EKS-SUS-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	442.2	1.4E-132	198	526	329

Status

Unreviewed

Ensembl Protein

ENSSSCP00000014144

UniProt Accession

F1SGR3;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK3

Gene Synonyms/Alias

HIPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000013312	ENSSSCP00000014144	ENSSSCT00000014538

Organism

Sus scrofa

Functional Description

Protein Length

1217

Protein Sequence
(FASTA)

MASQVLVYPP YIYQTQSSAF CSVKKLKVEP SSCIFQERRN YPWTYVTGRN IGNSHPPTKG 60

SAFQTKIPFN RPRGHNLSLQ TSAVVLKNTA GATKVIAAQA QQAQVEAPQI GAWRHRLHFL 120

EGVQRCGLKR KSEELDNHSS AMQIVDELSI LPAMLQTNMG NPVTVVTATT GTKQNCTTGE 180

GDYQLVQHEV LCSMKNTYEV LDFLGRGTFG QVVKCWKRGT NEIVAIKILK NHPSYARQGQ 240

IEVSILARLS TENADEYNFV RAYECFQHRN HTCLVFEMLE QNLYDFLKQN KFSPLPLKVI 300

RPILQQVATA LKKLKSLGLI HADLKPENIM LVDPVRQPYR VKVIDFGSAS HVSKTVCSTY 360

LQSRYYRAPE IILGLPFCEA IDMWSLGCVI AELFLGWPLY PGALEYDQIR YISQTQGLPG 420

EQLLNVGTKS TRFFCRETDI SHSGWRLKTL EEHETETGMK SKEARKYIFS SLDDIVHVNT 480

VMDLEGSDLL AEKADRREFV SLLKKMLLID ADLRITPIET LNHPFVNMKH LLDFPHSNHV 540

KSCFHIMDIC KSHPNSCDTN NHNKTSLLRP VAPSSAANLT ANFTKIGTLR SQALTTSAHS 600

VVHHGIPLQA GTAHFGCGDA FQQTLIICPP ALQGIPATHG KPTSYSIRVD NTVPLVTQAP 660

AVQPLQIRPG VLSQQTWSGR TQQMLVPAWQ QVTPMAPATT TLASEGVAGS QRLGDWGKMI 720

SHSNHYSSVM PQPLLTNQIT LSAPQPISVG IAHVVWPQPA TTKKNKLCQN RGILVKLMEW 780

EPGREEINAF SWSNSLQNTN NPQSAFISPK IVNGKDVEEV SCIETQDNHD SEGEARNCCE 840

TSIRQDSDAL VSDKQRQTII IADSPSPAVS VITISSDTDE EETSQRHSLR ECKGNLDCEA 900

CQSTLNIDRM CSLSSPDSTL STSSSGQSSP SPCKRPNSMS DEEQESGCDT VDGSPTSDSS 960

GHDSPFAESS FVEDTHQNTE LVTSTDSETK PAVCTVVVPP MGLENGLNAD EHMVNTDSIC 1020

QPLIKGRSVP GRLNQPSAVG NRQQKLTSAF QQQHLNFSQV QHFGSGHQEW NGNFGHRRQQ 1080

AYIPTSVTSN PFTLSHGSPG HTAVHAHLAG NAHLGGQPTL LPYPSSATLS SAAPVAHLLA 1140

SPCTSRPMLQ HPTYNISHPS GIVHQVPVGI NPRLLPSPTI HQTQYKPIFP PHSYIAASPA 1200

YTGFPLSPTK LSQYPYM 1217

Nucleotide Sequence
(FASTA)

ATGGCCTCAC AAGTCTTGGT CTACCCACCA TATATTTATC AAACTCAGTC AAGTGCCTTT 60

TGTAGTGTGA AGAAACTCAA AGTAGAGCCA AGCAGTTGTA TATTCCAGGA AAGAAGAAAC 120

TATCCATGGA CCTATGTGAC TGGTAGAAAT ATTGGAAATT CTCATCCTCC CACGAAGGGT 180

AGTGCTTTTC AGACAAAGAT ACCATTTAAC AGACCTCGAG GACACAACCT TTCATTGCAG 240

ACAAGTGCTG TTGTTTTAAA AAACACTGCG GGTGCTACAA AGGTTATAGC AGCTCAGGCT 300

CAGCAAGCTC AAGTGGAGGC ACCTCAGATT GGGGCGTGGC GACACAGGTT ACATTTCCTA 360

GAAGGTGTGC AGCGATGTGG ATTGAAGCGC AAGAGTGAGG AGTTGGATAA TCATAGCAGC 420

GCAATGCAGA TTGTCGACGA GTTGTCCATA CTTCCTGCAA TGTTGCAAAC CAACATGGGA 480

AATCCAGTGA CGGTTGTGAC AGCTACCACA GGAACAAAGC AGAATTGTAC CACTGGAGAA 540

GGTGACTATC AGTTAGTACA GCATGAAGTC TTGTGCTCCA TGAAAAATAC TTATGAAGTC 600

CTTGATTTTC TTGGTCGAGG CACTTTTGGC CAGGTAGTCA AATGCTGGAA AAGAGGGACA 660

AATGAAATCG TAGCAATCAA AATTTTGAAG AACCACCCTT CTTATGCACG TCAAGGTCAA 720

ATAGAAGTGA GCATATTAGC AAGGCTCAGT ACTGAAAATG CTGATGAATA TAACTTTGTT 780

CGAGCTTATG AATGCTTTCA GCACCGTAAC CATACTTGTT TAGTCTTTGA GATGCTGGAG 840

CAAAACTTAT ATGACTTTCT GAAACAAAAT AAGTTCAGTC CCCTGCCACT GAAAGTAATT 900

CGACCCATTC TTCAGCAAGT GGCCACTGCA CTGAAAAAAT TGAAAAGTCT TGGTTTAATT 960

CATGCAGACC TCAAACCAGA GAATATTATG TTGGTGGATC CTGTTCGGCA GCCATACAGG 1020

GTTAAAGTAA TAGACTTTGG GTCGGCCAGT CACGTATCAA AGACTGTTTG TTCAACATAT 1080

CTGCAATCTC GGTACTACAG AGCTCCAGAG ATTATATTGG GGTTGCCATT TTGTGAAGCC 1140

ATAGACATGT GGTCATTGGG ATGCGTGATT GCAGAATTAT TCCTTGGATG GCCTCTCTAC 1200

CCAGGAGCCT TGGAGTATGA CCAGATTCGA TACATTTCTC AGACTCAAGG ATTACCAGGA 1260

GAACAGTTGT TAAATGTGGG CACAAAATCC ACAAGATTTT TTTGCAGAGA AACAGATATC 1320

TCTCATTCTG GTTGGAGATT AAAGACACTG GAAGAACATG AGACAGAGAC AGGAATGAAG 1380

TCTAAAGAAG CCAGAAAGTA CATATTCAGC AGTCTGGATG ATATAGTGCA TGTGAACACA 1440

GTGATGGATT TAGAAGGAAG TGATCTTTTG GCTGAGAAAG CTGATAGACG AGAATTTGTT 1500

AGTCTGTTGA AAAAAATGTT GCTGATTGAT GCAGATTTAA GAATTACTCC AATTGAGACT 1560

TTGAACCATC CTTTTGTTAA CATGAAACAT CTTCTAGATT TTCCTCATAG CAACCATGTA 1620

AAGTCCTGTT TTCATATTAT GGATATCTGC AAGTCCCATC CAAATTCATG TGACACAAAT 1680

AATCACAATA AAACGTCACT TTTAAGACCA GTTGCTCCAA GCAGTGCTGC TAATCTGACA 1740

GCAAATTTCA CTAAAATTGG CACATTAAGA AGTCAGGCGT TAACCACATC TGCTCATTCA 1800

GTTGTGCACC ATGGAATTCC TCTGCAGGCC GGAACTGCTC ACTTTGGTTG TGGTGATGCT 1860

TTTCAGCAGA CACTGATTAT CTGTCCCCCA GCTCTTCAAG GTATTCCTGC AACACATGGT 1920

AAACCCACTA GTTATTCCAT AAGGGTGGAT AATACAGTTC CCCTTGTAAC TCAGGCCCCA 1980

GCCGTGCAGC CACTACAGAT TCGACCTGGA GTTCTTTCTC AGCAGACCTG GTCTGGTAGA 2040

ACACAGCAGA TGCTGGTGCC TGCCTGGCAA CAGGTAACAC CTATGGCTCC TGCCACTACT 2100

ACATTAGCTT CTGAGGGTGT GGCTGGTTCA CAAAGGCTCG GAGACTGGGG GAAAATGATT 2160

TCACACAGCA ATCATTATAG TTCAGTGATG CCACAACCTC TTCTAACCAA TCAGATCACT 2220

TTATCGGCCC CTCAGCCAAT TAGTGTGGGC ATCGCACATG TTGTCTGGCC TCAGCCTGCC 2280

ACTACCAAGA AAAATAAACT GTGCCAGAAC AGAGGTATTT TGGTAAAACT AATGGAATGG 2340

GAGCCAGGAA GAGAGGAAAT AAATGCTTTC AGTTGGAGTA ATTCTTTGCA GAATACAAAT 2400

AACCCACAAT CAGCATTTAT TTCTCCAAAG ATAGTAAATG GAAAAGATGT CGAGGAAGTA 2460

AGTTGTATTG AAACACAGGA CAATCATGAC TCAGAAGGAG AGGCAAGAAA TTGCTGTGAA 2520

ACATCAATCA GGCAGGACTC TGATGCATTA GTTTCAGATA AACAGCGGCA AACTATCATC 2580

ATCGCTGACT CCCCAAGTCC TGCGGTGAGT GTGATCACCA TTAGCAGCGA CACTGATGAG 2640

GAAGAGACAT CGCAGAGACA TTCACTCAGA GAATGTAAGG GTAATCTTGA TTGTGAAGCT 2700

TGCCAGAGCA CTTTGAATAT CGATCGGATG TGTTCCTTAA GTAGTCCTGA CAGTACTCTG 2760

AGCACCAGCT CCTCAGGGCA GTCCAGCCCA TCTCCTTGCA AGAGACCCAA CAGTATGTCA 2820

GATGAAGAAC AGGAAAGTGG TTGTGATACT GTGGATGGCT CTCCAACATC AGACTCTTCG 2880

GGACATGACA GTCCATTTGC AGAGAGCAGT TTTGTGGAGG ACACTCATCA AAACACAGAA 2940

CTGGTAACTT CTACTGACTC GGAAACCAAA CCAGCTGTTT GTACTGTGGT GGTGCCACCA 3000

ATGGGACTAG AAAATGGATT GAATGCCGAT GAGCATATGG TGAACACAGA TTCTATATGC 3060

CAGCCATTAA TAAAAGGACG ATCTGTTCCT GGAAGATTAA ACCAGCCTTC TGCAGTAGGT 3120

AATCGTCAGC AAAAATTGAC ATCAGCATTC CAACAGCAGC ATTTGAATTT CAGTCAGGTT 3180

CAGCACTTTG GATCTGGGCA TCAAGAGTGG AATGGAAACT TCGGCCATCG AAGACAGCAG 3240

GCTTATATCC CTACTAGTGT TACCAGTAAT CCATTCACTC TTTCTCATGG AAGTCCTGGT 3300

CATACAGCCG TGCATGCCCA TCTGGCTGGA AACGCGCACC TCGGAGGACA GCCTACTTTA 3360

CTTCCGTACC CATCATCAGC TACCCTCAGT AGTGCTGCAC CAGTGGCCCA CCTCTTAGCC 3420

TCTCCATGTA CCTCAAGACC TATGTTACAG CATCCAACTT ACAATATCTC CCATCCCAGT 3480

GGCATAGTTC ACCAAGTCCC AGTGGGCATA AATCCCCGTC TGTTACCATC CCCAACCATT 3540

CATCAGACTC AGTACAAACC AATCTTCCCA CCACATTCTT ACATTGCAGC ATCACCTGCA 3600

TATACTGGAT TTCCATTGAG TCCAACCAAA CTCAGCCAGT ATCCATATAT GTGA 3654

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 198   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  256

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+

Q: 257   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  316

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 317   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  376

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff

Q: 377   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFcr  436

         **********************************************************99

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t+ +++ ++lkt          ks++++k++++  +++ ++++ ++ e ++ l+ek+d+

Q: 437   eTDISHSGWRLKTLeehetetgmKSKEARKYIFSSLDDIVHVNTVMDLEGSDLLAEKADR  496

         88889999999999999******************************************9

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f++llk+ml +d++ Ritp e+l+hpfv

Q: 497   ReFVSLLKKMLLIDADLRITPIETLNHPFV  526

         99***************************7

Domain Sequence
(FASTA)

YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60

NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120

GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCRE 240

TDISHSGWRL KTLEEHETET GMKSKEARKY IFSSLDDIVH VNTVMDLEGS DLLAEKADRR 300

EFVSLLKKML LIDADLRITP IETLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009299	; P:mRNA transcription
GO:0043508	; P:negative regulation of JUN kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013