EKS-SUS-00204

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00204

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	416.0	7.4E-125	23	304	282

Status

Unreviewed

Ensembl Protein

ENSSSCP00000010557

UniProt Accession

B7U6F1; F1RJM1;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase-activated protein kinase 5;

Gene Name

MAPKAPK5

Gene Synonyms/Alias

MAPKAPK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000009890	ENSSSCP00000010557	ENSSSCT00000010840

Organism

Sus scrofa

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

MSEESDMEKA IKETSILEEY NINWTQKLGA GISGPVRVCV KKSTQERFAL KILFDRPKAR 60

NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF 120

TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL 180

MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP 240

FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 300

HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL 360

RKRKLLGTKP KDGIYIHDRE NGAEDSNVAL EKLRDVIAQC ILPQAGENED EKLNEVVQEA 420

WKYNRECKLL RDTLQSFSWN GRGFTDKVDR LKLAEIVKQV IEEQTTSHES Q 471

Nucleotide Sequence
(FASTA)

ATGTCGGAGG AGAGCGACAT GGAGAAAGCC ATCAAGGAAA CCTCCATTTT AGAAGAATAC 60

AATATCAATT GGACCCAGAA GCTGGGCGCT GGAATTAGTG GTCCAGTTAG AGTCTGTGTG 120

AAGAAATCTA CCCAAGAACG GTTTGCACTA AAAATTCTTT TTGATCGTCC AAAAGCTAGA 180

AATGAGGTAC GTCTGCACAT GATGTGTGCA ACACACCCCA ATATAGTGCA AATTATTGAA 240

GTGTTTGCTA ATAGTGTACA GTTTCCTCAT GAATCCAGCC CCAGGGCTCG ACTCTTAATT 300

GTAATGGAGA TGATGGAAGG GGGAGAGCTA TTTCACAGAA TCAGCCAGCA CCGGCACTTT 360

ACAGAGAAGC AAGCCAGCCA AGTAACAAAG CAGATAGCTT TGGCTCTACA ACACTGTCAC 420

TTGTTAAACA TCGCGCACAG AGACCTCAAG CCTGAAAATC TGCTTTTCAA GGATAACTCT 480

TTGGATGCCC CAGTGAAGTT ATGTGACTTT GGATTTGCCA AAATTGACCA AGGTGACTTG 540

ATGACACCGC AGTTCACCCC ATATTATGTA GCACCTCAGG TACTAGAGGC ACAGAGAAGG 600

CATCAGAAGG AGAAATCTGG CATCATACCT ACCTCGCCAA CACCCTACAC TTATAACAAG 660

AGCTGTGATT TGTGGTCCCT AGGGGTGATT ATCTACGTGA TGCTGTGTGG ATACCCTCCT 720

TTTTACTCCA AACACCATAG CCGGACCATC CCAAAGGACA TGCGGAAAAA AATCATGACA 780

GGCAGTTTTG AGTTCCCAGA AGAAGAATGG AGCCAGATCT CTGAGATGGC CAAAGATGTA 840

GTGAGAAAGC TCTTGAAGGT CAAACCAGAG GAAAGACTTA CCATCGAGGG AGTGTTGGAC 900

CACCCCTGGC TCAACTCTAC TGAGGCTCTG GATAATGTGC TACCCTCTGC TCAACTGATG 960

ATGGATAAGG CAGTGGTTGC AGGAATCCAG CAGGCCCATG CGGAACAGTT GGCCAACATG 1020

CGAATTCAGG ATTTGAAAGT CAGCCTCAAA CCCCTGCATT CTGTGAACAA CCCCATTCTG 1080

CGGAAGAGGA AATTACTCGG CACCAAGCCA AAGGATGGTA TTTATATCCA TGACCGTGAG 1140

AATGGAGCTG AGGATTCAAA TGTTGCCTTG GAAAAGCTTC GAGATGTGAT TGCTCAGTGT 1200

ATTCTCCCCC AGGCTGGAGA GAATGAAGAT GAAAAGCTGA ATGAAGTAGT GCAGGAAGCT 1260

TGGAAGTATA ACCGGGAATG CAAACTCCTA AGAGATACTC TGCAAAGCTT CAGCTGGAAT 1320

GGTCGTGGAT TCACAGATAA AGTAGATCGA CTAAAACTGG CAGAAATTGT GAAGCAAGTG 1380

ATAGAAGAGC AGACCACATC CCATGAATCC CAATAA 1416

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidvf  61

         +++++lG+Gisg v+ cvkk+t+e++alkil dr+k+r+ev+lh+++++h+niv++i+vf

Q: 23    NWTQKLGAGISGPVRVCVKKSTQERFALKILFDRPKARNEVRLHMMCATHPNIVQIIEVF  82

         689*********************************************************

S: 62    ensfe......dekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         +ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+ia al+++h

Q: 83    ANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLL  142

         ****99999999************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaeke  175

         niahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+vlea+++

Q: 143   NIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFTPYYVAPQVLEAQRR  200

         ********************************..89***********************9

S: 176   e.............allydksCDlWslGvilyillcGypPfyskk.graiskklkeriqe  221

         +             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++++i++

Q: 201   HqkeksgiiptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMRKKIMT  260

         99*****************************************9979*************

S: 222   gkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 261   GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL  304

         *******************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVRVCVKK STQERFALKI LFDRPKARNE VRLHMMCATH PNIVQIIEVF 60

ANSVQFPHES SPRARLLIVM EMMEGGELFH RISQHRHFTE KQASQVTKQI ALALQHCHLL 120

NIAHRDLKPE NLLFKDNSLD APVKLCDFGF AKIDQGDLMT PQFTPYYVAP QVLEAQRRHQ 180

KEKSGIIPTS PTPYTYNKSC DLWSLGVIIY VMLCGYPPFY SKHHSRTIPK DMRKKIMTGS 240

FEFPEEEWSQ ISEMAKDVVR KLLKVKPEER LTIEGVLDHP WL 282

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

ssc:100153404

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013