EKS-SUS-00389

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00389

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	476.0	3.9E-143	71	337	267

Status

Unreviewed

Ensembl Protein

ENSSSCP00000013843

UniProt Accession

F1RQR3;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPG

Gene Synonyms/Alias

CDC42BPG;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000013018	ENSSSCP00000013843	ENSSSCT00000014229

Organism

Sus scrofa

Functional Description

Protein Length

1552

Protein Sequence
(FASTA)

MERRLRALER LARGEAGGGP GLDGLLDLLL GLHHELSSAP LRRERNVAQF LNWVSPFVAK 60

VKELRLQRDD FEILKVIGRG AFGEVAVVRQ RDSGQIFAMK MLHKWEMLKR AETACFREER 120

DVLVKGDSRW VTALHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV 180

LAIHSLHQLG YVHRDVKPDN ILLDMNGHIR LADFGSCLRL NNSGMVDSSV AVGTPDYISP 240

EILQAMEEGK GHYGPQCDWW SLGVCAYELL FGETPFYAES LVGTYGKIMN HEDHLHFPPD 300

VPDVPASARD LIRQLLCRQE ERLGRGGLDD FRNHPFFEGV DWERLASSTA PYIPELRGPM 360

DTSNFDVDDD TLNHPGTLPP PSHGNFLGHH LPFVGFTYIS GSPGPESSSE QLAALERKLR 420

CVEQEKVELS RKLQEALQTP SDHRELEQLR KEVQILQDRL SEMLKDSTVD GPPVGRPGQD 480

SDLRQERDQL LQELAEARAG LQAQEQELCR AQGRQEELLR KLQEAQEREA AMASQTQALN 540

SQLEEAWGAQ KELQAQVAAL SQEVMRLQKQ RERSLEKESS RVNVTVHTAS ETNGTGSPEG 600

GPQEAQLRQE VAALRVQLEQ AHSHGPSGKE EALCRLREEN QRLSREQERL LEELEREQQS 660

KQRLEGEQRE TESNWEAQIA DILTWVNDEK VSRGYLQALA TKMAEELESL RNVGTQTLPA 720

RSLDHQWKAR RLQKMEASAR LELQSALEAE IRAKQGLQER LTQVQEAQLR AESRLQETEK 780

QNQGLQQELA ALREELRARG PGDTKPSNSL IPFLSFWSTE KDSAKDPGIS GEAPRSGLEP 840

ELRPEGRRSL RLGAVFPRAP AATTASPESP PAKPGSHTLR PRSFPSPTKC LRCTSLMLGL 900

GRQGLGCDAC GYFCHSTCAP QAPPCPVPPD LLHTALGVHP ETGTGTAYEG FLSVPRPSGV 960

RRGWQRVFAA LSDSRLLLFD APDPRLSPAS GALLQTLDLR DPQFSATPVL ASDVIHAQSR 1020

DLPRIFRVTA SQLTVPPATC TVLLLAESEG ERERWLQVLG ELQRLLLDAR PRPRPVYTLK 1080

EAYDNGLPLL PHTLCAAIID QERLALGTEE GLFIIHLHSN DIFQVGECRR VQRLAVSPTA 1140

GLLAVLCGRG PSVRLFPLAE LENAEASGAK IPESRGCQAL AAGRILQART PVLCVAVKRQ 1200

VLCYQLGPGP GPWQRRIREL QAPAPVQSLG LLGDRLCVGA AGAFVLYPLL NEAAPLALGA 1260

GLVPEELPPS RGGLGEALGA VELSLSEFLL LFTTAGIYVD NAGRRSRIQE LLWPAVPTGW 1320

GYAAPYLTVF SENAIDVFDV RRAEWVQTVP LKKVRPLNPE GSLFLYGTEK VRLTYLRNPL 1380

AEKDEFDIPN LTDNSRRQLF RSKSKRRFFF RVSEAQLQQQ RREMLKDPFV RSKLISTPTN 1440

FNHLVHVGPA DGRPCAGELP PGRAPDQKGR GARSSGPQRP HSFSEAPRRP ASMSSDGFAG 1500

DSDPTVKKKP WTSLSSESVS CPQGPPSPPA SPVQVSERPR SLPPAPESES SP 1552

Nucleotide Sequence
(FASTA)

ATGGAGCGGC GGCTGCGCGC GCTGGAGCGG CTGGCGCGGG GCGAGGCCGG CGGCGGCCCG 60

GGGCTCGACG GCCTCCTGGA TCTGCTGCTG GGGCTGCACC ACGAGCTCAG CAGCGCCCCC 120

CTGCGGCGGG AGCGCAACGT GGCGCAGTTC CTGAACTGGG TCAGCCCCTT CGTAGCAAAG 180

GTCAAAGAGC TGCGGCTGCA GAGAGATGAC TTTGAGATCT TGAAGGTGAT CGGCCGAGGG 240

GCCTTCGGGG AGGTGGCTGT GGTGAGGCAG AGGGACAGTG GACAGATTTT TGCCATGAAA 300

ATGCTGCACA AGTGGGAGAT GCTGAAGAGG GCTGAGACGG CCTGTTTCCG GGAGGAGCGG 360

GACGTTCTGG TGAAAGGGGA CAGCCGCTGG GTGACCGCTC TGCATTACGC CTTCCAAGAT 420

GAGGAGTACC TGTATCTGGT GATGGACTAC TACGCAGGAG GGGACCTCCT CACTCTGCTG 480

AGCCGCTTCG AGGACCGCCT CCCGCCCGAG CTGGCCCAGT TCTACCTGGC CGAGATGGTG 540

CTGGCCATCC ACTCGCTGCA TCAGCTGGGC TATGTCCACA GGGACGTCAA GCCAGACAAC 600

ATCCTCCTGG ACATGAACGG GCACATCCGC TTGGCCGACT TTGGCTCCTG CCTGCGTCTC 660

AACAACAGTG GCATGGTGGA TTCCTCCGTG GCAGTGGGGA CGCCAGACTA CATCTCCCCC 720

GAGATCCTGC AGGCCATGGA GGAGGGCAAG GGCCACTATG GCCCCCAGTG CGACTGGTGG 780

TCCCTGGGGG TCTGTGCCTA CGAGCTGCTC TTTGGGGAGA CGCCCTTCTA CGCCGAGTCC 840

CTGGTGGGGA CCTACGGCAA GATCATGAAC CACGAGGACC ACCTGCACTT CCCCCCAGAT 900

GTGCCCGATG TGCCGGCCAG TGCCCGAGAC CTGATCCGCC AGCTGCTGTG CCGCCAGGAG 960

GAGCGTCTGG GCCGTGGAGG GCTGGATGAC TTCCGGAACC ACCCCTTCTT CGAAGGCGTG 1020

GACTGGGAGC GGCTGGCGAG CAGCACCGCT CCTTACATCC CTGAGCTCCG CGGGCCCATG 1080

GACACCTCCA ACTTTGACGT GGACGACGAC ACCCTCAACC ATCCAGGGAC CCTGCCGCCA 1140

CCCTCCCATG GGAACTTCTT AGGCCACCAC CTGCCATTCG TGGGCTTCAC CTACATCTCA 1200

GGCAGTCCAG GCCCTGAGAG CAGTTCCGAG CAGTTGGCTG CCCTGGAGCG GAAGCTCCGT 1260

TGTGTGGAGC AGGAGAAGGT GGAGCTGAGC CGGAAGCTCC AAGAAGCTCT GCAGACCCCC 1320

TCAGACCATC GGGAGCTGGA GCAGCTACGG AAGGAAGTGC AGATTCTGCA GGACAGGCTG 1380

TCAGAGATGC TGAAGGACAG CACAGTGGAC GGTCCCCCAG TGGGTAGGCC CGGCCAGGAC 1440

AGTGACCTGA GGCAGGAGAG AGACCAACTC CTCCAGGAGC TGGCCGAGGC TCGGGCTGGG 1500

CTGCAGGCGC AGGAGCAGGA GCTCTGCAGG GCCCAGGGGC GGCAGGAGGA GCTGCTCCGG 1560

AAGCTGCAGG AGGCCCAGGA GAGAGAGGCG GCCATGGCCA GCCAGACCCA AGCCCTGAAC 1620

TCCCAGCTGG AGGAAGCCTG GGGTGCCCAG AAGGAGCTGC AGGCCCAGGT GGCTGCCCTG 1680

AGCCAGGAAG TGATGCGGCT CCAGAAACAG AGGGAACGAA GCCTCGAGAA GGAGTCATCC 1740

CGGGTCAACG TGACTGTCCA CACTGCCTCT GAGACCAACG GCACAGGATC GCCCGAGGGC 1800

GGGCCTCAGG AGGCACAGCT GAGGCAGGAG GTGGCCGCCC TGCGTGTGCA GCTGGAGCAG 1860

GCCCACAGCC ACGGGCCGAG TGGAAAGGAG GAGGCTCTAT GCCGGCTACG GGAGGAGAAC 1920

CAGCGACTGA GCCGGGAGCA GGAGCGGCTG CTGGAAGAGC TGGAGCGGGA GCAGCAGAGC 1980

AAGCAGAGGC TGGAGGGAGA GCAGCGGGAG ACAGAGAGCA ACTGGGAGGC CCAGATTGCC 2040

GACATCCTTA CCTGGGTGAA TGATGAGAAG GTGTCAAGAG GCTACCTGCA GGCCCTGGCC 2100

ACCAAGATGG CCGAGGAGCT GGAGTCCTTG CGGAATGTGG GCACCCAGAC TCTCCCTGCC 2160

CGGTCGCTGG ATCACCAGTG GAAGGCACGG CGGCTGCAGA AGATGGAGGC CTCAGCCAGG 2220

CTGGAGCTGC AGTCAGCACT AGAGGCCGAG ATCCGGGCCA AGCAGGGCCT GCAGGAGCGG 2280

CTGACGCAGG TGCAGGAGGC CCAGCTGAGG GCTGAGAGCC GTCTGCAGGA GACTGAGAAG 2340

CAGAACCAGG GCCTGCAGCA GGAACTGGCT GCACTCCGGG AGGAGCTGCG GGCCCGTGGC 2400

CCAGGAGACA CCAAGCCCTC CAACTCCCTG ATTCCCTTCT TGTCCTTCTG GAGCACAGAG 2460

AAGGATTCCG CCAAGGACCC TGGCATCTCA GGAGAAGCCC CCAGGTCTGG ATTGGAGCCA 2520

GAGCTGAGGC CAGAGGGCCG TCGCAGCCTG CGCCTGGGGG CCGTGTTCCC CAGGGCGCCT 2580

GCTGCTACCA CAGCCTCCCC AGAAAGTCCT CCTGCGAAGC CCGGCTCACA CACGCTGCGC 2640

CCCCGGAGCT TCCCGTCCCC CACCAAGTGT CTCCGCTGCA CCTCGCTGAT GCTGGGTCTG 2700

GGCCGCCAGG GCCTGGGCTG TGACGCCTGC GGCTACTTCT GTCACTCGAC TTGTGCCCCA 2760

CAGGCCCCGC CCTGCCCCGT GCCCCCTGAC CTCCTCCACA CGGCCCTGGG AGTGCACCCC 2820

GAGACGGGCA CGGGCACCGC CTACGAGGGC TTCCTGTCGG TGCCACGGCC CTCTGGTGTC 2880

CGGCGGGGCT GGCAACGAGT GTTTGCCGCC CTCAGTGACT CGCGCCTGCT GCTGTTTGAC 2940

GCCCCGGACC CGAGGCTCAG CCCGGCCAGC GGGGCCCTCC TGCAGACACT CGATCTGAGG 3000

GACCCCCAGT TCTCAGCTAC CCCTGTGCTG GCCTCTGATG TTATCCACGC CCAATCCAGG 3060

GACCTGCCAC GTATCTTTAG GGTGACGGCC TCCCAGCTGA CGGTGCCACC TGCCACATGC 3120

ACCGTGCTGC TGCTGGCAGA GAGCGAGGGG GAGCGGGAGC GCTGGCTGCA GGTGCTGGGC 3180

GAGCTGCAGC GGCTGCTGCT GGACGCGCGG CCAAGGCCCC GGCCCGTGTA CACACTCAAG 3240

GAGGCCTACG ACAACGGGCT GCCGCTGCTG CCCCACACGC TCTGCGCCGC CATCATCGAC 3300

CAGGAACGGC TTGCCCTGGG CACCGAGGAG GGCCTGTTTA TAATCCACCT GCACAGCAAC 3360

GACATCTTCC AGGTGGGCGA GTGCCGGCGG GTGCAGAGGC TGGCAGTGAG CCCCACAGCA 3420

GGCCTTCTGG CCGTGCTCTG CGGCCGTGGC CCCAGCGTGC GCCTCTTCCC CCTGGCCGAG 3480

CTGGAGAATG CAGAGGCATC CGGTGCCAAG ATCCCTGAGT CTCGAGGCTG CCAGGCACTG 3540

GCAGCCGGGC GCATCCTGCA GGCCCGCACC CCTGTGCTCT GTGTCGCAGT CAAGCGCCAG 3600

GTGCTCTGCT ACCAGCTGGG CCCAGGCCCG GGGCCCTGGC AGCGCCGCAT CCGCGAGCTG 3660

CAGGCGCCAG CACCTGTGCA GAGCCTGGGG CTGCTGGGCG ACCGGCTGTG CGTGGGAGCG 3720

GCCGGTGCCT TTGTCCTCTA CCCGCTGCTC AACGAGGCTG CGCCCTTAGC GCTAGGGGCT 3780

GGCCTGGTGC CTGAGGAGCT GCCACCGTCC CGTGGGGGCC TGGGCGAGGC ACTGGGGGCC 3840

GTGGAGCTCA GCCTCAGTGA GTTCCTGCTG CTCTTCACCA CTGCTGGGAT CTACGTGGAC 3900

AATGCCGGCC GGAGGTCTCG CATCCAGGAG CTGCTGTGGC CAGCAGTGCC CACGGGCTGG 3960

GGTTATGCAG CCCCGTACCT GACAGTGTTC AGCGAGAACG CCATTGACGT GTTTGATGTG 4020

AGGCGGGCAG AGTGGGTCCA GACGGTGCCA CTCAAGAAGG TGCGACCCCT GAACCCAGAG 4080

GGTTCCCTGT TCCTCTACGG CACAGAGAAG GTCCGCCTGA CCTACCTCAG GAACCCACTC 4140

GCAGAGAAGG ACGAGTTCGA CATCCCGAAC CTCACCGACA ATAGCCGGCG CCAGCTGTTC 4200

CGCTCCAAGA GCAAGCGCCG CTTCTTTTTC CGCGTGTCGG AAGCGCAGCT GCAGCAGCAG 4260

CGCAGGGAGA TGCTGAAGGA TCCTTTTGTG CGCTCCAAGC TCATTTCCAC GCCCACCAAC 4320

TTCAACCACT TGGTGCACGT AGGCCCTGCG GACGGGAGGC CCTGCGCCGG GGAACTGCCC 4380

CCAGGACGGG CTCCAGACCA GAAGGGCCGA GGTGCCCGCA GCTCTGGCCC ACAGCGGCCT 4440

CACAGCTTCT CAGAGGCCCC GCGACGTCCG GCCTCCATGA GCAGTGACGG CTTCGCTGGA 4500

GACTCAGACC CCACAGTGAA GAAGAAACCT TGGACATCAC TGTCCAGCGA GTCCGTGTCC 4560

TGCCCCCAGG GACCTCCAAG CCCCCCAGCC TCTCCTGTGC AGGTCTCAGA GCGGCCCCGG 4620

AGCCTCCCCC CGGCCCCTGA ATCTGAGAGC TCCCCTTGA 4659

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavvr++++++++amk+l+k+e+lkrae+a+freerdvlvk+ds+w

Q: 71    FEILKVIGRGAFGEVAVVRQRDSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRW  130

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +++l+yafqde+ylylvm+y++GGdlltlls++ed+lp ela+fylae+vla++s+h+lg

Q: 131   VTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLG  190

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrd+kpdnilld++Ghi+ladfGscl+ln+ g+v+ssvavGtpdyispe+l+a+eegk

Q: 191   YVHRDVKPDNILLDMNGHIRLADFGSCLRLNNSGMVDSSVAVGTPDYISPEILQAMEEGK  250

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg++cdwwslGv++yell+getpfyaeslv ty+ki+nh+++l+fp d+ +v+++a+d

Q: 251   GHYGPQCDWWSLGVCAYELLFGETPFYAESLVGTYGKIMNHEDHLHFPPDVpDVPASARD  310

         ************************************************9999********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++ll+++eerlgr g++d+++hpff

Q: 311   LIRQLLCRQEERLGRGGLDDFRNHPFF  337

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVRQ RDSGQIFAMK MLHKWEMLKR AETACFREER DVLVKGDSRW 60

VTALHYAFQD EEYLYLVMDY YAGGDLLTLL SRFEDRLPPE LAQFYLAEMV LAIHSLHQLG 120

YVHRDVKPDN ILLDMNGHIR LADFGSCLRL NNSGMVDSSV AVGTPDYISP EILQAMEEGK 180

GHYGPQCDWW SLGVCAYELL FGETPFYAES LVGTYGKIMN HEDHLHFPPD VPDVPASARD 240

LIRQLLCRQE ERLGRGGLDD FRNHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>

Gene Ontology

GO:0031252	; C:cell leading edge
GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013