EKS-SUS-00027
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00027
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak341.45.0E-1028221095274
StatusUnreviewed
Ensembl ProteinENSSSCP00000014768
UniProt AccessionF1S936;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000013888ENSSSCP00000029533ENSSSCT00000032597
ENSSSCG00000013888ENSSSCP00000014768ENSSSCT00000015174
ENSSSCG00000013888ENSSSCP00000030830ENSSSCT00000033248
OrganismSus scrofa
Functional Description
Protein Length1104
Protein Sequence
(FASTA)
MAPPSEETPL IPQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDHSA EELCVWAAKA 60
SGILPVYHSL FALATEDLSC WFPPSHIFSV EDAGTQVLVY RLRFYFPNWF GLEKCHRFGL 120
RKDLTSAILD LPVLEHLFAQ HRNDLVSGRL PVGLGLKEQG ECLSLAVLDL ARMALEKAQR 180
PEELLKIVSY KVCLPPALRD LIQGLSFVTR RRIRRTVRRA LRRVAACQAD RHSLMAKYIM 240
DLERLDPARA AETFRVGLPA AAGGQDAPGL LRVAGGSGIS WSPGEEVLQP FCDFPEIVDI 300
SIKQAPRVGP AGEHRLVTVT RTDNQILEAE FPGLPAALSF VALVDGYFRL TTDSQHFFCK 360
EVAPPRLLEE VAEQCHGPIT LDFAINKLKT GGSLPGSYVL RRSPQDFDSY LLTVCVQTPL 420
GPDYKGCLIR CDPTGTFSLV GLSRPHNSLR ALLAACWDGG LHVDGVELNL TFCCTPRPKE 480
KSNLIVIRRG CSLPTSSPVQ PQSQCQLSQM TFHKIPADSL EWHENLGHGS FTKIYRGCRH 540
EAVDGEARET EVLLKVMDAK HKNCMESFLE AASLMSQVSY QHLVLLHGVC MAGDSIMVQE 600
FVHLGALDTY LRKCGHLVPA SWKLQVIKQL AYALNYLEDK GLPHGNVSAR KVLLAREGAD 660
GNPPFIKLSD PGVSPTVLSL EMLTDRIPWV APECLQEART LGLEADKWGF GATVWEVFSG 720
VMMPISTLDP AKKLQFYQER QQLPAPKWME LALLIQQCMA YEPGQRPSFR AVIRDLNSLI 780
TSADYELLSD PTPGALAPRD GLWNGAQLYA CQDPTIFEER HLKYISQLGK GNFGSVELCR 840
YDPLGDNTGA LVAVKQLQHS GPEQQRDFQR EIQILKALHS DFIVKYRGVS YGPGRQSLRL 900
VMEYLPSGCL RDFLQRHRAR LDAGRLLLYA SQICKGMEYL GSRRCVHRDL AARNILVESE 960
THVKIADFGL AKLLPLDKDY YVVREPGQSP IFWYAPESLS DNIFSRQSDV WSFGVVLYEL 1020
FTYSDKSCSP SAEFLRMMGC ERDVPALCRL LELLAEGQRL PAPPACPSEV HELMKLCWAP 1080
SPQDRPSFST LGPQLDALWS GGRG 1104
Nucleotide Sequence
(FASTA)
ATGGCACCTC CAAGTGAAGA GACACCCTTG ATCCCTCAGC GCTCCTGCAG CCTCTCCTCT 60
TCAGAGGCTG GTGCCCTGCA TGTTCTGCTG CCCCCTCGGG GCCCTGGACC CCCACAGCGC 120
CTATCCTTCT CCTTTGGGGA CCACTCCGCT GAAGAGCTGT GTGTTTGGGC TGCTAAGGCC 180
AGTGGTATCC TGCCTGTGTA CCACTCCCTC TTTGCTCTGG CCACGGAGGA CCTGTCCTGT 240
TGGTTCCCCC CAAGCCACAT CTTCTCCGTG GAGGATGCAG GCACCCAAGT CCTCGTCTAC 300
AGGCTCCGCT TTTACTTCCC CAACTGGTTT GGGCTAGAGA AATGCCACCG CTTTGGGCTA 360
CGAAAGGACT TAACCAGTGC CATTCTTGAC CTGCCAGTCC TGGAGCATCT CTTTGCTCAG 420
CATCGCAACG ACTTGGTGAG TGGCCGCCTC CCAGTGGGCC TCGGCCTCAA GGAGCAGGGT 480
GAGTGTCTCA GCTTGGCCGT CCTGGACCTG GCCCGGATGG CCCTCGAGAA GGCTCAGCGG 540
CCTGAAGAGC TGCTGAAGAT TGTCAGCTAC AAGGTCTGCC TGCCCCCTGC TCTACGTGAC 600
CTGATCCAAG GCCTGAGTTT CGTGACGCGG AGGCGTATTC GAAGGACAGT GCGTCGGGCC 660
CTGCGTCGCG TGGCCGCCTG CCAGGCTGAC CGACACTCGC TCATGGCCAA GTACATTATG 720
GACCTCGAGC GTCTGGACCC AGCCAGGGCA GCCGAGACCT TCCGCGTGGG CCTTCCCGCG 780
GCTGCTGGTG GTCAGGATGC GCCAGGGCTG CTCCGTGTGG CTGGTGGCAG CGGCATCTCC 840
TGGAGCCCAG GAGAAGAGGT TCTTCAGCCC TTCTGCGACT TTCCAGAAAT CGTGGATATC 900
AGCATCAAGC AGGCCCCGCG CGTTGGCCCC GCCGGGGAGC ATCGCCTGGT CACAGTCACC 960
AGGACAGACA ACCAGATCCT GGAGGCTGAG TTCCCCGGGC TGCCTGCCGC GCTGTCCTTC 1020
GTGGCGCTGG TGGATGGCTA CTTCCGGCTG ACCACCGACT CGCAGCACTT CTTCTGCAAG 1080
GAGGTGGCGC CGCCGCGGCT TCTGGAAGAG GTGGCTGAGC AGTGCCATGG CCCCATCACC 1140
CTGGATTTTG CCATCAACAA ACTCAAGACT GGGGGCTCAC TTCCTGGCTC CTACGTTCTC 1200
CGTCGCAGCC CTCAGGATTT CGACAGTTAC CTCCTAACTG TCTGTGTCCA GACCCCTCTG 1260
GGCCCTGATT ACAAGGGCTG CCTCATCCGG TGTGACCCTA CGGGAACCTT CTCCCTGGTT 1320
GGCCTTAGCC GTCCCCACAA CAGTCTTCGA GCGCTCCTGG CAGCCTGTTG GGATGGTGGG 1380
TTGCACGTGG ATGGGGTTGA GCTGAATCTC ACTTTCTGCT GCACCCCCAG ACCCAAAGAA 1440
AAGTCCAATC TGATAGTGAT CCGGAGGGGT TGCAGTCTGC CCACCTCATC CCCTGTTCAG 1500
CCCCAGTCCC AATGCCAGCT GAGCCAGATG ACATTTCACA AGATCCCTGC CGACAGCCTA 1560
GAGTGGCATG AGAACTTGGG TCATGGATCC TTCACCAAGA TTTACCGGGG CTGTCGCCAC 1620
GAGGCTGTGG ATGGGGAGGC CCGGGAGACA GAAGTCCTGC TCAAAGTGAT GGATGCCAAG 1680
CACAAGAACT GCATGGAGTC ATTCCTGGAA GCAGCGAGCT TGATGAGCCA AGTATCATAC 1740
CAGCATCTCG TGTTGCTCCA TGGCGTATGC ATGGCTGGAG ACAGCATCAT GGTGCAGGAA 1800
TTCGTACACC TGGGAGCATT GGACACGTAT CTGCGCAAGT GTGGCCACCT GGTGCCAGCA 1860
AGCTGGAAGC TACAGGTGAT CAAACAGCTG GCCTATGCCC TCAACTATCT GGAAGACAAA 1920
GGTCTCCCCC ATGGCAACGT CTCAGCCCGG AAGGTGCTCC TGGCTCGAGA GGGGGCCGAT 1980
GGGAACCCGC CTTTTATCAA GCTGAGTGAT CCTGGTGTCA GCCCCACTGT ACTAAGCCTG 2040
GAGATGCTTA CCGACAGGAT CCCCTGGGTG GCCCCTGAGT GTCTCCAGGA GGCCCGAACA 2100
CTTGGCTTGG AAGCTGACAA GTGGGGCTTT GGTGCCACAG TCTGGGAGGT GTTCAGCGGT 2160
GTCATGATGC CCATCAGCAC TCTGGATCCT GCCAAGAAGC TACAGTTTTA CCAGGAACGG 2220
CAACAGCTCC CTGCCCCCAA GTGGATGGAG CTGGCCCTGC TGATCCAGCA GTGCATGGCC 2280
TACGAGCCAG GCCAGAGGCC TTCCTTCCGT GCTGTCATCC GTGACCTGAA CAGCCTCATC 2340
ACTTCAGCAG ATTATGAACT CCTCTCAGAC CCCACGCCTG GTGCCCTAGC ACCCCGTGAC 2400
GGGCTTTGGA ATGGCGCCCA GCTCTATGCC TGCCAGGACC CTACCATCTT TGAGGAGAGA 2460
CACCTCAAGT ACATCTCACA GCTGGGCAAG GGCAACTTTG GCAGCGTGGA ACTCTGCCGC 2520
TACGACCCAC TGGGCGACAA CACAGGTGCT CTGGTGGCCG TGAAGCAGCT GCAGCACAGT 2580
GGCCCAGAAC AGCAGAGGGA CTTCCAGCGG GAGATCCAGA TCCTTAAAGC CCTCCACAGC 2640
GACTTCATTG TCAAGTACCG GGGTGTCAGC TATGGCCCAG GCCGCCAGAG TCTGCGGCTG 2700
GTCATGGAAT ATCTGCCAAG CGGCTGCCTG CGGGACTTCC TGCAGAGGCA CCGCGCGCGC 2760
CTAGATGCTG GCCGCCTGCT CCTCTACGCC TCGCAAATCT GCAAGGGCAT GGAGTACCTG 2820
GGCTCCCGCC GCTGCGTGCA CCGCGACCTG GCAGCCCGTA ACATCCTGGT GGAGAGCGAA 2880
ACGCACGTCA AGATCGCCGA CTTCGGCCTC GCGAAGCTGC TGCCGCTAGA CAAAGACTAC 2940
TATGTGGTCC GCGAGCCCGG CCAGAGCCCC ATCTTCTGGT ATGCCCCGGA GTCCCTCTCA 3000
GACAATATCT TCTCGCGCCA GTCGGATGTC TGGAGCTTCG GGGTCGTGCT GTATGAGCTC 3060
TTCACCTACA GCGACAAGAG CTGTAGCCCC TCAGCCGAGT TCCTGCGGAT GATGGGATGT 3120
GAGCGAGATG TCCCAGCCCT CTGTCGTCTC CTGGAGCTGC TGGCCGAAGG CCAGAGGCTG 3180
CCCGCACCTC CTGCCTGTCC TAGTGAGGTT CATGAGCTCA TGAAGCTGTG CTGGGCCCCT 3240
AGCCCTCAAG ATCGGCCATC ATTCAGCACC CTGGGCCCTC AGCTGGATGC ACTGTGGAGT 3300
GGAGGCCGGG GATAG 3315
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg++++rdf+re++il++l+++
Q: 822   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPEQQRDFQREIQILKALHSD  881
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l++ +ll +a+q++k+meYL+
Q: 882   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLG  941
         ************************************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         ++++vhrd+aarn+Lve+e +      vk++d+glak+++ d +Yy+vre+++s+i+w+a
Q: 942   SRRCVHRDLAARNILVESETH------VKIADFGLAKLLPLDkDYYVVREPGQSPIFWYA  995
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225
         pe+ls++  +s++sdvWsFgv+lyel+t  +k++sp    lr++++e       r+lell
Q: 996   PESLSDNI-FSRQSDVWSFGVVLYELFTySDKSCSPsaefLRMMGCErdvpalcRLLELL  1054
         ********.*******************999*****************************
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
          e++rlp+p+ cp+e++elm+ c++ +p++rpsF+++  +l
Q: 1055  AEGQRLPAPPaCPSEVHELMKLCWAPSPQDRPSFSTLGPQL  1095
         ************************************98776
Domain Sequence
(FASTA)
LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PEQQRDFQRE IQILKALHSD 60
FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL DAGRLLLYAS QICKGMEYLG 120
SRRCVHRDLA ARNILVESET HVKIADFGLA KLLPLDKDYY VVREPGQSPI FWYAPESLSD 180
NIFSRQSDVW SFGVVLYELF TYSDKSCSPS AEFLRMMGCE RDVPALCRLL ELLAEGQRLP 240
APPACPSEVH ELMKLCWAPS PQDRPSFSTL GPQL 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-CII-00224
EKS-DAR-00042
EKS-DRM-00011
EKS-EQC-00030
EKS-FEC-00029
EKS-GAM-00013
EKS-GAA-00046
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LAC-00034
EKS-LOA-00032
EKS-MAM-00030
EKS-MEG-00024
EKS-MIM-00015
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-OCP-00021
EKS-ORN-00047
EKS-ORA-00026
EKS-ORL-00043
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PRC-00015
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-TAR-00046
EKS-TEN-00052
EKS-XET-00033
EKS-XIM-00044
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013