATTGG 1380

CAGCTGGAGA CCGAGTGCTC CTATAAGCCC ACCCAAGCTG CCCTAGCGAC AAACCCATAT 1440

ACTTGTAAAG AATGGAGAAA CGTGGAGGAC TTCCAAGGGG GAAACAGAAT TGAAGTCAAC 1500

AAAAATCAGT TTGCCCTAAT TGAAGGAAAA AACAAGACTG TAAGTACCCT TGTTATCCAA 1560

GCAGCCAATG TGTCCGCTTT GTACAAATGT GAGGCGGTGA ACAAAGCCGG GAGAAGAGAG 1620

AGGGTTATCT CCTTCCATGT GACCAGGGGT CCGGAAATCA CTTTGCAACC CAGCATCCAG 1680

CCAACCGAGC AGGAGACCGT GTCTCTGCTG TGCTCCGCGG ACAGAACTAT GTTTGAGAAC 1740

CTCACGTGGT ACAGACTTGA CCCACAGGCT CTGCCGATCC ACACGGGAGA GCTGCCCACA 1800

CCTGTTTGCA AGAACTTGGA TGCTCTTTGG AAAATGAATG CTACCATGGT CTCTAATAGC 1860

ACGAATGACA TTTTGATCAT GGAACTGCAG AATGCATCCT TGCAGGACCA AGGAGACTAC 1920

GTCTGCTTTG CTCAGGACAG GAAGACCAAG AAAAGACATT GCGTGGCCAG GCAGCTCACA 1980

GTCCTAGAGC GCATGGCACC CGCGATCACA GGAAACCTCG AGAATCAGAC GACAAGTATT 2040

GGTGAAACCA TTGAAGTTTC CTGCACAGCA TCTGGGAATC CTTCTCCACA GATTACATGG 2100

TTTAAAGATA ATGAGACACT CGTGGAAGAC TCAGGCATCG TGCTAAAAGA TGGGAACCGG 2160

AACCTTACTA TCCGCAGGGT GAGGAAGGAG GATGAAGGCC TGTACACCTG CCAGGCTTGC 2220

AGTGTGCTCG GGTGTGCAAA AGTGGAGGCG TTTTTCATAG TGGAAGGTGC TCAGGAAAAG 2280

ACAAACTTGG AAGTCATTAT CCTAGTAGGC ACTGCAGTGA TTGCCATGTT CTTCTGGCTG 2340

CTTCTTGTCA TCGTTCTCCG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACGGGC 2400

TACTTATCCA TCGTCATGGA TCCAGATGAA CTGCCCTTGG ATGAGCACTG TGAGCGCCTG 2460

CCTTATGATG CCAGCAAGTG GGAATTTCCC AGGGACCGGC TGAAACTAGG GAAGCCTCTT 2520

GGCCGTGGCG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA 2580

ACTTGCAAGA CAGTGGCCGT AAAAATGTTG AAAGAAGGAG CAACACACAG CGAACACCGA 2640

GCCCTCATGT CCGAACTCAA GATCCTCATT CACATTGGCC ACCATCTCAA CGTGGTCAAT 2700

CTTCTGGGTG CCTGTACCAA GCCAGGGGGG CCACTCATGG TGATTGTGGA ATTCTGCAAG 2760

TTTGGAAATC TGTCCACTTA CTTAAGGAGC AAGAGAAACG AATTTGTCCC CTACAAGACT 2820

AAAGGGGCAC GGTTCCGGCA AGGAAAAGAA TATGTTGGTG AGATCACTGT GGATCCCAAA 2880

CGCCGCTTGG ACAGCATCAC CAGTAGCCAA AGCTCAGCCA GCTCTGGATT CGTGGAGGAG 2940

AAATCCCTCA GCGATGTGGA GGAAGAGGAA GTCTCAGAAG ATCTGTACAA GAACTTTCTG 3000

ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AAGGCATGGA GTTTTTGGCA 3060

TCGCGAAAGT GTATCCACAG GGACCTGGCG GCTCGAAACA TCCTCTTGTC AGAGAAGAAC 3120

GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAGGACCC GGATTACGTC 3180

AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA 3240

GTATACACCA TTCAGAGTGA CGTGTGGTCT TTTGGTGTCC TGCTCTGGGA AATATTTTCC 3300

TTAGGTGCTT CTCCATATCC TGGAGTAAAG ATTGATGAGG AATTTTGTAG GCGCTTGAAA 3360

GAAGGAACTA GAATGAGAGC CCCTGATTAC ACCACCCCAG AGATGTACCA GACGATGCTT 3420

GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACATTCT CCGAGCTGGT GGAGCACTTG 3480

GGAAATCTCT TACAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCCATA 3540

TCAGAGACTC TGAGCATGGA AGAGGATTCC GGACTCTCTC TGCCTACCTC ACCTGTTTCC 3600

TGCATGGAAG AAGAGGAAGT GTGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC 3660

AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA 3720

GATATCCCAT TGGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAGCCA GACAGACAGC 3780

GGGATGGTTC TTGCATCCGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTAGCGCCA 3840

TCTTTTAGCG GCCTGATGCC CAGCAAAAGC AAGGAGTCTG TGGCATCTGA AGGCTCCAAC 3900

CAGACGAGTG GCTACCAGTC TGGGTATCAC TCGGACGACA CGGACACCAC CGTGTACTCC 3960

AGCGAGGAGG CGGAACTTTT AAGGCTGATG GAGATGGGGC CGCAGGCTGG CAGTGCAGCT 4020

CAGATCCTGC AGCCTGACTC TGGGACCACA CTGAGCTCTC CTCCTGTTTA A 4071

Domain Profile

S: 1     lklGkslGeGafGkvveasafgikkeetcktvavkmlkegatasevrallselkilihiG  60

         lklGk lG+GafG+v+ea+afgi+k++tcktvavkmlkegat+se+ral+selkilihiG

Q: 834   LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIG  893

         79**********************************************************

S: 61    khlnvvnllGactkakgpllviveyckyGnlsnylrskrdefvlykekaaelrkkkeale  120

         +hlnvvnllGactk++gpl+vive+ck+Gnls+ylrskr+efv+yk+k+a++r+ ke++

Q: 894   HHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKEYVG  953

         ************************************************************

S: 121   alevdkkr...svsssrslassgfkeekslsdveeeeeaedlykepltledlisysfqva  177

         +++vd kr   s++ss+s+assgf+eekslsdveeee +edlyk++ltle+li+ysfqva

Q: 954   EITVDPKRrldSITSSQSSASSGFVEEKSLSDVEEEEVSEDLYKNFLTLEHLICYSFQVA  1013

         *****998899*************************************************

S: 178   rGmeflasrkvihrdlaarnillsennvvkicdfGlardiykdpdyvrkgdarlPlkWla  237

         +Gmeflasrk+ihrdlaarnillse+nvvkicdfGlardiykdpdyvrkgdarlPlkW+a

Q: 1014  KGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA  1073

         ************************************************************

S: 238   lesifdkvystksdvWsyGvllWeifslgasPyPgvqineelikrlkeGtrlraPelatp  297

         +e+ifd+vy+++sdvWs+GvllWeifslgasPyPgv+i+ee+++rlkeGtr+raP+++tp

Q: 1074  PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTP  1133

         ************************************************************

S: 298   eiyeimldcWkkdPeerPafaelvekl  324

         e+y++mldcW+++P++rP+f+elve+l

Q: 1134  EMYQTMLDCWHGEPSQRPTFSELVEHL  1160

         *************************97

Domain Sequence
(FASTA)

LKLGKPLGRG AFGQVIEADA FGIDKTATCK TVAVKMLKEG ATHSEHRALM SELKILIHIG 60

HHLNVVNLLG ACTKPGGPLM VIVEFCKFGN LSTYLRSKRN EFVPYKTKGA RFRQGKEYVG 120

EITVDPKRRL DSITSSQSSA SSGFVEEKSL SDVEEEEVSE DLYKNFLTLE HLICYSFQVA 180

KGMEFLASRK CIHRDLAARN ILLSEKNVVK ICDFGLARDI YKDPDYVRKG DARLPLKWMA 240

PETIFDRVYT IQSDVWSFGV LLWEIFSLGA SPYPGVKIDE EFCRRLKEGT RMRAPDYTTP 300

EMYQTMLDCW HGEPSQRPTF SELVEHL 327

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009897	; C:external side of plasma membrane
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048754	; P:branching morphogenesis of a tube
GO:0055074	; P:calcium ion homeostasis
GO:0035584	; P:calcium-mediated signaling using intracellular calcium source
GO:0045165	; P:cell fate commitment
GO:0048469	; P:cell maturation
GO:0016477	; P:cell migration
GO:0045446	; P:endothelial cell differentiation
GO:0030097	; P:hemopoiesis
GO:0048286	; P:lung alveolus development
GO:0001945	; P:lymph vessel development
GO:2000352	; P:negative regulation of endothelial cell apoptotic process
GO:0001541	; P:ovarian follicle development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0045766	; P:positive regulation of angiogenesis
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051770	; P:positive regulation of nitric-oxide synthase biosynthetic process
GO:0014068	; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0050927	; P:positive regulation of positive chemotaxis
GO:0046777	; P:protein autophosphorylation
GO:0008360	; P:regulation of cell shape
GO:0043129	; P:surfactant homeostasis
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013106	; Ig_V-set.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009136	; Tyr_kinase_VEGFR2_rcpt.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.
PF07686	; V-set; 1.

SMARTs

SM00409	; IG; 5.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 5.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832	; VEGFRECEPTOR.
PR01834	; VEGFRECEPTR2.

Created Date

20-Feb-2013