EKS-SUS-00250

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SUS-00250

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	390.1	7.3E-117	178	476	299

Status

Unreviewed

Ensembl Protein

ENSSSCP00000030123

UniProt Accession

F1SI16; F1CK16;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein type II receptor;

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSSCG00000016113	ENSSSCP00000030123	ENSSSCT00000034104
ENSSSCG00000016113	ENSSSCP00000030356	ENSSSCT00000034414
ENSSSCG00000016113	ENSSSCP00000017072	ENSSSCT00000017544
ENSSSCG00000016113	ENSSSCP00000028426	ENSSSCT00000034069

Organism

Sus scrofa

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

ASQNQERLCA FKDPYQQDLG IGESRISHEN GTILCSKGST CYGLWEKSKG DINLVKQGCW 60

SHIGDPQECH YEECVVTTTP PSIQNGTYRF CCCSTDLCNV NFTENFPPPD TTPLSPPHSF 120

NQDETIIIAL ASVSVLAVLI VALCFGYRML TGDRKQGLHS MNMMEAAASE PSLDLDNLKL 180

LELIGRGRYG SVYKGSLDER PVAVKVFSFA NRQNFINEKS IYRVPLMEHD NIARFIVGDE 240

RVTADGRMEY LLVMEYYPNG SLCKYLSLHT SDWVSSCRLA HSVTRGLAYL HTELPRGDHY 300

KPAISHRDLN SRNVLVKNDG TCVISDFGLS MRLTGNRLVR PGEEDNAAIS EVGTIRYMAP 360

EVLEGAVNLR DCESALKQVD MYALGLIYWE IFMRCTDLFP GESVPEYQMA FQTEVGNHPT 420

FEDMQVLVSR EKQRPKFPEA WKENSLAVRS LKETIEDCWD QDAEARLTAQ CAEERMAELM 480

MIWERNKSVS PTVNPMSTAM QNERR 505

Nucleotide Sequence
(FASTA)

GCTTCTCAGA ATCAAGAACG TCTGTGTGCA TTTAAAGATC CATATCAGCA AGACCTTGGA 60

ATAGGTGAGA GTCGAATCTC TCATGAAAAT GGAACAATAT TATGCTCAAA AGGTAGCACC 120

TGCTATGGCC TTTGGGAGAA ATCAAAAGGG GACATAAATC TGGTAAAACA AGGATGTTGG 180

TCTCACATTG GAGATCCCCA GGAGTGTCAC TATGAAGAAT GTGTAGTAAC TACCACCCCA 240

CCCTCCATTC AGAATGGAAC ATATCGTTTC TGCTGCTGTA GCACAGATTT GTGTAATGTC 300

AACTTTACTG AGAATTTTCC ACCTCCAGAC ACAACACCAC TCAGTCCACC TCATTCATTT 360

AACCAAGATG AGACAATAAT CATTGCTCTG GCATCAGTTT CTGTATTAGC TGTTTTGATA 420

GTTGCCTTAT GCTTTGGATA CAGGATGCTG ACAGGAGATC GTAAACAAGG TCTTCACAGT 480

ATGAACATGA TGGAGGCAGC GGCATCAGAG CCCTCTCTCG ACCTGGATAA TCTGAAACTG 540

TTGGAGCTGA TTGGCCGTGG TCGATATGGA TCTGTATATA AAGGTTCCTT AGATGAACGT 600

CCAGTTGCTG TAAAGGTGTT TTCCTTTGCA AACCGCCAGA ATTTTATCAA TGAGAAGAGT 660

ATTTACAGAG TGCCTTTGAT GGAACATGAC AACATTGCTC GCTTTATAGT TGGAGATGAG 720

AGAGTTACTG CTGATGGACG CATGGAGTAT TTGCTTGTGA TGGAGTATTA TCCCAATGGA 780

TCTCTATGCA AGTATTTAAG CCTCCATACA AGTGACTGGG TAAGCTCTTG CCGCCTGGCT 840

CATTCTGTGA CTAGAGGACT GGCTTATCTT CATACAGAAT TACCTCGAGG AGATCACTAT 900

AAACCTGCAA TTTCCCATCG CGATTTAAAT AGCAGAAATG TTCTGGTGAA AAATGATGGG 960

ACCTGTGTTA TTAGTGACTT TGGGCTGTCC ATGAGACTGA CTGGAAATAG ATTGGTGCGC 1020

CCAGGGGAGG AAGATAATGC AGCCATAAGT GAGGTTGGCA CAATCAGATA CATGGCACCA 1080

GAAGTTCTAG AAGGAGCTGT GAACCTGAGG GACTGTGAAT CAGCTTTGAA ACAAGTAGAC 1140

ATGTATGCAC TTGGACTAAT CTATTGGGAG ATATTTATGA GATGTACAGA TCTCTTCCCA 1200

GGTGAATCTG TACCAGAATA CCAGATGGCT TTTCAGACAG AGGTTGGAAA TCATCCCACT 1260

TTTGAAGATA TGCAGGTTCT GGTGTCTAGA GAAAAACAGA GACCCAAGTT CCCAGAAGCT 1320

TGGAAAGAAA ATAGCCTGGC AGTGAGGTCA CTCAAGGAGA CAATCGAAGA CTGTTGGGAC 1380

CAGGATGCAG AGGCTCGGCT TACTGCACAG TGTGCTGAGG AGAGGATGGC TGAACTTATG 1440

ATGATATGGG AAAGAAACAA ATCTGTGAGC CCAACAGTCA ATCCCATGTC TACTGCTATG 1500

CAGAATGAGC GTAGGTGA 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek iy+++l++h+ni +fi+

Q: 178   LKLLELIGRGRYGSVYKGSLDERPVAVKVFSFANRQNFINEKSIYRVPLMEHDNIARFIV  237

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 238   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  297

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 298   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  356

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 357   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  416

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 417   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  476

         ***************************9999*************************9997

Domain Sequence
(FASTA)

LKLLELIGRG RYGSVYKGSL DERPVAVKVF SFANRQNFIN EKSIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Receptor; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0009267	; P:cellular response to starvation
GO:0048286	; P:lung alveolus development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0001707	; P:mesoderm formation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0003085	; P:negative regulation of systemic arterial blood pressure
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	; P:regulation of lung blood pressure
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841	; P:venous blood vessel development

KEGG

ssc:100127483

;

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013