EKS-SUS-00355
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00355
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR559.34.6E-168584913330
StatusUnreviewed
Ensembl ProteinENSSSCP00000015371
UniProt AccessionF1RL77;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000014441ENSSSCP00000015371ENSSSCT00000015787
OrganismSus scrofa
Functional Description
Protein Length969
Protein Sequence
(FASTA)
MGLGTLLLLL AVTAWPGQGV PVIEPSGPEL VVEPGAAVTL RCVSNVSVEW DGPISRSWTL 60
DPDAPSSALT TNNATFQNTG TYRCTELGDP LGGSATIHLY VKDHRRPWRV LAPEVTVLEG 120
QDARLPCLLT DPALAGGVSL ALLRRLSVLP GRAVLRQTNY SFSPWHGFTI HKAKFIEGQD 180
YACTVLVDGR VVWSSVRLNV QKVIPGPPTL TLKPTELVRI RGEAAQIVCS ATDVDVHFEV 240
FLHRGDTKLA ISQQSDFHDN RYQKVLTLDL DPVGFQDAGN YTCMATNARG THATSMVFRV 300
VEGAYLTLTS EQSLRQEVAV GEKLDLKVKV EAYPSLQSFN WTYQGPFSDQ QPELSFETSK 360
DTYRYASTLT LPRLKPSEAG RYSFLARNAR GEGVLTFELT LLYPPEVRIT WSLVNGSRAL 420
VCQASGYPQP NVTWVWCGGH TDRCEGAGVL VQEALGPEVL SQEPFHKATV QRLLAVGTLE 480
RNRTYECRAC NSLGNSSHAF QPVSVAAQVH SPDEPLFTPV LVACVSIMAL LLLLLLLLLY 540
KYKQKPKYQV RWKIIESFAG NSYTFIDPTQ LPYSEKWEFP RNKLQFGKTL GAGAFGKVVE 600
ATAFGLGQED AVLKVAVKML KSTAHADEKE ALMSELKIMS HLGPHENTVN LLGACTHGGP 660
VLVITEYCCY GDLLNFLRRK AEAMLGPGLN PGQSPEPGPG YKNIPLEKKY TRRDSGFSSQ 720
GVDAYVEMRP VSTSSSNDSF SEQDLDKEDG RPLELCDLLR FSSQVAQGMA FLASKNCIHR 780
DVAARNVLLT SGHVAKIGDF GLARDIMNDS NYIVKGNARL PVKWMAPESI FDCVYTVQSD 840
VWSYGILLWE IFSLGLNPYP GILVNSKFYK LVKDGYQMAQ PAFAPKNIYS IMQACWALEP 900
TRRPTFQQIC SLLQEQSHGD QRARDYSNLP SSSSSSSEPE EGSSGEHLAC CEQGDAAQPL 960
LQPNTYQFC 969
Nucleotide Sequence
(FASTA)
ATGGGCCTGG GCACGCTGCT GCTCCTGCTG GCAGTCACAG CCTGGCCTGG TCAGGGGGTC 60
CCGGTGATTG AGCCCAGCGG CCCTGAGCTG GTGGTGGAGC CGGGCGCAGC TGTGACCTTG 120
CGATGCGTGA GCAATGTCAG CGTGGAGTGG GACGGCCCCA TCTCCCGCTC CTGGACCTTG 180
GACCCCGACG CCCCCAGCAG CGCCCTGACC ACAAACAACG CCACCTTCCA AAACACGGGC 240
ACATACCGCT GCACCGAGCT CGGAGACCCG CTGGGGGGCA GCGCCACCAT CCACCTGTAT 300
GTCAAAGACC ATCGTCGGCC CTGGAGGGTC CTGGCCCCGG AAGTGACGGT GCTGGAGGGC 360
CAGGATGCGA GGCTGCCCTG CCTGCTCACC GACCCGGCCC TGGCAGGGGG CGTCTCGCTG 420
GCACTGCTGC GCAGACTGTC TGTCTTGCCC GGCCGGGCTG TCTTGCGCCA AACCAACTAC 480
TCCTTCTCGC CCTGGCATGG CTTCACTATC CACAAGGCCA AGTTCATCGA GGGCCAGGAC 540
TACGCGTGCA CCGTCCTGGT AGACGGCAGG GTGGTGTGGA GCAGCGTCCG GCTCAACGTG 600
CAGAAAGTCA TCCCAGGCCC CCCGACCTTG ACGCTGAAGC CCACAGAGCT GGTGCGCATT 660
CGGGGAGAGG CCGCCCAGAT CGTGTGCTCG GCCACCGACG TGGATGTCCA CTTCGAGGTC 720
TTCCTCCACC GCGGAGACAC CAAGCTGGCC ATCTCTCAAC AATCCGACTT CCACGACAAC 780
CGTTACCAAA AAGTCCTGAC CCTCGACCTC GATCCCGTGG GCTTCCAAGA CGCCGGCAAC 840
TACACCTGCA TGGCCACCAA TGCCCGGGGC ACGCACGCCA CCTCCATGGT CTTCCGGGTG 900
GTAGAGGGGG CCTACCTGAC CTTGACCTCT GAGCAGAGCC TCCGCCAGGA GGTAGCAGTG 960
GGAGAGAAGC TCGACCTCAA AGTCAAGGTG GAGGCCTACC CGAGCCTGCA GAGTTTCAAC 1020
TGGACCTACC AGGGACCCTT CTCGGACCAG CAGCCTGAGC TCAGTTTTGA AACCAGCAAG 1080
GACACGTACA GATACGCCTC CACCCTCACC CTGCCTCGCC TGAAGCCCTC CGAAGCCGGC 1140
CGCTACTCCT TCCTGGCCAG AAACGCCAGA GGCGAGGGTG TCCTGACCTT TGAACTCACC 1200
CTTCTGTACC CACCGGAGGT CAGGATCACG TGGAGCCTCG TCAACGGCTC CAGAGCCCTG 1260
GTCTGCCAAG CCTCGGGCTA CCCGCAGCCC AACGTGACCT GGGTGTGGTG TGGGGGCCAC 1320
ACGGACAGGT GTGAGGGCGC CGGAGTGCTG GTCCAGGAGG CCCTCGGCCC TGAGGTCCTG 1380
AGCCAGGAGC CCTTCCACAA GGCGACTGTC CAGAGGCTGC TGGCCGTTGG GACCTTGGAG 1440
CGCAACAGGA CGTACGAGTG CCGGGCCTGC AACAGCCTGG GCAACAGCTC CCACGCCTTC 1500
CAGCCCGTCT CCGTAGCAGC CCAGGTGCAC TCGCCGGATG AACCCCTCTT CACCCCGGTG 1560
CTGGTGGCCT GTGTGTCCAT CATGGCCTTG CTGCTGCTGC TGCTCCTGCT GCTCCTTTAC 1620
AAGTACAAGC AGAAGCCCAA GTACCAGGTG CGCTGGAAGA TCATCGAGAG CTTCGCGGGC 1680
AACAGCTACA CGTTCATCGA CCCCACGCAG CTGCCCTACA GCGAGAAGTG GGAGTTCCCC 1740
CGGAACAAGC TGCAGTTCGG TAAGACGCTG GGAGCCGGCG CCTTCGGGAA GGTGGTGGAG 1800
GCCACAGCCT TCGGTCTGGG CCAGGAAGAC GCTGTCCTGA AGGTGGCTGT GAAGATGCTG 1860
AAGTCCACGG CCCACGCTGA CGAGAAGGAG GCCCTCATGT CGGAGCTGAA GATCATGAGT 1920
CACCTGGGCC CGCACGAGAA CACGGTCAAC CTGCTGGGCG CCTGTACCCA CGGAGGCCCT 1980
GTCCTGGTCA TCACCGAGTA CTGCTGCTAC GGGGACCTGC TCAACTTCCT GCGAAGGAAG 2040
GCAGAGGCCA TGCTGGGACC CGGCCTGAAC CCAGGCCAGA GCCCCGAGCC AGGCCCCGGC 2100
TACAAAAACA TCCCCTTGGA AAAGAAATAC ACCCGCAGGG ACAGCGGCTT CTCCAGCCAG 2160
GGTGTGGACG CCTACGTGGA GATGAGGCCC GTCTCCACGT CGTCTTCCAA CGACTCGTTC 2220
TCTGAGCAAG ACCTGGACAA GGAGGACGGA CGGCCGCTGG AGCTGTGCGA CCTGCTCCGC 2280
TTCTCGAGCC AGGTGGCCCA GGGCATGGCC TTCCTCGCTT CCAAGAACTG CATCCACCGG 2340
GACGTGGCAG CCCGGAATGT GCTGCTGACC AGCGGCCACG TGGCCAAGAT TGGGGACTTT 2400
GGTCTGGCAA GGGACATCAT GAACGACTCC AACTACATTG TCAAGGGCAA CGCCCGCCTG 2460
CCCGTGAAGT GGATGGCCCC CGAGAGCATC TTCGACTGCG TCTACACGGT GCAGAGTGAC 2520
GTCTGGTCCT ACGGCATCCT GCTCTGGGAG ATCTTCTCGC TGGGGCTGAA CCCCTACCCT 2580
GGCATCCTGG TGAACAGCAA GTTCTACAAG CTGGTGAAGG ACGGGTACCA GATGGCCCAG 2640
CCTGCGTTCG CCCCCAAGAA CATATACAGC ATCATGCAGG CCTGCTGGGC CCTGGAGCCG 2700
ACGCGCAGAC CCACCTTCCA GCAGATCTGC TCCCTCCTTC AGGAGCAGAG CCACGGCGAC 2760
CAGAGAGCGC GGGACTACAG CAACCTGCCG AGCAGCAGCA GCAGCAGCAG CGAGCCCGAG 2820
GAGGGGAGCT CCGGCGAGCA CCTGGCCTGC TGCGAGCAGG GGGATGCGGC CCAGCCCCTG 2880
CTGCAACCCA ACACCTACCA GTTCTGCTGA 2910
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+++davlkvavkmlksta+++ekealmselki+shlG
Q: 584   LQFGKTLGAGAFGKVVEATAFGLGQEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  643
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +hen vnllGact+gGp++viteyccyGdlln+lrrk+e++l   l+  + +e    +k+
Q: 644   PHENTVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPGLNPGQSPEPGPGYKN  703
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ + yv++++    vs+s+++   se+            l++e
Q: 704   IpLEKKYTRRDSGFSSQGVDAYVEMRP----VSTSSSNDSFSEQ-----------DLDKE  748
         *88899*********************....6666555544444...........37899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel dll fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 749   DGRPLELCDLLRFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMN  808
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 809   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  868
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q+++ll
Q: 869   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTRRPTFQQICSLL  913
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGQEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
PHENTVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPGLNPGQ SPEPGPGYKN 120
IPLEKKYTRR DSGFSSQGVD AYVEMRPVST SSSNDSFSEQ DLDKEDGRPL ELCDLLRFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTSGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APKNIYSIMQ ACWALEPTRR PTFQQICSLL 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
ssc:100517086;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013