EKS-SUS-00137

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00137

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	614.2	3.3E-185	410	688	279

Status

Unreviewed

Ensembl Protein

ENSSSCP00000016897

UniProt Accession

F1S1U4;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000015944	ENSSSCP00000016897	ENSSSCT00000017361

Organism

Sus scrofa

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVASGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SESSRGRKRK AENQNESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQSSHS HSTPSSSVRP NSPSPTALAF GDHPIVQPKQ LSFKITQTDL TMLKLAALES 180

NKNQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LSSREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTANN SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATDVQ FPVKPVVSSE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTASP TPPSSSIITY 720

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAACTTCA TAGTCTGGAT CCAAGAAGGC AAGAATTATT GGAAGCTAGA 60

TTTACAGGAG TTGCAAGTGG GAGCACAGGG AGCACGGGCA GTTGCAGTGT TGGAGCTAAA 120

GCCTCAACAA ATAATGAAAG CTCTAATCAC AGTTTTGGAA GCTTGGGATC TTTAAGTGAC 180

AAAGAATCAG AGACACCAGA GAAGAAGCAA TCAGAATCAT CTAGAGGAAG AAAGAGAAAA 240

GCAGAAAACC AGAATGAAAG TAGTCAGGGA AAAAGTATTG GGGGACGTGG CCACAAAATT 300

AGCGACTATT TTGAATACCA AGGTGGGAAT GGCTCAAGTC CAGTAAGAGG CATACCTCCT 360

GCAATCCGTT CTCCTCAGAG TTCACATTCA CATTCCACTC CTTCCTCATC TGTTCGACCG 420

AATAGCCCTT CTCCTACTGC GTTAGCTTTT GGGGACCACC CTATTGTACA ACCAAAGCAG 480

TTATCCTTTA AAATAACTCA GACTGATCTT ACAATGCTGA AATTAGCAGC ATTAGAAAGT 540

AATAAAAACC AGGACCTGGA AAAGAAGGAA GGTCGTATAG ATGACTTGCT CAGGGCTAAC 600

TGTGATCTCA GACGGCAGAT AGATGAACAA CAAAAATTAC TTGAAAAATA CAAAGAACGA 660

TTAAATAAAT GTATATCAAT GAGCAAGAAA CTGCTTATTG AAAAGAGTAC ACAAGAAAAA 720

TTGTCAAGCC GAGAGAAGAG TATGCAAGAC CGATTACGCC TTGGGCATTT TACAACAGTT 780

AGACATGGTG CTTCATTTAC TGAACAATGG ACAGATGGTT TTGCATTTCA GAATCTCGTA 840

AAGCAACAAG AATGGGTGAA TCAGCAAAGG GAAGATATTG AAAGGCAAAG GAAACTTCTA 900

GCCAAACGCA AACCTCCCAC AGCTAATAAT TCTCAGGCAC CCTCTACCAA TTCTGAACCA 960

AAACAAAGGA AAAATAAAGC AGTCAATGGA GCAGAAAATG ATCCTTTTGT TAGACCAAAT 1020

TTACCACAAT TGTTGACTCT GGCAGAATAT CATGAACAGG AGGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAGGCAGAA ATCCAGGCAG AACTTGAACG TTTGGAAAGA 1140

GTTAGAAATC TTCACATCCG AGAGCTCAAA AGAATAAATA ATGAAGATAA TTCACAGTTC 1200

AAGGATCATC CAACATTAAA TGAAAGATAT TTATTACTTC ATCTGCTTGG TAGAGGTGGC 1260

TTTAGTGAAG TGTATAAGGC TTTTGACCTT TATGAACAAC GATATGCTGC TGTGAAGATC 1320

CATCAGCTTA ATAAAAGCTG GAGGGATGAG AAGAAGGAAA ACTACCACAA ACATGCCTGT 1380

AGAGAATATA GAATACACAA GGAACTGGAT CACCCCAGAA TAGTTAAACT CTATGATTAT 1440

TTCTCCTTGG ATACAGATAC GTTTTGTACA GTGTTGGAAT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TGAAGCAACA TAAGTTAATG TCAGAGAAAG AAGCTAGGTC TATTGTAATG 1560

CAAATTGTAA ATGCACTAAG ATATCTTAAT GAAATCAAAC CCCCTATTAT ACATTATGAT 1620

CTTAAACCAG GAAACATCCT TCTGGTAGAT GGAACAGCAT GTGGGGAAAT CAAAATCACT 1680

GATTTTGGTC TGTCCAAGAT TATGGATGAT GATAGCTATG GTGTAGATGG AATGGATCTA 1740

ACCTCCCAAG GGGCAGGCAC TTACTGGTAT TTACCTCCTG AGTGTTTTGT AGTTGGAAAA 1800

GAACCACCAA AGATTTCCAA CAAGGTTGAT GTGTGGTCAG TAGGAGTCAT CTTCTTTCAG 1860

TGTCTTTATG GTAGAAAGCC ATTTGGTCAC AATCAATCTC AACAAGACAT TCTCCAAGAA 1920

AATACAATAT TAAAAGCCAC GGATGTCCAG TTCCCTGTGA AACCGGTTGT AAGCAGTGAA 1980

GCAAAGGCCT TTATAAGACG CTGTTTGGCA TACCGAAAAG AAGATAGATT TGACGTGCAC 2040

CAACTGGCAA ATGACCCCTA CCTTCTCCCG CACATGAGAA GATCCAATTC TTCAGGAAAC 2100

TTACACATGG CTGGGCTGAC GGCATCCCCT ACACCCCCTT CTTCAAGCAT AATTACTTAC 2160

TGA 2163

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkat+

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATD  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATDV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013