EKS-SUS-00354
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00354
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR576.62.6E-173591924334
StatusUnreviewed
Ensembl ProteinENSSSCP00000009936
UniProt AccessionF1RSW2;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000009314ENSSSCP00000009936ENSSSCT00000010202
ENSSSCG00000009314ENSSSCP00000028275ENSSSCT00000033941
OrganismSus scrofa
Functional Description
Protein Length971
Protein Sequence
(FASTA)
MIFETITNQD LPVIQCILIN HRNNDSSVGT TSSNPMASEA QEDLGCALRP KSKGTVYEAA 60
TVEVDVSASI TLQVLVATPG NISCLWVFKN SSRNCQPHFD LQNRGVVSMV ILKMTETQAG 120
EYQLFIQSEA VNYTVLFTVS IRNTLLYTLR RPYFRKMENQ DALVCISEGI PEPTVEWVFC 180
DAQSDSCKGE SPAVVTKEES VLHELFGTDI RCCARNELGR ECTKLFTIDL NQTPQTTPPQ 240
LFLKVGEPLW IRCKAVHVNH GFGLSWELEN KALEEGSCFE MSTYSTNRTM IRILFAFVSS 300
VGRNDTGYYT CSSSEHPSKS ALVTILEKGF INASKSNEDY EIDQYEEFCF SVRFKAYPQI 360
RCTWTFSRKS FPCEQRGLDD GYSISKFCNH KHQPGQYIFH AENDDAQFTK MFTLNIRRKP 420
QVLAEASASQ ASCSSDGYPL PSWTWKKCSD KSPNCTEEIT EGIWNKKANR KVFGQWISSS 480
TLNMSEAVKG FLVKCCAYNS LGTSCETILL NSPGPFPFIQ DNISFYATIG LCLPFIAVLT 540
MLICHKYKKR FRYESQLQMV QVTGSLDNDY FYIDFREYEY DLKWEFPREN LEFGKVLGSG 600
AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG SHENIVNLLG 660
ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF QSHPNSSMPG 720
SREVQIHPDS DPISGFNGNS FQSEDEIEYE NQKRLEEEED LNVLTFEDLL CFAYQVAKGM 780
EFLEFKSCVH RDLAARNVLV THGKVVKIGD FGLARDIMSD SNYVIRGNAR LPVKWMAPES 840
LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPADANFY KLIQSGFKMD QPFYATEEIY 900
FIMQSCWAFD SRKRPSFPNL TSFLGCQLAD AEEAMYQNTD GRASERPLYQ NRRPFSRQVD 960
SGPPSPQAED S 971
Nucleotide Sequence
(FASTA)
ATGATCTTTG AGACTATTAC AAATCAAGAC CTGCCTGTGA TCCAGTGCAT TTTAATCAAC 60
CATAGGAACA ATGATTCATC GGTGGGGACC ACGTCATCGA ATCCTATGGC GTCAGAAGCC 120
CAGGAAGACC TGGGTTGTGC CTTGAGGCCC AAGAGCAAGG GGACAGTCTA CGAAGCAGCC 180
ACTGTGGAGG TGGACGTGTC CGCGTCCATC ACGCTGCAGG TGCTGGTCGC CACCCCAGGG 240
AACATTTCCT GCCTCTGGGT CTTTAAAAAT AGCTCCCGGA ATTGCCAGCC ACACTTCGAC 300
TTGCAAAACA GAGGAGTTGT TTCCATGGTC ATTTTGAAAA TGACAGAAAC CCAGGCTGGA 360
GAATACCAAC TTTTTATTCA GAGCGAAGCT GTCAATTACA CAGTGTTGTT TACAGTGAGT 420
ATAAGAAATA CACTGCTTTA CACACTAAGG AGACCCTACT TTAGAAAAAT GGAAAACCAG 480
GACGCCCTGG TCTGCATCTC TGAGGGCATT CCAGAGCCCA CCGTGGAATG GGTGTTCTGC 540
GATGCGCAGA GTGACAGCTG TAAAGGAGAA AGTCCAGCTG TTGTTACGAA GGAGGAGAGC 600
GTACTCCATG AGTTATTTGG GACTGACATA AGGTGCTGTG CAAGGAACGA GCTGGGCAGG 660
GAGTGTACCA AGCTCTTCAC TATAGATCTA AACCAAACTC CTCAGACCAC ACCGCCACAG 720
TTATTTCTGA AAGTAGGGGA GCCCTTGTGG ATAAGGTGCA AAGCTGTTCA CGTAAACCAC 780
GGATTCGGGC TCAGCTGGGA ATTAGAGAAT AAAGCCCTGG AGGAGGGCAG CTGCTTTGAG 840
ATGAGTACCT ATTCCACAAA CAGAACTATG ATACGGATTC TGTTTGCTTT TGTATCATCA 900
GTGGGAAGAA ACGACACTGG ATATTACACT TGTTCCTCTT CAGAGCATCC CAGTAAATCA 960
GCTTTGGTCA CCATCCTAGA AAAGGGATTT ATAAATGCTT CCAAATCAAA TGAGGATTAT 1020
GAAATTGACC AGTATGAAGA GTTTTGCTTT TCTGTCAGGT TTAAAGCGTA TCCACAAATC 1080
AGGTGCACGT GGACCTTCTC TCGCAAATCA TTTCCTTGTG AGCAAAGGGG ACTCGACGAC 1140
GGGTACAGCA TATCTAAGTT TTGCAACCAT AAACACCAGC CAGGACAATA CATCTTCCAT 1200
GCAGAAAATG ACGACGCCCA GTTCACAAAG ATGTTCACGC TGAATATAAG AAGGAAACCG 1260
CAAGTGCTGG CCGAGGCATC GGCAAGTCAG GCTTCCTGCT CCTCTGATGG TTACCCGTTA 1320
CCGTCTTGGA CCTGGAAGAA GTGTTCAGAC AAGTCTCCCA ACTGCACGGA AGAGATCACG 1380
GAAGGCATCT GGAATAAAAA GGCCAACAGG AAAGTATTTG GACAGTGGAT TTCCAGCAGC 1440
ACTCTGAACA TGAGCGAGGC TGTCAAAGGG TTTCTGGTGA AGTGCTGTGC CTACAATTCC 1500
CTGGGCACGT CTTGTGAAAC GATCCTCTTA AACTCACCAG GCCCCTTCCC TTTCATCCAG 1560
GACAACATCT CATTCTATGC AACAATTGGC CTCTGTCTTC CCTTCATCGC CGTTTTAACC 1620
ATGCTAATTT GTCACAAGTA CAAAAAGCGA TTCCGGTACG AAAGCCAGCT GCAGATGGTC 1680
CAGGTGACGG GGTCCCTGGA TAACGACTAC TTCTACATCG ACTTCAGAGA ATATGAATAT 1740
GACCTCAAAT GGGAGTTTCC CAGGGAAAAT TTAGAATTTG GGAAGGTTCT GGGATCCGGC 1800
GCTTTTGGAA AAGTGATGAA CGCAACTGCC TATGGAATCA GTAAAACTGG AGTGTCAATC 1860
CAGGTGGCAG TCAAAATGCT GAAAGAAAAA GCAGACAGCT CGGAACGAGA GGCTCTCATG 1920
TCTGAACTCA AAATGATGAC CCACCTGGGC AGCCATGAGA ATATAGTGAA CCTGCTGGGC 1980
GCCTGCACCC TGTCAGGGCC CATTTACTTG ATTTTTGAAT ATTGTTGCTA CGGTGATCTT 2040
CTCAACTATC TAAGAAGTAA AAGAGAGAAA TTTCATAGGA CATGGACCGA GATTTTCAAG 2100
GAACATAATT TCAGTTTTTA TCCTACTTTC CAATCACACC CAAATTCCAG TATGCCGGGT 2160
TCAAGAGAAG TTCAAATACA CCCAGACTCG GATCCTATCT CAGGATTCAA TGGGAATTCA 2220
TTTCAATCTG AAGATGAAAT TGAATACGAA AACCAGAAAA GGCTGGAGGA GGAAGAGGAC 2280
TTGAATGTCC TCACCTTTGA AGACCTTCTT TGCTTTGCCT ATCAAGTGGC CAAAGGGATG 2340
GAATTTCTGG AATTTAAGTC GTGCGTTCAC AGAGACCTGG CAGCCAGGAA CGTCCTGGTG 2400
ACCCACGGGA AAGTGGTGAA GATCGGTGAC TTTGGCCTGG CTCGCGACAT CATGAGTGAC 2460
TCCAACTACG TGATCCGGGG CAATGCCCGT CTGCCTGTCA AGTGGATGGC TCCCGAAAGC 2520
TTGTTTGAGG GAATCTACAC CATTAAGAGC GATGTCTGGT CATACGGAAT ACTGCTCTGG 2580
GAAATATTCT CGCTTGGTGT GAATCCTTAC CCTGGGATTC CGGCTGATGC TAATTTCTAC 2640
AAACTCATCC AGAGCGGATT TAAAATGGAT CAGCCATTTT ACGCTACGGA AGAAATATAC 2700
TTTATAATGC AGTCCTGCTG GGCTTTTGAC TCCAGGAAAC GGCCCTCCTT CCCAAACCTG 2760
ACTTCATTCT TGGGATGTCA GCTGGCGGAT GCAGAAGAAG CGATGTACCA GAACACCGAT 2820
GGCCGCGCTT CCGAACGTCC TCTCTACCAA AACAGGCGAC CTTTCAGCAG ACAGGTGGAT 2880
TCAGGGCCAC CCTCTCCACA GGCTGAAGAT TCGTAG 2916
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 591   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  650
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 651   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  709
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++ +s ++ ++++se++ +++++++   +eeed
Q: 710   ------FQSHPNSSMPGSRE-VQIHPDSDPISGFNGNSFQSEDEIEYENQKRL--EEEED  760
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+Gkvvki+dfGlardim+d
Q: 761   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIGDFGLARDIMSD  820
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyv++Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++ d++fy
Q: 821   SNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPADANFY  880
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 881   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  924
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SREVQIHPDS DPISGFNGNS FQSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKIGD FGLARDIMSD SNYVIRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPADANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-TAG-00475
EKS-TAR-00506
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013