EPS-SUS-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SUS-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	186.7	8.1E-55	153	409	257

Status

Unreviewed

Ensembl Protein

ENSSSCP00000010752

UniProt Accession

F1RL04;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000010079	ENSSSCP00000010752	ENSSSCT00000011040

Organism

Sus scrofa

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

MASGASQQDS QTAEEIPSFL DVFLHDFPAP LSPDSPLPWK VPGVVLSQEE VEGELAELAM 60

GLLGSRNAPP LLAASLAHEA VSRLLQMDLS EFRKLLEQED EDGDEEEKAP VTLLDAAGLA 120

RSLFNQLWEV CSQQQVQEHE PVEAQVLQRP WLVSVHAVRN ARRRMEDRHV CLPAFNQLFG 180

LSDSVDRAYF AVFDGHGGVD AARYASVHVH ANAARQPELP TDPAAALRAA FRCTDEMFLR 240

KAKRERLQSG TTGVCALIAG STLHVAWLGD SQVLLVQQGQ VVKLMEPHRP ERQDEKDRIE 300

ALGGFVSHVD CWRVNGTLAV SRAIGPGDVF QKPYVSGEAD AASRELTGSE DYLLLACDGF 360

FDVVPHQEVA GLVQSHLVGQ EGSGQRVAEE LVAAARERGS HDNITVMVVF LRDPRDLLEG 420

GARGAGLSEP ETPAAARS 438

Nucleotide Sequence
(FASTA)

ATGGCCTCGG GAGCCTCACA GCAGGACAGC CAGACGGCAG AGGAGATCCC CAGCTTCCTG 60

GACGTGTTCC TCCACGACTT CCCAGCCCCG CTGAGTCCAG ACAGCCCTTT GCCGTGGAAG 120

GTCCCAGGCG TGGTGCTGAG CCAGGAGGAG GTGGAGGGCG AGCTGGCCGA GCTGGCGATG 180

GGCCTCCTGG GCAGCAGGAA CGCTCCACCA CTGCTTGCGG CAAGTCTGGC CCACGAGGCT 240

GTTTCCCGGC TGCTACAGAT GGACCTTTCT GAGTTTAGGA AGTTGCTGGA GCAGGAGGAT 300

GAGGATGGTG ATGAGGAGGA GAAGGCCCCC GTGACCTTGC TGGACGCTGC AGGCCTGGCG 360

CGGAGCCTCT TCAACCAGCT GTGGGAAGTG TGCAGCCAGC AGCAGGTGCA GGAGCATGAG 420

CCTGTGGAGG CCCAGGTTCT GCAGCGGCCG TGGCTGGTTT CTGTCCACGC CGTCCGCAAT 480

GCCCGCCGCA GGATGGAGGA CCGACATGTG TGTCTCCCCG CCTTCAACCA GCTCTTTGGC 540

CTGTCAGACT CTGTGGACCG TGCCTACTTT GCTGTGTTTG ACGGGCATGG TGGGGTGGAC 600

GCCGCGAGGT ATGCAAGTGT GCATGTGCAT GCCAATGCTG CCCGCCAGCC GGAGTTGCCC 660

ACAGACCCTG CAGCGGCTCT CCGAGCAGCC TTCCGTTGCA CCGATGAGAT GTTCCTCCGG 720

AAAGCCAAGA GGGAGCGGCT GCAGAGCGGC ACCACAGGGG TGTGTGCGCT CATTGCCGGG 780

AGCACCCTGC ACGTCGCCTG GCTCGGGGAC TCACAGGTGC TCCTGGTGCA GCAGGGGCAG 840

GTGGTGAAGC TGATGGAGCC ACACAGACCC GAGCGACAGG ATGAGAAGGA CCGCATCGAG 900

GCGCTGGGCG GCTTCGTGTC ACACGTAGAT TGCTGGAGAG TCAATGGGAC ACTGGCCGTC 960

TCCAGAGCCA TCGGCCCAGG GGACGTCTTC CAGAAGCCCT ACGTGTCTGG GGAGGCGGAC 1020

GCAGCCTCGC GGGAGCTGAC GGGCTCTGAG GATTACCTGC TGTTGGCCTG CGATGGCTTC 1080

TTTGATGTGG TCCCTCACCA GGAGGTGGCT GGCCTTGTGC AGAGCCACCT GGTCGGGCAG 1140

GAGGGCAGTG GGCAGCGCGT GGCCGAGGAG CTGGTGGCTG CAGCCCGAGA GCGGGGCTCC 1200

CACGACAACA TCACGGTTAT GGTGGTCTTC CTCAGGGACC CCCGAGACCT ACTGGAGGGT 1260

GGGGCCCGGG GGGCGGGCCT CTCTGAGCCA GAGACCCCAG CTGCCGCCAG AAGCTAG 1317

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v+v +v + r+ med++   p f +  + +d    a+f+v+DGhgg ++a+++s ++h

Q: 153   VSVHAVRNARRRMEDRHVCLPAFNQLFGLSDSvdRAYFAVFDGHGGVDAARYASVHVHAN  212

         6788999***************9998887777667*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

          a++ e      ++  +al+ aF  tde +  l +++ +  +sG+t v+ali +s+l+va

Q: 213   AARQPE----LPTDPAAALRAAFRCTDEMF--LRKAKRERLQSGTTGVCALIAGSTLHVA  266

         ****77....77888899************..8888889999******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalG.  179

          +GdS+++L ++g++v+l + H+p+r+dE++Rie+ gg v   d+ Rv+G LavsRa+G

Q: 267   WLGDSQVLLVQQGQVVKLMEPHRPERQDEKDRIEALGGFVSHVDCWRVNGTLAVSRAIGp  326

         ********************************************99************54

S: 180   .dlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqe  237

          d++ kpyv+ e +  s +lt ++++l La+DG +dvv+ +e+  lv+++l  ++ + q

Q: 327   gDVFQKPYVSGEADAASRELTGSEDYLLLACDGFFDVVPHQEVAGLVQSHLVgQEGSGQR  386

         499***********************************************9988899***

S: 238   aakkLvklalargskdnvsaivv  260

         +a++Lv+ a++rgs+dn++++vv

Q: 387   VAEELVAAARERGSHDNITVMVV  409

         *******************9997

Domain Sequence
(FASTA)

VSVHAVRNAR RRMEDRHVCL PAFNQLFGLS DSVDRAYFAV FDGHGGVDAA RYASVHVHAN 60

AARQPELPTD PAAALRAAFR CTDEMFLRKA KRERLQSGTT GVCALIAGST LHVAWLGDSQ 120

VLLVQQGQVV KLMEPHRPER QDEKDRIEAL GGFVSHVDCW RVNGTLAVSR AIGPGDVFQK 180

PYVSGEADAA SRELTGSEDY LLLACDGFFD VVPHQEVAGL VQSHLVGQEG SGQRVAEELV 240

AAARERGSHD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013