EKS-SUS-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	389.8	7.3E-117	12	265	254

Status

Unreviewed

Ensembl Protein

ENSSSCP00000009686

UniProt Accession

F1RRA8;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000009076	ENSSSCP00000009686	ENSSSCT00000009942

Organism

Sus scrofa

Functional Description

Protein Length

964

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRRKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDIWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSREAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKNKDLGTVE DSIDSGHATI STAITASSST 300

SICGSLFDRR KLLIDQPLPN KVTIFPKNKN SSDFTSSGDR SSFYTQWGNQ EQETSNSGRG 360

RIIQEAEERP HSRYLRRAHS SDRSGTSNQS RAKTYTMERC HSAEMLSKSK RSGVDENEEG 420

YSPTNSNANI FNVFKEKTSS GSGSFEGPDN NQALSNHLCP GKTPFPFPDQ TAQTEMVQQW 480

FGNLQIHAHL RETTEHNSIN PNRDFQGHLN LQAISRNVWF DKRAKKSPSA SDNAHPTKQL 540

TAFHSKPEII QQESFFGSDP FSEQSKTRGT EPPLGYQKRT LRSITSPLTA YRLKPIRQKT 600

KKAVVSILDS EEVCVELLKE FASQEYVKEV LQISSDGSMI TIYYPNDGRG FPLADRPPSP 660

TDNISRYRFD NLPEKYWRKY QYASRFVQLV RSKSPKITYF TRYAKCVLME NSPGADFEVW 720

FYDGAKIHKT EDLIQVIEKT GKSYNLKGES EVNSLKEEIK MYMDHANEGH RICLALESII 780

SEEEKKSGSA PFFPIIIGRK PSSTSSPKAL SPLSPVDPDY PMTDTPSLNR MIINSAASPK 840

QAPIPNPSMV TNEGFSLTGA ASGTNIPSNS PKDCLPKSAQ LLKSVFVKNV GWATQLTSGA 900

VWVQFNDGSQ LVVQAGVSSI SYTSPNGQTT RYGENEKLPE YIKQKLHCLS SILLMFSNPT 960

PSFH 964

Nucleotide Sequence
(FASTA)

ATGGCGACGT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATTC ATTGCCAATT GAAACATCCT TCTATCTTGG AGCTGTATAA CTACTTTGAA 240

GATAGCAATT ATGTGTACCT AGTATTAGAA ATGTGCCATA ATGGAGAAAT GAATAGGTAT 300

CTAAAAAACA GAAGAAAACC ATTCTCAGAA AATGAAGCTC GACACTTCAT GCACCAGATC 360

ATCACAGGAA TGTTGTATCT CCATTCTCAT GGTATATTAC ACCGGGACCT CACACTTTCT 420

AACCTCTTAC TTACACGTAA TATGAACATC AAGATTGCCG ATTTTGGGCT AGCAACTCAG 480

TTGAAGATGC CACATGAAAA GCACTATACT TTATGTGGAA CTCCTAATTA TATTTCTCCT 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATA TTTGGTCCTT GGGATGTATG 600

TTTTATACAT TACTTATTGG GAGACCACCT TTTGACACTG ACACAGTGAA GAACACATTA 660

AATAAAGTCG TACTGGCAGA TTATGAAATG CCAACTTTTT TGTCAAGAGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTATC TTCAGTATTA 780

GACCATCCTT TTATGTCCCG AAACTCTTCA ACAAAAAATA AAGATTTGGG AACTGTAGAA 840

GACTCAATAG ATAGTGGACA TGCCACAATT TCTACTGCAA TTACGGCTTC TTCCAGTACC 900

AGTATTTGTG GTAGTTTATT TGATAGAAGA AAACTTTTGA TTGATCAGCC ACTCCCAAAT 960

AAAGTGACTA TATTTCCAAA GAATAAAAAT TCAAGTGATT TTACTTCTTC AGGAGACAGA 1020

AGCAGCTTTT ATACTCAGTG GGGAAATCAA GAGCAAGAAA CTAGTAATAG TGGAAGGGGA 1080

AGGATAATCC AAGAGGCAGA AGAAAGACCA CATTCTCGAT ACCTTCGTAG AGCCCATTCC 1140

TCTGATAGAT CTGGCACTTC TAACCAATCT CGAGCAAAAA CATATACAAT GGAACGATGT 1200

CACTCAGCAG AAATGCTTTC AAAATCCAAA AGATCAGGAG TAGATGAAAA TGAAGAAGGA 1260

TACTCACCCA CAAACAGCAA TGCTAATATT TTTAACGTCT TTAAAGAAAA GACATCCAGT 1320

GGTTCTGGAT CTTTTGAAGG ACCTGATAAC AATCAAGCAC TCTCCAATCA TCTTTGTCCA 1380

GGAAAAACTC CTTTCCCATT TCCAGACCAG ACAGCTCAGA CTGAAATGGT GCAACAGTGG 1440

TTTGGTAATC TGCAAATACA TGCTCATTTA AGAGAAACTA CTGAGCACAA CAGCATTAAC 1500

CCAAACAGAG ATTTCCAGGG CCATCTAAAT TTGCAGGCCA TATCAAGAAA TGTTTGGTTT 1560

GATAAAAGAG CCAAAAAGAG CCCCAGTGCT TCTGATAATG CACATCCTAC AAAACAGCTG 1620

ACTGCATTTC ACAGTAAACC TGAGATAATT CAACAAGAAT CTTTTTTTGG CTCAGATCCT 1680

TTTTCCGAAC AAAGCAAGAC CAGGGGTACG GAGCCACCAT TGGGTTATCA GAAACGTACA 1740

TTACGAAGCA TTACATCTCC CTTGACTGCC TACAGGTTAA AACCAATCAG ACAGAAAACC 1800

AAAAAGGCTG TGGTGAGCAT ACTTGATTCA GAGGAGGTAT GTGTGGAGCT TCTAAAAGAG 1860

TTTGCATCTC AAGAATATGT GAAAGAAGTT CTTCAAATAT CTAGTGATGG AAGTATGATT 1920

ACTATTTATT ATCCAAATGA TGGAAGAGGT TTTCCTCTTG CTGATAGACC ACCCTCACCT 1980

ACTGACAACA TCAGTAGGTA CAGGTTTGAC AATTTACCAG AAAAGTACTG GCGAAAGTAT 2040

CAATATGCTT CCAGATTTGT ACAGCTTGTA AGATCTAAAT CTCCCAAAAT CACTTATTTT 2100

ACAAGATATG CTAAGTGTGT TTTAATGGAG AATTCTCCTG GTGCTGATTT TGAAGTTTGG 2160

TTTTATGATG GGGCAAAGAT ACACAAAACA GAAGATTTAA TTCAGGTAAT TGAAAAGACT 2220

GGGAAATCTT ATAACTTAAA AGGTGAAAGT GAAGTTAATA GCTTGAAAGA GGAAATAAAA 2280

ATGTATATGG ACCATGCTAA TGAGGGCCAC CGTATTTGTT TAGCACTGGA ATCCATAATT 2340

TCAGAAGAGG AAAAGAAAAG TGGAAGTGCT CCCTTTTTCC CAATAATCAT TGGAAGAAAA 2400

CCTAGTAGTA CTAGTTCACC CAAGGCCTTA TCACCTCTTT CTCCTGTGGA TCCAGACTAC 2460

CCCATGACAG ATACACCATC TCTGAATAGA ATGATCATAA ATAGTGCTGC TTCTCCGAAA 2520

CAGGCACCAA TACCTAATCC TTCTATGGTT ACAAATGAAG GATTTAGCCT CACAGGTGCA 2580

GCTTCTGGAA CAAACATCCC TTCCAATAGT CCAAAAGATT GTCTCCCTAA ATCAGCACAA 2640

CTTTTGAAGT CCGTTTTTGT GAAAAATGTT GGTTGGGCTA CACAGTTAAC TAGTGGAGCT 2700

GTGTGGGTTC AGTTTAATGA TGGGTCCCAG CTGGTCGTGC AAGCCGGAGT TTCTTCTATT 2760

AGTTACACAT CACCAAATGG TCAGACAACT AGGTATGGAG AAAATGAAAA ACTACCAGAA 2820

TACATCAAAC AGAAATTACA TTGTCTTTCT TCCATCCTTT TGATGTTTTC TAATCCAACT 2880

CCTAGTTTTC ATTGA 2895

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRrKPFSENEARHFMHQIITGMLYLHSHG  131

         ******************************98879*************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +diWslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 192   SDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLVLEM CHNGEMNRYL KNRRKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDIWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSREAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

ssc:100517044

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013