EKS-SUS-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph427.22.1E-128607819213
StatusUnreviewed
Ensembl ProteinENSSSCP00000009514
UniProt AccessionF1RVG1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA5
Gene Synonyms/Alias EPHA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000008919ENSSSCP00000009514ENSSSCT00000009766
OrganismSus scrofa
Functional Description
Protein Length819
Protein Sequence
(FASTA)
MGDLGWIAFP KNGWEEIGEV DENYAPIHTY QVCKVMEQNQ NNWLLTSWIS NEGASRIFIE 60
LKFTLRDCNS LPGGLGTCKE TFNMYYFESD GENGRNIKEN QYIKIDTIAA DESFTELDLG 120
DRVMKLNTEV RDVGPLSKKG FYLAFQDVGA CIALVSVRVY YKKCPSVVRH LAVFPDTITG 180
ADSSQLLEVS GSCVNHSVTD EPPKMHCSAE GEWLVPIGKC MCKAGYEEKN GTCQVCRPGF 240
FKASPHSQSC SKCPPHSYTH EEASTSCVCE KDYFRRESDP PTMACTRPPS APRNAISNVN 300
ETSVFLEWIP PADTGGRKDV SYYIACKKCS SHAGVCDECG GHVRYLPQQI GLKNTSVMMV 360
DLLAHTNYTF EIEAVNGVSD LSPGARQYVS VNVTTNQAAP SPVTNVKKGK IAKNSISLSW 420
QEPDRPNGII LEYEIKYFEK DQETSYTIIK SKETTITAEG LKPASVYVFQ IRARTAAGYG 480
VFSRRFEFET IPVSVAASSD QSQIPIIAVS VTVGVILLAV VIGFLLSGSC CDCGCGRASS 540
LCAVAHPSLI WRCGYSKAKQ DPEEEKMHFH NGHIKLPGVR TYIDPHTYED PNQAVHEFAK 600
EIEASCITIE RVIGAGEFGE VCSGRLKLPG KRELPVAIKT LKVGYTEKQR RDFLGEASIM 660
GQFDHPNIIH LEGVVTKSKP VMIVTEYMEN GSLDTFLKKN DGQFTVIQLV GMLRGIAAGM 720
KYLSDMGYVH RDLAARNILI NSNLVCKVSD FGLSRVLEDD PEAAYTTRGG KIPIRWTAPE 780
AIAFRKFTSA SDVWSYGIVM WEVVSYGERP YWEMTNQDV 819
Nucleotide Sequence
(FASTA)
ATGGGAGACT TGGGATGGAT TGCTTTTCCA AAAAATGGGT GGGAAGAGAT TGGTGAAGTT 60
GATGAAAATT ATGCCCCTAT CCATACATAC CAAGTATGCA AAGTTATGGA ACAGAATCAG 120
AATAACTGGC TTTTGACCAG TTGGATCTCC AACGAAGGTG CTTCCAGAAT CTTCATAGAA 180
CTCAAGTTTA CTCTGCGGGA CTGCAACAGC CTTCCCGGAG GACTGGGGAC CTGTAAGGAA 240
ACTTTTAACA TGTATTATTT TGAGTCAGAT GGTGAGAATG GGAGAAACAT CAAGGAAAAC 300
CAGTACATCA AAATTGATAC CATTGCTGCC GATGAAAGCT TTACAGAACT TGATCTTGGC 360
GACCGTGTCA TGAAACTGAA TACAGAGGTC AGGGATGTAG GACCTCTAAG CAAAAAGGGA 420
TTTTATCTTG CTTTTCAAGA TGTAGGTGCA TGCATCGCTC TGGTTTCTGT GCGTGTGTAT 480
TATAAAAAAT GCCCTTCTGT GGTACGGCAC CTGGCTGTCT TCCCTGACAC GATCACCGGA 540
GCTGATTCTT CGCAGTTGCT TGAGGTGTCG GGGTCCTGTG TCAACCATTC TGTGACAGAT 600
GAACCTCCCA AAATGCACTG CAGTGCTGAA GGGGAGTGGC TGGTTCCCAT CGGGAAATGC 660
ATGTGCAAGG CAGGCTATGA AGAGAAAAAT GGCACCTGTC AAGTGTGCAG ACCTGGGTTC 720
TTCAAAGCCT CACCTCACAG CCAGAGCTGC AGCAAATGTC CACCTCACAG TTATACCCAT 780
GAGGAAGCTT CAACCTCTTG TGTCTGTGAA AAGGATTATT TCAGGAGGGA GTCTGATCCA 840
CCCACAATGG CATGTACAAG ACCCCCCTCA GCTCCTCGGA ATGCCATCTC AAATGTTAAT 900
GAAACTAGTG TCTTTCTGGA ATGGATTCCT CCTGCTGACA CTGGTGGAAG GAAAGATGTG 960
TCATATTATA TTGCATGCAA GAAGTGCAGC TCCCATGCAG GTGTGTGTGA CGAGTGTGGC 1020
GGTCATGTCA GGTACCTCCC CCAGCAAATC GGCCTGAAAA ACACCTCTGT CATGATGGTG 1080
GATCTGCTCG CTCACACAAA CTATACCTTT GAGATTGAGG CAGTGAATGG AGTGTCCGAC 1140
TTGAGCCCAG GAGCCCGGCA GTATGTGTCT GTTAATGTAA CCACAAATCA AGCAGCCCCT 1200
TCTCCAGTCA CCAATGTGAA AAAGGGGAAG ATTGCAAAAA ACAGCATCTC TCTGTCTTGG 1260
CAAGAGCCAG ATCGCCCCAA TGGAATCATC CTGGAGTATG AAATCAAATA TTTTGAAAAG 1320
GACCAAGAGA CCAGCTATAC AATTATCAAA TCTAAAGAGA CAACTATAAC TGCAGAGGGC 1380
TTGAAACCAG CTTCAGTGTA TGTCTTCCAA ATTCGTGCAC GTACAGCTGC AGGCTATGGT 1440
GTCTTCAGTC GAAGATTTGA GTTTGAAACC ATCCCAGTGT CAGTTGCAGC CTCCAGCGAT 1500
CAAAGCCAGA TTCCTATAAT TGCTGTGTCT GTGACAGTGG GAGTCATTTT GTTGGCAGTG 1560
GTTATCGGCT TCCTCCTCAG TGGAAGTTGC TGCGATTGTG GCTGTGGAAG GGCTTCTTCC 1620
CTGTGCGCTG TTGCCCATCC AAGCCTAATA TGGCGGTGCG GTTACAGCAA AGCAAAACAA 1680
GATCCAGAAG AGGAAAAGAT GCATTTTCAT AATGGGCACA TTAAACTGCC AGGAGTAAGA 1740
ACATATATTG ATCCGCATAC CTATGAGGAT CCCAATCAAG CTGTCCATGA ATTTGCCAAG 1800
GAGATAGAAG CTTCATGTAT CACCATTGAA AGAGTCATTG GAGCGGGTGA ATTTGGTGAA 1860
GTTTGTAGTG GACGTTTGAA GCTTCCAGGA AAAAGAGAAT TACCTGTGGC GATTAAAACC 1920
CTTAAAGTAG GCTATACGGA AAAGCAACGC AGAGACTTCC TGGGTGAAGC AAGCATCATG 1980
GGTCAGTTTG ACCATCCGAA CATCATTCAC CTAGAAGGTG TGGTAACCAA AAGTAAACCA 2040
GTGATGATAG TGACAGAGTA TATGGAAAAT GGCTCTTTAG ATACATTTTT AAAGAAAAAC 2100
GACGGGCAGT TCACTGTGAT TCAGCTGGTT GGCATGCTGC GAGGCATCGC TGCAGGAATG 2160
AAGTACCTTT CCGACATGGG CTATGTGCAT AGAGACCTTG CTGCCAGAAA CATCTTAATC 2220
AACAGTAACC TTGTGTGCAA AGTGTCTGAC TTTGGGCTAT CTAGGGTCCT GGAAGATGAT 2280
CCTGAAGCAG CCTACACCAC AAGGGGAGGC AAAATTCCAA TCAGATGGAC TGCCCCAGAA 2340
GCTATAGCTT TCCGAAAGTT CACCTCTGCC AGCGATGTCT GGAGCTATGG AATCGTGATG 2400
TGGGAGGTTG TGTCTTATGG AGAGAGACCC TACTGGGAGA TGACCAATCA AGATGTA 2457
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ie+viGaGefGevcsGrlklpgkre++vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 607   ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  666
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtkskpvmivteymeng+ld+fl+k+dgqftviqlvgmlrGia+gmkylsdm
Q: 667   NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDM  726
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk
Q: 727   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK  786
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdv  213
         ftsasdvwsyGiv+wev+syGerpyw+m+nqdv
Q: 787   FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDV  819
         ********************************8
Domain Sequence
(FASTA)
ITIERVIGAG EFGEVCSGRL KLPGKRELPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI AAGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAFRK 180
FTSASDVWSY GIVMWEVVSY GERPYWEMTN QDV 213
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00005
EKS-BOT-00003
EKS-CAJ-00003
EKS-CAP-00002
EKS-DAR-00003
EKS-ECT-00001
EKS-EQC-00002
EKS-GAG-00002
EKS-GOG-00011
EKS-ICT-00003
EKS-LOA-00003
EKS-MAM-00003
EKS-MOD-00003
EKS-MUP-00005
EKS-MYL-00007
EKS-NOL-00003
EKS-ORA-00002
EKS-OTG-00008
EKS-PAT-00004
EKS-PES-00002
EKS-POA-00003
EKS-PTV-00002
EKS-SAH-00003
EKS-SOA-00001
EKS-TAG-00002
Gene Ontology
GO:0030425; C:dendrite
GO:0009897; C:external side of plasma membrane
GO:0016021; C:integral to membrane
GO:0043025; C:neuronal cell body
GO:0048471; C:perinuclear region of cytoplasm
GO:0005791; C:rough endoplasmic reticulum
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0021766; P:hippocampus development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0032314; P:regulation of Rac GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013