EKS-SUS-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK394.04.8E-118211515305
StatusUnreviewed
Ensembl ProteinENSSSCP00000013604
UniProt AccessionF1RZU1;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK1
Gene Synonyms/Alias IRAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000012795ENSSSCP00000030283ENSSSCT00000036104
ENSSSCG00000012795ENSSSCP00000030485ENSSSCT00000036679
ENSSSCG00000012795ENSSSCP00000013604ENSSSCT00000013987
OrganismSus scrofa
Functional Description
Protein Length704
Protein Sequence
(FASTA)
MAGGPGPGDP AVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60
RSGQRTASVL WPWINRNARV ADLVRILTHL QLLRARDIIT AWHPSAPFLP PSSTTPRPNS 120
ISAPLEAKAP SPRKLHSSAS TLLSPAFPGS QTHSDPELGP HTSPAALQPP ALSAAPLSTQ 180
PSPESSGSLL PGAPSSFCWP LHEIRQGTQD FSDALKIGEG GFGCVYRAVM RNTVYAVKRL 240
KQEADLEWST VKQSFRTEVE QLSRFRHPNI VDFAGYCAQS GCYCLVYGFL PNGSLEDRLH 300
VQAWPPLSWP QRLDILVGTA RAIQFLHQDS PSLVHGDVKS SNVLLDERLM PKLGDFGLAR 360
LSRFAGAQPG QSSAVARTRT VRGTLAYLPE DYVKTGRLAV DTDTFSFGVV LLETLAGQRA 420
VSTHGAQTKY LKDLVDDEAE EAGVVLRSTQ SALQAGLAED AWAAPIATQI YKKHVDPRPG 480
PCPPELGLAL GQLACCCLHR RAKRRPPMTQ VYKRLETLQA AVAGPSPEPE AASRTPSSPQ 540
ENSYVSTSGA QATERLQKGT NQPVESDESV SGLSAALRSW HLTPSCPPGP AQPGSLGPGA 600
AVWTPAPLRQ AGRTQGASTG QSGWESGPGP QPTVVEGSLP GGSASSPPPQ IVINPARQKM 660
LQKLALYEDG VLDSLQLLSS SSLPGLGLER QSRRGPEESD EFQS 704
Nucleotide Sequence
(FASTA)
ATGGCCGGGG GGCCAGGCCC GGGAGACCCC GCGGTCCCCG GCGCCCAGCA CTTCTTGTAC 60
GAGGTGCCGC CCTGGGTCAT GTGCCGCTTC TACAAGGTGA TGGACGCCCT GGAGCCCGCC 120
GACTGGTGCC AGTTCGCCGC CCTGATCGTG CGCGACCAGA CCGAGCTGAG GCTGTGCGAG 180
CGCTCCGGGC AGCGCACGGC CAGCGTCCTG TGGCCGTGGA TCAACCGCAA CGCCCGCGTG 240
GCCGACCTCG TGCGCATTCT CACGCACCTG CAGCTGCTCC GCGCGCGGGA CATCATCACA 300
GCATGGCACC CTTCCGCCCC TTTTCTGCCC CCGAGCAGCA CCACCCCCAG GCCCAACAGC 360
ATCTCTGCAC CCTTGGAGGC CAAGGCCCCC AGCCCCCGGA AGTTGCACTC GTCAGCCTCC 420
ACCCTCCTCT CCCCAGCTTT TCCAGGCTCC CAGACTCATT CTGACCCTGA GCTCGGCCCT 480
CACACAAGCC CTGCCGCCCT CCAGCCCCCA GCACTATCTG CAGCCCCTCT CTCTACCCAG 540
CCAAGCCCAG AAAGCTCAGG GTCCCTCTTG CCGGGGGCCC CCTCTTCGTT CTGCTGGCCC 600
CTCCACGAGA TCCGCCAGGG CACCCAGGAC TTCTCAGACG CTCTGAAGAT CGGGGAGGGC 660
GGCTTCGGGT GTGTGTACCG GGCGGTGATG AGAAACACGG TGTACGCTGT GAAGAGGCTG 720
AAGCAGGAGG CAGACCTGGA GTGGAGCACG GTGAAGCAGA GCTTCCGCAC CGAAGTGGAG 780
CAGTTGTCAC GGTTTCGTCA CCCCAACATC GTGGACTTTG CTGGCTACTG TGCTCAGAGT 840
GGCTGCTACT GCCTCGTCTA CGGCTTCCTG CCCAACGGCT CCTTGGAAGA CCGCCTCCAC 900
GTCCAGGCCT GGCCCCCTCT CTCCTGGCCT CAGCGACTGG ACATCCTTGT GGGCACGGCC 960
CGGGCGATTC AGTTTTTACA CCAGGACAGT CCCAGCCTCG TCCACGGAGA TGTCAAGAGT 1020
TCCAACGTCC TTCTGGATGA GAGGCTGATG CCCAAACTGG GAGACTTCGG CCTGGCCCGT 1080
CTCAGCCGTT TTGCTGGGGC CCAGCCCGGC CAGAGCAGCG CCGTGGCTCG GACACGGACC 1140
GTGCGTGGCA CCCTGGCCTA CCTGCCCGAG GACTACGTCA AGACCGGGAG GCTGGCTGTG 1200
GACACCGACA CCTTCAGCTT CGGCGTGGTG CTGCTGGAGA CCCTGGCTGG CCAGAGGGCT 1260
GTGAGCACGC ACGGCGCCCA GACCAAGTAC CTGAAAGACC TGGTTGATGA CGAAGCCGAG 1320
GAGGCCGGGG TGGTCCTGAG AAGCACCCAG TCCGCGCTCC AAGCCGGCCT GGCCGAAGAC 1380
GCCTGGGCGG CCCCGATCGC CACCCAGATC TACAAGAAGC ACGTGGACCC CAGGCCTGGG 1440
CCGTGCCCCC CGGAGCTGGG CCTGGCCCTG GGTCAGCTGG CCTGCTGCTG CCTGCACCGC 1500
CGGGCCAAGC GGAGGCCCCC CATGACCCAG GTGTACAAGA GGCTGGAGAC GCTGCAGGCG 1560
GCAGTCGCAG GGCCATCCCC GGAGCCAGAG GCTGCCAGCC GCACCCCCTC TTCCCCGCAG 1620
GAGAACTCCT ATGTGTCCAC CTCAGGAGCC CAGGCAACAG AGCGGCTTCA GAAAGGCACC 1680
AACCAGCCCG TGGAGAGCGA CGAGAGTGTG TCCGGCCTGT CTGCTGCCCT GCGTTCCTGG 1740
CACCTGACCC CGAGCTGCCC CCCGGGCCCA GCCCAGCCAG GCAGCCTGGG CCCAGGGGCC 1800
GCCGTGTGGA CACCAGCACC CCTCAGGCAG GCTGGCCGTA CGCAAGGGGC TTCCACTGGA 1860
CAGTCCGGCT GGGAGAGCGG CCCGGGGCCC CAGCCCACAG TTGTGGAAGG CTCCCTCCCG 1920
GGCGGCTCCG CGTCATCCCC GCCCCCGCAG ATTGTCATCA ACCCAGCCCG ACAGAAGATG 1980
CTGCAGAAGC TGGCCCTGTA CGAGGATGGG GTTCTGGACA GCCTGCAGCT GCTGTCGTCA 2040
AGCTCCCTCC CAGGCCTGGG CCTGGAGCGG CAGAGCAGAC GGGGGCCCGA AGAGAGTGAT 2100
GAATTTCAGA GCTGA 2115
Domain Profile
S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60
         fs+  +igeGgfg+vyr+ ++nt++avk+lk+eadl+++++kqsf tE+++l+rfrH+ni
Q: 211   FSDALKIGEGGFGCVYRAVMRNTVYAVKRLKQEADLEWSTVKQSFRTEVEQLSRFRHPNI  270
         67889*******************************************************
S: 61    lellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHea  120
         ++++gy+a+s+ +cLvY++++nGsLedrL++q + +pLsWpqRl+il+Gtarai+fLH++
Q: 271   VDFAGYCAQSGCYCLVYGFLPNGSLEDRLHVQ-AWPPLSWPQRLDILVGTARAIQFLHQD  329
         *****************************985.89*************************
S: 121   spslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYlp  177
         spsl+hgd+ks+N+LLDe+l+pKlgDfglar   fa++++ qss+v+rt +vrgtlaYlp
Q: 330   SPSLVHGDVKSSNVLLDERLMPKLGDFGLARlsrFAGAQPGQSSAVARTRTVRGTLAYLP  389
         ******************************99999*************************
S: 178   eefirvgqltvkvDvySfGiVllEvltGlra.vdedrktkyLkdllkeeieeekv.....  231
         e+++++g+l+v++D++SfG+VllE+l+G+ra  +++++tkyLkdl+ +e+ee++v     
Q: 390   EDYVKTGRLAVDTDTFSFGVVLLETLAGQRAvSTHGAQTKYLKDLVDDEAEEAGVvlrst  449
         *******************************668899***********************
S: 232   ...................eilekfldkkagkleeellealielalaclaekakkrPtms  272
                            +i++k++d ++g++++el  al +la++cl+++ak+rP+m+
Q: 450   qsalqaglaedawaapiatQIYKKHVDPRPGPCPPELGLALGQLACCCLHRRAKRRPPMT  509
         ************************************************************
S: 273   qvlell  278
         qv+++l
Q: 510   QVYKRL  515
         ***987
Domain Sequence
(FASTA)
FSDALKIGEG GFGCVYRAVM RNTVYAVKRL KQEADLEWST VKQSFRTEVE QLSRFRHPNI 60
VDFAGYCAQS GCYCLVYGFL PNGSLEDRLH VQAWPPLSWP QRLDILVGTA RAIQFLHQDS 120
PSLVHGDVKS SNVLLDERLM PKLGDFGLAR LSRFAGAQPG QSSAVARTRT VRGTLAYLPE 180
DYVKTGRLAV DTDTFSFGVV LLETLAGQRA VSTHGAQTKY LKDLVDDEAE EAGVVLRSTQ 240
SALQAGLAED AWAAPIATQI YKKHVDPRPG PCPPELGLAL GQLACCCLHR RAKRRPPMTQ 300
VYKRL 305
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00380
EKS-ANC-00394
EKS-BOT-00406
EKS-CAJ-00411
EKS-CAF-00406
EKS-CII-00238
EKS-DAR-00793
EKS-DRM-00191
EKS-EQC-00398
EKS-ERE-00006
EKS-FEC-00392
EKS-GAG-00345
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MAM-00407
EKS-MEG-00339
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-ORN-00520
EKS-ORA-00354
EKS-ORC-00381
EKS-OTG-00408
EKS-PAT-00384
EKS-PES-00362
EKS-PEM-00221
EKS-POA-00398
EKS-PRC-00006
EKS-PTV-00116
EKS-RAN-00420
EKS-SAH-00376
EKS-TAG-00479
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007250; P:activation of NF-kappaB-inducing kinase activity
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0032088; P:negative regulation of NF-kappaB transcription factor activity
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0051259; P:protein oligomerization
GO:0001959; P:regulation of cytokine-mediated signaling pathway
GO:0032494; P:response to peptidoglycan
GO:0034134; P:toll-like receptor 2 signaling pathway
GO:0034142; P:toll-like receptor 4 signaling pathway
KEGG
ssc:396606;
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013