EKS-SUS-00246
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00246
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR447.42.6E-134234521288
StatusUnreviewed
Ensembl ProteinENSSSCP00000011048
UniProt AccessionE9M2M3;
Protein Name
Protein Synonyms/Alias Bone morphogenetic protein type IA receptor;
Gene NameBMPR1A
Gene Synonyms/Alias BMPR1A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000010360ENSSSCP00000011048ENSSSCT00000011342
OrganismSus scrofa
Functional Description
Protein Length532
Protein Sequence
(FASTA)
MTQLYIYIRL LGAYLFIVSH VQGQNLDSML HGTGMKSDSD QKKSESGVTL APEDTLPFLK 60
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLALLVSM AVCIIAMIIF SSCFCYKHYC 180
KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPNDPSYEDM REVVCVKRLR 480
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532
Nucleotide Sequence
(FASTA)
ATGACTCAGC TATATATTTA CATCAGATTA TTGGGAGCCT ATTTATTCAT CGTTTCTCAT 60
GTTCAAGGGC AGAATCTAGA CAGCATGCTC CATGGTACTG GGATGAAATC AGACTCCGAC 120
CAGAAAAAGT CAGAAAGTGG AGTGACCTTA GCACCAGAGG ATACCTTGCC TTTTTTAAAG 180
TGCTATTGCT CAGGACACTG CCCGGATGAT GCTATTAATA ACACATGCAT AACTAATGGT 240
CATTGCTTTG CCATCATAGA AGAAGATGAC CAGGGAGAAA CCACATTAGC TTCAGGGTGT 300
ATGAAATATG AAGGATCTGA TTTTCAATGC AAGGATTCAC CGAAAGCCCA GCTACGCAGG 360
ACAATAGAAT GTTGTCGGAC CAACTTATGT AACCAGTATT TACAACCTAC ACTGCCCCCT 420
GTTGTTATAG GTCCATTTTT TGATGGCAGC ATTCGATGGC TGGCTTTGCT CGTTTCTATG 480
GCTGTCTGCA TAATTGCTAT GATCATCTTC TCCAGCTGCT TTTGTTACAA ACACTATTGC 540
AAGAGCATCT CAAGCAGACG TCGTTACAAT CGTGATTTGG AACAGGATGA AGCATTTATT 600
CCAGTTGGAG AATCATTAAA AGACCTTATT GATCAATCAC AAAGTTCTGG TAGTGGATCT 660
GGACTACCCT TGTTGGTTCA GCGAACTATT GCCAAACAGA TACAGATGGT TCGGCAAGTT 720
GGTAAAGGCC GATATGGAGA GGTGTGGATG GGTAAATGGC GTGGTGAGAA AGTGGCAGTC 780
AAAGTGTTTT TTACCACTGA AGAAGCTAGC TGGTTTCGGG AAACAGAAAT CTATCAAACT 840
GTGCTAATGC GCCATGAAAA CATACTTGGT TTTATAGCTG CAGATATTAA AGGTACAGGT 900
TCCTGGACCC AGCTCTATTT GATTACTGAT TACCATGAAA ACGGATCTCT CTATGATTTC 960
CTGAAATGTG CTACGCTAGA TACCAGAGCC CTGCTTAAGT TGGCTTACTC CGCTGCTTGT 1020
GGTCTGTGCC ATCTCCACAC AGAAATTTAT GGCACTCAAG GAAAGCCTGC AATTGCTCAT 1080
AGAGACTTAA AGAGCAAAAA CATCCTCATT AAGAAAAACG GAAGTTGTTG TATTGCTGAC 1140
CTGGGCCTTG CTGTTAAATT CAACAGTGAT ACAAATGAAG TCGATGTACC TTTGAATACT 1200
AGAGTGGGTA CCAAACGCTA CATGGCTCCA GAAGTGCTGG ATGAAAGCCT GAATAAAAAC 1260
CATTTCCAGC CCTACATAAT GGCTGACATC TATAGCTTTG GCCTGATCAT TTGGGAAATG 1320
GCTCGTCGTT GTATCACAGG AGGAATAGTA GAAGAGTACC AGTTGCCATA TTATAACATG 1380
GTACCCAATG ATCCATCATA TGAAGATATG CGTGAGGTTG TGTGTGTCAA ACGTTTGCGG 1440
CCAATTGTAT CTAATCGATG GAACAGTGAT GAATGTCTAC GAGCAGTTTT GAAGCTAATG 1500
TCGGAATGCT GGGCCCACAA TCCAGCCTCC AGACTTACAG CTCTGAGAAT CAAGAAGACA 1560
CTTGCTAAGA TGGTTGAATC TCAAGATGTA AAGATTTGA 1599
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia
Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293
         799*********************************************************
S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+
Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353
         ************************************************************
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180
         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE
Q: 354   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  411
         *..*********************************************************
S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240
         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v++dPs+e+m
Q: 412   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCIT-GGIVEEYQLPYYNMVPNDPSYEDM  470
         ***********************************.************************
S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l
Q: 471   REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521
         *************************************************97
Domain Sequence
(FASTA)
IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60
ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120
GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180
DESLNKNHFQ PYIMADIYSF GLIIWEMARR CITGGIVEEY QLPYYNMVPN DPSYEDMREV 240
VCVKRLRPIV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00262
EKS-ANC-00268
EKS-BOT-00280
EKS-CAE-00243
EKS-CAJ-00285
EKS-CAF-00286
EKS-CAP-00315
EKS-DAR-00620
EKS-DRM-00142
EKS-EQC-00272
EKS-FEC-00266
EKS-GAM-00174
EKS-GAG-00234
EKS-GAA-00341
EKS-GOG-00279
EKS-HOS-00286
EKS-ICT-00264
EKS-LAC-00288
EKS-LOA-00290
EKS-MAM-00282
EKS-MEG-00219
EKS-MOD-00276
EKS-MUM-00311
EKS-MUP-00275
EKS-MYL-00283
EKS-NOL-00258
EKS-OCP-00026
EKS-ORN-00361
EKS-ORA-00244
EKS-ORC-00264
EKS-ORL-00336
EKS-OTG-00291
EKS-PAT-00264
EKS-PES-00249
EKS-POA-00270
EKS-PRC-00028
EKS-RAN-00295
EKS-SAH-00262
EKS-TAG-00292
EKS-TAR-00363
EKS-TEN-00362
EKS-TUB-00022
EKS-TUT-00040
EKS-VIP-00017
EKS-XET-00352
EKS-XIM-00352
Gene Ontology
GO:0005901; C:caveola
GO:0005524; F:ATP binding
GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0030509; P:BMP signaling pathway
GO:0051216; P:cartilage development
GO:0048589; P:developmental growth
GO:0009950; P:dorsal/ventral axis specification
GO:0007398; P:ectoderm development
GO:0042733; P:embryonic digit morphogenesis
GO:0048568; P:embryonic organ development
GO:0003272; P:endocardial cushion formation
GO:0060914; P:heart formation
GO:0035137; P:hindlimb morphogenesis
GO:0006955; P:immune response
GO:0001701; P:in utero embryonic development
GO:0048368; P:lateral mesoderm development
GO:0030324; P:lung development
GO:0048382; P:mesendoderm development
GO:0001707; P:mesoderm formation
GO:0001880; P:Mullerian duct regression
GO:0050768; P:negative regulation of neurogenesis
GO:0014032; P:neural crest cell development
GO:0021998; P:neural plate mediolateral regionalization
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048352; P:paraxial mesoderm structural organization
GO:0021983; P:pituitary gland development
GO:0030501; P:positive regulation of bone mineralization
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391; P:positive regulation of SMAD protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0048378; P:regulation of lateral mesodermal cell fate specification
GO:0001756; P:somitogenesis
GO:0019827; P:stem cell maintenance
KEGG
ssc:100169652;
InterPros
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013