EKS-SUS-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	495.7	3.1E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSSSCP00000009864

UniProt Accession

F1RVC8;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000009250	ENSSSCP00000009864	ENSSSCT00000010130

Organism

Sus scrofa

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH SKNPDGHAGN LTASALRSKV TELERELRRK AAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPQQASPDK VPLEVHRKTS GLVSLHSRRG 120

AKAGVSAEPT SRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNFQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISEDVRSANI IAEEDDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSSWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDSKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LHGFNWEGLK 720

ARNLPSPLQR ELSGPTDHSY FDKYPPEKGV PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCCGTGAA ACCCAAACAT TCCAAGAATC CAGATGGCCA CGCTGGGAAC 60

CTCACTGCCA GCGCCCTCCG GAGCAAGGTG ACGGAGCTGG AGAGGGAGCT GAGGAGGAAG 120

GCTGCTGAGA TCCAGGAGCG GGAGTACCAT TTGAAGGAGC TGCGAGAGCA GCTGTCCAAG 180

CAGACTGTGG CCATTGCTGA GCTGACGGAG GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTTCAGG ATGTGGTGCA CATGCAGGGA GGAAGCCCGC AGCAGGCCTC CCCGGATAAA 300

GTGCCTCTCG AGGTCCACCG CAAGACCTCC GGCTTGGTCT CCCTGCACAG CAGGCGGGGA 360

GCAAAGGCTG GAGTGTCTGC TGAGCCGACC TCCCGCACCT ATGACCTCAA CAAACCCCCC 420

GAATTTTCTT TTGAGAAAGC CAGAGTCAGA AAGGACTCCA GTGAGAAGAA GCTCATTACA 480

GATGCTCTTA ACAAAAATCA GTTTCTGAAG AGACTGGATC CTCAGCAGAT CAAGGACATG 540

GTGGAATGCA TGTATGGGAG AAACTTCCAG CAGGGCAGTT ACATTATTAA GCAAGGAGAA 600

CCCGGAAACC ACATCTTCGT GCTGGCAGAG GGTCGGCTGG AGGTGTTCCA AGGGGAGAAA 660

TTGCTCTCAT CCATTCCTAT GTGGACAACG TTTGGGGAAC TTGCCATTTT ATACAACTGC 720

ACAAGGACAG CCTCTGTGAA AGCTATTACC AATGTTAAAA CATGGGCACT AGATCGGGAA 780

GTATTCCAGA ACATAATGAG AAGAACAGCT CAAGCTAGAG ATGAACAGTA CAGAAATTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCCGAAGATA AATTAACGAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA CGACAAAGGA GATTACATTA TTAGAGAGGG CGAGGAAGGA 960

AGTACCTTTT TCATCTTAGC AAAAGGAAAG GTAAAAGTCA CCCAGAGTAC GGAAGGCCAC 1020

GATCAGCCGC AACTGATCAA AACACTGCAG AAAGGAGAGT ATTTTGGAGA AAAAGCGCTC 1080

ATCAGTGAGG ATGTCAGATC GGCTAACATC ATTGCTGAGG AAGATGACGT CGCCTGCCTG 1140

GTCATTGATC GGGAAACATT CAACCAAACA GTGGGGACTT TTGAAGAACT CCAGAAATAC 1200

CTTGAAGGGT ACGTGGCAAA CCTGAACCGG GATGATGAAA AAAGACATGC CAAGAGGTCC 1260

ATGTCTAGCT GGAAGCTGTC CAAAGCACTC TCTCTGGAGA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCCTC GTCCCCTTTC CAGAACCTTG AGATTATCGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTAAAAA ATGAGAACGT TGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA ACACATAGTG GACACGAAGC AGCAGGAGCA CGTCTACTCA 1500

GAGAAGAGGA TCCTGGAGGA GCTGTGCTCG CCCTTCATCG TCAAGTTATA CCGCACGTTC 1560

AAGGACAGCA AGTACGTCTA CATGCTGCTG GAGGCCTGCT TAGGCGGGGA GCTGTGGAGC 1620

ATATTAAGGG ACAGAGGCAG CTTTGATGAG CCCACCTCCA AGTTCTGCGT GGCCTGCGTG 1680

ACAGAAGCGT TTGATTACCT GCATCGGCTG GGGATTATCT ACAGGGACCT GAAACCAGAA 1740

AACCTAATTC TCGATGCTGA GGGCTATCTT AAGTTGGTGG ACTTTGGATT CGCTAAAAAG 1800

ATCGGATCTG GACAGAAGAC ATGGACGTTC TGCGGAACTC CAGAATACGT AGCCCCTGAG 1860

GTCATTCTCA ACAAAGGACA TGACTTCAGC GTGGATTTCT GGTCCCTGGG AATTCTGGTG 1920

TATGAGCTGC TGACGGGCAA CCCGCCCTTT TCTGGAATTG ACCAAATGAT GACCTACAAC 1980

TTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCCAGGA AGATAACAAG ACGACCCGAG 2040

GATTTGATTC GGAGACTCTG CAGGCAAAAT CCGACAGAAA GACTGGGAAA CCTGAAGAAC 2100

GGAATCAATG ACATTAAGAA ACACAGGTGG TTACATGGCT TTAACTGGGA GGGGCTGAAA 2160

GCGCGGAACC TTCCGTCACC TTTGCAGAGA GAGCTCAGTG GCCCCACAGA TCACAGCTAC 2220

TTCGACAAGT ATCCTCCTGA GAAGGGAGTG CCTCCAGATG AGCTCTCGGG CTGGGACAAG 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDSKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD SKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

ssc:100512796

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013