EKS-SUS-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	313.9	1.0E-93	17	262	246

Status

Unreviewed

Ensembl Protein

ENSSSCP00000016913

UniProt Accession

F1S066;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100152572

Gene Synonyms/Alias

LOC100152572;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000015960	ENSSSCP00000016913	ENSSSCT00000017378

Organism

Sus scrofa

Functional Description

Protein Length

629

Protein Sequence
(FASTA)

MSSLGTSFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMDHIMTW ATDVAKGKGM 120

HYLHMEAPVK VIHRDLKSRN VVIAADGVLK ICDFGASRFH NHTTHMSLVG TFPWMAPEVI 180

QSLPVSETCD TYSYGVVLWE MLTREVPFKG LEGLQVAWLV VEKNERLTIP SSCPRSFAEL 240

LHQCWEADPK KRPSFKQIIS ILESMSNDTN LPDQCNSFLH NKAEWRCEIE ATLERLKKLE 300

RDLSFKEQEL KERERRLKMW EQKLTEQSNT PLLPSFEIGA WTEDDVYFWV QQLVRKGDSS 360

AEMSVYASLF KENNITGKRL LLLEEEDLKD MGIVSKGHII HLKSAIEKLT HDYLNLFHFP 420

PLIKDSVGEP EENEEKIVNL ELVFGFHLKP GTGPQDCKWK MYMEMDGDEI AITYIKDVTF 480

NTNLPDAEIL KMTKPPFVME KWIIGILENQ TVECTVTYES DVRTPKSTKH VHSIKWSKTK 540

PQDEVKAVQL AIQTSFSNSE GNPRSRSDSS ADCQWLDTLR MRQIASNTSL QRSQSNPILG 600

SQFFPYFHDP DSYAAAVRRT QVPIKYQQI 629

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGTACCTC CTTTGTGCAA ATTAAATTTG ATGACTTGCA GTTTTTCGAA 60

AACTGCGGCG GAGGAAGTTT TGGGAGTGTC TATCGAGCCA AATGGATATC ACAGGACAAG 120

GAGGTGGCTG TGAAGAAGCT ACTCAAAATA GAGAAAGAGG CAGAAATACT CAGTGTCCTC 180

AGTCACAGAA ACATCATCCA GTTTTATGGA GTAATTCTTG AACCTCCCAA CTATGGTATC 240

GTCACAGAAT ATGCTTCTCT GGGATCACTC TATGATTACA TTAACAGTAA CAGAAGTGAA 300

GAGATGGACA TGGATCACAT TATGACCTGG GCCACTGATG TAGCCAAAGG AAAAGGAATG 360

CACTATTTAC ACATGGAGGC TCCTGTCAAG GTGATTCACA GAGATCTCAA GTCAAGAAAT 420

GTTGTTATAG CTGCTGATGG GGTGTTGAAG ATCTGCGACT TTGGCGCCTC TCGGTTCCAC 480

AACCATACAA CACACATGTC CTTGGTGGGA ACTTTCCCAT GGATGGCACC AGAAGTTATC 540

CAAAGTCTCC CTGTGTCTGA AACTTGTGAC ACATATTCCT ATGGTGTGGT TCTCTGGGAG 600

ATGCTAACAA GGGAGGTCCC CTTTAAAGGT TTGGAAGGAT TACAAGTAGC TTGGCTTGTA 660

GTGGAAAAAA ACGAGAGATT AACCATTCCA AGCAGTTGCC CCAGGAGTTT TGCTGAACTG 720

TTACATCAGT GTTGGGAAGC TGATCCCAAG AAACGGCCAT CTTTCAAGCA GATCATTTCA 780

ATTCTGGAGT CCATGTCGAA TGACACGAAC CTTCCTGACC AGTGTAACTC ATTCCTGCAC 840

AACAAGGCAG AGTGGAGGTG CGAAATCGAA GCAACTCTTG AGAGGCTGAA GAAACTAGAA 900

CGTGACCTCA GCTTTAAAGA GCAGGAGCTC AAAGAACGAG AAAGGCGTCT GAAGATGTGG 960

GAGCAAAAGC TGACGGAGCA GTCCAACACC CCGCTGCTGC CTTCCTTTGA GATTGGTGCT 1020

TGGACGGAAG ATGACGTGTA TTTTTGGGTT CAGCAACTCG TCAGAAAAGG TGACTCGTCA 1080

GCAGAGATGA GTGTGTATGC AAGCTTGTTT AAGGAAAACA ACATAACGGG AAAGCGACTG 1140

CTGCTTCTCG AGGAAGAAGA CTTGAAAGAC ATGGGCATCG TCTCCAAGGG GCATATCATC 1200

CATTTAAAGT CAGCCATTGA GAAATTAACC CACGATTACC TAAACTTGTT TCACTTCCCA 1260

CCACTTATTA AGGACTCAGT AGGAGAACCT GAAGAAAATG AGGAAAAAAT AGTGAACCTT 1320

GAACTTGTTT TTGGTTTTCA CTTGAAACCA GGAACTGGCC CACAGGATTG TAAGTGGAAA 1380

ATGTATATGG AGATGGATGG GGATGAAATT GCAATAACGT ACATCAAAGA TGTAACATTC 1440

AACACTAACC TGCCTGACGC AGAGATTTTA AAGATGACAA AGCCCCCGTT TGTAATGGAG 1500

AAGTGGATTA TAGGAATACT GGAAAATCAG ACTGTAGAAT GCACTGTCAC ATACGAGAGC 1560

GACGTTAGAA CTCCAAAAAG CACTAAACAC GTCCATTCAA TTAAGTGGAG TAAAACGAAA 1620

CCTCAGGATG AAGTGAAAGC CGTCCAGCTT GCCATTCAGA CGTCATTCTC CAACTCAGAG 1680

GGCAACCCCA GAAGCAGGTC TGACTCAAGT GCCGACTGCC AGTGGTTGGA CACTCTGAGG 1740

ATGCGGCAGA TTGCGTCCAA CACGTCTTTA CAGCGCTCCC AGAGCAACCC CATCCTGGGG 1800

TCACAATTCT TTCCCTACTT CCATGACCCA GACTCCTATG CTGCTGCTGT GAGGCGGACT 1860

CAGGTGCCCA TTAAGTATCA ACAGATAA 1888

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiAr..GmaYLhse  117

         +++Gv+le+pn+++v+ey++ gsL++++++++++e+d++++++wa+++A+  Gm+YLh e

Q: 67    QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKgkGMHYLHME  126

         *************************************************6337*******

S: 118   apkkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekv  177

         ap+k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +v

Q: 127   APVKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPV  185

         *****************.******************************************

S: 178   seksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecw  237

         se++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw

Q: 186   SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW  245

         ************************************************************

S: 238   nedpekRpsfseivksl  254

         ++dp+kRpsf++i+++l

Q: 246   EADPKKRPSFKQIISIL  262

         *************9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII QFYGVILEPP 60

NYGIVTEYAS LGSLYDYINS NRSEEMDMDH IMTWATDVAK GKGMHYLHME APVKVIHRDL 120

KSRNVVIAAD GVLKICDFGA SRFHNHTTHM SLVGTFPWMA PEVIQSLPVS ETCDTYSYGV 180

VLWEMLTREV PFKGLEGLQV AWLVVEKNER LTIPSSCPRS FAELLHQCWE ADPKKRPSFK 240

QIISIL 246

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0007050	; P:cell cycle arrest
GO:0007010	; P:cytoskeleton organization
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013