EPS-SUS-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SUS-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	277.6	1.4E-82	131	334	204

Status

Unreviewed

Ensembl Protein

ENSSSCP00000009574

UniProt Accession

F1RYU8;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000008972	ENSSSCP00000009574	ENSSSCT00000009827

Organism

Sus scrofa

Functional Description

Protein Length

754

Protein Sequence
(FASTA)

MGSGTSNPHH FTFQNTEKAF KAAALIQRWF RRYMARLEMR RHCTWSIFQS IEYAGQQDQV 60

KLHDFFSYLL DHFTPSSHDE TDFLNRIFTE EKCPQDSEME SCGDYESMEV PGSYTGPHLS 120

FPLLPEHATA LVEAFRLKQE RLHARYVLNL LHEARKHLVQ LPNINRVSTC YSEEITVCGD 180

LHGQLDDLIF IFHKNGLPSP ERAYVFNGDF VDRGKDSVEV LMVLFAFMLV YPKEFHLNRG 240

NHEDYMVNLR YGFTKEVMQK YKTHGKKILK ILQDVFCWLP LATLVDEKVL ILHGGVSDMT 300

DLELLAKLDR HKIVSTLRYK TRKENKKQAE KKGKATQTSS AGRPSPWFLP QSHSFPSSPL 360

HPSAHKAHRT GRSSSVPCSL PLDPKELSRR VRRSVDLELE RCRQQAGFPV IKEKEESSPS 420

ASEADLDADE WPEPTQEEWR QVVDILWSDP MPQEGCRANT VRGGGCYFGP NVTEWLLQKY 480

NLQFLIRSHE CKPEGYEFCH GRKVLTIFSA SNYYAVGSNR GAYVKLGPAL TPHIVQFQAN 540

KATHTLTMRQ RISRVEESAL RALREKFFAH SSDLLVEFKK HDKDDTGLIT LSDWAVAVES 600

VLHLGLPWRM LRPQLVNSSL DNKLEYKAWL GNMAKKQLSH ENIQSSLLET LYRNRSNLET 660

IFRIIDSDHS GFISLDEFRQ IWKLFSAHMN TDVTDDCICD LARSIDFNKD GRIDVNEFLE 720

AFRLVEQSCS EADASACPQA TSISSGDHSS FGAH 754

Nucleotide Sequence
(FASTA)

ATGGGAAGCG GCACCTCGAA CCCACATCAT TTTACCTTCC AGAACACAGA GAAAGCCTTC 60

AAGGCAGCGG CCCTGATCCA GAGGTGGTTC CGGCGCTACA TGGCACGCCT GGAGATGAGG 120

CGGCACTGCA CCTGGAGCAT CTTCCAGTCT ATAGAGTACG CTGGGCAGCA AGACCAGGTC 180

AAGCTCCATG ATTTCTTCAG CTACCTGTTG GATCACTTCA CCCCCAGCAG TCACGACGAG 240

ACAGATTTCC TGAACCGCAT ATTCACTGAA GAGAAATGCC CCCAGGACTC GGAGATGGAG 300

AGCTGCGGTG ACTACGAGTC CATGGAGGTG CCGGGCAGTT ACACGGGGCC GCACCTCTCC 360

TTCCCGCTCC TTCCCGAGCA CGCAACCGCC CTGGTGGAAG CTTTCAGACT GAAACAAGAG 420

AGGCTCCACG CTCGCTACGT CTTGAATCTT CTACATGAAG CCAGGAAGCA TCTGGTACAA 480

CTGCCAAACA TCAACCGTGT CTCCACCTGC TACAGCGAGG AAATCACAGT GTGTGGAGAT 540

TTACATGGCC AATTGGACGA CTTAATATTT ATATTTCATA AGAATGGCCT CCCGTCACCA 600

GAGCGGGCCT ATGTGTTCAA CGGCGACTTT GTGGATCGAG GCAAGGATTC AGTCGAGGTC 660

CTGATGGTTC TTTTTGCCTT CATGTTGGTT TACCCCAAAG AGTTCCATCT CAACCGAGGA 720

AACCATGAGG ACTATATGGT GAACCTACGC TATGGTTTCA CCAAGGAAGT GATGCAAAAA 780

TATAAGACAC ATGGCAAGAA AATACTAAAA ATACTGCAAG ATGTGTTCTG TTGGCTTCCG 840

CTGGCCACTC TGGTTGATGA GAAAGTCCTG ATTCTTCACG GTGGCGTGTC AGACATGACT 900

GACTTGGAGC TCTTGGCTAA ACTAGACAGA CATAAGATTG TTTCCACCTT GAGATACAAA 960

ACAAGAAAGG AGAATAAGAA GCAGGCGGAG AAAAAGGGGA AAGCCACCCA GACAAGCTCT 1020

GCCGGGAGAC CCTCCCCGTG GTTCCTCCCC CAAAGCCACT CTTTCCCCTC CTCACCCCTG 1080

CATCCCAGCG CCCACAAAGC CCACAGAACC GGGCGCTCAT CCAGCGTCCC CTGTAGCCTC 1140

CCTCTGGACC CCAAGGAGCT CTCCCGGCGG GTGCGGCGCT CGGTGGACCT GGAGCTGGAG 1200

AGGTGCCGGC AGCAAGCGGG CTTCCCAGTG ATCAAGGAGA AGGAGGAGTC ATCACCCTCG 1260

GCGTCAGAAG CGGATTTGGA TGCTGACGAG TGGCCCGAGC CCACTCAGGA GGAGTGGAGG 1320

CAGGTGGTGG ATATACTGTG GAGCGACCCC ATGCCTCAGG AGGGCTGCAG GGCCAACACC 1380

GTTCGAGGAG GCGGCTGTTA TTTTGGACCT AATGTGACAG AATGGTTGCT ACAGAAATAC 1440

AACCTGCAAT TCCTGATCCG CTCACACGAG TGCAAACCCG AAGGCTACGA ATTCTGCCAC 1500

GGCCGCAAGG TGTTAACCAT CTTTTCTGCC TCCAACTACT ACGCAGTCGG CAGTAACAGA 1560

GGCGCCTATG TCAAACTGGG GCCGGCCTTG ACCCCTCACA TCGTGCAGTT TCAAGCTAAC 1620

AAGGCCACCC ACACACTCAC CATGAGGCAA AGGATTAGCA GAGTAGAAGA GTCAGCTCTG 1680

AGAGCCCTGC GGGAAAAGTT CTTTGCCCAT TCCTCAGATC TTCTTGTTGA ATTTAAGAAG 1740

CATGATAAAG ATGACACTGG TCTAATCACA CTGAGTGACT GGGCAGTGGC CGTGGAGTCT 1800

GTGTTGCATC TGGGGCTACC CTGGCGGATG CTGAGGCCAC AGCTGGTGAA CAGCTCACTG 1860

GATAACAAGC TGGAATACAA GGCCTGGCTG GGGAACATGG CCAAAAAACA GCTGAGCCAC 1920

GAGAACATAC AGTCAAGTTT GCTGGAAACG CTATACCGAA ATCGATCCAA CTTGGAGACG 1980

ATTTTTAGGA TCATAGACAG TGATCATTCA GGGTTCATCT CACTGGACGA GTTCAGGCAG 2040

ATTTGGAAGC TGTTCAGCGC TCACATGAAC ACTGATGTCA CAGACGACTG CATCTGTGAC 2100

CTCGCCCGAA GCATCGACTT CAACAAGGAC GGCCGCATTG ATGTCAATGA GTTCCTGGAG 2160

GCCTTCCGCC TTGTGGAGCA ATCCTGCTCA GAGGCCGATG CCTCAGCTTG CCCTCAAGCC 2220

ACAAGCATTA GCAGTGGTGA CCACAGCAGC TTTGGCGCAC ACTAA 2265

Domain Profile

S: 4     llevfkkkr.ilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlll  62

         l+e+f+ k+ +lha+yvl++l+ea+k l qlpni++vst+ s+e+tv+GdlhG+lddl++

Q: 131   LVEAFRLKQeRLHARYVLNLLHEARKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIF  190

         89****8777**************************************************

S: 63    vlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnar  122

         +++knGlPs +++yvfnGdfvdrGk ++evl+vl +++lv+P++ +lnrGnhed ++n+r

Q: 191   IFHKNGLPSPERAYVFNGDFVDRGKDSVEVLMVLFAFMLVYPKEFHLNRGNHEDYMVNLR  250

         ************************************************************

S: 123   yGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksver  182

         yGf+kev++kyk++gk+il+il++v+ wlPl+++vd++vl++hGG+s+ t+l+ll +++r

Q: 251   YGFTKEVMQKYKTHGKKILKILQDVFCWLPLATLVDEKVLILHGGVSDMTDLELLAKLDR  310

         ************************************************************

S: 183   kkrksvllpPeessrdlgrldtdge  207

         +k +s l+  +  + ++ + +++g+

Q: 311   HKIVSTLRYKTRKENKK-QAEKKGK  334

         *******9887544432.3333333

Domain Sequence
(FASTA)

LVEAFRLKQE RLHARYVLNL LHEARKHLVQ LPNINRVSTC YSEEITVCGD LHGQLDDLIF 60

IFHKNGLPSP ERAYVFNGDF VDRGKDSVEV LMVLFAFMLV YPKEFHLNRG NHEDYMVNLR 120

YGFTKEVMQK YKTHGKKILK ILQDVFCWLP LATLVDEKVL ILHGGVSDMT DLELLAKLDR 180

HKIVSTLRYK TRKENKKQAE KKGK 204

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception
GO:0043409	; P:negative regulation of MAPK cascade
GO:0010801	; P:negative regulation of peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013