EKS-SUS-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	7.8E-126	192	478	287

Status

Unreviewed

Ensembl Protein

ENSSSCP00000016612

UniProt Accession

F1S0H6;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000015669	ENSSSCP00000016612	ENSSSCT00000017067

Organism

Sus scrofa

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGSMC NERFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCTTGTTC TTCAGGTGCT 60

ATACTTGGTA GATCAGAAAC TCAGGAGTGT ATTTTCTATA ACGCTAATTG GGAAAGAGAT 120

AGAACCAATC GAACTGGTGT TGAATCCTGT TACGGTGACA AAGATAAACG GCGGCATTGT 180

TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGATAG CCCTGAAGTA 300

TATTTTTGTT GCTGTGAGGG CAGTATGTGT AATGAAAGGT TTTCTTATTT TCCGGAGATG 360

GAAGTCACAC AGCCTACTTC GAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCTTG 420

CTCTATTCTT TGGTGCCACT TATGTTAATT GCGGGAATTG TCATTTGTGC GTTTTGGGTG 480

TACAGGCATC ATAAGATGGC TTATCCTCCT GTGCTTGTTC CAACTCAAGA CCCAGGACCA 540

CCCCCACCTT CTCCATTATT AGGTTTGAAG CCACTGCAAT TACTAGAAGT AAAAGCAAGA 600

GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTACTCAATG AATATGTGGC TGTGAAAATA 660

TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATATG AAGTCTATAG TTTGCCTGGA 720

ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGTAC CAGTGTTGAT 780

GTGGATCTTT GGCTAATCAC AGCATTTCAT GAAAAGGGTT CATTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAATTGTGT CATATTGCAG AAACCATGGC TCGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTATTG AAGAACAATC TGACTGCTTG TATTGCTGAC 1020

TTTGGGTTGG CATTAAAGTT TGAGGCTGGC AAGTCTGCAG GTGATACCCA TGGGCAGGTT 1080

GGTACCCGGA GGTATATGGC TCCAGAAGTA TTAGAGGGTG CTATTAACTT CCAAAGGGAT 1140

GCATTTTTGA GGATAGATAT GTATGCCATG GGATTAGTCC TATGGGAGCT GGCTTCTCGT 1200

TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGTTGC CATTTGAGGA GGAAATTGGC 1260

CAGCATCCCT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC AATAGAAGAA 1380

TGTTGGGATC ACGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATCATTACG ACAGAGGACA TTGTAACAGT GGTCACGATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCCAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013