EKS-SUS-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.2	4.5E-136	197	484	288

Status

Unreviewed

Ensembl Protein

ENSSSCP00000016822

UniProt Accession

F1RPT9;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000015873	ENSSSCP00000016822	ENSSSCT00000017284

Organism

Sus scrofa

Functional Description

Protein Length

495

Protein Sequence
(FASTA)

LFKCYEINLH NVSCILKLFV SPFPGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60

KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TVKASPDAPK LGPMELTIII 120

TVPVCLLSLA SVLTVWACQG RPCTYRKKKR PNVEEPLSEC NLVNAGKTLK DLIYDVTASG 180

SGSGLPLLVQ RTIARTIVLQ EIVGKGRFGE VWHGRWCGED VAVKIFSSRD ERSWFREAEI 240

YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSEYHEQGSL YDYLNRNIVT VAGMIKLALS 300

IASGLAHLHM EIVGTQGKPA IAHRDIKSKN ILVKKCETCA IADLGLAVKH DSILNTIDIP 360

QNPKVGTKRY MAPEMLDDTM NVNIFESFKR ADIYSVGLVY WEIARRCSVG GIVEEYQLPY 420

YDMVPSDPSI EEMRKVVCDQ KFRPSIPNQW QSCEALRVMG RIMRECWYAN GAARLTALRI 480

KKTISQLCVK EDCKA 495

Nucleotide Sequence
(FASTA)

CTCTTCAAGT GTTATGAAAT AAATTTGCAT AATGTCTCTT GTATCTTAAA GCTTTTTGTC 60

TCACCTTTTC CAGGTTTGAA GTGTGTTTGT CTTTTGTGTG ACTCTTCAAA CTTTACCTGC 120

CAAACAGAAG GAGCATGCTG GGCTTCAGTT ATGCTCACCA ATGGAAAGGA ACAGGTGATC 180

AAGTCCTGTG TCTCTCTCCC AGAATTAAAT GCACAAGTCT TCTGTCATAG TTCCAACAAT 240

GTTACCAAAA CAGAATGCTG CTTCACAGAT TTTTGCAACA ACATAACACT GCACCTTCCA 300

ACAGTTAAAG CATCACCAGA TGCCCCCAAA CTTGGACCCA TGGAGCTGAC CATTATTATT 360

ACTGTGCCAG TTTGCCTCTT GTCCTTGGCT TCAGTGCTGA CAGTGTGGGC ATGCCAAGGT 420

CGACCGTGCA CCTACAGAAA GAAAAAGAGA CCGAATGTGG AGGAGCCCCT CTCCGAGTGC 480

AATCTGGTAA ATGCAGGGAA AACTCTAAAA GACCTGATTT ACGACGTGAC CGCCTCTGGA 540

TCTGGCTCTG GTCTACCTCT GTTGGTTCAA AGAACAATTG CAAGGACAAT TGTACTTCAG 600

GAAATAGTAG GAAAAGGCAG ATTTGGTGAG GTCTGGCATG GAAGATGGTG TGGGGAAGAT 660

GTGGCTGTGA AGATATTCTC CTCTAGAGAT GAAAGATCTT GGTTCCGAGA GGCAGAAATT 720

TATCAGACGG TTATGCTGAG GCATGAAAAC ATCCTTGGTT TCATTGCTGC TGACAACAAA 780

GATAATGGAA CCTGGACTCA ACTTTGGCTT GTCTCTGAAT ATCATGAACA AGGCTCCCTA 840

TATGACTATT TGAACAGAAA CATAGTGACA GTGGCTGGAA TGATCAAACT GGCACTTTCA 900

ATAGCCAGTG GTCTGGCCCA CCTTCATATG GAGATTGTTG GTACACAAGG TAAACCTGCT 960

ATTGCTCATC GAGATATAAA ATCAAAGAAT ATCTTGGTGA AAAAATGTGA AACTTGTGCC 1020

ATAGCAGACT TAGGGTTGGC TGTAAAGCAT GATTCAATAC TTAACACTAT TGACATACCT 1080

CAGAATCCTA AAGTGGGAAC CAAAAGGTAC ATGGCCCCGG AAATGCTTGA TGATACTATG 1140

AATGTGAATA TCTTTGAGTC CTTCAAACGA GCTGACATCT ATTCTGTTGG TCTGGTTTAC 1200

TGGGAAATAG CTCGGAGGTG TTCAGTTGGA GGAATTGTTG AGGAGTATCA GTTGCCTTAT 1260

TATGACATGG TGCCTTCAGA TCCTTCAATA GAGGAAATGA GGAAAGTTGT TTGTGATCAG 1320

AAGTTCCGAC CAAGTATCCC AAACCAATGG CAAAGCTGTG AAGCACTCCG AGTCATGGGG 1380

AGAATAATGC GTGAGTGTTG GTATGCCAAT GGGGCAGCCC GCCTAACCGC TCTTCGGATT 1440

AAGAAGACTA TTTCTCAACT TTGTGTCAAA GAAGACTGCA AAGCCTGA 1488

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 197   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  256

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 257   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  316

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 317   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  374

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 375   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  433

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 434   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  484

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013