EKS-SUS-00130
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00130
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR526.71.3E-158467743277
StatusUnreviewed
Ensembl ProteinENSSSCP00000014936
UniProt AccessionF1S3B8;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000014047ENSSSCP00000030593ENSSSCT00000032671
ENSSSCG00000014047ENSSSCP00000029518ENSSSCT00000035801
ENSSSCG00000014047ENSSSCP00000014936ENSSSCT00000015344
ENSSSCG00000014047ENSSSCP00000030825ENSSSCT00000035649
ENSSSCG00000014047ENSSSCP00000030615ENSSSCT00000035375
ENSSSCG00000014047ENSSSCP00000028453ENSSSCT00000035552
ENSSSCG00000014047ENSSSCP00000030959ENSSSCT00000036577
ENSSSCG00000014047ENSSSCP00000028288ENSSSCT00000033076
OrganismSus scrofa
Functional Description
Protein Length800
Protein Sequence
(FASTA)
MQLLLALLGV LLAVPGAPAL SLEASEETEL EPCLAPSPEE QERELTVVLG QSVRLCCGRA 60
ERSGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYF CLARGSMLVL HNVTLVMDDS 120
MISSNGDEDP GTHSGPSNGH IYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPMP 180
TIRWLKDGQD FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENSL GSIRYSYLLD 240
VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP 300
YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDLTWTA 360
AGPEARYTDV ILYASGSLAL LVLLLLAGLY RRQVLHGRHP RQPATVQKLS RFPLARQFSL 420
ESGSSAKSSS SLVRGVRLSS SGPPLLAGLV SLDLPLDPLW EFPRDRLVLG KPLGEGCFGQ 480
VVCAEAFGMD PTRPDQASTV AVKMLKDNAS DKDLADLVSE MEVMKLIGRH KNIINLLGVC 540
TQEGPLYVIV ECAAKGNLRE FLRARRPPGP DLSPDGPRSS EGPLSFPALV SCAYQVARGM 600
QYLESQKCIH RDLAARNVLV TEDNVMKIAD FGLARGIHHI DYYKKTSNGR LPVKWMAPEA 660
LFDRVYTHQS DVWSFGILLW EIFTLGGSPY PGIPVEELFS LLREGHRMDR PPHCPPELYG 720
LMRECWHAAP SQRPTFKQLV EALDKVLLAV SEEYLDLRLT FGPYSPAGGD ASSSCSSSDS 780
VFSHEPLPLG PSSFFPGVQT 800
Nucleotide Sequence
(FASTA)
ATGCAGCTGC TGCTGGCCCT GTTGGGGGTC CTGCTGGCAG TGCCTGGGGC TCCAGCTTTG 60
TCTCTTGAGG CCTCTGAGGA AACGGAGCTG GAGCCCTGCC TGGCCCCCAG CCCGGAGGAG 120
CAAGAGCGGG AGCTGACTGT GGTCCTTGGG CAGTCTGTGC GGTTATGCTG TGGGCGGGCT 180
GAACGTAGTG GCCACTGGTA CAAGGAGGGT AGTCGCCTGG CACCTGCTGG CCGAGTACGA 240
GGCTGGAGAG GCCGCTTGGA GATTGCCAGC TTCCTACCCG AGGATGCTGG CCGATACTTC 300
TGCCTGGCAC GAGGCTCCAT GCTTGTCCTG CACAATGTCA CCTTGGTTAT GGATGACTCC 360
ATGATCTCCA GCAACGGTGA TGAGGACCCC GGGACCCACA GTGGCCCCTC GAATGGGCAC 420
ATTTACCCCC AGCAAGCACC CTACTGGACA CACCCCCAGC GCATGGAGAA GAAACTGCAT 480
GCAGTGCCTG CTGGGAACAC TGTCAAGTTT CGCTGTCCAG CGGCAGGCAA CCCCATGCCC 540
ACCATCCGCT GGCTTAAGGA TGGACAGGAC TTCCATGGGG AGAATCGCAT TGGAGGCATT 600
AGGCTGCGCC ACCAGCACTG GAGCCTGGTG ATGGAAAGCG TGGTGCCATC GGACCGTGGC 660
ACATACACCT GCCTCGTGGA GAACTCTTTG GGCAGCATCC GCTACAGCTA TCTGCTGGAT 720
GTACTGGAGC GGTCCCCGCA CCGGCCCATC CTGCAGGCGG GGCTCCCAGC CAATACCACA 780
GCCGTGGTGG GCAGCGACGT GGAGCTGTTA TGCAAGGTGT ACAGCGATGC CCAGCCTCAC 840
ATCCAGTGGC TGAAGCACAT TGTCATCAAC GGCAGCAGCT TTGGTGCCGA CGGCTTCCCC 900
TATGTGCAAG TCTTAAAGAC AGCAGACATC AATAGCTCAG AGGTGGAGGT CCTATACCTT 960
CGGAATGTGT CTGCCGAGGA CGCAGGTGAA TACACCTGTC TGGCAGGCAA CTCTATCGGC 1020
CTTTCCTACC AGTCAGCTTG GCTCACAGTG TTGCCAGAAG AGGACCTCAC GTGGACGGCA 1080
GCAGGGCCCG AGGCTAGGTA CACGGATGTC ATCCTGTACG CATCAGGCTC TCTGGCTTTG 1140
CTTGTGCTTC TGCTGCTGGC TGGGCTCTAT CGCCGGCAGG TGCTCCACGG CCGGCACCCC 1200
CGGCAGCCCG CCACCGTGCA GAAACTCTCC CGCTTCCCCT TGGCACGACA GTTCTCCCTG 1260
GAGTCGGGCT CCTCAGCCAA GTCAAGCTCG TCTCTGGTGC GGGGTGTCCG TCTCTCCTCC 1320
AGCGGCCCCC CATTGCTCGC TGGCCTCGTG AGTCTAGACC TACCTCTCGA CCCACTGTGG 1380
GAGTTCCCCC GGGACAGGCT GGTGCTCGGA AAGCCCCTGG GTGAGGGCTG CTTCGGGCAG 1440
GTGGTGTGTG CAGAGGCCTT TGGCATGGAC CCCACCCGGC CCGATCAAGC CAGCACCGTG 1500
GCTGTCAAGA TGCTTAAGGA CAATGCTTCT GACAAGGACT TGGCTGACCT AGTCTCTGAG 1560
ATGGAGGTGA TGAAGCTGAT TGGCCGACAC AAGAACATCA TCAATCTGCT GGGAGTCTGC 1620
ACCCAGGAAG GGCCCCTGTA CGTGATTGTG GAGTGTGCTG CCAAGGGAAA CCTGCGGGAG 1680
TTCCTGCGGG CCCGCCGCCC CCCAGGCCCT GACCTCAGCC CTGATGGGCC TCGGAGCAGT 1740
GAGGGACCAC TTTCCTTCCC TGCCCTGGTC TCCTGCGCAT ATCAGGTGGC CCGAGGCATG 1800
CAGTACCTGG AGTCACAAAA GTGCATCCAC CGGGACCTGG CTGCCCGCAA CGTGCTGGTG 1860
ACTGAGGACA ATGTGATGAA GATCGCTGAC TTTGGGCTGG CCCGAGGCAT CCACCATATT 1920
GACTACTACA AGAAAACAAG CAACGGCCGC CTGCCTGTCA AGTGGATGGC ACCTGAGGCC 1980
TTGTTTGACA GAGTCTACAC ACACCAGAGT GACGTGTGGT CATTTGGGAT CCTGCTGTGG 2040
GAGATCTTTA CCCTCGGGGG CTCCCCGTAC CCTGGCATCC CCGTGGAGGA GCTGTTCTCG 2100
CTGCTACGGG AGGGCCATCG GATGGACCGG CCCCCACACT GCCCTCCAGA GTTGTATGGG 2160
CTGATGCGTG AGTGTTGGCA CGCAGCACCC TCTCAGAGGC CCACTTTCAA GCAGCTGGTG 2220
GAGGCACTGG ACAAGGTCCT GCTGGCTGTC TCTGAAGAGT ACCTTGACCT CCGCTTAACC 2280
TTTGGACCCT ACTCCCCCGC CGGTGGGGAC GCCAGCAGCT CCTGCTCCTC CAGCGACTCG 2340
GTCTTCAGCC ATGAGCCCCT GCCCCTGGGA CCCAGCTCCT TCTTCCCTGG GGTGCAGACG 2400
TGA 2403
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv aea+g+d  ++++++tvavkmlk++a+dkdladlvsemev+kl
Q: 467   LVLGKPLGEGCFGQVVCAEAFGMDPTRPDQASTVAVKMLKDNASDKDLADLVSEMEVMKL  526
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iG+hkniinllG+ctqeGplyvive+aakGnlreflrarrp+g + s d +++se  l++
Q: 527   IGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSF  586
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
           lvs+ayqvarGm+yl+s+kcihrdlaarnvlvtednv+kiadfGlar++h+idyykkt
Q: 587   PALVSCAYQVARGMQYLESQKCIHRDLAARNVLVTEDNVMKIADFGLARGIHHIDYYKKT  646
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+llwei+tlGgspypgi+veelf+ll+eGh
Q: 647   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH  706
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p +c+ ely lmrecwha++s+rptfkqlve+l
Q: 707   RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL  743
         **********************************986
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVCAEA FGMDPTRPDQ ASTVAVKMLK DNASDKDLAD LVSEMEVMKL 60
IGRHKNIINL LGVCTQEGPL YVIVECAAKG NLREFLRARR PPGPDLSPDG PRSSEGPLSF 120
PALVSCAYQV ARGMQYLESQ KCIHRDLAAR NVLVTEDNVM KIADFGLARG IHHIDYYKKT 180
SNGRLPVKWM APEALFDRVY THQSDVWSFG ILLWEIFTLG GSPYPGIPVE ELFSLLREGH 240
RMDRPPHCPP ELYGLMRECW HAAPSQRPTF KQLVEAL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAF-00157
EKS-CAP-00150
EKS-DAR-00435
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LAC-00159
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORN-00184
EKS-ORC-00140
EKS-ORL-00172
EKS-PAT-00140
EKS-RAN-00148
EKS-SAH-00144
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0061144; P:alveolar secondary septum development
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
ssc:100127133;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013