EKS-SUS-00305
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00305
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack451.11.3E-135117375259
StatusUnreviewed
Ensembl ProteinENSSSCP00000023403
UniProt AccessionF1SQ79;
Protein Name
Protein Synonyms/Alias
Gene NameTNK2
Gene Synonyms/Alias TNK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000011849ENSSSCP00000023403ENSSSCT00000024458
ENSSSCG00000011849ENSSSCP00000012620ENSSSCT00000012961
OrganismSus scrofa
Functional Description
Protein Length673
Protein Sequence
(FASTA)
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60
EAVKRRKAAC KRRSWMSKLL GGRTEQRPEE ALRLDSPLPQ RDKPLSLTCL IGEKDLHLFE 120
KLGDGSFGVV RRGEWDAPSG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA MHSLDHRNLI 180
RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM GYLESKRFIH 240
RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE SLKTRTFSHA 300
SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDV YNVMVQCWAH 360
KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA ENYWWRGQNT 420
RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD KIDDRPCIPA 480
PAHQSTKPWE GAHGCLLRAR LYLGNPMDPP DLLSVELSAS RPPQHLGRVK REPPPRPPQP 540
AIFTQTSHPT QPRQQRSSRH CSRPQVCHTP GDPGTWPPGR PLHLTHCPRW QEDKIQMLQA 600
MVHGVTTEEC QAALQSHSWS VQRAAQYLKV EQLFGLGLRP RGECHKVLEM FDWNLEQAGC 660
HLLGSCGSAH HKR 673
Nucleotide Sequence
(FASTA)
ATGCAGCCGG AGGAGGGCAC AGGCTGGCTG CTGGAGCTGC TGTCCGAGGT GCAGCTGCAA 60
CAGTATTTCC TGCGGCTCCG TGACGACCTC AACGTTACCC GCCTGTCCCA CTTTGAGTAC 120
GTCAAGAATG AGGACCTGGA GAAGATTGGC ATGGGCCGGC CTGGCCAGCG GCGGCTGTGG 180
GAGGCTGTGA AGAGGCGCAA GGCTGCATGC AAACGCAGGT CCTGGATGAG CAAGTTGCTG 240
GGAGGGAGGA CAGAGCAGCG GCCAGAAGAA GCCCTCAGAC TAGACAGCCC CCTGCCCCAA 300
AGAGACAAGC CTCTGAGCCT CACCTGCCTC ATTGGGGAGA AGGACCTGCA TCTCTTCGAG 360
AAGCTAGGAG ATGGCTCCTT TGGCGTGGTG CGCAGGGGCG AGTGGGACGC CCCGTCGGGG 420
AAGACGGTGA GTGTAGCTGT GAAGTGCCTG AAGCCCGATG TGCTGAGCCA GCCAGAGGCC 480
ATGGACGACT TTATCCGGGA GGTCAACGCC ATGCACTCGC TTGACCACCG AAACCTGATT 540
CGCCTCTACG GTGTGGTGCT CACACCACCC ATGAAGATGG TGACAGAGCT GGCACCTCTG 600
GGATCGTTGT TGGACCGGCT GCGCAAGCAC CAGGGCCACT TCCTCCTAGG TACTCTGAGT 660
CGCTATGCTG TGCAGGTGGC TGAGGGCATG GGCTACCTGG AGTCCAAGCG CTTTATTCAC 720
CGTGACCTGG CCGCCCGCAA CCTGCTGTTG GCCACCCGTG ACCTGGTCAA GATCGGGGAC 780
TTCGGGCTGA TGCGAGCACT ACCCCAGAAT GACGACCACT ACGTCATGCA GGAGCATCGC 840
AAGGTGCCCT TTGCCTGGTG TGCCCCTGAG AGCCTGAAGA CTCGAACCTT CTCCCACGCT 900
AGCGACACCT GGATGTTTGG GGTAACGCTG TGGGAGATGT TTACCTACGG CCAGGAGCCC 960
TGGATTGGCC TCAATGGCAG TCAGATCCTG CATAAGATTG ACAAAGAAGG GGAGCGTCTG 1020
CCCCGGCCTG AGGACTGCCC CCAGGACGTC TACAATGTCA TGGTCCAGTG CTGGGCTCAC 1080
AAGCCGGAGG ACAGACCCAC CTTTGTGGCC CTGAGGGACT TCCTGCTGGA GGCACAGCCC 1140
ACGGATATGC GGGCCCTTCA GGACTTTGAG GAACCGGACA AGCTGCATAT CCAGATGAAT 1200
GACGTCATAA CCGTCATCGA GGGGAGGGCT GAGAATTACT GGTGGCGTGG GCAGAACACG 1260
CGGACGCTGT GCGTGGGGCC CTTCCCTCGC AACGTGGTGA CCTCCGTGGC TGGCCTTTCA 1320
GCCCAGGACA TCAGCCAGCC CTTGCAGAAT AGCTTCATCC ACACAGGGCA TGGCGACAGC 1380
GACCCCCGCC ACTGCTGGGG CTTTCCCGAC AAGATTGATG ACAGGCCCTG CATCCCTGCC 1440
CCCGCACACC AGAGCACTAA GCCCTGGGAG GGTGCCCATG GCTGCCTCCT AAGAGCCAGA 1500
CTCTATCTGG GAAACCCCAT GGACCCTCCC GACCTGCTGA GCGTGGAACT AAGCGCCTCC 1560
AGACCCCCCC AGCACCTGGG CAGGGTGAAA AGGGAGCCTC CACCTCGCCC TCCTCAGCCT 1620
GCCATCTTCA CTCAGACAAG CCACCCAACT CAGCCCAGAC AGCAGAGATC TTCCAGGCAC 1680
TGCAGCAGAC CCCAAGTATG CCACACCCCA GGTGATCCAG GCACCTGGCC CCCGGGCCGG 1740
CCCCTGCATC TTACCCATTG TCCGAGATGG CAAGAAGACA AGATCCAGAT GCTACAGGCC 1800
ATGGTGCATG GGGTGACCAC AGAGGAGTGC CAGGCGGCCT TGCAGAGCCA CAGCTGGAGC 1860
GTGCAGAGGG CTGCCCAGTA TCTGAAGGTG GAGCAGCTAT TTGGGTTGGG TCTGCGGCCC 1920
CGAGGCGAGT GCCACAAAGT GCTGGAGATG TTCGACTGGA ACCTGGAGCA GGCGGGCTGT 1980
CACCTGCTGG GCTCCTGCGG CTCCGCCCAC CACAAGCGCT GA 2022
Domain Profile
S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60
         +l eklG+Gsfgvv+rgeW+apsgk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h
Q: 117   HLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  176
         5789***************************************99***************
S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120
         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle
Q: 177   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  234
         ***********************************9..9*********************
S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180
         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t
Q: 235   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  294
         ************************************************************
S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240
         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+d+y+++
Q: 295   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDVYNVM  354
         ************************************************************
S: 241   lkcWakkpadrpkfsalkekl  261
         ++cWa+kp+drp+f+al+++l
Q: 355   VQCWAHKPEDRPTFVALRDFL  375
         ******************986
Domain Sequence
(FASTA)
HLFEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60
RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120
RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180
FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDVYNVMVQ 240
CWAHKPEDRP TFVALRDFL 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00323
EKS-ANC-00334
EKS-BOT-00345
EKS-CAE-00280
EKS-CAJ-00351
EKS-CAF-00350
EKS-CAP-00379
EKS-CII-00192
EKS-CIS-00099
EKS-DAR-00712
EKS-DRM-00169
EKS-EQC-00337
EKS-FEC-00333
EKS-GAA-00426
EKS-GOG-00342
EKS-HOS-00352
EKS-ICT-00326
EKS-LAC-00357
EKS-LOA-00354
EKS-MAM-00346
EKS-MEG-00282
EKS-MOD-00338
EKS-MUM-00377
EKS-MUP-00340
EKS-MYL-00346
EKS-NOL-00315
EKS-OCP-00064
EKS-ORN-00449
EKS-ORC-00324
EKS-ORL-00414
EKS-OTG-00350
EKS-PES-00305
EKS-POA-00335
EKS-PTV-00086
EKS-RAN-00360
EKS-TAG-00421
EKS-TAR-00449
EKS-TEN-00446
EKS-XET-00440
EKS-XIM-00439
Gene Ontology
GO:0030424; C:axon
GO:0030136; C:clathrin-coated vesicle
GO:0005905; C:coated pit
GO:0030425; C:dendrite
GO:0070436; C:Grb2-EGFR complex
GO:0030426; C:growth cone
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369; P:regulation of clathrin-mediated endocytosis
KEGG
InterPros
IPR015116; GTPase_binding.
IPR021619; Inhibitor_Mig-6.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR000449; UBA/transl_elong_EF1B_N.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF09027; GTPase_binding; 1.
PF11555; Inhibitor_Mig-6; 1.
PF07714; Pkinase_Tyr; 1.
PF00627; UBA; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
SM00165; UBA; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50002; SH3; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013