EKS-SUS-00044

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00044

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	403.7	5.3E-121	521	782	262

Status

Unreviewed

Ensembl Protein

ENSSSCP00000010519

UniProt Accession

F1RKG1;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR2

Gene Synonyms/Alias

KSR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000009855	ENSSSCP00000010519	ENSSSCT00000010802

Organism

Sus scrofa

Functional Description

Protein Length

804

Protein Sequence
(FASTA)

SGGNLSKQDW TIQWPTTETG KENNPVCPPE PTPWIRTHLS QSPRVQSKCI QHYCHASPTP 60

GTPVYTHVDR LTVDAYPGLC PPPPLESGHR SLPPSPRQRH AVRTPPRTPN IVTTVTPPGT 120

PPMRRKNKLK PPGTPPPSSR KLIHLIPGFT ALHRSKSHEF QLGHRVDEAH TPKAKKKSKP 180

LNLKIHSSVG SCENIPSQQR SPLLSERSLR SFFVGHAPFL PSTPPVHTEV NFSANTLSVP 240

RWSPQIPRRD LGNSIKHRFS TKYWMSQTCT VCGKGMLFGL KCKNCKLKCH NKCTKEAPPC 300

HLLIIHRGDS PIAVFTPTDP ARLVRTESVP CDINNPLRKP PRYSDLHISQ TLPKTNKINK 360

DHIPVPYQPD SSSNPSSTTS STPSSPAPPL PPSATPPSPL HPSPQCTRQQ KNFNLPASHY 420

YKYRQQFIFP DVVPVPETPT RAPQVILHPV TSNPILEGNP LLQIEVEPTS ENEEGHDEAE 480

ESEDDFEEMN LSLLSARSFP RKASQTSIFL QEWDIPFEQL EIGELIGKGR FGQVYHGRWH 540

GEVAIRLIDI ERDNEEQLKA FKREVMAYRQ TRHENVVLFM GACMSPPHLA IITSLCKGRT 600

LYSVVRDAKI VLDVNKTRQI AQEIVKAMGY LHAKGILHKD LKSKNVFYDN GKVVITDFGL 660

FSISGVLQAG RRDDKLRIQN GWLCHLAPEI IRQLSPDTEE DKLPFSKHSD VFALGTIWYE 720

LHAREWPFKT QPAEAIIWQM GTGMKPNLSQ IGMGKEISDI LLFCWAFEQE ERPTFTKLMD 780

MLEKLPKRNR RLSHPGHFWK SAEL 804

Nucleotide Sequence
(FASTA)

TCAGGAGGCA ACCTTTCCAA ACAAGACTGG ACCATCCAGT GGCCCACCAC AGAGACGGGG 60

AAGGAAAACA ACCCCGTGTG CCCTCCGGAG CCGACCCCGT GGATCCGCAC CCATCTCTCC 120

CAGAGCCCCA GGGTCCAGTC CAAGTGCATC CAGCACTACT GTCACGCCAG CCCCACCCCC 180

GGGACCCCCG TGTACACCCA CGTGGACAGG CTCACCGTGG ATGCCTACCC GGGCCTGTGC 240

CCGCCCCCGC CACTGGAGTC GGGCCACCGT TCCCTGCCCC CATCCCCCCG GCAGCGGCAT 300

GCGGTCCGCA CCCCACCGCG CACCCCCAAC ATTGTCACCA CCGTGACCCC ACCGGGCACG 360

CCACCCATGA GGAGGAAGAA CAAACTGAAG CCCCCGGGGA CCCCACCGCC TTCTTCCCGG 420

AAGCTGATCC ACTTGATCCC GGGTTTCACG GCCCTGCATC GGAGCAAGTC GCACGAATTC 480

CAGCTGGGTC ACCGCGTAGA CGAGGCCCAC ACACCCAAAG CCAAGAAGAA AAGCAAGCCC 540

TTGAACCTCA AGATACACAG CAGCGTGGGC AGCTGTGAGA ACATCCCCTC CCAGCAGCGC 600

TCCCCCCTGC TGTCCGAGCG CTCCCTCCGC TCCTTCTTCG TGGGACACGC GCCCTTCCTG 660

CCCTCCACCC CTCCTGTCCA CACCGAGGTT AACTTCTCAG CAAACACACT GTCAGTGCCA 720

CGCTGGTCCC CGCAAATCCC TCGCAGAGAC CTCGGCAACT CCATCAAGCA CAGGTTTTCC 780

ACGAAGTACT GGATGTCTCA GACCTGCACA GTCTGTGGGA AGGGGATGCT TTTTGGCCTC 840

AAATGTAAAA ACTGCAAGTT AAAGTGCCAC AACAAATGCA CCAAAGAAGC CCCACCCTGC 900

CATCTCCTAA TCATCCACCG AGGAGACTCC CCGATCGCTG TTTTTACCCC TACGGATCCA 960

GCAAGGTTAG TCCGGACAGA GTCTGTCCCA TGTGACATCA ACAACCCTCT CCGAAAGCCA 1020

CCCCGGTATT CGGACCTCCA CATCAGTCAG ACGCTCCCCA AAACCAACAA AATCAACAAG 1080

GACCACATCC CGGTTCCTTA CCAGCCAGAC TCTAGCAGCA ACCCCTCATC CACGACCTCC 1140

TCCACACCCT CCTCGCCAGC GCCCCCACTC CCTCCCAGTG CCACACCGCC TTCTCCCCTG 1200

CACCCTTCTC CACAGTGCAC AAGACAGCAG AAGAACTTCA ATCTGCCAGC GTCCCACTAC 1260

TACAAATACA GGCAGCAGTT CATTTTCCCA GATGTGGTGC CGGTGCCGGA GACGCCAACC 1320

CGGGCGCCCC AGGTCATCCT GCATCCAGTG ACCTCGAATC CAATCTTGGA AGGAAATCCA 1380

TTACTTCAAA TTGAAGTGGA GCCAACATCA GAGAACGAAG AGGGCCATGA TGAAGCCGAG 1440

GAGTCGGAGG ATGACTTTGA GGAGATGAAC CTGTCCCTCC TCTCGGCCCG GAGCTTCCCG 1500

CGCAAGGCCA GCCAGACCAG CATCTTCCTG CAGGAGTGGG ACATCCCCTT CGAGCAGCTG 1560

GAGATCGGCG AGCTCATCGG AAAGGGCCGC TTCGGGCAGG TGTATCACGG CCGCTGGCAC 1620

GGTGAGGTGG CCATCCGGCT GATTGACATC GAGAGGGATA ATGAAGAGCA GCTGAAGGCC 1680

TTCAAGCGGG AGGTCATGGC CTACAGGCAG ACACGGCACG AGAACGTGGT GCTCTTCATG 1740

GGTGCCTGCA TGAGCCCGCC CCACCTGGCC ATCATCACCA GCCTCTGCAA GGGACGGACA 1800

CTCTATTCTG TGGTGAGGGA TGCCAAGATC GTCCTGGATG TCAACAAAAC GAGGCAGATT 1860

GCCCAAGAAA TTGTGAAGGC CATGGGCTAT CTGCACGCCA AGGGAATCCT GCACAAGGAC 1920

CTCAAGTCCA AGAACGTCTT CTATGACAAT GGCAAAGTGG TGATCACAGA CTTTGGGCTC 1980

TTCAGCATTT CCGGGGTGCT GCAGGCTGGC AGGCGTGATG ACAAGCTGCG TATCCAGAAT 2040

GGCTGGCTGT GCCACTTGGC CCCGGAGATC ATCCGCCAGC TTTCCCCCGA CACAGAGGAA 2100

GACAAGCTCC CCTTCTCCAA ACACTCAGAT GTCTTTGCGC TCGGGACAAT CTGGTATGAG 2160

CTCCATGCCA GAGAGTGGCC TTTTAAGACC CAGCCAGCAG AGGCAATAAT CTGGCAAATG 2220

GGCACAGGCA TGAAACCCAA CCTCAGCCAG ATCGGCATGG GAAAAGAAAT CTCGGATATA 2280

CTTCTCTTCT GCTGGGCCTT TGAACAAGAA GAGAGACCTA CCTTCACCAA GCTCATGGAC 2340

ATGCTAGAGA AACTGCCAAA GCGAAACCGC CGCCTGTCTC ACCCTGGACA TTTCTGGAAG 2400

TCTGCAGAGC TGTGA 2415

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         e++e iG+GrfG+vy+g+whG+va++l+++e+++eeql+aFk+ev+ay++tRhen+vLFm

Q: 521   EIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRQTRHENVVLFM  580

         7899********************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++s+p+lai+tslckg++Ly+++++++  ld++k+++ia++i+++m+YLhak+ilhkD

Q: 581   GaCMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKAMGYLHAKGILHKD  640

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+s++ +l++ rr+++l+i++gw+++lape+ir+ls+d+e

Q: 641   LKSKNVFYDNG-KVVITDFGLFSISGVLQAgRRDDKLRIQNGWLCHLAPEIIRQLSPDTE  699

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrGlkpdlskvksklpkel  239

         +d+lpfsk+sDv+a+G+++yel+are+p+k+++a++i++++g+G+kp+ls++   ++ke+

Q: 700   EDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI--GMGKEI  757

         ****************************************************..******

S: 240   kellleClkfekeeRPlftqilkkl  264

         +++ll C++fe+eeRP+ft+++++l

Q: 758   SDILLFCWAFEQEERPTFTKLMDML  782

         **********************986

Domain Sequence
(FASTA)

EIGELIGKGR FGQVYHGRWH GEVAIRLIDI ERDNEEQLKA FKREVMAYRQ TRHENVVLFM 60

GACMSPPHLA IITSLCKGRT LYSVVRDAKI VLDVNKTRQI AQEIVKAMGY LHAKGILHKD 120

LKSKNVFYDN GKVVITDFGL FSISGVLQAG RRDDKLRIQN GWLCHLAPEI IRQLSPDTEE 180

DKLPFSKHSD VFALGTIWYE LHAREWPFKT QPAEAIIWQM GTGMKPNLSQ IGMGKEISDI 240

LLFCWAFEQE ERPTFTKLMD ML 262

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013