EKS-SUS-00358
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00358
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR305.85.7E-91599961363
StatusUnreviewed
Ensembl ProteinENSSSCP00000015372
UniProt AccessionF1RL76;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000014442ENSSSCP00000024469ENSSSCT00000025374
ENSSSCG00000014442ENSSSCP00000015372ENSSSCT00000015788
ENSSSCG00000014442ENSSSCP00000031091ENSSSCT00000035484
OrganismSus scrofa
Functional Description
Protein Length1109
Protein Sequence
(FASTA)
MQLPRAVPAS VLIGQVLLLP PLLLLGPQAS WGLVITPPGP ELVLNLSSTF VLTCSGPAPV 60
VWERMSQKPP QEMTGTQDGT FSSVLTLANV TGLDTGEYFC TYKGSPGLEA SERKRLYIFV 120
PDPAVGFLPV DPEELFIFLT EITETTIPCR VTDPRLVVTL HEKKVDVPLP ISYDHQRGFS 180
GTFEDKTYVC KTTIGDREVD SDAYYVYSLQ VSSINVSVGA VQTVVRQGEN ITVMCIVTGN 240
EVVNFEWTYP RLETGRLVEP VTDFLFEMPH IRSILHIPSA ELGDSGTYIC NVSESVSDHR 300
DEKAINVTVV ESGYVRLIGE LDAVQFAELH RSRTLQVVFE AYPPPTVIWF KDNRTLGDSG 360
AGEIALSTRN VSETRYVSEL TLVRVKVAEA GRYTMRAFHE DAEAQISFQL QVNVPVRVLE 420
LSESHPASGE QTVRCRGRGM PQPHLTWSTC SDLKRCPREL PPTPLGNSSE EESQLETNVT 480
YWPQEQEFEV VSTLRLRRVD QPLSVRCTLH NLLGHDAQEV TVVPHSLPFQ VVVVSAVLAL 540
VVLTVISLII LVMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPMQLPYDS TWELPRDQLV 600
LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 660
LNVVNLLGAC TKGGTRPRVA ETCRWECLWQ VLPRGPHCFL RNDPKPAPHP PTEELCALHL 720
PADESVRRVV TMTPTADGGK GVTDPSTDAM VGALPDTSVR PRVRYFRITT GNTRSPVSQW 780
LPSAWEKNFN INLRGRGPVR SYIPFFSFCY RAGNCLRFLG AKRCIYRSVC ARVVYICVNV 840
HMRICMILLS RPASRPSQLQ TEGRTCPTES WTEPPDQLFH SEWTVLNSFL SLSFILSQVF 900
SLSGTPYPEL PMNEQFYNAI KRGYRMAQPA HASDEIYEIM QKCWEEKFEI RPPFSQLVLL 960
LERLLGEGYK KKYQQVDEEF LRSDHPAVLR SQARLPGFPG LRSPLDSSPV LYTAVQPNEG 1020
DNDYIIPLPD PKPEVADEGP LEGAPSLASS TLNEVNTAST ISCDSPLEPQ EEPEPEPQLE 1080
PRGELEPEPE RPLEAGCPGP RAEAEDSFL 1109
Nucleotide Sequence
(FASTA)
ATGCAGCTTC CGAGGGCCGT GCCAGCTTCT GTCCTCATAG GCCAGGTGCT GCTGCTGCCT 60
CCGCTGCTGC TGCTGGGACC GCAGGCCTCC TGGGGCCTGG TCATTACGCC CCCGGGGCCA 120
GAGCTGGTCC TCAATCTCTC CAGCACCTTT GTGCTCACCT GCTCGGGGCC AGCGCCGGTG 180
GTGTGGGAAC GCATGTCCCA GAAGCCCCCG CAGGAAATGA CCGGAACCCA GGACGGCACG 240
TTCTCCAGCG TGCTGACACT GGCCAATGTC ACTGGGCTGG ACACCGGAGA ATACTTTTGT 300
ACCTACAAAG GCTCCCCCGG GCTGGAGGCC AGCGAGCGGA AACGGCTGTA CATCTTCGTG 360
CCAGATCCTG CCGTGGGCTT TCTCCCTGTT GACCCCGAGG AACTGTTCAT CTTTCTCACG 420
GAAATAACGG AGACCACAAT TCCATGCCGA GTGACGGACC CGAGACTGGT GGTGACGCTG 480
CACGAGAAGA AGGTGGACGT CCCGCTGCCC ATCTCCTATG ACCACCAGCG TGGCTTCTCT 540
GGGACCTTTG AGGACAAGAC CTACGTCTGC AAAACCACCA TCGGGGACAG GGAAGTGGAT 600
TCCGACGCCT ACTATGTCTA CAGCCTCCAG GTGTCGTCCA TCAACGTCTC GGTGGGCGCC 660
GTGCAGACCG TGGTCCGCCA GGGCGAGAAC ATCACTGTCA TGTGCATCGT GACGGGCAAC 720
GAGGTGGTCA ACTTCGAGTG GACGTACCCA CGCCTGGAGA CTGGGCGGCT GGTGGAGCCA 780
GTGACGGACT TCCTCTTTGA GATGCCCCAC ATCCGTTCTA TCCTGCACAT CCCCAGTGCC 840
GAGCTGGGGG ACTCGGGGAC CTACATCTGC AACGTATCGG AGAGTGTGAG CGACCATCGA 900
GACGAAAAGG CCATCAATGT CACAGTCGTC GAGAGCGGCT ACGTGCGGCT GATTGGAGAG 960
CTGGACGCCG TGCAATTTGC GGAGCTGCAC CGCAGCCGGA CGCTGCAGGT GGTGTTCGAG 1020
GCCTACCCGC CACCCACTGT CATATGGTTC AAGGACAACC GGACCCTGGG TGACTCCGGC 1080
GCGGGCGAGA TCGCGCTGTC CACGCGCAAT GTGTCTGAGA CCCGGTATGT GTCAGAACTG 1140
ACACTGGTGC GGGTGAAGGT GGCCGAGGCT GGCCGCTACA CCATGCGCGC CTTCCACGAG 1200
GACGCCGAGG CCCAGATCTC CTTCCAGCTG CAGGTCAATG TGCCCGTCCG TGTGCTGGAG 1260
CTGAGCGAGA GCCACCCCGC CAGTGGCGAG CAGACAGTCC GCTGTCGTGG CCGAGGCATG 1320
CCCCAGCCAC ACCTCACCTG GTCCACCTGC AGCGACCTCA AAAGGTGTCC GCGCGAGCTG 1380
CCACCCACGC CGCTGGGGAA CAGCTCTGAG GAGGAGAGCC AGCTGGAGAC CAACGTGACC 1440
TACTGGCCGC AGGAGCAGGA GTTCGAGGTG GTGAGCACAC TGCGCCTGCG CCGCGTGGAT 1500
CAGCCACTCT CCGTGCGCTG CACGCTGCAC AACCTGCTGG GCCACGACGC GCAGGAGGTC 1560
ACCGTGGTGC CGCATTCCCT GCCCTTCCAG GTGGTGGTGG TCTCCGCGGT CCTGGCGCTG 1620
GTGGTCCTCA CCGTCATCTC CCTCATTATC CTCGTCATGC TCTGGCAGAA GAAGCCGCGC 1680
TACGAGATCC GGTGGAAAGT GATCGAATCC GTGAGCTCTG ATGGCCACGA GTACATTTAC 1740
GTGGACCCCA TGCAGCTGCC GTACGACTCC ACCTGGGAGC TGCCACGGGA CCAGCTCGTG 1800
CTTGGACGCA CCCTGGGCTC TGGGGCCTTT GGTCAGGTGG TGGAGGCCAC GGCTCACGGC 1860
CTGAGCCATT CTCAGGCTAC CATGAAAGTG GCCGTCAAGA TGCTGAAATC CACAGCGCGC 1920
AGCAGTGAGA AGCAAGCCCT CATGTCGGAG CTGAAGATCA TGAGTCATCT CGGGCCTCAT 1980
CTGAACGTGG TCAACCTGCT GGGGGCCTGC ACTAAAGGAG GTACCCGCCC CAGAGTGGCT 2040
GAGACCTGCC GTTGGGAATG CTTATGGCAG GTCCTCCCCC GGGGCCCCCA CTGCTTCCTG 2100
AGAAATGATC CCAAACCGGC CCCCCACCCT CCAACGGAGG AGCTCTGCGC CCTTCACCTC 2160
CCTGCAGATG AGAGCGTGAG GCGAGTCGTG ACAATGACCC CAACAGCTGA CGGGGGAAAA 2220
GGGGTGACGG ACCCAAGCAC AGATGCCATG GTTGGTGCCC TTCCCGACAC GAGTGTGCGT 2280
CCCCGGGTCC GGTATTTCAG AATTACTACT GGTAATACTA GATCCCCAGT ATCTCAGTGG 2340
TTACCCAGCG CATGGGAGAA AAACTTTAAT ATAAATTTGA GAGGGCGGGG GCCGGTGCGC 2400
AGCTACATTC CTTTTTTTTC CTTTTGTTAC AGGGCAGGTA ATTGCCTGCG TTTTCTGGGT 2460
GCCAAAAGGT GTATATATAG GAGTGTGTGT GCACGTGTTG TATACATATG TGTCAATGTG 2520
CATATGCGCA TATGCATGAT TCTCCTCTCA CGTCCTGCTT CCAGGCCAAG CCAGCTGCAG 2580
ACGGAAGGAC GGACTTGCCC GACGGAGTCC TGGACGGAGC CGCCTGATCA GCTGTTCCAT 2640
TCAGAATGGA CAGTGCTCAA CTCATTTCTG AGTCTATCAT TCATTTTAAG TCAAGTTTTT 2700
TCATTAAGTG GCACCCCGTA CCCAGAGCTG CCCATGAACG AGCAGTTCTA CAACGCCATC 2760
AAGCGGGGCT ACCGCATGGC ACAGCCTGCC CACGCCTCGG ATGAGATCTA TGAGATCATG 2820
CAGAAGTGCT GGGAAGAGAA GTTTGAGATT CGGCCCCCCT TCTCCCAGCT GGTGCTGCTT 2880
CTCGAGAGAC TCCTGGGCGA GGGTTACAAA AAGAAGTACC AGCAGGTGGA TGAGGAGTTT 2940
CTGAGGAGCG ACCACCCAGC TGTGCTCCGG TCCCAAGCCC GCCTGCCCGG CTTCCCTGGG 3000
CTGCGATCCC CCCTGGACAG CAGCCCCGTC CTCTATACGG CCGTGCAGCC CAACGAGGGT 3060
GACAACGACT ACATCATCCC CCTGCCCGAC CCCAAGCCCG AGGTGGCCGA CGAGGGCCCG 3120
CTGGAGGGCG CCCCCAGCCT GGCCAGCTCC ACCCTGAATG AAGTCAACAC CGCCTCCACC 3180
ATCTCCTGTG ACAGCCCCCT GGAGCCCCAA GAGGAGCCAG AGCCAGAGCC GCAGCTTGAA 3240
CCCCGGGGGG AGCTGGAGCC AGAACCAGAG CGGCCGCTGG AGGCAGGCTG CCCCGGGCCC 3300
CGGGCCGAGG CGGAGGACAG CTTCCTCTAG 3330
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 599   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  658
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekk.kekeeeldsk  119
         +h+n+vnllGactkgG    + e c++  l + l r  + fl++  +   ++++eel   
Q: 659   PHLNVVNLLGACTKGGTRPRVAETCRWECLWQVLPRGPHCFLRNDPKPApHPPTEELCAL  718
         ******************************************999887625678899999
S: 120   alladkslrsksslssesse..eyvdlkkd................vsdvssskadklas  161
          l+ad+s+r+ ++++  +++     d + d                +  +++ ++ ++ s
Q: 719   HLPADESVRRVVTMTPTADGgkGVTDPSTDamvgalpdtsvrprvrYFRITTGNTRSPVS  778
         9*********999876555500445555559**************999************
S: 162   ekkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllt  221
         +   sa e++ + +l      v ++  ++sf+y+  + + fl +k c++r + ar v ++
Q: 779   QWLPSAWEKNFNINLRGR-GPVRSYIPFFSFCYRAGNCLRFLGAKRCIYRSVCARVVYIC  837
         **********99887766.99***************************************
S: 222   eGkvvkicdfGlardimkdsnyvvkGnarlpvkwma.pesifdslytvksdvwsyGillw  280
             ++ic   l+r   + s+  + G +     w   p+ +f+s +tv     s   +l 
Q: 838   VNVHMRICMILLSRPASRPSQLQTEGRTCPTESWTEpPDQLFHSEWTVLNSFLSLSFILS  897
         ****************************88889*863699********************
S: 281   eifslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkql  340
         ++fsl +tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+ql
Q: 898   QVFSLSGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQL  957
         ************************************************************
S: 341   vell  344
         v ll
Q: 958   VLLL  961
         9986
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGGTRPR VAETCRWECL WQVLPRGPHC FLRNDPKPAP HPPTEELCAL 120
HLPADESVRR VVTMTPTADG GKGVTDPSTD AMVGALPDTS VRPRVRYFRI TTGNTRSPVS 180
QWLPSAWEKN FNINLRGRGP VRSYIPFFSF CYRAGNCLRF LGAKRCIYRS VCARVVYICV 240
NVHMRICMIL LSRPASRPSQ LQTEGRTCPT ESWTEPPDQL FHSEWTVLNS FLSLSFILSQ 300
VFSLSGTPYP ELPMNEQFYN AIKRGYRMAQ PAHASDEIYE IMQKCWEEKF EIRPPFSQLV 360
LLL 363
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-TUT-00117
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0060326; P:cell chemotaxis
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013