EKS-SUS-00009
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SUS-00009
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph433.23.1E-130631885255
StatusUnreviewed
Ensembl ProteinENSSSCP00000017441
UniProt AccessionF1SRW1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSSCG00000016459ENSSSCP00000017441ENSSSCT00000017922
OrganismSus scrofa
Functional Description
Protein Length982
Protein Sequence
(FASTA)
MERRWAPGLR LLLLLLCALL PPGARAKEVT LMDTSTAQGE LGWLLDPPED GWSEVQQILN 60
GKPLYMYQDC PVQEGRDTDH WLRSNWIYRG EEASRVHVEL QFTVRDCKSF PGEAGPLGCK 120
ETFNLLYMES DQDVGVQLRR PLFQKVTTVA ADQSFTVRDL ASGAVKLNVE RCSLGHLTRR 180
GLYLAFHNPG ACVALVSVRV FYQRCPEAVH GLARFPDTLP GPGGLVEVAG TCLPHAQVIP 240
GPSGAPRMHC SPDGEWLVPV GQCHCEPGYE EGSGGAEGCL ACPSGSYRPD VDTAHCLKCP 300
QHSTAASEGA TVCTCEGGHY RAPGEGPQAA CTRPPSVPRN LSFSVSGTQL SLHWEPPADM 360
GGRQDVRYNV RCSQCQGAAL DEGPCQPCGG SVRFSPGPSG LTTPAVRVDG LEPYANYTFN 420
VEAQNGVSGL TASMHTSASI SISMGHAESL SGLSLRLVKK APRQLELTWA GSRPRSPGGN 480
LSYELHVLNQ NEERHQMVLE PRVLLTELQP DTTYIVRVRM LTPLGPGPFS PDHEFRTSPP 540
VSRVLTGGEI VAIVFGLLLG VALLLGVLVF RSRKSQQRRR HQRQQRQRDR VTDGDREDKL 600
WLKPYVDLQA YEDPAQGALD FTQELDPAWL VVDTVIGEGE FGEVYRGSLR TPSQDAKTVA 660
IKTLKDTSPD GQWWNFLREA TIMGQFNHPH ILHLEGVVTK RKPIMIITEF MENGALDAFL 720
REREDQLVPG QLVAMLQGIA SGMNYLSDHN YVHRDLAARN ILVNQNLCCK VSDFGLTRLL 780
DNFDGTYETQ GGKIPIRWTA PEAIAHRIFT TASDVWSFGI VMWEVLSFGD KPYGEMSNQE 840
VMKSIEDGYR LPPPVDCPAP LYELMKNCWA YERARRPPFH RLKAQLEHLH ANPHSLRTIA 900
NFDPRVTLRL PSLSGSDGIP YRSVAEWLES IRMKRYILHF RSAGLDTMEC VLELTAEDLT 960
QMGITLPGHQ KRILCSIQGF KD 982
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GTTGGGCCCC GGGGCTCAGG CTGCTGCTGC TGCTGCTCTG CGCCCTGCTG 60
CCCCCGGGGG CGCGCGCCAA GGAAGTCACT CTGATGGACA CTAGCACAGC GCAGGGAGAG 120
CTGGGCTGGC TGCTGGATCC CCCAGAGGAT GGGTGGAGTG AGGTGCAGCA GATACTGAAT 180
GGGAAACCCC TCTACATGTA CCAGGACTGC CCAGTGCAAG AGGGCAGAGA CACTGACCAC 240
TGGCTTCGCT CCAATTGGAT CTACCGGGGG GAAGAAGCCT CGCGTGTCCA CGTGGAGCTG 300
CAGTTCACTG TGCGGGACTG CAAGAGTTTC CCCGGGGAAG CCGGGCCTCT GGGCTGCAAG 360
GAGACCTTCA ACCTGCTGTA CATGGAGAGT GACCAGGACG TGGGCGTTCA GCTCCGGCGG 420
CCCTTGTTCC AGAAGGTCAC CACGGTGGCT GCAGACCAGA GCTTCACCGT TCGAGACCTC 480
GCATCTGGAG CCGTGAAGCT GAACGTGGAG CGCTGCTCCT TGGGCCACCT GACCCGCCGA 540
GGCCTCTACC TCGCCTTCCA TAACCCCGGT GCCTGTGTGG CCCTGGTGTC TGTCCGGGTG 600
TTCTACCAGC GTTGTCCAGA GGCTGTGCAT GGCTTGGCCC GATTCCCGGA CACTCTCCCC 660
GGACCCGGCG GGTTGGTGGA AGTGGCGGGG ACCTGCTTGC CCCATGCCCA GGTCATCCCT 720
GGCCCCTCCG GTGCACCCCG CATGCACTGC AGCCCGGATG GCGAGTGGTT GGTGCCCGTG 780
GGGCAGTGCC ACTGTGAGCC TGGCTATGAG GAAGGCAGCG GCGGCGCTGA GGGATGCCTT 840
GCCTGCCCAA GCGGCTCCTA CCGGCCTGAT GTGGACACAG CCCACTGTCT CAAGTGCCCC 900
CAGCACAGCA CAGCCGCGTC TGAAGGAGCC ACTGTCTGTA CCTGCGAGGG GGGGCACTAC 960
CGAGCCCCTG GGGAGGGCCC CCAGGCAGCC TGCACACGAC CCCCCTCAGT CCCCCGAAAC 1020
CTGAGCTTCT CTGTTTCGGG GACCCAGCTC TCCCTGCACT GGGAACCCCC AGCAGACATG 1080
GGGGGGCGCC AGGATGTCAG ATACAACGTG AGGTGTTCCC AGTGTCAGGG AGCAGCGCTG 1140
GACGAGGGGC CCTGCCAGCC CTGTGGGGGA AGCGTGCGCT TCTCCCCGGG GCCCAGTGGG 1200
CTCACCACGC CTGCGGTGCG TGTGGACGGC CTCGAACCCT ACGCCAACTA CACCTTTAAC 1260
GTCGAAGCCC AGAATGGAGT GTCAGGGCTG ACCGCCTCCA TGCACACCAG CGCCTCCATC 1320
AGCATCAGCA TGGGGCATGC AGAGTCCCTG TCAGGCCTGT CCCTGAGGCT GGTGAAGAAG 1380
GCGCCACGGC AGCTGGAGCT GACCTGGGCA GGGTCCCGGC CTCGCAGCCC TGGGGGGAAC 1440
CTCAGCTACG AGCTGCACGT GCTGAACCAG AACGAAGAAC GGCACCAGAT GGTTCTAGAA 1500
CCCAGGGTCC TGCTGACCGA ACTGCAGCCA GACACCACGT ACATCGTCAG AGTCCGGATG 1560
TTGACCCCTC TGGGCCCTGG CCCCTTCTCC CCTGACCATG AGTTTCGGAC CAGCCCACCA 1620
GTTTCCAGGG TCCTGACCGG AGGAGAGATT GTGGCCATCG TCTTCGGGCT GCTGTTGGGT 1680
GTAGCTCTGC TGCTCGGGGT TCTTGTCTTC CGTTCCAGGA AATCTCAGCA GCGACGACGA 1740
CACCAGAGGC AGCAGAGGCA GCGTGATCGT GTCACTGATG GGGACAGGGA GGATAAGCTG 1800
TGGCTGAAGC CTTACGTGGA CCTCCAGGCC TATGAGGACC CTGCCCAGGG AGCCCTGGAC 1860
TTCACCCAGG AGCTGGATCC AGCCTGGCTG GTTGTGGACA CCGTCATAGG AGAGGGAGAG 1920
TTTGGGGAAG TGTATCGAGG GTCCCTGAGA ACCCCCAGCC AGGACGCCAA GACTGTGGCC 1980
ATCAAGACCT TGAAAGACAC CTCTCCAGAC GGCCAGTGGT GGAACTTCCT TCGAGAGGCT 2040
ACAATCATGG GCCAGTTCAA CCACCCACAC ATTCTGCACC TGGAAGGCGT TGTCACAAAG 2100
CGAAAGCCCA TTATGATCAT CACGGAGTTT ATGGAGAACG GAGCTCTGGA TGCTTTCCTG 2160
AGGGAACGAG AGGACCAGCT AGTCCCTGGG CAGCTGGTGG CCATGCTGCA GGGCATAGCA 2220
TCCGGCATGA ACTACCTCAG TGACCACAAT TATGTCCACC GGGACCTGGC CGCCAGGAAC 2280
ATCTTGGTGA ATCAGAACCT GTGCTGCAAG GTGTCTGACT TTGGCCTGAC CCGCTTGTTG 2340
GACAACTTTG ATGGCACCTA TGAAACCCAG GGAGGCAAGA TCCCCATCCG CTGGACAGCC 2400
CCCGAAGCCA TTGCCCACCG GATCTTCACC ACCGCCAGCG ACGTGTGGAG CTTTGGCATC 2460
GTGATGTGGG AGGTGCTGAG CTTTGGGGAC AAGCCCTATG GGGAGATGAG CAATCAGGAG 2520
GTAATGAAGA GCATTGAGGA TGGGTACCGG CTGCCCCCGC CCGTGGACTG CCCTGCGCCC 2580
CTGTATGAAC TCATGAAGAA CTGCTGGGCC TATGAGCGAG CCCGTCGGCC CCCCTTCCAT 2640
CGCCTGAAGG CACAGCTGGA GCATTTGCAT GCCAACCCGC ACTCCCTGCG GACCATTGCC 2700
AATTTTGATC CCAGGGTGAC CCTGCGCCTG CCCAGCTTGA GTGGCTCGGA CGGGATCCCC 2760
TACCGAAGCG TGGCTGAGTG GCTGGAGTCC ATCCGAATGA AACGCTACAT CCTGCACTTC 2820
CGCTCGGCCG GGCTGGACAC CATGGAGTGT GTGCTGGAGC TGACGGCGGA GGACCTGACG 2880
CAGATGGGAA TCACGCTGCC GGGACACCAG AAGCGCATTC TTTGCAGTAT TCAGGGGTTC 2940
AAAGACTGA 2949
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
          +++viG+GefGev++G+l++p++   +vaiktlk++s + q+++fl+ea+i+Gqf+hp+
Q: 631   VVDTVIGEGEFGEVYRGSLRTPSQDAKTVAIKTLKDTSPDGQWWNFLREATIMGQFNHPH  690
         5899********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGvvtk+kp+mi+te+mengald+flr++++q++  qlv+ml+Giasgm+ylsd++
Q: 691   ILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSDHN  750
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvn+nl+ckvsdfGl+r l d+ + +y+t+ggkipirwtapeaia+r f
Q: 751   YVHRDLAARNILVNQNLCCKVSDFGLTRLL-DNFDGTYETQGGKIPIRWTAPEAIAHRIF  809
         ****************************98.7789*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 810   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  869
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           +ra+rp f+++++ 
Q: 870   AYERARRPPFHRLKAQ  885
         **********999875
Domain Sequence
(FASTA)
VVDTVIGEGE FGEVYRGSLR TPSQDAKTVA IKTLKDTSPD GQWWNFLREA TIMGQFNHPH 60
ILHLEGVVTK RKPIMIITEF MENGALDAFL REREDQLVPG QLVAMLQGIA SGMNYLSDHN 120
YVHRDLAARN ILVNQNLCCK VSDFGLTRLL DNFDGTYETQ GGKIPIRWTA PEAIAHRIFT 180
TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YERARRPPFH RLKAQ 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
ssc:100519989;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013