EKS-SUS-00407

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00407

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.6	6.0E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSSSCP00000029707

UniProt Accession

F1RW16;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000009228	ENSSSCP00000031045	ENSSSCT00000036195
ENSSSCG00000009228	ENSSSCP00000009841	ENSSSCT00000010107
ENSSSCG00000009228	ENSSSCP00000029707	ENSSSCT00000033080

Organism

Sus scrofa

Functional Description

Protein Length

426

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300

MLVIDPAKRI SVDDALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTIE EWKELIYKEV 360

MLSEEKTKNG VVKGQPSPSG AAVNSSESLP PSSSVNDISS MSTDQTLASD TDSSLEASAG 420

PLGCCR 426

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTTGA CAACCAGTTC TACAGTGTGG AAGTGGGAGA CTCAACCTTC 60

ACAGTTCTCA AGCGCTACCA GAATCTAAAG CCGATTGGCT CTGGGGCTCA GGGAATAGTT 120

TGTGCTGCCT ATGACGCTGT TCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCC 180

TTTCAGAACC AAACTCATGC CAAGAGAGCT TACCGGGAGC TGGTCCTCAT GAAATGTGTG 240

AACCATAAAA ACATTATTAG TTTATTAAAT GTCTTCACAC CCCAGAAGAC GCTGGAGGAG 300

TTTCAAGATG TTTACTTAGT GATGGAACTG ATGGATGCCA ACTTGTGTCA GGTGATTCAG 360

ATGGAGTTAG ACCATGAGCG AATGTCTTAC CTGCTATACC AAATGTTATG TGGCATCAAG 420

CACCTTCACT CTGCTGGGAT TATTCACAGG GACTTAAAAC CAAGTAACAT TGTAGTCAAG 480

TCTGATTGTA CACTGAAAAT CCTGGACTTT GGCCTGGCCA GGACAGCAGG CACAAGCTTC 540

ATGATGACTC CTTATGTGGT GACACGTTAT TACAGGGCCC CCGAGGTCAT TCTAGGAATG 600

GGCTACAAGG AAAATGTGGA TATATGGTCT GTGGGATGCA TTATGGGAGA AATGGTTCGT 660

CACAAAATCC TCTTTCCAGG AAGGGACTAT ATTGACCAGT GGAACAAGGT AATTGAGCAG 720

CTGGGAACGC CATGTCCAGA ATTCATGAAG AAATTACAAC CCACGGTAAG AAACTATGTG 780

GAGAATCGAC CCAAGTACGC AGGACTCACC TTCCCCAAGC TCTTCCCAGA TTCCCTCTTC 840

CCAGCGGACT CCGAGCACAA TAAACTCAAA GCCAGCCAAG CCAGGGACTT GTTGTCAAAG 900

ATGCTAGTGA TTGACCCAGC AAAAAGGATA TCAGTGGATG ACGCCTTACA GCATCCGTAT 960

ATCAATGTCT GGTACGACCC TGCTGAAGTG GAGGCGCCTC CGCCTCAGAT ATATGACAAA 1020

CAGCTGGATG AGAGAGAACA CACCATCGAA GAATGGAAAG AACTCATCTA CAAGGAGGTG 1080

ATGCTTTCGG AAGAGAAGAC GAAGAACGGC GTCGTGAAAG GCCAGCCCTC TCCCTCAGGT 1140

GCAGCAGTGA ACAGCAGTGA GAGTCTCCCT CCTTCCTCTT CTGTCAACGA CATCTCCTCC 1200

ATGTCCACCG ACCAGACCCT GGCATCCGAC ACTGACAGCA GCCTGGAAGC CTCGGCGGGA 1260

CCCCTGGGTT GTTGCAGGTG A 1281

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 261   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ssc:100521736

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013