EKS-SUS-00071

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00071

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	450.8	2.4E-135	31	315	285

Status

Unreviewed

Ensembl Protein

ENSSSCP00000012664

UniProt Accession

I6YP72;

Protein Name

Protein Synonyms/Alias

Glycogen synthase kinase 3 beta variant 2;

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000011889	ENSSSCP00000030963	ENSSSCT00000035981
ENSSSCG00000011889	ENSSSCP00000030994	ENSSSCT00000036443
ENSSSCG00000011889	ENSSSCP00000012664	ENSSSCT00000013006

Organism

Sus scrofa

Functional Description

Protein Length

395

Protein Sequence
(FASTA)

MKVSRDKDGS KVTTVVATPG QGPDRPQEVS YTDTKVIGNG SFGVVYQAKL CDSGELVAIK 60

KVLQDKRFKN RELQIMRKLD HCNIVRLRYF FYSSGEKKDE VYLNLVLDYV PETVYRVARH 120

YSRAKQTLPV IYVKLYMYQL FRSLAYIHSF GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK 180

QLVRGEPNVS YICSRYYRAP ELIFGATDYT SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ 240

LVEIIKVLGT PTREQIREMN PNYTEFKFPQ IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP 300

TARLTPLEAC AHSFFDELRD PNVKLPNGRD TPALFNFTTQ ELSSNPPLAT ILIPPHARIQ 360

AAASTPSNAT AASDTNAGDR GQTNNTASAS ASNST 395

Nucleotide Sequence
(FASTA)

ATGAAAGTTA GCAGAGACAA GGATGGCAGC AAGGTGACCA CAGTGGTGGC AACTCCTGGG 60

CAGGGTCCAG ACAGGCCACA AGAAGTCAGC TATACAGACA CTAAAGTGAT TGGAAATGGG 120

TCATTTGGTG TGGTGTATCA AGCCAAGCTT TGTGATTCAG GAGAACTGGT TGCCATCAAG 180

AAAGTATTGC AGGACAAGAG ATTTAAGAAC CGAGAGCTCC AAATCATGAG AAAGCTAGAT 240

CACTGTAACA TAGTCCGATT GCGTTATTTC TTCTACTCAA GTGGTGAAAA GAAAGATGAG 300

GTCTATCTTA ATCTGGTGCT GGACTATGTT CCGGAAACAG TATACAGAGT TGCCAGACAC 360

TATAGTCGAG CCAAACAGAC GCTCCCTGTG ATCTATGTCA AGTTGTATAT GTATCAGCTG 420

TTCCGAAGTT TAGCCTATAT CCATTCCTTT GGAATCTGCC ATCGGGATAT TAAACCACAG 480

AACCTCTTGT TGGATCCTGA TACAGCTGTC TTAAAACTCT GTGACTTTGG AAGTGCAAAG 540

CAGCTGGTCC GAGGAGAACC CAATGTTTCG TATATCTGTT CTCGGTACTA TAGGGCACCA 600

GAGTTGATCT TTGGAGCCAC TGATTATACC TCTAGTATAG ATGTGTGGTC TGCAGGCTGT 660

GTGTTGGCTG AACTGTTGCT AGGACAACCT ATATTTCCAG GGGATAGTGG TGTGGATCAA 720

TTGGTGGAAA TAATCAAGGT CCTAGGGACA CCAACAAGGG AGCAAATTAG AGAAATGAAC 780

CCAAACTACA CAGAATTCAA ATTCCCTCAA ATTAAGGCAC ATCCTTGGAC TAAGGTCTTC 840

CGGCCCCGAA CTCCCCCAGA GGCCATTGCA CTATGTAGCC GTCTGTTGGA GTACACACCA 900

ACTGCCCGAT TGACACCACT GGAAGCTTGT GCGCATTCAT TTTTTGATGA ATTACGGGAC 960

CCAAATGTCA AATTACCAAA TGGGCGAGAC ACACCTGCAC TCTTCAACTT CACCACTCAA 1020

GAATTGTCAA GTAATCCACC TCTAGCTACC ATCCTTATTC CTCCTCATGC TCGGATTCAA 1080

GCAGCTGCTT CAACCCCTTC AAATGCCACA GCAGCCTCAG ATACTAATGC CGGAGATCGT 1140

GGGCAGACCA ATAACACCGC TTCTGCGTCA GCTTCCAATT CCACCTGA 1188

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 31    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  89

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l+v++vkly+yQlfr+lay+hs

Q: 90    FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS  149

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 150   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  209

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 210   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  269

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 270   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  315

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPV IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013