EKS-SUS-00144
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00144
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG510.59.3E-154149407259
StatusUnreviewed
Ensembl ProteinENSSSCP00000011118
UniProt AccessionA0MLS8;
Protein NamecGMP-dependent protein kinase
Protein Synonyms/Alias
Gene NamePRKG1
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000010429ENSSSCP00000011118ENSSSCT00000011414
OrganismSus scrofa
Functional Description
Protein Length459
Protein Sequence
(FASTA)
MEFLKSVPTF QSLPEEILSK LADVLEETHY ENGEYIIRQG ARGDTFFIIS KGKVNVTRED 60
SPSEDPIFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS 120
NKAYEDAEAK AKYEAEAAFF ANLKLSDFNI IDTLGVGGFG RVELVQLKSE ESKTFAMKIL 180
KKRHIVDTRQ QEHIRSEKQI MQGAHSDFIV RLYRTFKDSK YLYMLMEACL GGELWTILRD 240
RGSFEDSTTR FYTACVVEAF AYLHSKGIIY RDLKPENLIL DHRGYAKLVD FGFAKKIGFG 300
KKTWTFCGTP EYVAPEIILN KGHDISADYW SLGILMYELL TGSPPFSGPD PMKTYNIILR 360
GIDMIEFPKK IAKNAANLIK KLCRDNPSER LGNLKNGVKD IQKHKWFEGF NWEGLRKGTL 420
TPPIIPSVAS PTDTSNFDSF PEDSDEPPPD DNSGWDIDF 459
Nucleotide Sequence
(FASTA)
ATGGAATTTT TAAAAAGCGT TCCAACATTC CAGAGCCTTC CTGAAGAGAT CCTTAGTAAG 60
CTTGCTGACG TCCTTGAAGA GACCCACTAT GAAAATGGGG AATATATCAT CAGGCAAGGT 120
GCAAGAGGGG ACACCTTCTT TATCATCAGC AAAGGAAAGG TAAATGTCAC TCGTGAAGAC 180
TCACCAAGTG AAGATCCCAT CTTTCTTAGA ACTTTAGGAA AAGGAGATTG GTTTGGAGAG 240
AAAGCCTTGC AGGGGGAAGA TGTGAGAACA GCAAATGTAA TTGCTGCGGA AGCTGTAACC 300
TGCCTTGTGA TTGACAGAGA TTCTTTCAAG CATTTGATTG GAGGATTGGA TGATGTGTCT 360
AATAAAGCCT ATGAAGATGC AGAAGCTAAA GCAAAATATG AAGCTGAAGC TGCTTTCTTC 420
GCCAACCTGA AGCTGTCTGA TTTCAACATC ATTGACACCC TTGGAGTTGG AGGTTTTGGA 480
CGAGTAGAAC TGGTCCAGTT GAAAAGTGAA GAATCCAAAA CCTTTGCAAT GAAGATTCTC 540
AAGAAACGCC ATATCGTGGA TACAAGACAG CAGGAGCACA TCCGCTCTGA GAAGCAGATC 600
ATGCAGGGGG CTCATTCTGA TTTCATAGTG AGATTATACA GAACATTTAA GGACAGCAAA 660
TATTTGTATA TGTTGATGGA AGCTTGCTTA GGTGGAGAGC TCTGGACCAT TCTCAGGGAT 720
CGAGGCTCAT TTGAAGATTC TACAACCCGA TTTTATACAG CATGTGTGGT AGAAGCCTTT 780
GCCTATCTGC ATTCCAAAGG AATCATTTAC AGGGACCTCA AGCCAGAAAA TCTCATCCTA 840
GATCACCGAG GTTATGCCAA ACTGGTTGAT TTTGGCTTTG CAAAGAAAAT AGGATTTGGA 900
AAGAAAACAT GGACTTTTTG TGGGACTCCA GAGTACGTAG CCCCAGAGAT CATCTTGAAC 960
AAAGGCCATG ACATTTCAGC CGACTACTGG TCACTGGGAA TCCTAATGTA TGAACTTCTG 1020
ACTGGCAGCC CACCCTTCTC AGGCCCAGAT CCTATGAAAA CCTATAACAT CATATTAAGG 1080
GGGATTGACA TGATAGAATT TCCAAAGAAG ATTGCCAAAA ATGCTGCTAA TTTAATTAAA 1140
AAACTATGCA GGGATAATCC ATCAGAAAGA TTGGGTAATT TGAAAAATGG AGTGAAAGAC 1200
ATCCAGAAGC ACAAGTGGTT TGAGGGCTTT AATTGGGAAG GCTTAAGAAA AGGCACCTTG 1260
ACACCTCCTA TAATACCAAG TGTTGCATCA CCCACAGACA CAAGCAATTT TGACAGTTTC 1320
CCTGAGGACA GTGATGAACC ACCACCTGAT GACAACTCAG GATGGGACAT AGACTTCTAA 1380
Domain Profile
S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61
         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf
Q: 149   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  208
         79**********************************************************
S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121
         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i
Q: 209   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  268
         ************************************************************
S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181
         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d
Q: 269   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  328
         ************************************************************
S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241
         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+
Q: 329   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  388
         ************************************************************
S: 242   erlgylkggikdikkhkwf  260
         erlg+lk+g+kdi+khkwf
Q: 389   ERLGNLKNGVKDIQKHKWF  407
         ******************9
Domain Sequence
(FASTA)
NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60
IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120
IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180
YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240
ERLGNLKNGV KDIQKHKWF 259
KeywordATP-binding; cGMP; cGMP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00157
EKS-ANC-00161
EKS-BOT-00165
EKS-CAE-00128
EKS-CAJ-00169
EKS-CAF-00172
EKS-CAP-00164
EKS-CHH-00026
EKS-CII-00108
EKS-CIS-00196
EKS-DAR-00454
EKS-EQC-00164
EKS-GAM-00084
EKS-GAG-00141
EKS-GAA-00195
EKS-HOS-00171
EKS-ICT-00160
EKS-LAC-00175
EKS-LOA-00164
EKS-MAM-00163
EKS-MOD-00164
EKS-MUM-00170
EKS-MUP-00169
EKS-MYL-00175
EKS-NOL-00158
EKS-ORN-00205
EKS-ORA-00146
EKS-ORC-00152
EKS-ORL-00191
EKS-OTG-00171
EKS-PAT-00156
EKS-PES-00146
EKS-SAH-00160
EKS-TAG-00194
EKS-TAR-00212
EKS-TEN-00205
EKS-TUT-00151
EKS-VIP-00078
EKS-XIM-00200
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
GO:0016358; P:dendrite development
GO:0030900; P:forebrain development
GO:0090331; P:negative regulation of platelet aggregation
GO:0001764; P:neuron migration
GO:0043087; P:regulation of GTPase activity
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR016232; cGMP-dependent_protein_kinase.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 2.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013